Cited by 1,005Exercise and Physiological ResponsesMuscle Physiology and DisordersCardiovascular and exercise physiology

The DOI matches its Crossref record.

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Fridén, J., Sjöström, M., Ekblom, B.·1983·International Journal of Sports Medicine

DOI 10.1055/s-2008-1026030

Open this paper in CoChat — free account

Abstract

Muscle soreness that has a delayed onset is a common feature among both athletes and untrained individuals who engage in unusual exercises. This study was designed to provide additional morphological data to assess the relevance and significance of our previous findings that the sore muscles contain fibers with disorganized myofibrillar material. Muscle biopsies were obtained from 12 males (mean age 25 +/- 7 years), who suffered from severe soreness in their thigh muscles 18--72 h following eccentric bicycle exercise. Their strength performance were tested in parallel. Knee extensor strength was decreased at all angular velocities soon after exercise but gradually increased over the subsequent days although slower at the fastest contractions. Disturbances of the cross-striated band pattern were constantly observed. They originated from the myofibrillar Z-band, which showed marked streaming, broadening and, at places, total disruption. The disturbances were found in every second to every third fiber up to 3 days after exercise and in one tenth of the fibers 6 days following the exercise. Type 2 fibers were predominantly affected. Thus, the eccentric exercise gives rise to muscles soreness and influences, on mechanical basis and selectively with regard to fiber type, the fine structure of the contractile apparatus.

Integrity signals

Registry

Crossref · 10.1055/s-2008-1026030

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 701–800 of 999

ASPIRIN MAY BE AN EFFECTIVE TREATMENT FOR EXERCISE-INDUCED MUSCLE SORENESS
Riasati, S., Moghadasi, M., Torkfar, A., Shirazinejad, R., & Arvin, H. (2010) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 6
Eccentric Training in Pulmonary Rehabilitation of Post-COVID-19 Patients: An Alternative for Improving the Functional Capacity, Inflammation, and Oxidative Stress
Briceño, F. A. C., Espinosa‐Ramírez, M., Rozenberg, D., & Reid, W. D. (2022) · Biology · doi:10.3390/biology11101446 · Cited by 8
“Injury at the light microscopic or ultrastructural level is shown by disruption of contractile and structural proteins, increased permeability of plasma membranes and an influx of inflammatory cells [113,114].”
Background
Joint angle-specific neuromuscular time course of recovery after isometric resistance exercise at shorter and longer muscle lengths
McMahon, G. E., & Onambélé-Pearson, G. L. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00820.2023 · Cited by 6
Response of creatine kinase and lactate dehydrogenase enzymes to rest interval between sets and set-repetition configuration during bouts of eccentric exercise
Mohammadi, H., Afzalpour, M. E., & Ievary, S. H. A. (2018) · Interventional Medicine and Applied Science · doi:10.1556/1646.10.2018.09 · Cited by 6
Changes in nerve growth factor in vastus lateralis muscle after the first versus second bout of one‐leg eccentric cycling
Koeda, T., Mavropalias, G., Mizumura, K., et al. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14497 · Cited by 6
Isocinétisme : le travail musculaire excentrique
Middleton, P., Gaujard, E., Petit, H., Guillermo, A., Vidal, M. C., Bientz, I., & Monguillot, P. (2013) · La Lettre de médecine physique et de réadaptation · doi:10.1007/s11659-013-0347-2 · Cited by 5
Effects of massage and compression treatment on performance in three consecutive days
Hiruma, E., Umimura, M., Naıto, H., & Katamoto, S. (2014) · Medical Express · doi:10.5935/medicalexpress.2014.06.07 · Cited by 6
Pediatric Sports Injuries
Strassberg, J., & Ahmed, A. (2021) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2021.08.003 · Cited by 6
A convenient prediction model for complete recovery time after exhaustion in high-intensity work
Ye, T., & Pan, X. (2015) · Ergonomics · doi:10.1080/00140139.2015.1008587 · Cited by 6
“…to recover to baseline after high-intensity work, lactate removal requires up to an hour and muscle repair after eccentric damage may take weeks (Fridén, Sjostrom, and Ekblom 1983; Newham, Jones, and Clarkson 1987; Howell, Chleboun, and Conatser 1993; Rinard et al. 2000; Wu, Hsu, and Chen…”
Background
Muscular Pain Mechanisms: Brief Review with Special Consideration of Delayed-Onset Muscle Soreness
Mizumura, K. (2008) · Springer eBooks · doi:10.1007/978-4-431-73464-2_12 · Cited by 6
Consequences of Skeletal Muscle Injury Induced by Unaccustomed Exercise
Schneider, B. S. P., & Sannes, H. J. (2001) · Orthopaedic Nursing · doi:10.1097/00006416-200109000-00009 · Cited by 6
NAVA: brain over machine?
