Leisure Time Physical Activity and the 16-Year Risks of Mortality from Coronary Heart Disease and All-Causes in the Multiple Risk Factor Intervention Trial (MRFIT)
Abstract
PURPOSE: To examine the long-term association of leisure time physical activity (LTPA) and risk of death from coronary heart disease (CHD) and all-causes. METHODS: Data are from a prospective study of 12,138 middle-aged men at high risk for CHD participating in the MRFIT. Men were classified into deciles based on average min/d of LTPA reported at baseline, which were compared with cumulative CHD and all-cause mortality endpoints at the 16-year follow-up. RESULTS: Men in the least-active decile of LTPA who averaged 4.9 min/d of LTPA (range 0 to .9 min/d) had excess age-adjusted mortality rates of 29% and 22% for CHD and all-causes, respectively, as compared to those in combined deciles 2 to 4, who averaged 22.7 min/d of predominantly light and moderate LTPA (range 10-36 min/d). No further decrement in mortality rates was noted in those in the higher declines of LTPA. These associations remained significant (P < 0.05) after proportional hazards adjustments for additional possible confounding variables. CONCLUSION: These data suggest that a relatively small amount (10 to 36 min/d) of daily moderate intensity LTPA can significantly reduce premature mortality, particularly from CHD, in middle-aged and older men at high risk for CHD.
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The amount of daily physical activity, leisure time physical activity and physical fitness level are negatively correlated with mortality due to cerebrovascular disease and cancer, as well as all-cause mortality.
“The amount of daily physical activity, leisure time physical activity and physical fitness level have been found to be negatively correlated with morality due to cerebrovascular disease and cancer, as well as all-cause mortality in studies conducted worldwide596–606) and cohort studies in Japan577).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [596]
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Subcommittee, G. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917020-00001 · Cited by 3,895 · see citing works
Wood, D., Backer, G. D., Færgeman, O., Graham, I. D., Mancia, G., & Pyörälà, K. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)90209-x · Cited by 1,251 · see citing works
Prepared, B. (2005) · Heart · doi:10.1136/hrt.2005.079988 · Cited by 1,217 · see citing works
Chalmers, J. P., MacMahon, S., Mancia, G., Whitworth, J., Beilin, L., Hansson, L., Neal, B. C., Rodgers, A., Mhurchu, C. N., & Clark, T. (1999) · Clinical and Experimental Hypertension · doi:10.3109/10641969909061028 · Cited by 1,214 · see citing works
Second Joint Task Force of European (1998) · European Heart Journal · doi:10.1053/euhj.1998.1243 · Cited by 1,131 · see citing works
Nocon, M., Hiemann, T., Müller-Riemenschneider, F., Thalau, F., Roll, S., & Willich, S. N. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f55e09 · Cited by 1,080 · see citing works
Strath, S. J., Kaminsky, L. A., Ainsworth, B. E., Ekelund, U., Freedson, P. S., Gary, R. A., Richardson, C. R., Smith, D. T., & Swartz, A. M. (2013) · Circulation · doi:10.1161/01.cir.0000435708.67487.da · Cited by 1,029 · see citing works
Dose Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis
Sattelmair, J., Pertman, J., Ding, E. L., Kohl, H. W., Haskell, W., & Lee, I.-M. (2011) · Circulation · doi:10.1161/circulationaha.110.010710 · Cited by 1,052 · see citing works
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
Mosca, L. J., Appel, L. J., Benjamin, E. J., Berra, K. A., Chandra‐Strobos, N., Fabunmi, R. P., Grady, D. G., Haan, C. K., Hayes, S. N., Judelson, D. R., et al. (2004) · Circulation · doi:10.1161/01.cir.0000114834.85476.81 · Cited by 917 · see citing works
A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults
Warburton, D. E., Charlesworth, S., Ivey, A., Nettlefold, L., & Bredin, S. S. (2010) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-7-39 · Cited by 902 · see citing works
Samitz, G., Egger, M., & Zwahlen, M. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr112 · Cited by 836 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Physical fitness and activity as separate heart disease risk factors: a meta-analysis
WILLIAMS, P. T. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200105000-00012 · Cited by 724 · see citing works
“8 to 20 yr follow-up (43)) and the Multiple Risk Factor Intervention Trial (from 7 to 16 yr follow-up (28)).”
