A Suprachiasmatic Nucleus Generated Rhythm In Basal Glucose Concentrations
Abstract
The daily rhythm in feeding activity in mammals, as driven by the biological clock, largely determines the daily fluctuations in basal concentrations of glucose and insulin. To investigate a possible direct impact of the suprachiasmatic nucleus (SCN) on these parameters, we subjected intact rats and SCN‐lesioned rats to a fasting regimen of 36 h, or to a scheduled feeding regimen of six identical meals equally distributed over the light:dark‐cycle. Plasma profiles of glucose and insulin in rats during the final 24 h of the 36 h of fasting, and in rats subjected to the scheduled feeding regimen were compared to profiles in rats fed ad libitum. In rats fed ad libitum, in fasted rats and in rats subjected to a scheduled feeding regimen basal glucose concentrations showed a pronounced 24‐h rhythm that was not found in rats that had been SCN‐lesioned. Basal insulin levels showed a 24‐h rhythm in 50% of the rats fed ad libitum and in 50% of the rats subjected to a scheduled feeding regimen; neither rhythms were present in SCN‐lesioned rats. However, none of the fasted rats showed a 24‐h rhythm in basal insulin concentrations. These data provide clear evidence that the SCN directly controls basal glucose concentrations independent of its influence on feeding activity. At the same time, we found no consistent evidence for a strong impact of the SCN on basal insulin concentrations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
We did not find an obvious and direct influence of the SCN on basal plasma insulin or glucagon concentrations.
“On the other hand, we did not find an obvious and direct influence of the SCN on basal plasma insulin or glucagon concentrations [58,59].”
From Circadian control of glucose metabolism (2014) · cites this paper as [58]
The SCN has a direct influence on plasma glucose concentrations independent of the feeding rhythm.
“which clearly suggests a direct influence of the SCN on plasma glucose concentrations, independent of the feeding rhythm [58].”
From Circadian control of glucose metabolism (2014) · cites this paper as [58]
The daily rhythm in basal plasma glucose concentrations of 6-meals-a-day fed animals resembled the daily rhythm observed in ad libitum fed animals.
“In addition, the daily rhythm in basal plasma glucose concentrations of the 6-meals-a-day fed animals nicely resembled the daily rhythm – a daily rise at the time of awakening – observed in animals fed ad libitum”
From Circadian control of glucose metabolism (2014) · cites this paper as [58]
Cites
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402 · see citing works
Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
Dallman, M. F., Strack, A. M., Akana, S. F., Bradbury, M. J., Hanson, E. S., Scribner, K. A., & Smith, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1010 · Cited by 796 · see citing works
Steffens, A. B. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90126-7 · Cited by 499 · see citing works
Buijs, R. M., Wortel, J., Van Heerikhuize, J. J., Feenstra, M. G. P., Ter Horst, G. J., Romijn, H. J., & Kalsbeek, A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00575.x · Cited by 485 · see citing works
Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm
Van Cauter, E., Shapiro, E. T., Tillil, H., & Polonsky, K. S. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.4.e467 · Cited by 240 · see citing works
Diurnal and Ultradian Rhythms in Human Endocrine Function: A Minireview
Cauter, E. V. (2008) · Hormone Research · doi:10.1159/000181794 · Cited by 231 · see citing works
Diurnal Variation in Glucose Tolerance and in Insulin Secretion in Man
Carroll, K. F., & Nestel, P. J. (1973) · Diabetes · doi:10.2337/diab.22.5.333 · Cited by 231 · see citing works
Boden, G., Chen, X., & Urbain, J. L. (1996) · Diabetes · doi:10.2337/diab.45.8.1044 · Cited by 228 · see citing works
Escobar, C., Díaz‐Muñoz, M., Encinas, F. L., & Aguilar‐Roblero, R. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1309 · Cited by 150 · see citing works
Suprachiasmatic nucleus lesion increases corticosterone secretion
