Cited by 2,489Cardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studiesCardiac Arrhythmias and Treatments

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A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

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Buxton, Alfred E., Lee, Kerry L., Fisher, John D., Josephson, Mark E., Prystowsky, Eric N., Hafley, Gail·1999·New England Journal of Medicine

DOI 10.1056/nejm199912163412503

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Abstract

BACKGROUND: Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death. METHODS: We conducted a randomized, controlled trial to test the hypothesis that electrophysiologically guided antiarrhythmic therapy would reduce the risk of sudden death among patients with coronary artery disease, a left ventricular ejection fraction of 40 percent or less, and asymptomatic, unsustained ventricular tachycardia. Patients in whom sustained ventricular tachyarrhythmias were induced by programmed stimulation were randomly assigned to receive either antiarrhythmic therapy, including drugs and implantable defibrillators, as indicated by the results of electrophysiologic testing, or no antiarrhythmic therapy. Angiotensin-converting-enzyme inhibitors and beta-adrenergic-blocking agents were administered if the patients could tolerate them. RESULTS: A total of 704 patients with inducible, sustained ventricular tachyarrhythmias were randomly assigned to treatment groups. Five-year Kaplan-Meier estimates of the incidence of the primary end point of cardiac arrest or death from arrhythmia were 25 percent among those receiving electrophysiologically guided therapy and 32 percent among the patients assigned to no antiarrhythmic therapy (relative risk, 0.73; 95 percent confidence interval, 0.53 to 0.99), representing a reduction in risk of 27 percent). The five-year estimates of overall mortality were 42 percent and 48 percent, respectively (relative risk, 0.80; 95 percent confidence interval, 0.64 to 1.01). The risk of cardiac arrest or death from arrhythmia among the patients who received treatment with defibrillators was significantly lower than that among the patients discharged without receiving defibrillator treatment (relative risk, 0.24; 95 percent confidence interval, 0.13 to 0.45; P<0.001). Neither the rate of cardiac arrest or death from arrhythmia nor the overall mortality rate was lower among the patients assigned to electrophysiologically guided therapy and treated with antiarrhythmic drugs than among the patients assigned to no antiarrhythmic therapy. CONCLUSIONS: Electrophysiologically guided antiarrhythmic therapy with implantable defibrillators, but not with antiarrhythmic drugs, reduces the risk of sudden death in high-risk patients with coronary disease.

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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
A Comparison of Antiarrhythmic-Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-Fatal Ventricular Arrhythmias
The AVID Investigators (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372202 · Cited by 3,221
Discrete Sequential Boundaries for Clinical Trials
Lan, K. K. G., & DeMets, D. L. (1983) · Biometrika · doi:10.2307/2336502 · Cited by 2,310
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
Julian, D. G., CAMM, A. J., Frangin, G., Janse, M. J., Munoz, A., Pj, S., & Simon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09145-3 · Cited by 1,100

Show all 34 references

Research works printed but not linked: 1

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Delayed intrinsicoid deflection of the QRS complex is associated with sudden cardiac arrest
Darouian, N., Narayanan, K., Aro, A. L., Reinier, K., Uy‐Evanado, A., Teodorescu, C., Gunson, K., Jui, J., & Chugh, S. S. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.12.022 · Cited by 28
Heart Failure Due to Reduced Ejection Fraction: Medical Management.