BackgroundThe Economic Costs Associated With Physical Inactivity and Obesity in Canada: An Update
Katzmarzyk, P. T., & Janssen, I. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-008 · Cited by 643 · see citing works
Shiroma, E. J., & Lee, I.-M. (2010) · Circulation · doi:10.1161/circulationaha.109.914721 · Cited by 578 · see citing works
The evolution of physical activity recommendations: how much is enough?
Blair, S. N., LaMonte, M. J., & Nichaman, M. Z. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.913s · Cited by 547 · see citing works
The Effects of Exercise and Physical Activity on Weight Loss and Maintenance
Swift, D. L., McGee, J. E., Earnest, C. P., Carlisle, E., Nygard, M., & Johannsen, N. M. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.014 · Cited by 536 · see citing works
Woodcock, J., Franco, O. H., Orsini, N., & Roberts, I. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq104 · Cited by 509 · see citing works
Sedentary Behavior and Depression Among Adults: A Review
Teychenne, M., Ball, K., & Salmon, J. (2010) · International Journal of Behavioral Medicine · doi:10.1007/s12529-010-9075-z · Cited by 511 · see citing works
A descriptive epidemiology of leisure-time physical activity in Brazil, 1996-1997.
Monteiro, C., Conde, W., Matsudo, S., Matsudo, V., Bonsenor, I. J. M., & Lotufo, P. (2003) · Revista Panamericana De Salud Publica-pan American Journal of Public Health · doi:10.1590/s1020-49892003000900005 · Cited by 365 · see citing works
O’Hare, A. M., Tawney, K. W., Bacchetti, P., & Johansen, K. L. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50055 · Cited by 350 · see citing works
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
Mosca, L. J., Appel, L. J., Benjamin, E. J., Berra, K. A., Chandra‐Strobos, N., Fabunmi, R. P., Grady, D. G., Haan, C. K., Hayes, S. N., Judelson, D. R., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000114834.85476.81 · Cited by 342 · see citing works
Physical inactivity, excess adiposity and premature mortality
Katzmarzyk, P. T., Janssen, I., & Ardern, C. I. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00120.x · Cited by 315 · see citing works
“However, it should be noted that most studies did not simply report a relative risk after adjusting for adiposity alone, rather the index of adiposity Upper Bavarian women (116) 844 15+ 5 Occasional vs. regular exercise None vs. regular exercise 1.14 (0.24–5.30) 1.51 (0.41–5.54) Upper Bavarian men (117) 652 15+ 13 Occ…”
InfluentialBarengo, N. C., HU, G., Lakka, T. A., Pekkarinen, H., Nissinen, A. M., & Tuomilehto, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.10.009 · Cited by 293 · see citing works
Association of physical activity with mortality in the US dialysis population
Stack, A. G., Molony, D. A., Rives, T. E., Tyson, J. E., & Murthy, B. V. R. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.12.013 · Cited by 266 · see citing works
Obesity: Overview of Prevalence, Etiology, and Treatment
Racette, S. B., Deusinger, S. S., & Deusinger, R. H. (2003) · Physical Therapy · doi:10.1093/ptj/83.3.276 · Cited by 238 · see citing works
Reproducibility and Validity of the Shanghai Women's Health Study Physical Activity Questionnaire
Matthews, C. E. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg255 · Cited by 184 · see citing works
Wood, D., Backer, G. D., Færgeman, O., Graham, I. M., Mancia, G., & Pyörälà, K. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816100-00003 · Cited by 180 · see citing works
Yu, S., Yarnell, J. W. G., Sweetnam, P. M., & Murray, L. (2003) · Heart · doi:10.1136/heart.89.5.502 · Cited by 176 · see citing works
Absolute versus relative intensity of physical activity in a dose-response context
Shephard, R. J. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200106001-00008 · Cited by 173 · see citing works
Changes in common activities of 3rd through 10th graders: the CHIC Study