Laghi, F. A. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1215-4 · Cited by 6
“more pronounced in Type 2 fibers than in Type 1 fibers [21].”
Background
Time course changes in plasma creatine kinase over four days of repetitive manual work
Malcolm, S. A., Anstee, A., & Halloran, M. J. (1995) · Ergonomics · doi:10.1080/00140139508925168 · Cited by 6
Alterations in Bilateral Force Judgment following Strenuous Eccentric Exercise
Vincent, H. K., Carlson, C., Hyatt, J. P., et al. (2000) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2000.10608917 · Cited by 6
LENGTH OF REST INTERVAL BETWEEN RESISTANCE EXERCISE SETS: PERFORMANCE AND INTER-INDIVIDUAL VARIABILITY OF CK ACTIVITY
Silva, L. E., Pereira, R., Rodrigues, V. C., da Silva, P. A. V., Silva, K. M., & Machado, M. (2010) · Journal of Musculoskeletal Research · doi:10.1142/s0218957710002636 · Cited by 6
“With regard to endurance-based exercises, a relationship is described between greater volume and serum CK activity magnitude variations,4 but this data apparently is not repeated in resistance exercises.11 Friden et al.12 demonstrated that following eccentric exercises, myofibril 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16…”
Background
Oxidative Effects of Physical Exercise
Quintanilha, A. T. (1988) · Springer eBooks · doi:10.1007/978-1-4757-0417-4_13 · Cited by 6
Muscle function after exercise-induced muscle damage.
Byrne, C. (2001) · Bangor University Research Portal (Bangor University) · Cited by 6
Changes in the biliary excretion of organic anions following exhaustive exercise in rats
Villa, G., Collado, P. S., Almar, M., et al. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90094-2 · Cited by 6
Cool Water Immersion after Downhill Running Suppresses Exercise-induced Muscle Damagein the Rat Soleus Muscle
Nonaka, K., Akiyama, J., Tatsuta, N., et al. (2012) · Journal of Physical Therapy Science · doi:10.1589/jpts.24.613 · Cited by 5
Fluctuations in the skeletal muscle power-velocity relationship and interferon-γ after a muscle-damaging event in humans
Barker, T., Henriksen, V. T., Martins, T. B., Kjeldsberg, C. R., & Hill, H. R. (2012) · Extreme Physiology & Medicine · doi:10.1186/2046-7648-1-6 · Cited by 6
“Third, fast muscle fibers are regarded as the predominant fiber type susceptible to muscle damage [35,36].”
Background
Mechanisms and Treatment of Delayed Onset Muscle Soreness in Athletes - A Review
McKeigue, M. E., Liang, M. T. C., Ulety, K., & Allen, T. W. (2022) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1519 · Cited by 5
The acute and repeated bout effects of multi-joint eccentric exercise on physical function and balance in older adults
Baxter, B., Baross, A., Ryan, D., Wright, B. H., & Kay, A. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05226-z · Cited by 3
“While RTD0-200, Impulse0-250, and Impulse0-300 were reduced at 24 hr post-exercise in Bout 2, these are considered late-phase explosive measures that may have been affected because eccentric exercise predominantly recruits (and therefore damages) fast-twitch muscle fibres (Friden et al. 1983) commonly associated with…”
Background
Nutritional Interventions as Potential Strategy to Minimize Exercise-Induced Muscle Injuries in Sports
D’Antona, G. (2013) · InTech eBooks · doi:10.5772/56590 · Cited by 5
Joint angle-torque characteristics of the knee extensors following eccentric exercise-induced muscle damage in young, active women
Jakeman, J., & Eston, R. G. (2013) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2013.05.001 · Cited by 5
Effects of Electrically Stimulated Exercise Training on Muscle Function in Multiple Sclerosis
Kent‐Braun, J. A., Sharma, K. R., Miller, R. G., et al. (1996) · Neurorehabilitation and neural repair · doi:10.1177/154596839601000301 · Cited by 5
Eccentric contraction-induced muscle injury does not change walking economy in older adults
Gault, M. L., Clements, R. E., & Willems, M. E. T. (2011) · Journal of Human Kinetics · doi:10.2478/v10078-011-0005-1 · Cited by 5
“Type I muscle fibres seem to be less susceptible to muscle injury from eccentric exercise than type II fibres (i.e. fast-twitch) (Fridén et al., 1983).”
