Cited by 1,005Exercise and Physiological ResponsesMuscle Physiology and DisordersCardiovascular and exercise physiology

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Myofibrillar Damage Following Intense Eccentric Exercise in Man

Fridén, J., Sjöström, M., Ekblom, B.·1983·International Journal of Sports Medicine

DOI 10.1055/s-2008-1026030

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Abstract

Muscle soreness that has a delayed onset is a common feature among both athletes and untrained individuals who engage in unusual exercises. This study was designed to provide additional morphological data to assess the relevance and significance of our previous findings that the sore muscles contain fibers with disorganized myofibrillar material. Muscle biopsies were obtained from 12 males (mean age 25 +/- 7 years), who suffered from severe soreness in their thigh muscles 18--72 h following eccentric bicycle exercise. Their strength performance were tested in parallel. Knee extensor strength was decreased at all angular velocities soon after exercise but gradually increased over the subsequent days although slower at the fastest contractions. Disturbances of the cross-striated band pattern were constantly observed. They originated from the myofibrillar Z-band, which showed marked streaming, broadening and, at places, total disruption. The disturbances were found in every second to every third fiber up to 3 days after exercise and in one tenth of the fibers 6 days following the exercise. Type 2 fibers were predominantly affected. Thus, the eccentric exercise gives rise to muscles soreness and influences, on mechanical basis and selectively with regard to fiber type, the fine structure of the contractile apparatus.

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“In the present experiments, disruption of the thick- and thin-filament lattice (18, 23) and ‘‘streaming’’ of the Z line (14, 23) were the more common forms of damage observed, with damage to substantial groups of sarcomeres.”
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Muscle damage and inflammation biomarkers after two ultra-endurance mountain races of different distances: 54 km vs 111 km
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Background
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“This comparison is also complicated by the finding that fast-twitch motor units are preferentially damaged (10, 21) and display the greatest low-frequency fatigue (27) after eccentric exercise, although slow-twitch motor units are also affected (33).”
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Muscle-Tendon Injuries in Young Athletes
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Background
Defining a role for non-satellite stem cells in the regulation of muscle repair following exercise
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Influential
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Muscle damage induced by stretch-shortening cycle exercise
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Authors: Fridén, J., Sjöström, M., & Ekblom, B.
Affiliations: Karolinska Institutet (SE)
ORCID: Fridén, J.
Ekblom, B.
Venue: International Journal of Sports Medicine
Publisher: Georg Thieme Verlag KG
Published: 1983-08
Volume: 04
Issue: 03
Pages: 170-176
ISSN: 0172-4622 (ISSN-L)
1439-3964
DOI: 10.1055/s-2008-1026030
OpenAlex: W2006955286
Cited by: 1,005
References: 0
Citations by year: 2026: 13 · 2025: 14 · 2024: 21 · 2023: 16 · 2022: 22 · 2021: 24 · 2020: 31 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 29 · 2014: 33 · 2013: 37 · 2012: 35
FWCI: 15.43
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Muscular Dystrophy Association
Vetenskapsrådet
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: delayed onset muscle soreness, eccentric exercise, myofibrillar damage, muscle fiber ultrastructure, fast-twitch muscle, quadriceps strength, muscle strength recovery, exercise-induced muscle damage, thigh muscle
MeSH terms: Adolescent, Adult, Biopsy, Physical Exertion, Humans, Knee, Male, Microscopy, Electron, Mitochondria, Muscle, Muscle Contraction, Myofibrils, Pain, Time Factors

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Myofibrillar Damage Following Intense Eccentric Exercise in Man

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