Cited by 235Diabetes Management and ResearchPancreatic function and diabetesDiabetes Treatment and Management

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The “Dawn-Phenomenon” – a common occurrence in both non-insulin-dependent and insulin-dependent diabetes mellitus

Bolli, Geremia B., Gerich, John E.·1984·New England Journal of Medicine

DOI 10.1056/nejm198403223101203

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Abstract

The dawn phenomenon is a condition recently described in patients with insulin-dependent diabetes mellitus (IDDM) that is characterized by abrupt increases in fasting levels of plasma glucose or insulin requirements or both between 5 and 9 a.m., in the absence of antecedent hypoglycemia. To determine its potential clinical relevance, we assessed its frequency and reproducibility in 20 patients with IDDM and in 13 patients with non-insulin-dependent diabetes mellitus (NIDDM) during overnight closed-loop (feedback-controlled) intravenous insulin infusion. After 6 a.m., plasma glucose levels increased similarly in NIDDM (89 +/- 2 mg per deciliter, midnight to 6 a.m., vs. 98 +/- 2 mg per deciliter, 6 to 9 a.m.; P less than 0.01). Insulin requirements increased at least 50 per cent for 1 1/2 hours in 77 per cent of patients with NIDDM and in 75 per cent of patients with IDDM. In five patients with IDDM who were studied on four occasions, the phenomenon occurred during 17 of the 20 observation periods, with insulin requirements after 6 a.m. increasing 225 +/- 34 per cent; coefficients of variation in individual patients ranged from 4 to 25 per cent. Thus, the dawn phenomenon occurs commonly in both NIDDM and IDDM, but its potential variability must be taken into consideration when one is attempting to adjust insulin doses.

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C-peptide Response to Glucagon: A Test for the Residual β-cell Function in Diabetes Mellitus
FABER, O. K., & Binder, C. (1977) · Diabetes · doi:10.2337/diab.26.7.605 · Cited by 396
Diurnal Variation in Glucose Tolerance and in Insulin Secretion in Man
Carroll, K. F., & Nestel, P. J. (1973) · Diabetes · doi:10.2337/diab.22.5.333 · Cited by 231
The Dawn Phenomenon, an Early Morning Glucose Rise: Implications for Diabetic Intraday Blood Glucose Variation
Schmidt, M. I., Hadji-Georgopoulos, A., Rendell, M., Margolis, S., & Kowarski, A. (1981) · Diabetes Care · doi:10.2337/diacare.4.6.579 · Cited by 216
Exacerbation of diabetes by excess insulin action
Somogyi, M. (1959) · The American Journal of Medicine · doi:10.1016/0002-9343(59)90307-9 · Cited by 203
Diurnal Variation in Oral Glucose Tolerance: Blood Sugar and Plasma Insulin Levels Morning, Afternoon, and Evening
Jarrett, R. J., Baker, I. A., KEEN, H., & Oakley, N. W. (1972) · BMJ · doi:10.1136/bmj.1.5794.199 · Cited by 176
Closed-loop and Open-loop Devices for Blood Glucose Control in Normal and Diabetic Subjects
Santiago, J. V., Clemens, A. H., Clarke, W. L., & KIPNIS, D. M. (1978) · Diabetes · doi:10.2337/diab.28.1.71 · Cited by 134
Altered Responsiveness to Cortisol, Epinephrine, and Glucagon in Insulin-infused Juvenile-onset Diabetics: A Mechanism for Diabetic Instability
Shamoon, H., Hendler, R., & Sherwin, R. S. (1980) · Diabetes · doi:10.2337/diab.29.4.284 · Cited by 133
DIURNAL VARIATION IN INSULIN SENSITIVITY
Gibson, T. C., & Jarrett, R. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92472-5 · Cited by 117
Regulation of brittle diabetics by a pre-planned insulin infusion programme
Deckert, T., & L�rup, B. (1976) · Diabetologia · doi:10.1007/bf01220633 · Cited by 84
Overnight Basal Insulin Requirements in Fasting Insulin-dependent Diabetics
Clarke, W. L., Haymond, M. W., & Santiago, J. V. (1980) · Diabetes · doi:10.2337/diab.29.1.78 · Cited by 84

