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Cited by 142Pancreatic function and diabetesCircadian rhythm and melatoninRegulation of Appetite and Obesity

Circadian Control of Insulin Secretion Is Independent of the Temporal Distribution of Feeding

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Kalsbeek, Andries, Strubbe, Jan H·1998·Physiology & Behavior
DOI 10.1016/s0031-9384(97)00493-9
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Abstract

To investigate whether there is a circadian regulation of insulin secretion, rats were adapted to a feeding regimen of six meals equally distributed over 24 h. Under these conditions basal glucose and insulin levels increased during the light phase and decreased during the dark phase. Maximal blood glucose responses were fairly similar during the six different meals, but glucose increments were clearly delayed during the last two meals consumed during the light period. Insulin increments were highest during the dark phase and clearly diminished during the second half of the light phase. This situation was reversed when the scheduled meals were replaced by i.v. glucose infusions, i.e., no significant differences were detected between insulin responses, whereas glucose increments were reduced during the dark period. These results show that there is a circadian regulation of basal blood glucose and feeding-induced insulin responses, which is independent of the temporal distribution of feeding activity.

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  • The model predicts peak OGTT responses during the inactive phase of the 24h cycle when circadian cortisol levels increase, and minimal responses during the active phase when cortisol levels decrease.

    “the model predicts peak responses during the inactive phase of the 24h cycle during which circadian CORT levels increase, and are minimal during the active phase, when CORT levels decrease.”

    From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [56]

    The Glucose Infusions section reports larger glucose responses at ZT6 and ZT10, during the rats’ inactive light period, than at ZT18 in the active dark period. The Discussion places the glucocorticoid peak shortly before activity begins. But the study used glucose infusions, not OGTTs, and does not establish the claimed pattern of cortisol rising during peak responses and falling during minimal responses. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In rats on a 6-meals-a-day feeding schedule, similar meals resulted in larger glucose and insulin responses when consumed during the dark period than during the light period.

    “The first experiments with this scheduled feeding regimen in rats revealed a clear daily rhythm in meal-induced responses in glucose and insulin, i.e., similar meals resulted in larger glucose and insulin responses when consumed during the dark period than when consumed during the light period (Figure 2; [57]).”

    From Circadian control of glucose metabolism (2014) · cites this paper as [57]

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Authors
Kalsbeek, A., & Strubbe, J. H.
Affiliations
University of Groningen (NL)
Corresponding author
Kalsbeek, Andries
ORCID
Kalsbeek, Andries
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
1998-02
Volume
63
Issue
4
Pages
553-560
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/s0031-9384(97)00493-9
OpenAlex
W2155305116
Cited by
142
References
57
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 16 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 6 · 2012: 7
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Physiology & Behavior (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
circadian rhythm, insulin secretion, feeding schedule, light-dark cycle, glucose tolerance, meal timing
MeSH terms
Animals, Blood Glucose, Circadian Rhythm, Feeding Behavior, Glucose, Insulin, Male, Pancreas, Rats, Wistar, Rats

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