Background
Overextended sarcomeres regain filament overlap following stretch
Panchangam, A., & Herzog, W. (2012) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2012.07.005 · Cited by 5
“…assumed that some sarcomeres ‘‘popped’’ and remained permanently overextended, thereby explaining both, force loss and the appearance of localized sarcomere disruptions (Friden et al., 1983; Newham et al., 1983; Brown and Hill, 1991; Wood et al., 1993; Brooks et al., 1995; Macpherson et al., 1996).”
Background
Heat pack treatment does not attenuate repeated muscle damage in collegiate females
Hiruma, E., Uchida, M., Sasaki, H., & Umimura, M. (2015) · Medical Express · doi:10.5935/medicalexpress.2015.06.07 · Cited by 5
Pathogenesis of Soft Tissue and Bone Repair
Zelle, B. A., & Fu, F. H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-323-07747-7.00001-0 · Cited by 5
Fast skeletal muscle troponin activator CK‐2066260 mitigates skeletal muscle weakness independently of the underlying cause
Cheng, A. J., Ström, J., Hwee, D. T., Malik, F. I., & Westerblad, H. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12624 · Cited by 5
“mechanisms underlying the decreased force‐generating capacity are still uncertain.(27,37,59,60) Although the force reduction after damaging eccentric contractions is larger at low than at high”
Background
Changes in Urinary Titin Fragment in Response to Different Types of Dynamic Eccentric Exercises
Lee, M., Góral, K., Flis, D. J., Skrobot, W. R., Ciemiński, K., Olek, R. A., Akimoto, T., & Ziółkowski, W. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1273-8082 · Cited by 6
“Single nucleotide polymorphisms (SNPs) of the myosin light-chain kinase (MLCK) gene, which plays important role in force development of fasttwitch fibers [29], show muscle strength decline and enhance increase of plasma CK and Mb levels in response to eccentric exercise-induced muscle damage [27].”
Background
Fatigue, Cognitive Performance, and Subjective Recovery Time Estimation in High-Intensity Work
Ye, T., & Pan, X. (2016) · IIE Transactions on Occupational Ergonomics and Human Factors · doi:10.1080/21577323.2016.1200161 · Cited by 5
Morphology and Anabolic Response of Skeletal Muscles Subjected to Eccentrically or Concentrically Biased Exercise.
