The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Bacterial Infections, Sepsis, and Multiorgan Failure in Cirrhosis
Abstract
Bacterial infections are an important complication of cirrhosis, particularly in hospitalized patients. In this article we review the prevalence, risk factors, and pathogenesis of bacterial infections in cirrhosis, focusing on the mechanisms of bacterial translocation such as impaired immunity and bacterial overgrowth, as well as maneuvers that may inhibit bacterial translocation and could be used not only to prevent infections but also to ameliorate the hyperdynamic circulatory state of cirrhosis. We also review the clinical features and management of the most common infection in cirrhosis, spontaneous bacterial peritonitis (SBP), specifically the evidence behind the therapy of acute SBP, the role of albumin, and the role of antibiotics in the prophylaxis of high-risk patients. It has been recognized that SBP and other bacterial infections lead to the systemic inflammatory response syndrome, sepsis, and multiorgan failure. We review the pathogenesis and management of these complications, the role of adrenal insufficiency, and the utility of intensive care prognostic models.
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Cites
Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
Fernández, J., Navasa, M., Planas, R., Montoliu, S., Monfort, D., Soriano, G., Vila, C., Pardo, A., Quintero, E., Vargas, V., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.065 · Cited by 709
Wilkes, M. M., & Navickis, R. J. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-3-200108070-00007 · Cited by 486
Lumsden, A. B., Henderson, M. J., & Kutner, M. H. (1988) · Hepatology · doi:10.1002/hep.1840080207 · Cited by 427
Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321
Pérez-Paramo, M., Muñoz, J., Albillos, A., Freile, I., Portero, F., Santos, M., & Ortiz-Berrocal, J. (2000) · Hepatology · doi:10.1002/hep.510310109 · Cited by 271
Navasa, M., Follo, A., Llovet, J., Clemente, G., Vargas, V, Rimola, A., Marco, F., Guarner, C., Forne, M., Planas, R., et al. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70069-0 · Cited by 258
Steffen, E. K., Berg, R. D., & Deitch, E. A. (1988) · Journal of Infectious Diseases · doi:10.1093/infdis/157.5.1032 · Cited by 234
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05791.x · Cited by 211
Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis
Pardo, A., Bartolí, R., Lorenzo-Zúñiga, V., Planas, R., Viñado, B., Riba, J., Cabré, E., Santos, J., Luque, T., Ausina, V., et al. (2000) · Hepatology · doi:10.1053/he.2000.5746 · Cited by 177
Monocyte Human Leukocyte Antigen–DR Transcriptional Downregulation by Cortisol during Septic Shock
Le Tulzo, Y., Pangault, C., Amiot, L., Guilloux, V., Tribut, O., Arvieux, C., Camus, C., Fauchet, R., Thomas, R., & Drénou, B. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1329oc · Cited by 166
Madrid, A. M., Hurtado, C., Venegas, M., Cumsille, F., & Defilippi, C. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03636.x · Cited by 158
Endotoxemia contributes to the immune paralysis in patients with cirrhosis
Lin, C.-Y., Tsai, I.-F., Ho, Y.-P., Huang, C.-T., Lin, Y.-C., Lin, C.-J., Tseng, S.-C., Lin, W.-P., Chen, W.-T., & Sheen, I.-S. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2006.12.018 · Cited by 145
Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis
Zhang, S.-C. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i3.534 · Cited by 42
Cited by
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346
EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720
Fernández, J., Acevedo, J., Castro, M., Garcia, O., de Lope, C. R., Roca, D., Pavesi, M., Sola, E., Moreira, L., Silva, A., et al. (2012) · Hepatology · doi:10.1002/hep.25532 · Cited by 620
Bajaj, J. S., O'Leary, J. G., Reddy, R. K., Wong, F., Biggins, S. W., Patton, H., Fallon, M. B., Garcia-Tsao, G., Maliakkal, B., Malik, R., et al. (2014) · Hepatology · doi:10.1002/hep.27077 · Cited by 574
Self-citation
Metadata
- Authors
- Tandon, P., & Garcia-Tsao, G.
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2008-02
- Volume
- 28
- Issue
- 1
- Pages
- 026-042
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W2153155205
- Cited by
- 551
- References
- 15
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
