Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.

MIGEON, CLAUDE J.; KELLER, ANNE R.; LAWRENCE, BETTY; SHEPARD, THOMAS H.

doi:10.1210/jcem-17-9-1051

Cited by 260Hormonal and reproductive studiesAdrenal Hormones and DisordersSexual Differentiation and Disorders

Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.

MIGEON, CLAUDE J., KELLER, ANNE R., LAWRENCE, BETTY, SHEPARD, THOMAS H.·1957·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-17-9-1051

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Abstract

METHODS have been described for the measurement of total 17-ketosteroids (17-KS) occurring in human plasma (1) and for their fractionation (2). Dehydroepiandrosterone (DHA) and androsterone have been isolated and found to be the principal 17-KS in the peripheral circulation of normal man (3, 4). The present study was carried out in order to obtain further information on the levels of DHA and androsterone in normal subjects and to ascertain the effect of age and sex on the concentrations of these steroids. It was also thought to be of interest to determine the diurnal variation as well as the day-to-day changes of the 17-KS levels in the same subjects. A 40-ml. sample of blood was drawn from each experimental subject between 8:30 and 9:30 a.m., except in the study of diurnal variations, when blood was obtained at various times of the day. The blood samples were heparinized. They were centrifuged within forty-five minutes following collection and the plasma was immediately separated from the red cells. When the determination was not carried out immediately, the plasma was kept in a freezer.

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Serum androgens as well as their precursors and metabolites decrease from the age of 30-40 yr in women.
“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [22]
At 70 yr of age, serum DHEA-S levels are decreased to approximately 20% of their peak values, whereas they can decrease by 95% by the age of 85-90 yr.
“at 70 yr of age, serum DHEA-S levels are decreased to approximately 20% of their peak values, whereas they can decrease by 95% by the age of 85-90 yr (22).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [22]

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Authors: MIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H.
Affiliations: Johns Hopkins University (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1957-09
Volume: 17
Issue: 9
Pages: 1051-1062
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-17-9-1051
OpenAlex: W2144503086
Cited by: 260
References: 0
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: dehydroepiandrosterone, androsterone, 17-ketosteroids, plasma steroid levels, age differences, sex differences, diurnal variation, day-to-day variability
MeSH terms: Aging, Androgens, Androsterone, Circadian Rhythm, Dehydroepiandrosterone, Humans, Sex Characteristics, Sexual Maturation

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Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.

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