Lepley, L. K., Davi, S. M., Hunt, E., Burland, J. P., White, M. S., McCormick, G. Y., & Butterfield, T. A. (2020) · Journal of athletic training · doi:10.4085/1062-6050-174-19 · Cited by 4
“However, again, the authors selected such high doses that muscle injury was unavoidable (30 minutes of continuous eccentric contractions to the untrained quadriceps muscle).(31) Remarkably, if the dose of eccentric exercise is”
Background
Skeletal Muscle Collagen: Age, Injury and Disease
Gosselin, L. E. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_8 · Cited by 5
Swelling of sarcoplasmic reticulum in the periphery of muscle fibres after isometric contractions in rat semimembranosus lateralis muscle
Willems, M. E. T., Huijing, P. A., & Fridén (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00516.x · Cited by 5
The “Oil Well Analogy” as a Comprehensive Interpretation of Factors Leading to Muscle Injury and Wasting
Orozco‐Levi, M., Lloreta, J., & Gea, J. (2006) · Ultrastructural Pathology · doi:10.1080/01913120600820146 · Cited by 5
The role of DNA hypermethylation in human neoplasia
Toyota, M., & Issa, J. J. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000101)21:2 · Cited by 55
Muscle rupture after minimal trauma of the spastic muscle: three case reports of patients with spinal cord injury
Carpentier, T. J. D., Kiekens, C., & Peers, K. (2013) · Spinal Cord · doi:10.1038/sc.2013.28 · Cited by 5
Thoracic Outlet Compression Syndrome
Meyer, R. D., & Jones, K. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5279-1.00031-9 · Cited by 5
Skeletal Muscle: Physiology, Training and Repair After Injury
Kjær, M., Kalimo, H., & Saltin, B. (2003) · Wiley eBooks · doi:10.1002/9780470757277.ch3 · Cited by 5
Delayed potentiation effect after high-load resistance priming: Effects of rest-redistribution set structures on athletic performance
Niu, X., Liu, F., Chen, Y., Chen, D., & Zhou, Z. (2025) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2025.10.001 · Cited by 4
Green Tea and Black Tea for Exercise Recovery: A Systematic Review
Zapata, M., & Hewlings, S. J. (2021) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000650 · Cited by 4
“Many sports and activities such as soccer, marathons, ultramarathons, and road cycling competitions will cause muscle damage (4,21,32,39), resulting in reduced ability to generate force which is exacerbated by DOMS (15,46).”
Background
Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1dw/dw) mouse
Rader, E. P., Naimo, M. A., Ensey, J. S., & Baker, B. A. (2022) · Aging · doi:10.18632/aging.203875 · Cited by 4
“Among different subtypes of type II fibers, slower fibers demonstrate less damage following eccentric contractions than faster fibers as illustrated by assessment of Z-band streaming in muscles of men following eccentric contractions [33].”
Background
Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage
Jacko, D., Schaaf, K., Aussieker, T., Masur, L., Zacher, J., Bersiner, K., Bloch, W., & Gehlert, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-79385-0 · Cited by 7
Adaptations mécaniques et neurophysiologiques induites par la sollicitation musculaire excentrique : l'effet protecteur
Michaut, A., & Pousson, M. (2004) · Science & Sports · doi:10.1016/j.scispo.2004.06.001 · Cited by 3
Influence of body mass index and weight lifting on bicep brachii muscle and distal bicep tendon stiffness evaluated using ultrasound elastography
Alqahtani, M., Altuwaijri, O., Altaf, M. M., Al-Enezi, M., Abulmeaty, M. M. A., & Javed, R. (2020) · BMC Medical Imaging · doi:10.1186/s12880-020-00531-x · Cited by 4
Positive (Concentric) and negative (Eccentric) muscular activity: A review
Rorke, S. C. (1995) · Sports medicine, training, and rehabilitation/Sports medicine, training and rehabilitation · doi:10.1080/15438629509512046 · Cited by 4
Genetic Aspects of Muscular Strength and Size
Hubal, M. J., Urso, M. L., & Clarkson, P. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-355-8_7 · Cited by 4
“Strenuous resistance exercise results in damage to muscle fibers that is most evident in myofibrillar Z-line streaming in Type II fibers [23, 24].”
Background
Enhanced fusion of myoblasts with myofibers for efficient gene delivery induced by a partially purified protein fraction from rat muscle extract
Cheng, L., Lai, M., Sanderson, J. E., et al. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.06.012 · Cited by 4
Effects of prolonged running performed at the intensity corresponding to the onset of blood lactate accumulation, on maximum isokinetic strength in active non-athletic individuals
Denadai, B. S., Greco, C., Tufík, S., & de Mello, M. T. (2007) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552007000300008 · Cited by 4
Effect of exercise on sarcoplasmic reticulum Ca2+ transport in muscle of mouse lines long-term selected for different Performance traits
Küchenmeister, U., Langhammer, M., Renne, U., et al. (2001) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-44-441-2001 · Cited by 4
“Muscle damage (BYRD, 1992), characterised by Zband Streaming, myofibrilar disOrganisation (FRIDEN et al., 1983), and membrane disruption (YASUDA et al.”