Chavey, W. E., Hogikyan, R. V., Harrison, R. V., & Nicklas, J. M. (2017) · PubMed · Cited by 26
Cardiac Interventions in Patients With Active, Advanced Solid and Hematologic Malignancies
Leong, D. P., Cirne, F., Aghel, N., Vila, R. C. B., Cavalli, G. D., Ellis, P. M., Healey, J. S., Whitlock, R. P., Khalaf, D., Mian, H. S., et al. (2023) · JACC CardioOncology · doi:10.1016/j.jaccao.2023.05.008 · Cited by 30
Decision-making, emotional distress, and quality of life in patients affected by the recall of their implantable cardioverter defibrillator
Gibson, D. P., Kuntz, K. K., Levenson, J. L., & Ellenbogen, K. A. (2008) · EP Europace · doi:10.1093/europace/eun082 · Cited by 28
Proportion of patients needing an implantable cardioverter defibrillator on the basis of current guidelines: impact on healthcare resources in Italy and the USA. Data from the ALPHA study registry
Pedretti, R. F. E., Curnis, A., Massa, R., Morandi, F., Tritto, M. V., Manca, M. L., Occhetta, E., Molon, G., Ferrari, G. M. D., Braga, S. S., et al. (2010) · EP Europace · doi:10.1093/europace/euq106 · Cited by 28
The Role of Antiarrhythmic Drug Therapy for the Prevention of Sudden Cardiac Death
Kamath, G. S., & Mittal, S. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.12.001 · Cited by 28
β2-Adrenoceptors and ventricular fibrillation
Altschuld, R. A. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00075-9 · Cited by 28
Identifying the High Risk Patient with Coronary Artery Disease—Is Ejection Fraction All You Need?
Buxton, A. E. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.50150.x · Cited by 28
Self-citation
Prediction of Nonarrhythmic Mortality in Primary Prevention Implantable Cardioverter-Defibrillator Patients With Ischemic and Nonischemic Cardiomyopathy
Providencia, R. A., Bovéda, S., Lambiase, P. D., Defaye, P., Algalarrondo, V., Sadoul, N., Piot, O., Klug, D., Perier, M., Bouzeman, A., et al. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.01.004 · Cited by 27
Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction
Ye, S., Grunert, M., Thune, J. J., Stephenson, K., Uno, H., Finn, P. V., McMurray, J. J. V., Velazquez, E. J., Califf, R. M., Pfeffer, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.990655 · Cited by 27
The Role of Electrophysiology Study in Risk Stratification of Sudden Cardiac Death
Thomas, K. E., & Josephson, M. E. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.05.001 · Cited by 27
Self-citation
Risk stratification for cardiac mortality using electrocardiographic markers based on 24-hour Holter recordings: the JANIES-SHD study
Kinoshita, T., Hashimoto, K., Yoshioka, K., Miwa, Y., Yodogawa, K., Watanabe, E., Nakamura, K., Nakagawa, M., Nakamura, K., Watanabe, T., et al. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.07.012 · Cited by 27
Outcome of Right Ventricular Bifocal Pacing in Patients with Permanent Atrial Fibrillation and Severe Dilated Cardiomiopathy Due to Chagas Disease: Three Years of Follow-up
Menezes, A. D. S. (2004) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/b:jice.0000048569.71590.c5 · Cited by 27
Sex-dependent gene regulatory networks of the heart rhythm
Iacobaş, D. A., Iacobaş, S., Thomas, N., & Spray, D. C. (2009) · Functional & Integrative Genomics · doi:10.1007/s10142-009-0137-8 · Cited by 27
“In general, malignant ventricular arrhythmias and sudden cardiac death are less common in women than in men (Albert et al. 1996; Kannel et al. 1998; Buxton et al. 1999a, b; AVID 1997).”
Background
Use of a Screening Tool Improves Appropriate Referral to an Electrophysiologist for Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death
Gravelin, L. M., Yuhas, J., Remetz, M. S., Radford, M. J., Foley, J., & Lampert, R. J. (2011) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.956987 · Cited by 27
Reducing mortality from sudden cardiac death in the community: lessons from epidemiology and clinical applications research
Sotoodehnia, N. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00260-7 · Cited by 27
Management of malignant ventricular arrhythmias and cardiac arrest
Fogel, R. I., & Prystowsky, E. N. (2000) · Critical Care Medicine · doi:10.1097/00003246-200010001-00009 · Cited by 27
Self-citation
T Wave Oversensing in Implantable Cardioverter Defibrillators
Hsu, S. S., Mohib, S., Schroeder, A., & Deger, F. T. (2004) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/b:jice.0000035932.25722.f1 · Cited by 27
Sudden cardiac death and channelopathies: a review of implantable defibrillator therapy
Choi, G. R., Porter, C.-B. J., & Ackerman, M. J. (2004) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2004.04.015 · Cited by 27
“The multicenter automatic defibrillator implant trial (MADIT) and multicenter unsustained tachycardia trial (MUSTT) studies showed a significant reduction in the risk of death in those who had implantation of an ICD versus those who received antiarrhythmic drugs [25–27].”
