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Life Extension
Abstract
Extension of the life span has become an increasingly prominent subject in the media. Vitamins, nutrient supplements, minerals, and skin creams have been aggressively promoted as being able to delay aging and prolong life. Books on longevity and life extension aimed at promoting such products have made several best-seller lists. A recent Congressional hearing on medical quackery devoted considerable time and effort to investigating anti-aging "cures."1 Unfortunately, there have been few attempts to examine the scientific basis for the claims of life extension made by promoters of such products.This article will examine several interventions that have been proposed to . . .
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Dietary additives that delay ageing and increase lifespan in rodent models have shown only weak effects to date.
“To date, dietary additives that delay ageing and increase lifespan in rodent models have shown only weak effects9–11.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [11]
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Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
A Natural History of Athleticism and Cardiovascular Health
Paffenbarger, R. S. (1984) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1984.03350040021015 · Cited by 405
THE IMMUNOLOGIC THEORY OF AGING
Walford, R. L. (1969) · Immunological Reviews · doi:10.1111/j.1600-065x.1969.tb00210.x · Cited by 284
MIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-9-1051 · Cited by 260
Immunological Senescence in Mice and Its Reversal by Coenzyme Q10
Bliznakov, E. G. (1978) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(78)90065-9 · Cited by 26
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Research works printed but not linked: 184
- 10.1056/NEJM198310063091411 · DOI
- McCay, 1935, J Nutr, 10, 63, 10.1093/jn/10.1.63 · DOI · Paper page
- McCay, 1939, J Nutr, 18, 1, 10.1093/jn/18.1.1 · DOI · Paper page
- McCay, 1943, Arch Biochem, 2, 469
- Berg, 1960, J Nutr, 71, 255, 10.1093/jn/71.3.255 · DOI
- Nolen, 1972, J Nutr, 102, 1477, 10.1093/jn/102.11.1477 · DOI
- 10.1080/03610738308258453 · DOI
- Ball, 1947, Am J Physiol, 150, 511, 10.1152/ajplegacy.1947.150.3.511 · DOI
- 10.1002/ijc.2910230611 · DOI
- 10.1093/geronj/37.2.130 · DOI
- 10.1016/0047-6374(76)90012-9 · DOI
- 10.1016/0531-5565(68)90006-5 · DOI
- 10.1126/science.1166309 · DOI
- 10.1016/0022-0248(77)90067-7 · DOI
- 10.1093/geronj/31.2.149 · DOI
- Nakagawa, 1974, J Nutr, 104, 1576, 10.1093/jn/104.12.1576 · DOI
- 10.1016/0531-5565(83)90021-9 · DOI
- Ross, 1972, Am J Clin Nutr, 25, 834, 10.1093/ajcn/25.8.834 · DOI
- Deyl, 1975, Adv Exp Med Biol, 53, 359, 10.1007/978-1-4757-0731-1_31 · DOI
- 10.1126/science.7063854 · DOI
- 10.1093/geronj/38.1.36 · DOI
- 10.1016/0531-5565(80)90029-7 · DOI
- Tannenbaum, 1940, Am J Cancer, 38, 335
- 10.1038/263504b0 · DOI
- Saxton, 1948, Acta Int Canc, 6, 423
- Ross, 1971, JNCI, 47, 1095
- Ross, 1973, J Nutr, 103, 944, 10.1093/jn/103.7.944 · DOI
- Ohno, 1983, Mt Sinai J Med (NY), 50, 338
- Fernandes, 1979, Clin Bull, 9, 91
- 10.1016/0047-6374(73)90035-3 · DOI
- 10.1159/000212044 · DOI
- Weindruch, 1979, Fed Proc, 38, 2007
- 10.1073/pnas.79.3.898 · DOI
- 10.1016/0531-5565(69)90005-9 · DOI
- Masoro, 1980, Fed Proc, 39, 3178
- Liepa, 1980, Am J Physiol, 238, E253
- Herlihy, 1980, Am J Physiol, 238, H652
- 10.1126/science.7291993 · DOI
- 10.1126/science.6729452 · DOI
- 10.1016/0026-0495(81)90096-2 · DOI
- Masoro, 1983, J Nutr, 113, 880, 10.1093/jn/113.4.880 · DOI
- 10.1016/0047-6374(84)90176-3 · DOI
- 10.1172/JCI110256 · DOI
- Andres R. Mortality and obesity: the rationale for age-specific height-weight tables. In: Andres R, Bierman E, Hazzard W, eds. Geriatrics. New York: McGraw-Hill, 1985:311–8.