Show all 21 references

Research works printed but not linked: 5

White, 1983, Diabetes, 33, 60
Hatlehol, 1924, Acta Med Scand [Suppl], 8, 1
Izzo, 1949, Proc Am Diabetes Assoc, 9, 247
Faiman, 1967, Clin Sci, 32, 111
Wildenhoff, 1972, Acta Med Scand, 191, 303

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Hypoglycemia: causes, neurological manifestations, and outcome.
Malouf, R., & Brust, J. C. M. (1985) · Annals of Neurology · doi:10.1002/ana.410170502 · Cited by 286
Evidence for a circadian rhythm of insulin secretion
Boden, G., Ruiz, J., Urbain, J. L., & Chen, X. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e246 · Cited by 261
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Dorsch, T. R. (2002) · JAMA · doi:10.1001/jama.287.19.2589 · Cited by 261
Control of glycaemia.
Gerich, J. E. (1993) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80207-1 · Cited by 224
Chronobiology in the endocrine system
Haus, E. L. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.01.001 · Cited by 228
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Nocturnal Decrease in Glucose Tolerance During Constant Glucose Infusion*
Cauter, E. V., Désir, D., Decoster, C. G., Féry, F., & BALASSE, E. O. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-604 · Cited by 160
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Nocturnal hypoglycaemia in patients receiving conventional treatment with insulin.
Pramming, S., Thorsteinsson, B., Bendtson, I., Rønn, B. B., & Binder, C. (1985) · BMJ · doi:10.1136/bmj.291.6492.376 · Cited by 108
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Fowelin, J., Attvall, S., von Schenck, H., Smith, U., & Lager, I. (1991) · Diabetologia · doi:10.1007/bf00403286 · Cited by 92
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Scheen, A. J., & Cauter, E. V. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023170 · Cited by 80
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24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J., Scheen, A. J., Leproult, R., Polonsky, K. S., & Cauter, E. V. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117817 · Cited by 69
Pharmacokinetics and Pharmacodynamics of Basal Insulins
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Nocturnal Elevation of Glucose Levels during Fasting in Noninsulin-Dependent Diabetes*
Shapiro, E. T., Polonsky, K. S., Copinschi, G., Bosson, D., TILLIL, H., Blackman, J. D., Lewis, G. F., & Cauter, E. V. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-444 · Cited by 65
Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions
Gerich, J. E., & Campbell, P. J. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040202 · Cited by 65
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Zhang, Y., Fang, X., Wei, J., Miao, R., Wu, H., Ma, K., & Tian, J. (2022) · Biomolecules · doi:10.3390/biom12121785 · Cited by 72
Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms
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Radziuk, J., & Pye, S. (2002) · Diabetologia · doi:10.1007/s00125-002-0841-6 · Cited by 64
Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon
Feo, P. D., Perriello, G., Ventura, M. M., Calcinaro, F., Basta, G., Lolli, C., Cruciani, G., Dell'Olio, A., Santeusanio, F., Brunetti, P., et al. (1986) · Diabetologia · doi:10.1007/bf00453496 · Cited by 60
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Lal, H., Verma, S. K., Wang, Y., Xie, M., & Young, M. E. (2024) · Circulation Research · doi:10.1161/circresaha.123.323520 · Cited by 67
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Ando, H., Ushijima, K., Shimba, S., & Fujimura, A. (2015) · Endocrinology · doi:10.1210/en.2015-1376 · Cited by 58
The dawn phenomenon and the Somogyi effect - two phenomena of morning hyperglycaemia.
Rybicka, M., Krysiak, R. G., & Okopień, B. (2011) · PubMed · Cited by 54
Biological Variation of Homeostasis Model Assessment-Derived Insulin Resistance in Type 2 Diabetes