Bradley, C., McMurray, R. G., Harrell, J. S., & DENG, A. S. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200012000-00017 · Cited by 171 · see citing works
Matsuzawa, R., Matsunaga, A., Wang, G., Kutsuna, T., Ishii, A., Abe, Y., Takagi, Y., Yoshida, A., & Takahira, N. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03660412 · Cited by 159 · see citing works
Blood hemostasis in exercise and training
El-Sayed, Sale, C., Jones, P., & CHESTER, M. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200005000-00007 · Cited by 160 · see citing works
Exercise and Training Effects on Blood Haemostasis in Health and Disease
Elsayed, M., Ali, Z. E.-S., & Ahmadizad, S. (2004) · Sports Medicine · doi:10.2165/00007256-200434030-00004 · Cited by 151 · see citing works
Backer, G. D., Ambrosio, G., Borch‐Johnsen, K., Brotons, C., Cífková, R., Dallongeville, J., Ebrahim, S. B. J., Færgeman, O., Graham, I. D., Mancia, G., et al. (2003) · PubMed · doi:10.1097/01.hjr.0000087913.96265.e2 · Cited by 151 · see citing works
McMurray, R. G., AINSWORTH, B. E., Harrell, J. S., Griggs, T. R., & Williams, O. D. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199810000-00009 · Cited by 136 · see citing works
Cardiovascular benefits of exercise
Agarwal, S. K. (2012) · International Journal of General Medicine · doi:10.2147/ijgm.s30113 · Cited by 121 · see citing works
“ing a 16 year follow up of men with high risk of coronary heart disease in the MRFIT study.(42) In the Honolulu Heart”
Kristjánsdóttir, G., & Vilhjálmsson, R. (2001) · Acta Paediatrica · doi:10.1111/j.1651-2227.2001.tb00445.x · Cited by 122 · see citing works
Williams, E. D., Stamatakis, E., Chandola, T., & Hamer, M. (2010) · Heart · doi:10.1136/hrt.2010.201012 · Cited by 123 · see citing works
“Previous research into physical activity and the risk of CHD mortality has predominantly been conducted in westernised white cohorts”
BackgroundPhysical Activity, Physical Fitness, and Risk of Dying
Villeneuve, P. J., MORRISON, H. I., Craig, C. L., & Schaubel, D. E. (1998) · Epidemiology · doi:10.1097/00001648-199811000-00011 · Cited by 109 · see citing works
Social Cognitive Theory in Diabetes Exercise Research: An Integrative Literature Review
Allen, N. A. (2004) · The diabetes educator · doi:10.1177/014572170403000516 · Cited by 123 · see citing works
Racette, S. B., Deusinger, S. S., Inman, C. L., Burlis, T. L., Highstein, G. R., Buskirk, T. D., Steger-May, K., & Peterson, L. R. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2009.06.022 · Cited by 100 · see citing works
“Prevention Program Research Group, 2002), Multiple Risk Factor Intervention Trial (Leon et al., 1997), and the Nurses' Health Study (Stampfer et al.”
MethodEmerging Technologies for Assessing Physical Activity Behaviors in Space and Time
Hurvitz, P. M., Moudon, A. V., Kang, B., Saelens, B. E., & Duncan, G. E. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00002 · Cited by 101 · see citing works
Beverly, E., & Wray, L. (2010) · Health Education Research · doi:10.1093/her/cyn032 · Cited by 108 · see citing works
“factors [5–13], joint flexibility [14] and quality of”
BackgroundHealth benefits of Tai Chi exercise: improved balance and blood pressure in middle-aged women
Thornton, E. W. (2004) · Health Promotion International · doi:10.1093/heapro/dah105 · Cited by 97 · see citing works
“exercise conveys increased health benefits, there is consensus that inactivity decreases longevity (Leon et al., 1997).”
BackgroundMatsuzawa, R., Matsunaga, A., Wang, G., Yamamoto, S., Kutsuna, T., Ishii, A., Abe, Y., Yoneki, K., Yoshida, A., & Takahira, N. (2014) · Physical Therapy · doi:10.2522/ptj.20130270 · Cited by 93 · see citing works
Physical activity and risk of cardiovascular disease events: inflammatory and metabolic mechanisms.
Hamer, M., & Stamatakis, E. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181971247 · Cited by 96 · see citing works
“egular physical activity is widely accepted as playing a crucial role in cardiovascular disease (CVD) prevention (6,7, 14 ,15,20,21).”
