The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Clinical and Biochemical Manifestations of Depression
Abstract
Thousands of studies have been conducted of the functioning of the many neurotransmitter systems in order to explore the biologic basis of major depressive disorder. Instead of reviewing this literature exhaustively, we have attempted to propose a model that accommodates the clinical observation that chronic stress early in life in vulnerable persons predisposes them to major depression with contemporary observations of the potential consequences of repeated central nervous system exposure to effectors of the stress response. This model accords with current clinical judgment that major depression is best treated with a combination of psychopharmacologic agents and psychotherapy. Accordingly, whereas psychopharmacologic intervention may be required to resolve an active episode of major depression and to prevent recurrences, psychotherapy may be equally important to lessen the burden of stress imposed by intense inner conflict and counterproductive defenses.
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Citations
Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
Phase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., & Gillin, J. C. (1979) · Science · doi:10.1126/science.227056 · Cited by 528
Self-citationHerkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520
Timing of REM Sleep is Coupled to the Circadian Rhythm of Body Temperature in Man
Charles, A. C., Janet, C. Z., Joseph, M. R., Martin, C. M.-E., & Elliot, D. W. (1980) · Sleep · doi:10.1093/sleep/2.3.329 · Cited by 362
Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*
RIVIER, C., & VALE, W. (1984) · Endocrinology · doi:10.1210/endo-114-3-914 · Cited by 356
Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide
Swerdlow, N. R., Geyer, M. A., Vale, W. W., & Koob, G. F. (1986) · Psychopharmacology · doi:10.1007/bf00652231 · Cited by 299
Casper, R. C. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790340082012 · Cited by 279
Lehnert, H., Reinstein, D. K., Strowbridge, B. W., & Wurtman, R. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91207-1 · Cited by 170
Schulte, H. M., Chrousos, G. P., Gold, P. W., Booth, J. D., Oldfield, E. H., Cutler, G. B., & Loriaux, D. L. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111890 · Cited by 103
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Cited by
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Self-citationHammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822
Self-citationRose, A. J., & Rudolph, K. D. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.1.98 · Cited by 2,517
BOYCE, W. T., & ELLIS, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050145 · Cited by 2,078
Metadata
- Authors
- Gold, P. W., Goodwin, F. K., & Chrousos, G. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-08-18
- Volume
- 319
- Issue
- 7
- Pages
- 413-420
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2340023437
- Cited by
- 1,053
- References
- 10
- FWCI
- 31.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988). Clinical and Biochemical Manifestations of Depression. New England Journal of Medicine. https://doi.org/10.1056/nejm198808183190706
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
