The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Prenatal Screening for Down's Syndrome with Use of Maternal Serum Markers
Open accessAbstract
BACKGROUND: Approximately 35 percent of all cases of Down's syndrome in fetuses can be detected by measuring maternal serum alpha-fetoprotein during the second trimester in the general population of pregnant women. Recent case-control studies indicate that this detection rate could be approximately doubled by measuring serum levels of unconjugated estriol and chorionic gonadotropin, which are abnormally low and abnormally high, respectively, in women carrying fetuses affected by Down's syndrome. METHODS: We prospectively screened 25,207 women and adolescents in the second trimester of pregnancy and assigned each a risk of fetal Down's syndrome with an algorithm that took into account measurements of all three serum markers in combination with maternal age. On this basis, 1661 subjects (6.6 percent) were initially assigned a second-trimester risk of fetal Down's syndrome of at least 1 in 190, and 962 (3.8 percent) were offered amniocentesis for chromosomal analysis after verification of gestational age. Gestational age was determined on the basis of the first day of the last menstrual period or, when available, by ultrasonography. RESULTS: Among the 760 women and adolescents who chose amniocentesis, 20 cases of fetal Down's syndrome were detected, along with 7 other chromosomal disorders. There was 1 additional case of fetal Down's syndrome among the 202 women who chose not to have amniocentesis. The rate of detection of Down's syndrome was thus 58 percent (21 of 36 expected cases), and the frequency of identifying a fetus with Down's syndrome in women undergoing amniocentesis was 1 per 38 amniocenteses (95 percent confidence interval, 1 in 25 to 1 in 62). CONCLUSIONS: Measuring serum alpha-fetoprotein, chorionic gonadotropin, and estriol is more effective in screening for fetal Down's syndrome than measuring maternal serum alpha-fetoprotein alone. Such an expanded protocol can readily be incorporated into existing prenatal screening programs.
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Cites
Maternal serum screening for Down's syndrome in early pregnancy.
Wald, N. J., Cuckle, H. S., Densem, J. W., Nanchahal, K., Royston, P., Chard, T., Haddow, J. E., Knight, G. J., Palomaki, G. E., & Canick, J. A. (1988) · BMJ · doi:10.1136/bmj.297.6653.883 · Cited by 966
Self-citationAn association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities
Merkatz, I. R., Nitowsky, H. M., Macri, J. N., & Johnson, W. E. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90530-1 · Cited by 735
CUCKLE, H. S., WALD, N. J., & THOMPSON, S. G. (1987) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1987.tb03115.x · Cited by 604
Bogart, M. H., Pandian, M. R., & Jones, O. W. (1987) · Prenatal Diagnosis · doi:10.1002/pd.1970070904 · Cited by 473
Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome
CANICK, J. A., KNIGHT, G. J., PALOMAK1, G. E., HADDOW, J. E., CUCKLE, H. S., & WALD, N. J. (1988) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1988.tb06601.x · Cited by 306
Self-citation
Cited by
Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., O'Heir, C. E., Mitchell, M. L., Hermos, R. J., Waisbren, S. E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410801 · Cited by 2,558
Self-citationPandya, P. P., Snijders, R. J. M., Johnson, S. P., de Lourdes Brizot, M., & Nicolaids, K. H. (1995) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb10902.x · Cited by 411
Antenatal Screening for Down's Syndrome
Wald, N. J., Kennard, A., Hackshaw, A., & McGuire, A. (1997) · Journal of Medical Screening · doi:10.1177/096914139700400402 · Cited by 406
Nicolaides, K. H., Brizot, M. L., & Snijders, R. J. M. (1994) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb11946.x · Cited by 351
Second-Trimester Ultrasound to Detect Fetuses With Down Syndrome: A Meta-analysis
Smith-Bindman, R., Hosmer, W., Feldstein, V. A., Deeks, J. J., & Goldberg, J. D. (2001) · JAMA · doi:10.1001/jama.285.8.1044 · Cited by 306
Metadata
- Authors
- Haddow, J. E., Palomaki, G. E., Knight, G. J., Williams, J., Pulkkinen, A., Canick, J. A., Saller, D. N., & Bowers, G. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-08-27
- Volume
- 327
- Issue
- 9
- Pages
- 588-593
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2030645242
- Cited by
- 454
- References
- 5
- FWCI
- 51.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Haddow, J. E., Palomaki, G. E., Knight, G. J., Williams, J., Pulkkinen, A., Canick, J. A., Saller, D. N., & Bowers, G. B. (1992). Prenatal Screening for Down's Syndrome with Use of Maternal Serum Markers. New England Journal of Medicine. https://doi.org/10.1056/nejm199208273270902
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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