- 10.7326/0003-4819-100-2-285 · DOI
- 10.1073/pnas.81.6.1835 · DOI
- Polednak, 1970, Hum Biol, 42, 28
- 10.1016/S0140-6736(71)92377-4 · DOI
- Beaglehole, 1983, NZ Med J, 96, 513
- Retzlaff, 1966, Geriatrics, 21, 171
- 10.1016/0531-5565(76)90007-3 · DOI
- 10.1093/geronj/27.3.341 · DOI
- 10.1159/000212252 · DOI
- 10.1093/geronj/29.2.129 · DOI
- 10.1001/jama.252.4.491 · DOI
- 10.1016/0002-9343(83)90882-3 · DOI
- 10.1001/archinte.139.8.857 · DOI
- 10.1016/0002-9149(78)90637-9 · DOI
- 10.1016/0026-0495(72)90034-0 · DOI
- Smith, 1981, Med Sci Sports Exerc, 13, 60
- 10.1093/geronj/11.3.298 · DOI · Paper page
- 10.1146/annurev.bi.44.070175.001051 · DOI
- 10.1111/j.1751-1097.1978.tb07020.x · DOI
- 10.1093/geronj/35.1.45 · DOI
- 10.1073/pnas.78.11.6858 · DOI
- 10.1093/geronj/12.3.257 · DOI
- 10.1093/geronj/26.3.378 · DOI
- 10.1016/0531-5565(77)90008-0 · DOI
- 10.1016/0300-483X(78)90070-7 · DOI
- 10.1093/geronj/16.3.247 · DOI
- 10.1093/geronj/23.4.476 · DOI
- 10.1093/geronj/34.4.497 · DOI
- Oeriu, 1965, J Gerontol, 20, 417
- 10.1038/229254a0 · DOI
- 10.1016/0047-6374(76)90010-5 · DOI
- Buu-Hoi, 1959, C R Soc Biol (Paris), 153, 1180
- 10.1016/0531-5565(79)90039-1 · DOI
- 10.1016/0531-5565(82)90043-2 · DOI
- 10.1093/geronj/26.4.451 · DOI
- French, 1953, J Nutr, 51, 329, 10.1093/jn/51.3.329 · DOI
- 10.1007/BF02136410 · DOI
- Horn, 1979, J Nutr, 109, 1234, 10.1093/jn/109.7.1234 · DOI
- 10.1093/geronj/28.4.415 · DOI
- 10.1016/0531-5565(80)90076-5 · DOI
- 10.1093/ageing/10.3.191 · DOI
- 10.1093/geronj/14.2.174 · DOI
- 10.1016/0047-6374(80)90128-1 · DOI
- Miquel, 1973, Gerontologist, 13, 37
- 10.1016/0531-5565(80)90039-X · DOI
- Epstein, 1972, Mech aging Dev, 1, 245, 10.1016/0047-6374(72)90091-7 · DOI
- 10.1073/pnas.71.12.4763 · DOI
- 10.1073/pnas.74.4.1640 · DOI
- 10.1247/csf.2.219 · DOI
- 10.1056/NEJM198403083101006 · DOI
- 10.1126/science.6351251 · DOI
- 10.1073/pnas.79.19.6023 · DOI
- 10.1016/0006-291X(76)90701-4 · DOI
- 10.1016/0047-6374(79)90073-3 · DOI
- 10.1111/j.1432-1033.1976.tb10266.x · DOI
- 10.1159/000212519 · DOI
- Lammi-Keefe, 1982, Fed Proc, 41, 464
- 10.1016/0047-6374(80)90051-2 · DOI
- 10.1093/geronj/31.4.405 · DOI
- 10.1073/pnas.77.5.2777 · DOI
- 10.1007/BF01963281 · DOI
- 10.1016/0047-6374(84)90177-5 · DOI
- Zidenberg-Cherr, 1983, Am J Clin Nutr, 37, 5, 10.1093/ajcn/37.1.5 · DOI
- 10.1016/0531-5565(68)90052-1 · DOI
- Wolman, 1980, Pathobiol Annu, 10, 253
- 10.1038/210313a0 · DOI
- 10.1007/BF00220143 · DOI
- 10.1016/0047-6374(74)90027-X · DOI
- 10.1016/0006-8993(74)90864-6 · DOI
- 10.1016/0047-6374(78)90013-1 · DOI
- 10.1016/0197-4580(83)90059-3 · DOI
- Totaro, 1980, Acta Neurol (Napoli), 35, 79
- 10.1016/0531-5565(83)90031-1 · DOI
- 10.1016/S0531-5565(71)80013-X · DOI
- 10.1016/0531-5565(73)90024-7 · DOI
- Schmid, 1979, Aktuel Gerontol, 9, 125
- 10.1002/cne.901550105 · DOI
- 10.1007/BF00316422 · DOI
- 10.1016/0024-3205(81)90271-X · DOI
- 10.1073/pnas.71.6.2466 · DOI
- 10.1126/science.850799 · DOI
- 10.1159/000212423 · DOI
- 10.1007/BF00313615 · DOI
- 10.1002/ana.410030205 · DOI
- 10.1016/0531-5565(73)90039-9 · DOI
- 10.1016/0047-6374(80)90092-5 · DOI
- 10.1038/206307b0 · DOI
- 10.1159/000211493 · DOI
- 10.1016/0047-6374(77)90016-1 · DOI
- Harrison, 1982, J Immunol, 129, 2673, 10.4049/jimmunol.129.6.2673 · DOI
- Mulinos, 1940, J Nutr, 19, 493, 10.1093/jn/19.5.493 · DOI
- 10.1159/000121958 · DOI
- 10.1037/h0033519 · DOI
- 10.1016/S0065-2776(08)60047-4 · DOI · Paper page
- 10.1038/240557a0 · DOI
- Perkins, 1972, Infect Immun, 6, 518, 10.1128/IAI.6.4.518-524.1972 · DOI