Result
Clinical effectiveness and cost-effectiveness of implantable cardioverter defibrillators for arrhythmias: A systematic review and economic evaluation
Bryant, J., Brodin, H., Loveman, E., & Clegg, A. J. (2007) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462307051586 · Cited by 27
Proarrhythmia
Naccarelli, G. V., Wolbrette, D. L., & Luck, J. C. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70324-2 · Cited by 27
MR and CT assessment for ischemic cardiac disease
White, R. D. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20068 · Cited by 27
Halothane, Isoflurane, and Fentanyl Increase the Minimally Effective Defibrillation Threshold of an Implantable Cardioverter Defibrillator: First Report in Humans
Weinbroum, A. A., Glick, A., Copperman, Y., Yashar, T., Rudick, V., & Flaishon, R. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200211000-00004 · Cited by 27
“patients (2), which concluded that this approach re-”
Background
T-Wave Alternans in the Sudden Cardiac Death in Heart Failure Trial Population
ROSENBAUM, D. S. (2008) · Circulation · doi:10.1161/circulationaha.108.818286 · Cited by 27
[Recommendations of the French Society of Cardiology concerning the treatment of myocardial infarction after the acute phase. Epidemiology and Prevention Group].
Delahaye, F., Bory, M., Cohen, A. A., Danchin, N., de Gévigney, G., Dellinger, A., Fraboulet, J.-Y., Gayet, J.-L., Guize, L., Iung, B., et al. (2001) · PubMed · Cited by 27
The evolving risk of sudden cardiac death after heart transplant. An analysis of the ISHLT Thoracic Transplant Registry
Alba, A. C., Fan, C. S., Manlhiot, C., Dipchand, A. I., Stehlik, J., & Ross, H. J. (2019) · Clinical Transplantation · doi:10.1111/ctr.13490 · Cited by 28
Arrhythmias and Heart Failure
SALTZMAN, H. E. (2013) · Cardiology Clinics · doi:10.1016/j.ccl.2013.09.005 · Cited by 26
Allelic variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease
Stecker, E. C., Sono, M., Wallace, E. R., Gunson, K., Jui, J., & Chugh, S. S. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.01.029 · Cited by 27
Implantable Cardioverter–Defibrillator Use in Older Adults
Kramer, D. B., Matlock, D. D., Buxton, A. E., Goldstein, N. E., Goodwin, C., Green, A. R., Kirkpatrick, J. N., Knoepke, C. E., Lampert, R. J., Mueller, P. S., et al. (2015) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.114.001660 · Cited by 26
Self-citation
Arrhythmia Detection in Single‐ and Dual‐Chamber Implantable Cardioverter Defibrillators: The More Leads, the Better?
Francia, P., Balla, C., Uccellini, A., & Cappato, R. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01477.x · Cited by 26
Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao, M. P., Al‐Khatib, S. M., Pokorney, S. D., She, L., Romanov, A. B., Nicolau, J. C., Lee, K. L., Carson, P. E., Selzman, C. H., Stępińska, J., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026075 · Cited by 29
Self-citation
Primary Prevention of Sudden Cardiac Death Early Post-Myocardial Infarction
Elayi, C. S., Charnigo, R. J., Heron, P. M., Lee, B. K., & Olgin, J. E. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005194 · Cited by 29
Predicting appropriate shocks in patients with heart failure: Patient level meta‐analysis from SCD‐HeFT and MADIT II
Zeitler, E. P., Al‐Khatib, S. M., Friedman, D. J., Han, J. Y., Poole, J. E., Bardy, G. H., Bigger, J. T., Buxton, A. E., Moss, A. J., Lee, K. L., et al. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13307 · Cited by 26
Self-citation
Clinical and Electrophysiologic Predictors of Ventricular Tachyarrhythmia Recurrence in Patients with Implantable Cardioverter Defibrillators
Gillis, A. M., Sheldon, R. S., Wyse, D. G., Duff, H. J., Cassidy, M. R., & Mitchell, L. B. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.02328.x · Cited by 26
Impact of the Main Implantable Cardioverter‐Defibrillator Trials for Primary and Secondary Prevention in Italy: A Survey of the National Activity During the Years 2001–2004
Proclemer, A., Ghidina, M., Cicuttini, G., Gregori, D., & FIORETTI, P. M. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00487.x · Cited by 26
Prevalence and prognostic impact of comorbidities in heart failure patients with implantable cardioverter–defibrillator
Bruch, C., Bruch, C., Sindermann, J. R., BREITHARDT, G. E., & Gradaus, R. (2007) · EP Europace · doi:10.1093/europace/eum097 · Cited by 26
Recognizing and Managing Asymptomatic Left Ventricular Dysfunction
Albert, N. M., & Lewis, C. M. (2008) · Critical Care Nurse · doi:10.4037/ccn2008.28.2.20 · Cited by 26
Should stimulation therapy for congestive heart failure be combined with defibrillation backup?