Buijs, R. M., Kalsbeek, A., van der Woude, T. P., van Heerikhuize, J. J., & Shinn, S. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.6.r1186 · Cited by 149 · see citing works
Food intake and chemical senses
Katsuki, Y., Sato, M., Takagi, S., et al. (1977) · Cited by 147 · see citing works
Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats
de Boer, S. F., & van der Gugten, J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90054-0 · Cited by 142 · see citing works
Circadian Control of Insulin Secretion Is Independent of the Temporal Distribution of Feeding
Kalsbeek, A., & Strubbe, J. H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00493-9 · Cited by 142 · see citing works
Kalsbeek, A., van der Vliet, J., & Buijs, R. M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04597.x · Cited by 138 · see citing works
Shamoon, H., Hendler, R., & Sherwin, R. S. (1980) · Diabetes · doi:10.2337/diab.29.4.284 · Cited by 133 · see citing works
Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans
Plat, L., Byrne, M. M., Sturis, J., Polonsky, K. S., Mockel, J., Fery, F., & Van Cauter, E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e36 · Cited by 132 · see citing works
Demonstration of a Dawn Phenomenon in Normal Human Volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P. J., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diab.33.12.1150 · Cited by 129 · see citing works
Buijs, R. M., Wortel, J., van Heerikhuize, J. J., & Kalsbeek, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00234-5 · Cited by 103 · see citing works
Peret, J., MaCaire, I., & Chanez, M. (1973) · The Journal of Nutrition · doi:10.1093/jn/103.6.866 · Cited by 91 · see citing works
Pauly, J. E., & Scheving, L. E. (1967) · American Journal of Anatomy · doi:10.1002/aja.1001200312 · Cited by 89 · see citing works
Circadian Insulin, GH, Prolactin, Corticosterone and Glucose Rhythms in Fed and Fasted Rats
Bellinger, L. L., Mendel, V. E., & Moberg, G. P. (1975) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093763 · Cited by 86 · see citing works
Interaction between circadian and caloric control of feeding behavior in the rat
STRUBBE, J. H., Keyser, J., Dijkstra, T., & Prins, A. J. A. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90320-3 · Cited by 82 · see citing works
Nocturnal Elevation of Glucose Levels during Fasting in Noninsulin-Dependent Diabetes*
Shapiro, E. T., Polonsky, K. S., Copinschi, G., Bosson, D., TILLIL, H., Blackman, J. D., Lewis, G. F., & Cauter, E. V. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-444 · Cited by 65 · see citing works
Bright, G. M., Melton, T. W., Rogol, A. D., & Clarke, W. L. (1980) · Diabetes · doi:10.2337/diab.29.8.662 · Cited by 60 · see citing works
Electrical stimulation of the suprachiasmatic nucleus of the hypothalamus causes hyperglycemia
Nagai, K., Fujii, T., Inoue, S., Takamura, Y., & Nakagawa, H. (1988) · Hormone and Metabolic Research · doi:10.1055/s-2007-1010743 · Cited by 59 · see citing works
Sympathoadrenal influence on glucose, FFA, and insulin levels in exercising rats
Scheurink, A. J. W., Steffens, A. B., Bouritius, H., et al. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.1.r161 · Cited by 49 · see citing works
STRUBBE, J. H., Prins, A. J. A., Bruggink, J. L. M., & Steffens, A. B. (1987) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(87)90108-1 · Cited by 46 · see citing works
Daily Rhythm of Plasma Glucose and Insulin Levels in Rats
Jolín, T., & Montes, A. (2008) · Hormone Research · doi:10.1159/000178303 · Cited by 45 · see citing works
ROLE OF THE SUPRACHIASMATIC NUCLEUS IN GLUCOSE HOMEOSTASIS
Yamamoto, H., Nagai, K., & Nakagawa, H. (1984) · Biomedical Research · doi:10.2220/biomedres.5.55 · Cited by 43 · see citing works
Food deprivation-induced activity in dietary obese, dietary lean, and normal-weight rats
Sclafani, A. J., & Rendel, A. (1978) · Behavioral Biology · doi:10.1016/s0091-6773(78)93084-5 · Cited by 41 · see citing works
Trümper, B., Reschke, K., & Molling, J. (1995) · Hormone and Metabolic Research · doi:10.1055/s-2007-979926 · Cited by 39 · see citing works
Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation
Fujii, T., Inoue, S., Nagai, K., & Nakagawa, H. (1989) · Hormone and Metabolic Research · doi:10.1055/s-2007-1009309 · Cited by 30 · see citing works
