The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Drug Therapy for Alcohol Dependence
Abstract
Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors.1 As defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders, it is characterized by increased tolerance of the effects of alcohol, impaired control over drinking, and continued drinking despite adverse consequences (Table 1).2 Alcohol dependence affects nearly 10 percent of the population and results in social problems, considerable morbidity and mortality, and high health care costs.3,4 Alcohol dependence is treated by medical, psychological, and social interventions that reduce or eliminate the desire to drink and the . . .
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“Disulfiram blocks the enzyme aldehyde dehydrogenase (ALDH).”
From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [8]
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“Despite these alarming figures, current treatment options for AUD are limited and have only modest success [2, 3].”
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“…a la presencia de craving, y a pesar del hecho del progreso de las neurociencias, quedan todavía numerosas cuestiones respecto a la existencia del craving como tal y consecuentemente, a la eventual eficacia de la medicación psicotrópica encaminada a reducir el craving del alcohol (Swift 1999).”
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“[9,14] Disulfiram acts by inhibiting the enzyme aldehyde dehydrogenase; when consumed along with alcohol, acetyldehyde accumulation occurs due to enzymatic inhibition, resulting in unpleasant disulfiram/ethanol reaction.[14,15] The effect of disulfiram on alcohol metabolism starts within 2 hours of its ingestion.”
BackgroundPharmacological management of alcohol dependence syndrome
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“Correct Answer: D) Disulfiram affects the metabolism of alcohol by blocking the enzyme (acetaldehyde dehydrogenase) responsible for breaking down acetaldehyde (Swift, 1999).”
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Metadata
- Authors
- Swift, R. M.
- Affiliations
- Brown University (US)
- Corresponding author
- Swift, Robert M.
- ORCID
- Swift, Robert M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-05-13
- Volume
- 340
- Issue
- 19
- Pages
- 1482-1490
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1984819772
- Cited by
- 255
- References
- 97
- Citations by year
- 2025: 3 · 2024: 7 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 11 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 5
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- alcoholism, pharmacotherapy, alcohol tolerance, impaired control, DSM-IV diagnostic criteria, health care costs
- MeSH terms
- Alcohol Deterrents, Ethanol, Alcoholism, Antidepressive Agents, Mental Disorders, Humans, Narcotic Antagonists, Receptors, Neurotransmitter, Dopamine Antagonists
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