Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*

RIVIER, CATHERINE; VALE, WYLIE

doi:10.1210/endo-114-3-914

Cited by 356Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*

RIVIER, CATHERINE, VALE, WYLIE·1984·Endocrinology

DOI 10.1210/endo-114-3-914

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Abstract

The acute administration of 0.015-1.5 nmol ovine corticotropin-releasing factor (CRF) into the lateral ventricle of gonadectomized (or gonadectomized/adrenalectomized) female rats caused a rapid and prolonged dose-related inhibition of LH (but not FSH) secretion. By contrast, the acute peripheral injection of up to 15 nmol CRF was without effect in the same animal preparations. In cycling intact female rats, injection of 1.5 nmol CRF into the brain or of 75 nmol CRF sc inhibited ovulation and blocked the proestrous LH surge in about 50% of the animals. Lower doses of peripherally administered CRF were ineffective. Finally, CRF injected daily sc (15 nmol/day) to female rats during the first 12 days after mating caused a 40% disruption of pregnancy. These results indicate that CRF will lower plasma LH levels and can exert this effect in the absence of circulating steroids of either adrenal or gonadal origin. CRF inhibition of LH secretion, which we have previously reported to be absent in vitro, was unaltered by the opiate receptor antagonist naltrexone or by the ganglionic blocker chlorisondamine. Furthermore, blockade of CRF-induced beta-endorphin or ACTH release into the general circulation by dexamethasone did not interfere with the inhibitory effect of CRF on LH secretion. Such observations suggest that CRF exerts deleterious actions on reproductive functions through brain sites of action which, at least under the experimental mental design used, do not appear to directly…

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CRH injected daily to female rats during the first 12 days after mating caused a 40% disruption of pregnancy.
“Additionally, CRH injected daily to female rats during the first 12 days after mating caused a 40% disruption of pregnancy [35].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [35]
Acute administration of ovine CRH into the lateral ventricle of gonadectomized, adrenalectomized female rats produces a rapid and prolonged dose-related inhibition of LH (but not FSH) secretion.
“In a study consisting of acute administration of ovine CRH into the lateral ventricle of gonadectomized, adrenalectomized female rats, a rapid and prolonged dose-related inhibition of LH (but not FSH) secretion was exhibited [35].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [35]
Animal studies have linked increased corticotropin releasing factor (CRF) to decreased LH and FSH secretion and hypercortisolemia.
“Animal studies have linked increased corticotropin releasing factor (CRF) to decreased LH [12,13] and FSH [12] secretion and hypercortisolemia.”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [13]
Direct implantation of CRF into the brain of rodents inhibits LH secretion, and peripheral infusion of CRF decreased LH and FSH secretion in the monkey.
“Direct implantation of CRF into the brain of rodents was observed to inhibit LH secretion [13], and peripheral infusion of CRF decreased LH and FSH secretion in the monkey [12].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [13]

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Authors: RIVIER, C., & VALE, W.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: VALE, WYLIE
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1984-03
Volume: 114
Issue: 3
Pages: 914-921
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo-114-3-914
OpenAlex: W2030989982
Cited by: 356
References: 56
Citations by year: 2024: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 6
FWCI: 13.58
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: corticotropin-releasing factor, luteinizing hormone secretion, LH inhibition, ovulation, luteinizing hormone surge, hypothalamic-pituitary-gonadal axis, gonadectomy, adrenalectomy, beta-endorphin, ACTH, naltrexone, chlorisondamine, dexamethasone, female reproduction
MeSH terms: Adrenalectomy, Animals, beta-Endorphin, Castration, Corticotropin-Releasing Hormone, Dexamethasone, Endorphins, Female, Luteinizing Hormone, Pregnancy, Pregnancy, Animal, Rats, Inbred Strains, Reproduction, Rats

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Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*

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