Chan, S. O., & Chung, K. Y. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990405)406:2 · Cited by 29 · see citing works
Kobayashi, K., & Takahashi, K. (2008) · Neuroendocrinology · doi:10.1159/000122924 · Cited by 18 · see citing works
Circadian Rhythms of Food Intake, Plasma Glucose and Insulin Levels in Fed and Fasted Rabbits
Lesault, A., Elchinger, B., & Desbals, B. (1991) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003744 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998 · see citing works
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523 · see citing works
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403 · see citing works
A Daily Rhythm in Glucose Tolerance
la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337 · see citing works
Circadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works
Kalsbeek, A., La Fleur, S., Van Heijningen, C., & Buijs, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5328-03.2004 · Cited by 244 · see citing works
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works
Effects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232 · see citing works
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works
Self-citationNeural connections between the hypothalamus and the liver
Uyama, N., Geerts, A., & Reynaert, H. (2004) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20086 · Cited by 201 · see citing works
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191 · see citing works
Kreier, F., Kap, Y. S., Mettenleiter, T. C., van Heijningen, C., van der Vliet, J., Kalsbeek, A., Sauerwein, H. P., Fliers, E., Romijn, J. A., & Buijs, R. M. (2006) · Endocrinology · doi:10.1210/en.2005-0667 · Cited by 183 · see citing works
Self-citationThe Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178 · see citing works
Kalsbeek, A., Fliers, E., Franke, A. N., Wortel, J., & Buijs, R. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7709 · Cited by 174 · see citing works
Ruiter, M., La Fleur, S. E., van Heijningen, C., van der Vliet, J., Kalsbeek, A., & Buijs, R. M. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1709 · Cited by 170 · see citing works
la Fleur, S. E., Kalsbeek, A., Wortel, J., & Buijs, R. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02423-9 · Cited by 160 · see citing works
Circadian Rhythms, Aging, and Life Span in Mammals
Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156 · see citing works
Barnea, M., Madar, Z., & Froy, O. (2009) · Endocrinology · doi:10.1210/en.2008-0944 · Cited by 138 · see citing works
The impact of glucocorticoids and statins on sleep quality
Szmyd, B., Rogut, M., Białasiewicz, P., & Gabryelska, A. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101380 · Cited by 66 · see citing works
Buijs, R. M., Guzmán Ruiz, M. A., Méndez Hernández, R., & Rodríguez Cortés, B. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.02.001 · Cited by 63 · see citing works
Bulik, S., Holzhütter, H.-G., & Berndt, N. (2016) · BMC Biology · doi:10.1186/s12915-016-0237-6 · Cited by 45 · see citing works
Central Circadian Clock Regulates Energy Metabolism
Ding, G., Gong, Y., Eckel-Mahan, K. L., & Sun, Z. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-1286-1_5 · Cited by 33 · see citing works
Metabolism as an integral cog in the mammalian circadian clockwork
Gamble, K. L., & Young, M. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.786672 · Cited by 18 · see citing works
- Authors
- Fleur, L., Kalsbeek, Wortel, & Buijs
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1999-08
- Volume
- 11
- Issue
- 8
- Pages
- 643-652
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1894005404
- Semantic Scholar
- 2152359a6688de6ae12cab9363654e04e945ae63
- Cited by
- 256
- References
- 35
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 17 · 2015: 18 · 2014: 12 · 2013: 8 · 2012: 16
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- suprachiasmatic nucleus, circadian rhythm, insulin, fasting, scheduled feeding, SCN lesions, biological clock, feeding rhythm
- MeSH terms
- Animals, Blood Glucose, Circadian Rhythm, Corticosterone, Fasting, Food, Insulin, Male, Suprachiasmatic Nucleus, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