Gaïta, F., Bocchiardo, M., Porciani, M. C., Vivalda, L., Colella, A., Donna, P. D., Caponi, D., Bruzzone, M., & Padeletti, L. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01229-7 · Cited by 26
Sudden Death after Myocardial Infarction — Who Needs Prophylaxis, and When?
Buxton, A. E. (2005) · New England Journal of Medicine · doi:10.1056/nejme058085 · Cited by 26
Self-citation
International Participation in Cardiovascular Randomized Controlled Trials Sponsored by the National Heart, Lung, and Blood Institute
Kim, E., Carrigan, T., & Menon, V. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.066 · Cited by 25
Sudden Cardiac Death Risk Stratification and Prevention in Chagas Disease: A Non-systematic Review of the Literature
Keegan, R. O., Yeung, C., & Baranchuk, A. M. (2020) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2020.27 · Cited by 25
Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023
Teixeira, R. A., Fagundes, A. A., Baggio, J. M., de Oliveira, J. C., Medeiros, P. D. T. J., Valdigem, B. P., Teno, L. A. C., Silva, R. T., de Melo, C. S., Elías, J., et al. (2023) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20220892 · Cited by 53
Predictive Value of Microvolt T-Wave Alternans for Cardiac Death or Ventricular Tachyarrhythmic Events in Ischemic and Nonischemic Cardiomyopathy Patients: A Meta-Analysis
Calò, L., Santo, T. D., Nuccio, F., Sciarra, L., Luca, L. D., Stefano, L. M. D. S., Piroli, E., Zuccaro, L. M., Rebecchi, M., Ruvo, E. D., et al. (2011) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2011.00467.x · Cited by 25
Development of a preclinical model of ischemic cardiomyopathy in swine
Ishikawa, K., Ladage, D., Takewa, Y., Yaniz‐Galende, E., Chen, J., Tilemann, L. M., Sakata, S., Badimón, J. J., Hajjar, R. J., & Kawase, Y. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01103.2010 · Cited by 25
Predictors of Early Mortality in Patients Age 80 and Older Receiving Implantable Defibrillators
Ertel, D., Phatak, K., Makati, K. J., HOLLAND, M., Baig, S., KIM, M. H., Link, M. S., & PASSMAN, R. S. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02729.x · Cited by 25
Myocardial scar burden predicts survival benefit with implantable cardioverter defibrillator implantation in patients with severe ischaemic cardiomyopathy: influence of gender
Kwon, D. H., Hachamovitch, R., Adeniyi, A., Nutter, B., Popović, Z., Wilkoff, B. L., Desai, M. Y., Flamm, S. D., & Marwick, T. H. (2013) · Heart · doi:10.1136/heartjnl-2013-304261 · Cited by 25
Development of the subcutaneous implantable cardioverter‐defibrillator for reducing sudden cardiac death
Sanghera, R., Sanders, R., Husby, M. P., & Bentsen, J. G. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12550 · Cited by 25
LV mechanical dispersion as a predictor of ventricular arrhythmia in patients with advanced systolic heart failure
Banasik, G., Segiet, O. A., Elwart, M., Szulik, M., Lenarczyk, R., Kalarus, Z. F., & Kukulski, T. (2016) · Herz · doi:10.1007/s00059-015-4398-9 · Cited by 25
Epidemiology, Risk Factors, and Outcomes of Out-of-Hospital Cardiac Arrest Caused by Stroke
Fukuda, T., Ohashi-Fukuda, N., Kondo, Y., Sera, T., Doi, K., & Yahagi, N. (2016) · Medicine · doi:10.1097/md.0000000000003107 · Cited by 25
Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy
Bergau, L., Willems, R., Sprenkeler, D. J., Fischer, T. H., Flevari, P. G., Hasenfuss, G. P., Katsaras, D. N., Kirova, A., Lehnart, S. E., Lüthje, L., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.06.103 · Cited by 25
Added Value of 3- Versus 2-Dimensional Echocardiography Left Ventricular Ejection Fraction to Predict Arrhythmic Risk in Patients With Left Ventricular Dysfunction