Background
Differential Effects of Unilateral Concentric Vs. Eccentric Exercise on the Dominant and Nondominant Forearm Flexors
Beck, T. W., Ye, X., & Wages, N. P. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001137 · Cited by 4
“However, it has been well documented (7,14,15) that activities with a high intensity or a high volume of eccentric muscle actions or”
Background
Architectural Design and Function of Human Back Muscles
Vasavada, A. N., Ward, S. R., Delp, S. L., et al. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6726-9.00003-1 · Cited by 4
Eccentric exercise induces spatial changes in the mechanomyographic activity of the upper trapezius muscle
Madeleine, P., Hansen, E. A., Andersen, R. E., et al. (2018) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13067 · Cited by 4
“The static contractions consisted of (1) a single bilateral 90°arm abduction and (2) 90°arm flexion maintained for 30 seconds with 1- minute rest in between.”
Method
Ovariectomy alters lengthening contraction induced heat shock protein expression
Locke, M., & Salerno, S. A. (2020) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2019-0212 · Cited by 4
Animal Models of Neuromuscular Diseases: Pathophysiology and Implications for Rehabilitation
Abresch, R. T., Walsh, S. A., & Wineinger, M. A. (1998) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/s1047-9651(18)30811-8 · Cited by 4
The Adrenal Medulla: Proenkephalins and Exercise Stress
Bush, J. A., & Triplett, N. T. (2005) · doi:10.1002/9780470757826.ch16 · Cited by 4
Influence of puberty on high intensity exercise induced skeletal muscle damage and inflammatory response in sedentary boys
Chaki, B., Pal, S., Chattopadhyay, S., & Bandyopadhyay, A. (2024) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2024.03.002 · Cited by 6
Recycle, repair, recover: the role of autophagy in modulating skeletal muscle repair and post-exercise recovery
Acheson, J., Joanisse, S., Sale, C., & Hodson, N. W. (2024) · Bioscience Reports · doi:10.1042/bsr20240137 · Cited by 4
Traumatic Skeletal Muscle Injury and Recovery
Greising, S. M., Call, J. A., & Baumann, C. W. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_10 · Cited by 4
Multisite electromyographic analysis of quadriceps muscle during exerciserelated fatigue, pain and recovery
Hedayatpour, N. (2008) · Cited by 3
Palmitoylethanolamide Does Not Affect Recovery from Exercise-Induced Muscle Damage in Healthy Males
Schouten, M., Dalle, S., Costamagna, D., Ramaekers, M., Bogaerts, S., Thienen, R. V., Peers, K. H. E., Thomis, M. A., & Koppo, K. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003517 · Cited by 7
“trenuous eccentric exercise (EE) is known to induce microstructural muscular disruption (i.e., Z-line streaming and fiber degradation), referred to as exercise-induced damage (EIMD) (1,2).”
Effect of the ACTN3 R577X Polymorphism on Serum Creatine Kinase and Interleukin-6 Levels After Maximal Eccentric Exercise
Deguchi, M., Homma, H., de Almeida, K. Y., et al. (2024) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000002623 · Cited by 3
Effects of Three Different Distance/Elevation Gain Ultra-Trail Races on Red Blood Cell Oxidative Stress and Senescence, and Blood Rheology
Carin, R., Nader, É., Bouscaren, N., Connes, P., Bègue, F., Lebeau, G., Paulo-Ramos, A., Descombes, G., Berly, L., Modrzyk, F., et al. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003653 · Cited by 3
Prepare to fail or failing to prepare? Acute performance after the 11+ with and without strength exercises
Støvland, V. R., Amundsen, R., Paulsen, G., & Dalen-Lorentsen, T. (2023) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2023-001634 · Cited by 3
“34 Our RPE results align with those of Chen et al , displaying a significantly higher RPE score after completing the 11+ compared with to a dynamic warm-up routine consisting of jogging and dynamic lower extremity exercises.”