BackgroundOlder Women's Beliefs About Physical Activity
Conn, V. S. (1998) · Public Health Nursing · doi:10.1111/j.1525-1446.1998.tb00362.x · Cited by 89 · see citing works
Niessner, A., Richter, B., Penka, M., Steiner, S., Strasser, B., Ziegler, S., Heeb-Elze, E., Zorn, G., Heinschink, A., Niessner, C., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.047 · Cited by 80 · see citing works
Smith, L. V. H., Borch-Johnsen, K., & Jørgensen, T. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9177-3 · Cited by 78 · see citing works
Reliability of Recall of Physical Activity in the Distant Past
Falkner, K. L., Trevisan, M., & McCann, S. E. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009980 · Cited by 75 · see citing works
“Results of studies examining the relations between disease development and different levels of physical activity are currently being reported in the literature (28-32).”
BackgroundBarengo, N. C., Kastarinen, M. J., Lakka, T. A., Nissinen, A. M., & Tuomilehto, J. O. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/00149831-200602000-00008 · Cited by 73 · see citing works
Physical inactivity causes endothelial dysfunction in healthy young mice
Suvorava, T., Lauer, N., & Kojda, G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.030 · Cited by 66 · see citing works
“In contrast, the Multiple Risk actor Interventiona Trial (MRFIT) study surveyed 12,138 en without cardiovascular disease for 16 years and found a ignificantly reduced incidence of cardiovascular deaths in en with normal daily physical activity compared to men ith a sedentary lifestyle (1).”
BackgroundPhysical activity and mortality in men and women with diagnosed cardiovascular disease
Hamer, M., & Stamatakis, E. (2009) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32831f1b77 · Cited by 67 · see citing works
Effects of Tai Chi Exercise on Physical and Psychological Health of Older People
Blake, H., & Hawley-Hague, H. (2012) · Current Aging Science · doi:10.2174/1874609811205010019 · Cited by 62 · see citing works
Stack, A. G., & Murthy, B. V. R. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.09.008 · Cited by 61 · see citing works
Kraus, W. E., Yates, T., Tuomilehto, J., Sun, J.-L., Thomas, L., McMurray, J. J. V., Bethel, M. A., & Holman, R. R. (2018) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2018-000523 · Cited by 59 · see citing works
Victorian Burden of Disease Study: Mortality
Vos, T., & Begg, S. J. (2020) · Figshare · doi:10.26181/5fab13e67ede8 · Cited by 58 · see citing works
Møller, N. C., Kristensen, P. L., Wedderkopp, N., et al. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2008.00774.x · Cited by 57 · see citing works
Leitlinie körperliche Aktivität zur Sekundärprävention und Therapie kardiovaskulärer Erkrankungen
Bjarnason‐Wehrens, B., Schulz, O., Gielen, S., Halle, M., Dürsch, M., Hambrecht, R., Lowis, H., Kindermann, W., Schulze, R., & Rauch, B. (2009) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-009-0078-8 · Cited by 56 · see citing works
Evidence-based guidelines for cardiovascular disease prevention in women
Mosca, L. D. P. C., Appel, L. J., & Benjamin, E. J. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.04.052 · Cited by 50 · see citing works
Bucksch, J., & Schlicht, W. (2006) · Sozial- und Präventivmedizin/Social and Preventive Medicine · doi:10.1007/s00038-006-5043-4 · Cited by 53 · see citing works
“Other studies fi nd a risk reduction for mortality only with moderate intensity PA (Leon et al. 1997; Villeneuve et al. 1998).”
BackgroundHealth effects resulting from exercise versus those from body fat loss
WILLIAMS, P. T. (2001) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200106001-00030 · Cited by 47 · see citing works
Unique Environmental Effects on Physical Activity Participation: A Twin Study
Duncan, G. E., Goldberg, J. H., Noonan, C., Moudon, A. V., Hurvitz, P. M., & Buchwald, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002019 · Cited by 47 · see citing works
Habitual physical activity levels and health outcomes of Ontario youth
Klentrou, P., Hay, J., & Plyley, M. J. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0814-6 · Cited by 46 · see citing works
“Although the benefits of physical activity during childhood have been well documented (Berenson and Pickoff 1995; Leon et al. 1997; Telama et al. 1997), physical activity declines throughout youth, and this decline is connected with puberty (Telama and Yang 2000; Trost et al. 2002; Van Mechelen et…”
BackgroundStamatakis, E., Hamer, M., & Primatesta, P. (2008) · Heart · doi:10.1136/hrt.2008.152041 · Cited by 44 · see citing works
“The beneficial effect of physical activity on CVD risk is well documented.”