Rodríguez‐Zanella, H., Muraru, D., Secco, E., Boccalini, F., Azzolina, D., Aruta, P., Surkova, E., Genovese, D., Cavalli, G., Sammarco, G., et al. (2018) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.07.011 · Cited by 25
Rationale and design of the randomized prospective ATLAS study: Avoid Transvenous Leads in Appropriate Subjects
Mondesert, B. A., Bashir, J. G., Philippon, F., Dubuc, M., Amit, G., Exner, D. V., Joza, J. E., Birnie, D. H., Lane, C., Tsang, B., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.09.008 · Cited by 25
Clinical review: Beyond immediate survival from resuscitation – long-term outcome considerations after cardiac arrest
Arawwawala, D., & Brett, S. J. (2007) · Critical Care · doi:10.1186/cc6139 · Cited by 25
Biventricular Implantable Cardioverter Defibrillators Improve Survival Compared with Biventricular Pacing Alone in Patients with Severe Left Ventricular Dysfunction
Ermiş, C., Lurie, K. G., Zhu, A. X., COLLINS, J., VanHeel, L., Sakaguchi, S., Lü, F., Pham, S., & Benditt, D. G. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.04044.x · Cited by 25
Relation of Advanced Heart Failure Symptoms to Risk of Inappropriate Defibrillator Shocks
Hreybe, H., Ezzeddine, R., Barrington, W., Bazaz, R. R., Jain, S. K., Ngwu, O., & Saba, S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.074 · Cited by 25
Effect of bundle branch block on microvolt T-wave alternans and electrophysiologic testing in patients with ischemic cardiomyopathy
Morin, D. P., Zacks, E. S., Mauer, A. C., Ageno, S., Janik, M. J., Markowitz, S. M., Mittal, S., Iwai, S., Shah, B. K., Lerman, B. B., et al. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.02.027 · Cited by 25
Management of Arrhythmias in Heart Failure
Ellison, K., Stevenson, W. G., Sweeney, M. O., Epstein, L. M., & Maisel, W. H. (2003) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2003.00271.x · Cited by 25
Changes in Health Status, Psychological Distress, and Quality of Life in Implantable Cardioverter Defibrillator Recipients Between 6 Months and 1 Year After Implantation
Carroll, D. L., Hamilton, G. A., & Kenney, B. J. (2002) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(02)00040-3 · Cited by 25
Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators.
Sherazi, S., Zaręba, W., Daubert, J. P., McNitt, S. A., Shah, A. H., Aktaş, M. K., & Block, R. (2010) · PubMed · Cited by 25
Outcomes and In-hospital Treatment of Out-of-Hospital Cardiac Arrest Patients Resuscitated From Ventricular Fibrillation by Early Defibrillation
Bunch, T. J., White, R. D., Gersh, B. J., Shen, W.-K., Hammill, S. C., & Packer, D. L. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.5.613 · Cited by 25
Changing Late Prognosis of Acute Myocardial Infarction
Hohnloser, S. H., & Gersh, B. J. (2003) · Circulation · doi:10.1161/01.cir.0000054211.00668.9b · Cited by 25
Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
Moss, A. J., Vyas, A. K., Greenberg, H., Case, R. B., Zaręba, W., Hall, W. J., Brown, M. W., McNitt, S. A., & Andrews, M. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.04.025 · Cited by 25
Arrhythmogenic and metabolic remodelling of failing human heart
Gloschat, C. R., Koppel, A. C., Aras, K. K., Brennan, J. A., Holzem, K. M., & Efimov, I. R. (2016) · The Journal of Physiology · doi:10.1113/jp271992 · Cited by 23
“Implantable cardioverter defibrillators are effective at preventing sudden cardiac death (Buxton et al. 1999; Glatter et al. 2006), to which HF patients are highly susceptible, but does nothing to reverse or slow disease progression.”