Result
THE EFFECT OF LOW-LEVEL LASER THERAPY ON DELAYED ONSET MUSCLE SORENESS WHEN DELIVERED PRE- AND POST- ECCENTRIC EXERCISE
Kobordo, T. A. (2015) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 3
Antioxidant vitamins and muscle soreness in humans: a brief review
Thompson, D., & McNaughton, L. R. (2001) · Physical Therapy in Sport · doi:10.1054/ptsp.2001.0050 · Cited by 3
Assessment of the quadriceps femoris muscle in women after injury induced by maximal eccentric isokinetic exercise with low angular speed.
Serrão, F. V., Serrão, P. R. M. D. S., Foerster, B., Tannús, A., Pedro, V. M., & Salvini, T. F. (2007) · Europe PMC (PubMed Central) · Cited by 3
Sprint training attenuates the deficits of force and dynamic stiffness in rat soleus muscle caused by eccentric contractions
Virgen‐Ortiz, A., Marin, J. L., Trujillo, X., et al. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.05.003 · Cited by 3
Muscle Strains: Pathophysiology and New Classification Models
Maffulli, N., & Buono, A. D. (2015) · Springer eBooks · doi:10.1007/978-3-662-46491-5_42 · Cited by 3
Benefits of Lactobacillus helveticus Fermented Milk in Sports and Health
Iwasa, M., & Aoi, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809868-4.00013-3 · Cited by 3
Effect of avian immunoglobulin on post-exercise muscle damage and muscular soreness
Jacobson, B. H., Monaghan, T. P., Sellers, J., Estrada, C., & Moghaddam, M. (2019) · Journal of Human Sport and Exercise · doi:10.14198/jhse.2019.144.09 · Cited by 3
Optimal training plans on physical performance considering supercompensation
Wada, N., Ito, K., & Nakagawa, T. (2020) · Communication in Statistics- Theory and Methods · doi:10.1080/03610926.2020.1722845 · Cited by 3
“Although its such exercise intensity becomes harder of athletes can get much fitness, there exists a limitation of exercise intensity because an athlete has own physical limitation and intense eccentric training may harm myofibrillar and cause pain (Friden, Sjostrom, and Ekblom 1983).”
Background
EFFECTS OF REPEATED EXERCISE ON MUSCLE SORENESS, CREATINE KINASE ACTIVITY AND WHITE BLOOD CELL COUNT
Inoue, K., Nishikawa, S., Kimura, N., et al. (1992) · 体力科學 · doi:10.7600/jspfsm1949.41.156 · Cited by 3
Los agonistas adrenérgicos β2 y su influencia en el rendimiento físico
Drobnic, F. (1997) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(15)30643-8 · Cited by 3
Immunological changes in human blood and skeletal muscle in response to physical exercise
Malm, C. (2001) · Figshare · Cited by 3
ERGONOMICS OF TREE PLANTING WORK AMONG BRITISH COLUMBIA FOREST WORKERS
Trites, D. G. (1992) · Summit (Simon Fraser University) · Cited by 3
Achilles Tendon Rupture
Visser, J. D. (2011) · Encyclopedia of Sports Medicine · doi:10.4135/9781412961165.n6 · Cited by 3
RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
Ström, K., Oskolkov, N., Karaderi, T., Kalamajski, S., Mir, B. A., Ekström, O., Miyamoto-Mikami, E., Ladenvall, C., Kakulidis, E. S., Reid, S., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116961 · Cited by 3
“High type II fiber proportion has been suggested to be associated with increased risk of muscle injury 46,47 and longer recovery time after exercise.”
The Effects of Short-term Exercise Training on Peak-Torque Are Time- and Fiber-Type Dependent
Ureczky, D., Vácz, G., Costa, A., et al. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000414 · Cited by 2
“Several studies observed greater susceptibility to damage in type II muscle fibers, fibers comprising type IIa and IIx myosin-heavy chains, and satellite cells associated with type II fibers in human (4,15,16,31,36), animal (35,50), and other models (18) follow-”
Background
Velocity-Dependent Changes in Electrical Efficiency of the Leg Extensors during Eccentric Isokinetic Muscle Actions
Hill, E. C., Housh, T. J., Camic, C. L., et al. (2018) · International Journal of Sports Medicine · doi:10.1055/s-0043-124368 · Cited by 2
“It has been hypothesized that the mechanisms underlying the velocity-related responses of muscle damage and hypertrophy may be a function of greater z-line streaming [7, 17, 18, 27, 47] and/or preferential recruitment of type II motor units during eccentric muscle actions [34, 37, 49].”