Jayagopal, V., Kilpatrick, E. S., Jennings, P. E., Hepburn, D. A., & Atkin, S. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2022 · Cited by 53
Combination Insulin-Sulfonylurea Therapy
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Lucidi, P., Porcellati, F., Rossetti, P., Candeloro, P., Cioli, P., Marzotti, S., Andreoli, A. M., Fede, R., Bolli, G. B., & Fanelli, C. G. (2011) · Diabetes Care · doi:10.2337/dc10-1911 · Cited by 51
Growth Factors and Diabetic Complications
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Frequency and Severity of the Dawn Phenomenon in Type 2 Diabetes
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Interactive educational simulators in diabetes care
Lehmann, E. D. (1997) · Medical Informatics · doi:10.3109/14639239709089834 · Cited by 48
Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children
Abbott, W. G. H., & Foley, J. E. (1987) · Metabolism · doi:10.1016/0026-0495(87)90170-3 · Cited by 46
Pharmacokinetics and pharmacodynamics of insulin glargine given in the evening as compared with in the morning in type 2 diabetes
Porcellati, F., Lucidi, P., Cioli, P., Candeloro, P., Marinelli Andreoli, A., Marzotti, S., Ambrogi, M., Bolli, G. B., & Fanelli, C. G. (2015) · Diabetes Care · doi:10.2337/dc14-0649 · Cited by 52
Sequence of events during development of the dawn phenomenon in insulin-dependent diabetes mellitus
Campbell, P. J., Bolli, G. B., Cryer, P. E., & Gerich, J. E. (1985) · Metabolism · doi:10.1016/0026-0495(85)90153-2 · Cited by 45
Circadian Variation in Blood Pressure: Dipper or Nondipper
Larochelle, P. M. (2002) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2002.01033.x · Cited by 44
The Relevance of Glucose Counterregulatory Systems to Patients with Insulin-Dependent Diabetes Mellitus*
CRYER, P. E., WHITE, N. H., & SANTIAGO, J. V. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-2-131 · Cited by 43
NEW TACTICS FOR TYPE 2 DIABETES: REGIMENS BASED ON INTERMEDIATE-ACTING INSULIN TAKEN AT BEDTIME
Riddle, M. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92029-x · Cited by 40
The Importance of Different Frequency Bands in Predicting Subcutaneous Glucose Concentration in Type 1 Diabetic Patients
Lu, Y., Gribok, A. V., Ward, W. K., & Jaques Reifman, A. (2010) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2010.2047504 · Cited by 39
Growth hormone controls lipolysis by regulation of FSP27 expression
Sharma, R., Luong, Q. V., Sharma, V. M., Harberson, M. T., Harper, B., Colborn, A., Berryman, D. E., Jessen, N., Jørgensen, J. O. L., Kopchick, J. J., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0282 · Cited by 38
Fasting Hyperglycemia: Etiology, Diagnosis, and Treatment
Sheehan, J. P. (2004) · Diabetes Technology & Therapeutics · doi:10.1089/1520915041705910 · Cited by 38
Development of gliclazide ionic liquid and the transdermal patches: An effective and noninvasive sustained release formulation to achieve hypoglycemic effects
Zhou, B.-J., Liu, S., Yin, H.-M., Qi, M., Hong, M., & Ren, G. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105915 · Cited by 37
Prevention of the Dawn phenomenon (early morning hyperglycemia) in insulin-dependent diabetes mellitus by bedtime intranasal administration of a long-acting somatostatin analog
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Type 2 diabetes: A well-characterised but suboptimally controlled disease. Can we bridge the divide?
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Ghrelin secretion is more closely aligned to energy balance than with feeding behaviour in the grower pig
Scrimgeour, K., Gresham, M., Giles, L. R., Thomson, P. C., WYNN, P. C., & Newman, R. E. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0627 · Cited by 35
An Adaptive Nonlinear Basal-Bolus Calculator for Patients With Type 1 Diabetes
Boiroux, D., Aradóttir, T. B., Nørgaard, K., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2016) · Journal of Diabetes Science and Technology · doi:10.1177/1932296816666295 · Cited by 35