Background
Baseline Characteristics of Contemporary Trial Participants with Heart Failure and Reduced Ejection Fraction: The VICTOR Trial
Saldarriaga, C., Zannad, F. M., McMullan, C. J., Xing, A., Gates, D. F., Anstrom, K. J., Bonaca, M. P., Corda, S., Ezekowitz, J. A., Lam, C. S. P., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3598 · Cited by 24
Ventricular Ectopy in Patients With Left Ventricular Dysfunction: Should It Be Treated?
Chen, T., Koene, R. J., Benditt, D. G., & Lü, F. (2012) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2012.11.004 · Cited by 25
Electromagnetic Interference of Automatic Implantable Cardioverter Defibrillator and HeartWare Left Ventricular Assist Device
Labedi, M. R., Alharethi, R. A., Kfoury, A. G., Budge, D., Bruce, R., Rasmusson, B. Y., & Bunch, T. J. (2013) · ASAIO Journal · doi:10.1097/mat.0b013e318285fe93 · Cited by 24
Comparison of outcomes in patients undergoing defibrillation threshold testing at the time of implantable cardioverter-defibrillator implantation versus no defibrillation threshold testing.
HALL, B. W., Jeevanantham, V., Levine, E., Daubert, J. P., McNitt, S., Hall, F., Jeevanantham, V., Levine, E., Daubert, J. P., McNitt, S. A., et al. (2007) · PubMed · Cited by 24
Inferior and anterior QRS fragmentation have different prognostic value in patients who received an implantable defibrillator in primary prevention of sudden cardiac death
Vandenberk, B., Robyns, T., Goovaerts, G., Soest, S. V., Floré, V., Garweg, C., Huffel, S. V., Ector, J., & Willems, R. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.02.131 · Cited by 24
Reliability and longevity of implantable defibrillators
Hauser, R. G., Casey, S. A., Gitter, C. B., Tang, C. Y., Abdelhadi, R. H., Gornick, C. C., Stanberry, L. I., & Sengupta, J. D. (2021) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00920-w · Cited by 24
Improved Survival of Cardiac Transplantation Candidates with Implantable Cardioverter Defibrillator Therapy:
Ermiş, C., Zadeii, G., Zhu, A. X., Fabian, W., Collins, J., Lurie, K. G., Sakaguchi, S., & Benditt, D. G. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.02590.x · Cited by 24
Longitudinal Study of Implantable Cardioverter-Defibrillators
Masoudi, F. A., Go, A. S., Magid, D. J., Cassidy‐Bushrow, A. E., Doris, J. M., Fiocchi, F., Garcia-Montilla, R. J., Glenn, K. A., Goldberg, R. J., Gupta, N., et al. (2012) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.112.965368 · Cited by 24
Recent Trends in Utilization of Implantable Cardioverter‐Defibrillators in Survivors of Cardiac Arrest in the United States
Saba, S., Ravipati, L. P., & Voigt, A. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02509.x · Cited by 24
Clinical practice of defibrillator implantation after myocardial infarction: impact of implant time: results from the PreSCD II Registry
Völler, H., Kamke, W., Klein, H., Block, M. S., Reibis, R. K., Treusch, S., Contzen, K., Wegscheider, K., & on behalf of the PreSCD II registry investigators (2010) · EP Europace · doi:10.1093/europace/euq426 · Cited by 24
Heart Rate Turbulence as Risk-Predictor after Myocardial Infarction
Zuern, C. S., Barthel, P., & Bauer, A. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00099 · Cited by 23
Ventricular Arrhythmias in Heart Failure Patients
Lo, R., & Hsia, H. H. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.03.009 · Cited by 23
Management of Postoperative Arrhythmias