- Teague, 1969, Immunology, 17, 665
- 10.1016/0090-1229(73)90043-3 · DOI
- 10.1016/0090-1229(82)90046-0 · DOI
- Astle, 1984, J Immunol, 132, 673, 10.4049/jimmunol.132.2.673 · DOI
- 10.1016/0090-1229(76)90046-5 · DOI
- 10.1084/jem.148.4.996 · DOI
- Goldstein, 1970, J Immunol, 104, 359, 10.4049/jimmunol.104.2.359 · DOI
- 10.1056/NEJM197501092920204 · DOI
- 10.1038/251545a0 · DOI
- 10.1016/0047-6374(83)90085-4 · DOI
- 10.1111/j.1749-6632.1975.tb29092.x · DOI
- 10.1016/0047-6374(83)90077-5 · DOI
- 10.1016/0008-8749(82)90487-7 · DOI
- Kishi H, Nishii S, Nishikawa K, Marata E, Hiraoka E. Clinical application of coenzyme Q10 and the quality control of its preparation in Japan. In: Folkers K, Yamamura Y, eds. Biomedical and clinical aspects of coenzyme Q. Vol. 3. Amsterdam: Elsevier/North Holland, 1981:45–52.
- Bliznakov, 1979, Adv Exp Med Biol, 121, 361
- Bliznakov, 1978, J Med, 9, 337
- Pignatti, 1980, Biochem Exp Biol, 16, 39
- Azuma, 1978, Int J Vitam Nutr Res, 48, 255
- 10.1073/pnas.70.2.390 · DOI
- Demopoulos HB, Flamm ES. Possible pathology induced by CoQ10. In: Folkers K, Yamamura Y, eds. Biomedical and clinical aspects of coenzyme Q. Vol. 3. Amsterdam: Elsevier/North Holland, 1981:373–84.
- 10.1172/JCI110143 · DOI
- Thoman, 1982, J Immunol, 128, 2358, 10.4049/jimmunol.128.5.2358 · DOI
- 10.1084/jem.157.6.2184 · DOI
- Thoman, 1985, J Immunol, 134, 949, 10.4049/jimmunol.134.2.949 · DOI
- Asian, 1956, Therapiewoche, 7, 14
- Idem. Theoretical and practical aspects of chemotherapeutic techniques in the retardation of the aging process. In: Rockstein M, Sussman ML, Chesky J, eds. Theoretical aspects of aging. New York: Academic Press, 1974:145–56.
- Ostfeld, 1977, J Am Geriatr Soc, 25, 1, 10.1111/j.1532-5415.1977.tb00917.x · DOI
- Zung, 1974, Psychosomatics, 15, 127, 10.1016/S0033-3182(74)71260-9 · DOI
- Sakalis, 1974, Curr Ther Res, 16, 59
- Cohen, 1974, Psychosomatics, 15, 15, 10.1016/S0033-3182(74)71288-9 · DOI
- MacFarlane, 1975, Fed Proc, 34, 108
- 10.1093/geronj/20.1.1 · DOI
- 10.1159/000210914 · DOI
- Baulieu, 1965, Recent Prog Horm Res, 21, 411
- 10.1210/jcem-29-2-273 · DOI
- 10.1210/jcem-59-3-551 · DOI · Paper page
- Sonka, 1976, Acta Univ Carol [Med Monogr] (Praha), 71, 1
- Schwartz, 1979, Cancer Res, 39, 1129
- 10.1093/carcin/2.12.1335 · DOI
- 10.1093/carcin/5.1.57 · DOI
- Tannen, 1982, Fed Proc, 41, 463
- 10.1016/0531-5565(84)90002-0 · DOI
- 10.1210/endo-103-6-2112 · DOI · Paper page
- 10.7326/0003-4819-98-3-395 · DOI
Cited by
Sorted by citations
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Physical Activity, All-Cause Mortality, and Longevity of College Alumni
Paffenbarger, R. S., Hyde, R., Wing, A. L., & Hsieh, C.-C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603063141003 · Cited by 2,742
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00414.x · Cited by 349
Pekkanen, J., Nissinen, A., Marti, B., Tuomilehto, J., Punsar, S., & Karvonen, M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92218-5 · Cited by 182
Mortality and the attribution of health problems to aging among older adults
Rakowski, W., & Hickey, T. (1992) · American Journal of Public Health · doi:10.2105/ajph.82.8.1139 · Cited by 58
Metadata
- Authors
- Schneider, E. L., & Reed, J. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-05-02
- Volume
- 312
- Issue
- 18
- Pages
- 1159-1168
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 56
- References
- 5
- Language
- en
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