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., & Challet, É. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00009-3 · Cited by 34
Effect of Temporal Distribution of Calories on Diurnal Patterns of Glucose Levels and Insulin Secretion in NIDDM
Beebe, C., Cauter, E. V., Shapiro, E. T., TILLIL, H., Lyons, R., Rubenstein, A. H., & Polonsky, K. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.7.748 · Cited by 32
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Frequency of the Dawn Phenomenon in Type 2 Diabetes: Implications for Diabetes Therapy
Carroll, M. F., Hardy, K. J., Burge, M. R., & Schade, D. S. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/152091502320798213 · Cited by 28
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Dawn phenomenon in Type 1 (insulin-dependent) diabetic adolescents: influence of nocturnal growth hormone secretion
Beaufr�re, B., Beylot, M., Metz, C. N., Ruitton, A., Fran�ois, R., Riou, J. P., & Mornex, R. (1988) · Diabetologia · doi:10.1007/bf00264768 · Cited by 28
The dawn phenomenon in type 2 diabetes: How to assess it in clinical practice?
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Dawn Phenomenon and Somogyi Effect in IDDM
Stephenson, J., & Schernthaner, G. (1989) · Diabetes Care · doi:10.2337/diacare.12.4.245 · Cited by 27
Somatostatin Analogues in Diabetes Mellitus
Davies, D. R. R., Turner, S. J., Alberti, K. G. M. M., & Johnston, D. G. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb02096.x · Cited by 29
Effects of Hepatic Glycogen Content on Hepatic Insulin Action in Humans: Alteration in the Relative Contributions of Glycogenolysis and Gluconeogenesis to Endogenous Glucose Production
Wise, S., Nielsen, M. F., & Rizza, R. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3971 · Cited by 26
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No seasonal variation of insulin sensitivity and glucose effectiveness in men.
Gravholt, C., Holck, P., Nyholm, B., Christiansen, E., Erlandsen, M., & Schmitz, O. (2000) · Metabolism: Clinical and Experimental · doi:10.1016/s0026-0495(00)90613-9 · Cited by 27
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Atiea, J., Creagh, F. M., Page, M. D., Owens, D. R., Scanlon, M. F., & Peters, J. R. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-2-390 · Cited by 23
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Fowelin, J., Attvall, S., von Schenck, H., Bengtsson, B. ‐., Smith, U., & Lager, I. (1993) · Metabolism · doi:10.1016/0026-0495(93)90092-3 · Cited by 21
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Prato, S. D., de Kreutzenberg, S. V., Riccio, A., Maifreni, L., Duner, E., LISATO, G., Iavicoli, M., & Tiengo, A. (1990) · Diabetologia · doi:10.1007/bf00400571 · Cited by 22
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la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00026-6 · Cited by 23
The Dawn Phenomenon Does Not Occur in Normal Elderly Subjects*
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Authors: Bolli, G. B., & Gerich, J. E.
Affiliations: Mayo Clinic (US)
ORCID: Bolli, Geremia B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1984-03-22
Volume: 310
Issue: 12
Pages: 746-750
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198403223101203
OpenAlex: W2317353168
Cited by: 235
References: 21
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 16 · 2013: 7 · 2012: 6
FWCI: 10.49
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: dawn phenomenon, type 1 diabetes, type 2 diabetes, insulin requirement, fasting blood glucose, nocturnal glucose, insulin dose adjustment
MeSH terms: Adult, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Infusion Systems, Male, Middle Aged, Time

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The “Dawn-Phenomenon” – a common occurrence in both non-insulin-dependent and insulin-dependent diabetes mellitus

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