The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Defective Lipoprotein Receptors and Atherosclerosis: Lessons from an Animal Counterpart of Familial Hypercholesterolemia
Abstract
In 1913, Anitschkow fed cholesterol to rabbits, and thereby demonstrated that a high blood level of cholesterol can produce atherosclerosis in animals just as it can in human beings — with one fundamental difference. Human hypercholesterolemia is caused by genetic or acquired abnormalities in the synthesis or degradation of plasma lipoproteins that shuttle endogenous cholesterol between body tissues; dietary cholesterol is only an indirect aggravating factor. In laboratory animals hypercholesterolemia is produced exogenously when the normal mechanisms of lipoprotein clearance are overwhelmed by large amounts of dietary cholesterol. Since dietary and endogenous cholesterol are transported by different plasma lipoproteins, the . . .
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Cites
LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
Brown, M. S., & Goldstein, J. L. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001255 · Cited by 2,300
Self-citationThe Pathogenesis of Atherosclerosis: (First of Two Parts)
Ross, R., & Glomset, J. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950707 · Cited by 2,014
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,818
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Self-citationLipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 755
Regulation of Plasma Cholesterol by Lipoprotein Receptors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 702
Self-citationWATANABE, Y. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90234-8 · Cited by 544
Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts
Brown, M. S., Dana, S. E., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42998-0 · Cited by 544
Self-citationRegulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
Kovanen, P. T., Bilheimer, D. W., Goldstein, J. L., Jaramillo, J. J., & Brown, M. S. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1194 · Cited by 421
Self-citationLipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
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Cited by
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Self-citationThe Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,877
Manninen, V, Tenkanen, L., Koskinen, P., Huttunen, J. K., Mänttäri, M., Heinonen, O. P., & Frick, M. H. (1992) · Circulation · doi:10.1161/01.cir.85.1.37 · Cited by 1,329
Kita, T., Nagano, Y., Yokode, M., Ishii, K., Kume, N., Ooshima, A., Yoshida, H., & Kawai, C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5928 · Cited by 870
Self-citation[1] Introduction to the plasma lipoproteins
Gotto, A. M., Pownall, H. J., & Havel, R. J. (1986) · Methods in Enzymology · doi:10.1016/0076-6879(86)28061-1 · Cited by 421
Metadata
- Authors
- Epstein, F. H., Goldstein, J. L., Kita, T., & Brown, M. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-08-04
- Volume
- 309
- Issue
- 5
- Pages
- 288-296
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2051742401
- Cited by
- 469
- References
- 37
- FWCI
- 61.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Defective Lipoprotein Receptors and Atherosclerosis: Lessons from an Animal Counterpart of Familial Hypercholesterolemia. https://app.cochat.ai/papers/10.1056/nejm198308043090507
- The paper
- Epstein, F. H., Goldstein, J. L., Kita, T., & Brown, M. S. (1983). Defective Lipoprotein Receptors and Atherosclerosis: Lessons from an Animal Counterpart of Familial Hypercholesterolemia. New England Journal of Medicine. https://doi.org/10.1056/nejm198308043090507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