BackgroundCardiovascular risk factors, monitoring, and therapy for HIV-infected patients
Lipshultz, S. E., Fisher, S. D., Lai, W. W., & Miller, T. L. (2003) · AIDS · doi:10.1097/00002030-200304001-00014 · Cited by 36 · see citing works
Development and initial validation of the Brunel lifestyle physical activity questionnaire
Karageorghis, C. I., Vencato, M. M., Chatzisarantis, N. L. D., & Carron, A. V. (2005) · British Journal of Sports Medicine · doi:10.1136/bjsm.2004.014258 · Cited by 36 · see citing works
Effects of Repeated Bouts of Exercise on the Hemostatic System
van der Vorm, L. N., Huskens, D., Kicken, C. H., Remijn, J. A., Roest, M., de Laat, B., & Miszta, A. (2018) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1673619 · Cited by 35 · see citing works
Spence, J. D. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0020-8 · Cited by 34 · see citing works
“Approximately 30 minutes per day of brisk walking or equivalent exercise substantially reduces risk [ 12 ,13] and achieves most of the benefit of more intensive exercise [14].”
BackgroundCalcium handling proteins: structure, function, and modulation by exercise
Locatelli, J., de Assis, L. D., & Isoldi, M. C. (2014) · Heart Failure Reviews · doi:10.1007/s10741-013-9373-z · Cited by 29 · see citing works
Chowdhury, M. A., Sholl, H. K., Sharrett, M. S., Haller, S. T., Cooper, C. C., Gupta, R., & Liu, L. (2018) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248418788575 · Cited by 30 · see citing works
Becerra, M. B., Herring, P., Marshak, H., & Banta, J. (2014) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-014-0074-z · Cited by 28 · see citing works
“Similarly, results from the Multiple Risk Factor Intervention Study showed that men with the lowest level of physical activity had the highest risk of coronary heart disease [5].”
ResultCardiovascular Risk Factors for Incident Hypertension in the Prehypertensive Population
Kim, S., Lee, J., Jee, S. H., Nam, C. M., Chun, K.-H., Park, I. S., & Lee, S. Y. (2010) · Epidemiology and Health · doi:10.4178/epih/e2010003 · Cited by 30 · see citing works
Treatment A) Lifestyle Modification
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.18820 · Cited by 27 · see citing works
Kirunda, B. E., Wamani, H., Fadnes, L. T., den Broeck, J. V., & Tylleskär, T. (2016) · Journal of Physical Activity and Health · doi:10.1123/jpah.2016-0025 · Cited by 24 · see citing works
Olusi, S. O., Al-Awadi, A. M., & Abraham, M. P. (2003) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2003.162 · Cited by 22 · see citing works
Cardiovascular Monitoring and Therapy for HIV‐Infected Patients
Lipshultz, S. E., Fisher, S. D., Lai, W. W., & Miller, T. L. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03916.x · Cited by 19 · see citing works
Effects of Levels of Cigarette Smoke Exposure on Symptom‐Limited Spiroergometry
Unverdorben, M., der Bijl, A., Potgieter, L., Liang, Q., Meyer, B. H., & Roethig, H. J. (2007) · Preventive Cardiology · doi:10.1111/j.1520-037x.2007.06036.x · Cited by 19 · see citing works
Sex-specific effects of leisure-time physical activity on cause-specific mortality in NHANES III
Saadany, T. E., Richard, A., Wanner, M., & Rohrmann, S. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.05.029 · Cited by 18 · see citing works
“In general, especially for CVD mortality, many studies have been published (Hu et al., 2013; Leon and Connett, 1991; Leon et al., 1997; Slattery et al., 1989; Sone et al., 2013).”