Rho, R. W., Bridges, C. R., & Kocovic, D. Z. (2000) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/stcs.2000.21117 · Cited by 24
A comparison of cardiac magnetic resonance imaging peri-infarct border zone quantification strategies for the prediction of ventricular tachyarrhythmia inducibility
Rubenstein, J., Lee, D. C., Wu, E., Kadish, A. H., PASSMAN, R. S., Bello, D. B., & Goldberger, J. J. (2013) · Cardiology Journal · doi:10.5603/cj.2013.0011 · Cited by 24
Cost-Effectiveness of Implantable Defibrillators after Myocardial Infarction Based on 8-Year Follow-Up Data (MADIT II)
Gandjour, A., Dipl-Ges-Ök, A. H., & Adarkwah, C. C. (2011) · Value in Health · doi:10.1016/j.jval.2011.02.1180 · Cited by 24
History of electrical therapy for the heart
Sutton, R., Fisher, J. D., Linde, C. M., & Benditt, D. G. (2007) · European Heart Journal Supplements · doi:10.1093/eurheartj/sum072 · Cited by 25
Self-citation
Non-invasive risk stratification for sudden cardiac death by heart rate turbulence and microvolt T-wave alternans in patients after myocardial infarction
Sulimov, V. A., Андреевна, О. Е., & Tsaregorodtsev, D. A. (2012) · EP Europace · doi:10.1093/europace/eus238 · Cited by 24
Management Strategies When Implanted Cardioverter Defibrillator Leads Fail: Survey Findings
Xu, W., Moore, H. J., Karasik, P., Franz, M. R., Singh, S., & Fletcher, R. D. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02454.x · Cited by 24
A Comparison of ICD Implantations in the United States Versus Italy
GREENBERG, S. M., Epstein, A. E., Deering, T. F., Goldman, D. S., Ghidina, M., NEASON, C., & Proclemer, A. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00625.x · Cited by 24
Low recurrence of syncope in patients with inducible sustained ventricular tachyarrhythmias treated with an implantable cardioverter-defibrillator
García‐Morán, E. (2002) · European Heart Journal · doi:10.1053/euhj.2001.3073 · Cited by 24
“It has proven its efficacy in the secondary prevention of sudden death([3]) and also in the primary prevention of sudden death in specific subgroups([4,5]).”
Background
Go red for women
Kornacewicz-Jach, Z., Kossuth, I., & Czechowska, M. (2006) · Menopause Review/Przegląd Menopauzalny · Cited by 24
Determinants of sudden death after discharge from hospital for myocardial infarction in the thrombolytic era
Jordaens, L. J. L. M. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2464 · Cited by 24
“Most recent studies, confirming data from the prethrombolytic era([37]), used invasive procedures (programmed electrical stimulation) to define high risk groups([9,10,19]).”
BackgroundResult
Combining electrical therapies for advanced heart failure: the Milan experience with biventricular pacing–defibrillation backup combination for primary prevention of sudden cardiac death
Pappone, C., Vicedomini, G., Augello, G., Mazzone, P., Nardi, S., & Rosanio, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03341-6 · Cited by 24
Geographic Differences in Implantable Cardioverter Defibrillator Usage
Seidl, K., & Senges, J. (2002) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2002.tb01961.x · Cited by 24
Cardiac Arrhythmias in the Athlete
Link, M. S., Homoud, M. K., Wang, P. J., & Estes, N. A. M. (2001) · Cardiology in Review · doi:10.1097/00045415-200101000-00006 · Cited by 26
“Asymptomatic patients with CAD and left ventricular ejection fractions#35% may benefit from electrophysiologic testing (40, 41).”
