Cited by 255Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

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Drug Therapy for Alcohol Dependence

Swift, Robert M.·1999·New England Journal of Medicine

DOI 10.1056/nejm199905133401907

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Abstract

Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors.1 As defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders, it is characterized by increased tolerance of the effects of alcohol, impaired control over drinking, and continued drinking despite adverse consequences (Table 1).2 Alcohol dependence affects nearly 10 percent of the population and results in social problems, considerable morbidity and mortality, and high health care costs.3,4 Alcohol dependence is treated by medical, psychological, and social interventions that reduce or eliminate the desire to drink and the . . .

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Alcohol and public health
Room, R., Babor, T., & Rehm, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17870-2 · Cited by 1,625
Gambling and the Health of the Public: Adopting a Public Health Perspective
Korn, D. A., & Shaffer, H. J. (1999) · Journal of Gambling Studies · doi:10.1023/a:1023005115932 · Cited by 536
Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review
Alvarez, C. B., Magro, A., Ana, M., & María, A. J. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00763.x · Cited by 504
“This figure, which coincides with that of previous publications [52,57,64], is clearly a cause for concern as adherence to treatment had shown itself to be a fundamental factor in the remission of alcohol dependence [4,51].”
BackgroundResult
BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY
Addolorato, G. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.5.504 · Cited by 479
“However, to date, drugs with proven efficacy are very few (see Garbutt et al., 1999; Swift, 1999; Kranzler, 2000) and the discovery of new medications capable of positively affecting the components of alcohol dependence syndrome, such as craving and loss of control on drinking or protracted…”
Background
Drug Addiction
Camí, J., & Farré, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023160 · Cited by 477

See all 255

Authors: Swift, R. M.
Affiliations: Brown University (US)
Corresponding author: Swift, Robert M.
ORCID: Swift, Robert M.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-05-13
Volume: 340
Issue: 19
Pages: 1482-1490
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199905133401907
OpenAlex: W1984819772
Cited by: 255
References: 97
Citations by year: 2025: 3 · 2024: 7 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 11 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 5
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: alcoholism, pharmacotherapy, alcohol tolerance, impaired control, DSM-IV diagnostic criteria, health care costs
MeSH terms: Alcohol Deterrents, Ethanol, Alcoholism, Antidepressive Agents, Mental Disorders, Humans, Narcotic Antagonists, Receptors, Neurotransmitter, Dopamine Antagonists

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