BackgroundLovegrove, J. A., & Jackson, K. G. (2000) · Elsevier eBooks · doi:10.1533/9781855736436.2.97 · Cited by 18 · see citing works
Physical activity recommendations and cardiovascular disease risk factors in young Hispanic women
Vella, C. A., Ontiveros, D., Zubia, R. Y., & Dalleck, L. C. (2010) · Journal of Sports Sciences · doi:10.1080/02640414.2010.520727 · Cited by 17 · see citing works
“Despite the large body of evidence showing an inverse relationship between total volume of physical activity and all-cause mortality for men and women (Leon, Myers, & Connett, 1997 ), the relationship between current physical activity guidelines and specific health outcomes is not well understood (Bucksch, 2005 ; Leit…”
BackgroundUnverdorben, M., van der Bijl, A., Potgieter, L., Venter, C., Munjal, S., Liang, Q., Meyer, B. H., & Röthig, H.-J. (2008) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248408321571 · Cited by 17 · see citing works
Accuracy of a novel multi-sensor board for measuring physical activity and energy expenditure
Duncan, G. E., Lester, J., Migotsky, S., Goh, J., Higgins, L., & Borriello, G. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1834-2 · Cited by 16 · see citing works
“In clinical and population-based research, measuring physical activity is necessary because it is a behavioral factor that plays a critical role in energy balance and in the etiology and prevention of chronic disease (Helmrich et al. 1991; Pate et al. 1995; Leon et al. 1997; Wannamethee and Shaper 2001; Knowler et al.…”
BackgroundMonfort‐Pires, M., Salvador, E. P., Siqueira-Catania, A., Folchetti, L. D., Cezaretto, A., & Ferreira, S. R. G. (2012) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2012.03.007 · Cited by 14 · see citing works
No Time to ‘Weight’: The Link between Obesity and Stroke in Women
Antillon, D., & Towfighi, A. (2011) · Women s Health · doi:10.2217/whe.11.36 · Cited by 15 · see citing works
Is Physical Activity Important for Aerobic Power in Young Males and Females?
Kemper, H. C. G., & Koppes, L. L. J. (2003) · KARGER eBooks · doi:10.1159/000076202 · Cited by 15 · see citing works
Boniface, D. R., Cottee, M., Neal, D., et al. (2001) · Public Health · doi:10.1038/sj.ph.1900762 · Cited by 15 · see citing works
Bewegung und Sport: eine unterschätzte Gesundheitsressource
Martin, B. W., & Marti, B. (1998) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-125115 · Cited by 12 · see citing works
Pharmacological therapies, lifestyle choices and nitric oxide deficiency: A perfect storm
Bryan, N. S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.009 · Cited by 10 · see citing works
Wakamiya, A., Hiraki, K., Hotta, C., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.387 · Cited by 9 · see citing works
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Bucksch, J., & Helmert, U. (2004) · Journal of Public Health · doi:10.1007/s10389-004-0069-7 · Cited by 7 · see citing works
Unverdorben, M., von Holt, K., & Winkelmann, B. R. (2009) · Biomarkers in Medicine · doi:10.2217/bmm.09.69 · Cited by 7 · see citing works
Goyal, P., Delgado, D., Hummel, S., & Dharmarajan, K. (2016) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-016-0514-5 · Cited by 6 · see citing works
Hanakam, F., & Ferrauti, A. (2020) · Springer eBooks · doi:10.1007/978-3-662-58227-5_7 · Cited by 6 · see citing works
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Folsom, A. R., & Pereira, M. A. (2000) · Wiley eBooks · doi:10.1002/9780470694930.ch47 · Cited by 4 · see citing works
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Sasaki, J. (2012) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.49.171 · Cited by 3 · see citing works
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Krysztofiak, H., Młyńczak, M., Małek, Ł., Folga, A., & Braksator, W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236632 · Cited by 3 · see citing works
- Authors
- Leon, A., Myers, M., & Connett, J.
- Affiliations
- University of Minnesota (US)
- University of Wisconsin–Madison (US)
- ORCID
- Connett, J.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1997-07
- Volume
- 18
- Issue
- S 3
- Pages
- S208-S215
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2024892457
- Cited by
- 126
- References
- 0
- Citations by year
- 2025: 2 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (1 RO1-HL43232, R01HL043232)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- leisure-time physical activity, coronary heart disease mortality, all-cause mortality, Multiple Risk Factor Intervention Trial, middle-aged men, high cardiovascular risk, moderate-intensity exercise, light physical activity, long-term mortality risk, physical inactivity
- MeSH terms
- Adult, Cause of Death, Child, Coronary Disease, Humans, Leisure Activities, Life Style, Male, Middle Aged, Physical Fitness, Prospective Studies, Exercise, Risk Assessment
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