Background
Pathophysiology of Physiologic Cardiac Pacing
Kass, D. A. (2002) · JAMA · doi:10.1001/jama.288.24.3159 · Cited by 24
The Association Between ICD Interventions and Mortality is Independent of their Modality: Clinical Implications
Bencardino, G., Monaco, A. D., Rio, T., Frontera, A., Santangeli, P., Leo, M., Pelargonio, G., Perna, F., Narducci, M. L., Gabrielli, F., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12499 · Cited by 23
Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure
On, Y. K. (2017) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2017.008 · Cited by 23
Management of Post-Myocardial Infarction Patients with Left Ventricular Systolic Dysfunction
Gheorghiade, M., & Fonarow, G. C. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.010 · Cited by 23
Noninvasive risk stratification after myocardial infarction: Rationale, current evidence and the need for definitive trials
Exner, D. V. (2009) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(09)71050-5 · Cited by 23
Rationale and design of the health economics evaluation registry for remote follow-up: TARIFF
Ricci, R. P., D’Onofrio, A., Padeletti, L., Sagone, A., Vicentini, A., Vincenti, A., Morichelli, L., Cavallaro, C., Ricciardi, W., Lombardi, L., et al. (2012) · EP Europace · doi:10.1093/europace/eus093 · Cited by 23
Cost-Effectiveness of Implantable Cardioverter-Defibrillators in Children With Dilated Cardiomyopathy
Feingold, B., Arora, G., Webber, S. A., & Smith, K. J. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.04.009 · Cited by 23
The Use of Implantable Cardioverter Defibrillators for the Prevention of Sudden Cardiac Death: A Review of the Evidence and Implications
Crespo, E. M., Selzman, K. A., Kim, J., Steinhoff, J. P., & Sheahan, R. G. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200505000-00005 · Cited by 23
MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS PRESENTING WITH PERSISTENT ST-SEGMENT ELEVATION
de Werf, F. V., Bax, J. J., Betriu, A., Blomström‐Lundqvist, C., Crea, F., Falk, V., Filippatos, G. S., Fox, K. A. A., Huber, K., Kastrati, A., et al. (2009) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2009-5-5-73-89 · Cited by 24
Comparison of male and female psychological outcomes related to implantable cardioverter defibrillators (COMFORTID)
Marshall, P., Malecki-Ketchell, A., & Maclean, J. (2011) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2011.06.010 · Cited by 25
“11) Ethnicity 1 Caucasian 46 (98) 32 (97) 14 (100) 2 Black 1 (2) 1 (3) 0 Marital status 1 Married/partner 34 (72) 25 (76) 9 (65) 2 Single 6 (13) 3 (9) 3 (21) 3 Separated/divorced 5 (11) 4 (12) 1 (7) 4 Widow/er 2 (4) 1 (3) 1 (7) Social Support 1 Live with next of kin 40 (85) 28 (85) 12 (86) 2 Next of kin nearby 5 (11)…”
Sex Differences in Utilisation and Response to Implantable Device Therapy
Narasimha, D., & Curtis, A. B. (2015) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2015.04.02.129 · Cited by 23
Is Defibrillation Testing Necessary for Implantable Transvenous Defibrillators?
Russo, A. M., & Chung, M. K. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000371 · Cited by 23

Authors: Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G.
Affiliations: Brown University (US)
Duke University (US)
Albert Einstein College of Medicine (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Buxton, Alfred E.
Lee, Kerry L.
Fisher, John D.
Prystowsky, Eric N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-12-16
Volume: 341
Issue: 25
Pages: 1882-1890
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199912163412503
OpenAlex: W2313547185
Cited by: 2,489
References: 34
Citations by year: 2026: 20 · 2025: 36 · 2024: 23 · 2023: 34 · 2022: 44 · 2021: 41 · 2020: 51 · 2019: 54 · 2018: 54 · 2017: 92 · 2016: 75 · 2015: 87 · 2014: 95 · 2013: 114 · 2012: 122
FWCI: 70.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01hl045726-06)
National Heart, Lung, and Blood Institute (UO1HL45700, UO1-HL45726, U01HL045700)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: coronary artery disease, asymptomatic ventricular arrhythmia, implantable cardioverter-defibrillator, antiarrhythmic drugs, electrophysiologic testing, programmed electrical stimulation, cardiac arrest, all-cause mortality, left ventricular ejection fraction, ACE inhibitors, beta-blockers
MeSH terms: Aged, Anti-Arrhythmia Agents, Cardiac Pacing, Artificial, Coronary Disease, Electrophysiology, Female, Humans, Male, Middle Aged, Survival Analysis, Death, Sudden, Cardiac, Defibrillators, Implantable, Tachycardia, Ventricular

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A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

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