The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation
Abstract
Objective To evaluate screening for chromosomal defects by a combination of fetal nuchal translucency thickness and maternal age. Design A prospective multicentre screening study where fetal nuchal translucency thickness was measured at 10 to 14 weeks of gestation. Subjects 20,804 women with singleton pregnancies screened at 10 to 14 weeks of gestation from 1 September 1992 to 28 October 1994. Main outcome measures Trisomy 21 and other chromosomal defects identified by increased nuchal translucency thickness and by a combination of nuchal translucency thickness and maternal age. Results In normal fetuses nuchal translucency thickness increased significantly with crown‐rump length. The nuchal translucency was above the 95th centile in 77% (66 of 86) of fetuses with trisomy 21 and in 78% (61 of 78) of those with other chromosomal defects. On the basis of the distribution of nuchal translucency measurements in normal fetuses and those with trisomy 21, a new method of screening is proposed which involves assessment of individual risk based on the combination of fetal nuchal translucency, crown rump length and maternal age. The minimum risk was 1/100 in 4.9% of the normal pregnancies, in 80% of those with trisomy 21 and in 77% of those with other chromosomal defects. Conclusion Screening for fetal trisomy 21 can be carried out effectively during the first trimester of pregnancy.
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Cites
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RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN
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Prenatal Screening for Down's Syndrome with Use of Maternal Serum Markers
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Nicolaides, K. H., Brizot, M. L., & Snijders, R. J. M. (1994) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb11946.x · Cited by 351
Self-citationRoutine ultrasound screening for the prediction of gestational age.
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Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency
Pandya, P. P., Kondylios, A., Hilbert, L., Snijders, R. J. M., & Nicolaides, K. H. (1995) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.1995.05010015.x · Cited by 232
Self-citationMaternal age‐specific risks for trisomies at 9—14 weeks' gestation
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Self-citationFirst-trimester fetal nuchal translucency thickness and risk for trisomies.
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Self-citationRepeatability of measurement of fetal nuchal translucency thickness
Pandya, P. P., Altman, D. G., Brizot, M. D. L., Pettersen, H., & Nicolaides, K. H. (1995) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1995.05050334.x · Cited by 116
Self-citationDuration Of Human Singleton Pregnancy: A Population‐based Study
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Cited by
Snijders, R., Noble, P., Sebire, N., Souka, A., & Nicolaides, K. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11280-6 · Cited by 1,572
The hidden mortality of monochorionic twin pregnancies
Sebire, N. J., Snijders, R. J. M., Hughes, K., Sepulveda, W., & Nicolaides, K. H. (1997) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb10948.x · Cited by 630
Self-citationNuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities
Nicolaides, K. H. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.090 · Cited by 626
Self-citationAfshar, Y., Gutkin, R., Krakow, D., Cuckle, H., Silverman, N. S., & Platt, L. D. (2019) · Journal of Ultrasound in Medicine · doi:10.1002/jum.14913 · Cited by 2
Metadata
- Authors
- Pandya, P. P., Snijders, R. J. M., Johnson, S. P., de Lourdes Brizot, M., & Nicolaids, K. H.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 102
- Issue
- 12
- Pages
- 957-962
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2058995602
- Cited by
- 411
- References
- 14
- FWCI
- 27.08
- Type
- journal article
- Language
- en
- Open access
- closed
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