Background
Plasma α-Actin as an Early Marker of Muscle Damage After Repeated Bouts of Eccentric Cycling
Jannas-Vela, S., Bustamante, A., Zbinden‐Foncea, H., et al. (2022) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2022.2060926 · Cited by 2
“These exercise bouts were performed at greater workloads than previous studies (i.e. 100% of the concentric POmax; Asp et al., 1995; Bruunsgaard et al., 1997; Evans et al., 1986; Friden et al., 1983; Klossner et al., 2007; Penailillo et al., 2013; Toft et al., 2002).”
Background
Influence of ACTN3 R577X Polymorphism on Blood Creatine Kinase Levels Relative to Number of Sprints in Brazilian Professional Soccer Players
de Almeida, K. Y., Zempo, H., Saito, M., Cetolin, T., Guimarães, R. D. S., Marrero, A. R., Aguiar, A. S., & Kikuchi, N. (2024) · Genes · doi:10.3390/genes15070896 · Cited by 2
“…when eccentric contractions occur, the regulation of calcium homeostasis, structural differences such as for example the narrower Z-line in fast-twitch fibers (type II) compared to slow-twitch fibers (type I), and the composition of the fibers with specific proteins and thin filaments [35–37].”
Background
Quantification of Exercise‐Induced Sarcomeric Damage in R349P Desmin Knock‐In Mice: A New Approach in Myofibrillar Myopathy Research
Holtzhausen, C., Schultheis, D., Berwanger, C., et al. (2025) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.70038 · Cited by 2
The Effects of Self-Myofascial Release Foam Rolling on Muscle Soreness or Pain After Experiencing Delayed Onset Muscle Soreness: A Critically Appraised Topic
Hjert, C. S., & Wright, C. J. (2020) · International Journal of Athletic Therapy & Training · doi:10.1123/ijatt.2019-0078 · Cited by 2
The Effect of Ginseng on Muscle Injury and Inflammation
Álvarez, A. I. (2004) · Journal of Ginseng Research · doi:10.5142/jgr.2004.28.1.018 · Cited by 2
Does Vitamin E and C Supplementation Improve the Recovery From Anterior Cruciate Ligament Surgery?
Barker, T., & Traber, M. G. (2011) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/1533210110392954 · Cited by 2
Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress
Laziz, I., Ferry, A., Armand, A., Gallien, C. L., Gaspera, B. D., Charbonnier, F., & Chanoine, C. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1784-0 · Cited by 2
“Indeed, it appears that eccentric exercise is able to involve some muscle lesions followed by the activation of satellite cells and the ensuing regenerative process (Friden et al. 1983; Carter et al. 1994; Friden and Lieber 2001; Smith et al. 2001; Armand et al. 2003).”
Background
Muscle Injury, Regeneration, and Repair
Huijbregts, P. A. (2001) · Journal of Manual & Manipulative Therapy · doi:10.1179/jmt.2001.9.1.9 · Cited by 2
Biomechanical Analysis of Eccentric and Concentric Lifting Exertions
Shu, Y. F. (2008) · NCSU Libraries Repository (North Carolina State University Libraries) · Cited by 2
Muscle Growth, Repair and Preservation
Erskine, R. M., & Degens, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396454-0.00025-4 · Cited by 3
“As well as structural damage to the sarcomere, eccentric exercise can cause raised intracellular calcium ion (Ca) levels (Belcastro, Albisser, Littlejohn, 1996), decreased muscle force production (Clarkson, Sayers, 1999; Friden et al., 1983), an increase in serum”
Background
The vestibulomyogenic balance response is elevated following high-intensity lengthening contractions of the lower limb
McIntosh, E. I., Power, G. A., & Dalton, B. H. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.056 · Cited by 2
Graded Compression Garments Worn During Resistance Exercise: Impact on Muscle Damage, Fatigue, and Oxygenation in Untrained Individuals
Cotter, J. A., Stade, M., Morse, B. G., et al. (2022) · International Journal of Kinesiology and Sports Science · doi:10.7575/aiac.ijkss.v.10n.2p.51 · Cited by 2
“Elevated serum CK following exercise indicates damage to myofibrillar machinery and increased permeability of the muscle fiber (Friden et al., 1983).”
Background
Severity of muscle impairment and its progression assessed using musculoskeletal magnetic resonance imaging and diffusion tension imaging in 78 boys with Duchenne muscular dystrophy: a retrospective study
Sane, H. M., Nivins, S., Paranjape, A., et al. (2024) · Polish Journal of Radiology · doi:10.5114/pjr.2024.135718 · Cited by 2
“Studies have demonstrated recruitment of mainly type II fibres during eccentric contractions [35,36].”
Background
TOTAL CREATINE KINASE AND ITS ISOENZYMES IN CORD BLOOD OF FULL TERM NEWBORNS
Khan, A., & Rathore, B. S. (2017) · Era s journal of medical research · doi:10.24041/ejmr2017.3 · Cited by 2
Resistance exercise on two consecutive days induces cortisol, CK, IgA responses in active young males
Arazi, H., Eghbali, E., Suzuki, K., & Mahdavi, M. (2019) · Apunts Sports Medicine · doi:10.1016/j.apunts.2019.11.001 · Cited by 2
“This may be due to the use of more type II muscle fibers in high-intensity eccentric exercise, which is known to be more sensitive to disorders than type I muscle fibers.(43,44) In contrast, Potteiger et al.”
Background
The effects of nutritional supplementation on regeneration of muscle function after damage
Cooke, M. B. (2005) · Victoria University Research Repository (Victoria University) · Cited by 2
Post-exercise muscle glycogen repletion in horses
Hyyppä, S. (2007) · Jukuri (Natural Resources Institute Finland (Luke)) · Cited by 2
The Effect of Concentric and Eccentric Training on the Strengthening of Tibialis Anterior
Reinking, M. F. (1991) · Isokinetics and Exercise Science · doi:10.3233/ies-1991-1404 · Cited by 2
“17 ,18.20.”
Influential
A Dynamic Biomechanical Model of the Hand and Arm in Pistol Grip Power Hand Tool Use
Lin, J., Radwin, R. G., & Richard, T. G. (1999) · Proceedings of the Human Factors and Ergonomics Society Annual Meeting · doi:10.1177/154193129904301213 · Cited by 2
“Eccentric contractions, however, have reported negative consequences including onset of muscle soreness (Komi and Buskirk, 1972; Talag, 1973), greater strength decrements compared to isometric and concentric exertions, and possibly greater risk for injuries (Fridén et al., 1983; Komi and Rusko, 1974; Lieber et al., 19…”
Background

Authors: Fridén, J., Sjöström, M., & Ekblom, B.
Affiliations: Karolinska Institutet (SE)
ORCID: Fridén, J.
Ekblom, B.
Venue: International Journal of Sports Medicine
Publisher: Georg Thieme Verlag KG
Published: 1983-08
Volume: 04
Issue: 03
Pages: 170-176
ISSN: 0172-4622 (ISSN-L)
1439-3964
DOI: 10.1055/s-2008-1026030
OpenAlex: W2006955286
Cited by: 1,005
References: 0
Citations by year: 2026: 13 · 2025: 14 · 2024: 21 · 2023: 16 · 2022: 22 · 2021: 24 · 2020: 31 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 29 · 2014: 33 · 2013: 37 · 2012: 35
FWCI: 15.43
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Muscular Dystrophy Association
Vetenskapsrådet
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: delayed onset muscle soreness, eccentric exercise, myofibrillar damage, muscle fiber ultrastructure, fast-twitch muscle, quadriceps strength, muscle strength recovery, exercise-induced muscle damage, thigh muscle
MeSH terms: Adolescent, Adult, Biopsy, Physical Exertion, Humans, Knee, Male, Microscopy, Electron, Mitochondria, Muscle, Muscle Contraction, Myofibrils, Pain, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Myofibrillar Damage Following Intense Eccentric Exercise in Man

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks