Cited by 2,489Cardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studiesCardiac Arrhythmias and Treatments

The DOI matches its Crossref record, with a small difference in title or year; 34 of the 34 references it cites were found in a registry or an index.

A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

Open access

Buxton, Alfred E., Lee, Kerry L., Fisher, John D., Josephson, Mark E., Prystowsky, Eric N., Hafley, Gail·1999·New England Journal of Medicine

DOI 10.1056/nejm199912163412503

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death. METHODS: We conducted a randomized, controlled trial to test the hypothesis that electrophysiologically guided antiarrhythmic therapy would reduce the risk of sudden death among patients with coronary artery disease, a left ventricular ejection fraction of 40 percent or less, and asymptomatic, unsustained ventricular tachycardia. Patients in whom sustained ventricular tachyarrhythmias were induced by programmed stimulation were randomly assigned to receive either antiarrhythmic therapy, including drugs and implantable defibrillators, as indicated by the results of electrophysiologic testing, or no antiarrhythmic therapy. Angiotensin-converting-enzyme inhibitors and beta-adrenergic-blocking agents were administered if the patients could tolerate them. RESULTS: A total of 704 patients with inducible, sustained ventricular tachyarrhythmias were randomly assigned to treatment groups. Five-year Kaplan-Meier estimates of the incidence of the primary end point of cardiac arrest or death from arrhythmia were 25 percent among those receiving electrophysiologically guided therapy and 32 percent among the patients assigned to no antiarrhythmic therapy (relative risk, 0.73; 95 percent confidence interval, 0.53 to 0.99), representing a reduction in risk of 27 percent). The five-year estimates of overall mortality were 42 percent and 48 percent, respectively (relative risk, 0.80; 95 percent confidence interval, 0.64 to 1.01). The risk of cardiac arrest or death from arrhythmia among the patients who received treatment with defibrillators was significantly lower than that among the patients discharged without receiving defibrillator treatment (relative risk, 0.24; 95 percent confidence interval, 0.13 to 0.45; P<0.001). Neither the rate of cardiac arrest or death from arrhythmia nor the overall mortality rate was lower among the patients assigned to electrophysiologically guided therapy and treated with antiarrhythmic drugs than among the patients assigned to no antiarrhythmic therapy. CONCLUSIONS: Electrophysiologically guided antiarrhythmic therapy with implantable defibrillators, but not with antiarrhythmic drugs, reduces the risk of sudden death in high-risk patients with coronary disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejm199912163412503

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
A Comparison of Antiarrhythmic-Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-Fatal Ventricular Arrhythmias
The AVID Investigators (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372202 · Cited by 3,221
Discrete Sequential Boundaries for Clinical Trials
Lan, K. K. G., & DeMets, D. L. (1983) · Biometrika · doi:10.2307/2336502 · Cited by 2,310
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
Julian, D. G., CAMM, A. J., Frangin, G., Janse, M. J., Munoz, A., Pj, S., & Simon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09145-3 · Cited by 1,100

Show all 34 references

Research works printed but not linked: 1

10.2307/2281868 · DOI · Paper page

Sorted by citations

Items 801–900 of 1,000

Current Device Therapies for Sudden Cardiac Death Prevention – the ICD, Subcutaneous ICD and Wearable ICD
Chieng, D., Paul, V., & Denman, R. A. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.09.011 · Cited by 23
DEFibrillators In Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE)
Schaechter, A., & Kadish, A. H. (2003) · Cardiac Electrophysiology Review · doi:10.1023/b:cepr.0000023162.45506.c4 · Cited by 23
“Most studies of ICD therapy for patients with systolic heart failure in the absence of known sustained ventricular arrhythmias have included subjects with coronary artery disease and previous myocardial infarction (MADIT, MADIT II, MUSTT) [2, 18 ,19].”
Background
Coronary artery reperfusion for ST elevation myocardial infarction is associated with shorter cycle length ventricular tachycardia and fewer spontaneous arrhythmias
Nalliah, C. J., Zaman, S., Narayan, A., Sullivan, J., & Kovoor, P. (2013) · EP Europace · doi:10.1093/europace/eut307 · Cited by 23
Interlead heterogeneity of R‐ and T‐wave morphology in standard 12‐lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy
Tan, A. Y., Nearing, B. D., Rosenberg, M. A., Nezafat, R., Josephson, M. E., & Verrier, R. L. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13288 · Cited by 23
Self-citation
A brief history of sudden cardiac death and its therapy
Janse, M. J. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00104-9 · Cited by 23
Antiarrhythmic Drugs:
Roden, D. M. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.03441.x · Cited by 23
Effect of Concomitant Antiarrhythmic Therapy on Survival in Patients with Implantable Cardioverter Defibrillators
Ho, A. T., Pai, S. M., Timothy, P., & Pai, R. G. (2005) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2005.00164.x · Cited by 23
Patients with an ICD Can Safely Resume Work in Industrial Facilities Following Simple Screening for Electromagnetic Interference
Gurevitz, O. T., Fogel, R. I., HERNER, M. E., Sample, R., Strickberger, A., Daoud, E. G., Morady, F., & Prystowsky, E. N. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00251.x · Cited by 23
“10 (3) EMI can cause the defibrillator to revert to a “protection mode” changing its programmed parameters to the default values.”
BackgroundSelf-citation
Microvolt T-wave alternans: A review of techniques, interpretation, utility, clinical studies, and future perspectives
Haghjoo, M., Arya, A., & Sadr‐Ameli, M. A. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.06.049 · Cited by 23
“Recently, programmed ventricular stimulation (PVS) during electrophysiology study (EPS) identified a cohort with left ventricular dysfunction who had improved survival with implantable cardioverter-defibrillator (ICD) placement [5,6].”
Background
Implantable Device Therapy
Goldenberg, I., & Moss, A. J. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.09.002 · Cited by 23
Can Sudden Cardiac Death Be Predicted from the T Wave of the ECG? A Critical Examination of T Wave Alternans and QT Interval Dispersion
Costantini, O., DRABEK, C. A., & ROSENBAUM, D. S. (2000) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2000.tb00971.x · Cited by 23
High risk of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy presenting with syncope
Phang, R. S., Kang, D., Tighiouart, H., Estes, N. A. M., & Link, M. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.063 · Cited by 22
Pathophysiology of syncope: current concepts and their development
Benditt, D. G., Fedorowski, A., Sutton, R., & van Dijk, J. G. (2024) · Physiological Reviews · doi:10.1152/physrev.00007.2024 · Cited by 23
Sudden cardiac arrest: Limitations in risk-stratification and treatment, and the potential for digital technologies and artificial intelligence to improve prediction and outcomes
Srivats, S. S., Zghyer, F., Shahrori, Z., Albert, C. M., Al‐Khatib, S. M., Chugh, S. S., Etheridge, S. P., Goldberger, Z. D., Gopinathannair, R., Lakkireddy, D., et al. (2025) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2025.06.005 · Cited by 26
The use of wearable cardioverter-defibrillators in Europe: results of the European Heart Rhythm Association survey
Lenarczyk, R., Potpara, T., Haugaa, K. H., Hernández‐Madrid, A., Sciaraffia, E., & Dagres, N. (2016) · EP Europace · doi:10.1093/europace/euw003 · Cited by 22
“Implantable cardioverter-defibrillators (ICDs) have proved effective in primary and secondary prevention of sudden cardiac death (SCD).(1,2) However, a significant proportion of patients presents with contraindications to ICD or does not meet the criteria for ICD implantation, as defined by current guidelines.”
Comparison of Detection of Arrhythmias in Patients With Chronic Heart Failure Secondary to Non-Ischemic Versus Ischemic Cardiomyopathy by 1 Versus 7-Day Holter Monitoring
Pastor‐Pérez, F. J., Manzano‐Fernández, S., Goya–Esteban, R., Pascual-Figal, D. A., Barquero‐Pérez, Ó., Rojo‐Álvarez, J. L., Martinez-Espejo, M. D. M., Chávarri, M. V., & Garcı́a-Alberola, A. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.04.027 · Cited by 22
Clinical and serum-based markers are associated with death within 1 year of de novo implant in primary prevention ICD recipients
Zhang, Y., Güallar, E., Blasco‐Colmenares, E., Dalal, D., Butcher, B., Norgard, S., Tjong, F. V. Y., ELDADAH, Z. A., Dickfeld, T. L., Ellenbogen, K. A., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.10.034 · Cited by 22
Position paper for management of elderly patients with pacemakers and implantable cardiac defibrillators: Groupe de Rythmologie et Stimulation Cardiaque de la Société Française de Cardiologie and Société Française de Gériatrie et Gérontologie
Fauchier, L., Alonso, C., Anselme, F., Blangy, H., Bordachar, P., Bovéda, S., Clémenty, N., Defaye, P., Deharo, J., Friocourt, P., et al. (2016) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2016.04.004 · Cited by 22
“[2] Buxton AE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN,”
Background
Isopimaric acid – a multi‐targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line
Salari, S., Ejneby, M. S., Brask, J., & Elinder, F. (2017) · Acta Physiologica · doi:10.1111/apha.12895 · Cited by 22
Sudden Cardiac Death in Ischemic Heart Disease
El‐Sherif, N., Boutjdir, M., & Turitto, G. (2017) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2017.08.003 · Cited by 22
Impact of Implantable Defibrillators and Resynchronization Therapy on Outcome in Patients with Left Ventricular Dysfunction – A Meta-Analysis
Abdulla, J., Haarbo, J., Køber, L., & Torp-Pedersen, C. T. (2006) · Cardiology · doi:10.1159/000093234 · Cited by 22
Modern management of arrhythmias
HALL, M. C., & TODD, D. M. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.033654 · Cited by 22
Cardiac Pacing and Defibrillation Devices: Cost and Effectiveness
Groeneveld, P. W., & Dixit, S. (2016) · Annual Review of Medicine · doi:10.1146/annurev-med-043015-123540 · Cited by 23
Expanding Indications for Defibrillators after Myocardial Infarction: Risk Stratification and Cost Effectiveness
Essebag, V., & Eisenberg, M. J. (2003) · Cardiac Electrophysiology Review · doi:10.1023/a:1023639006565 · Cited by 22
Implantable Cardioverter Defibrillator Events in Patients with Asymptomatic Nonsustained Ventricular Tachycardia:
Russo, A. M., Nayak, H. M., Verdino, R. J., Springman, J., Gerstenfeld, E. P., Hsia, H. H., & Marchlinski, F. E. (2003) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2003.00361.x · Cited by 22
Life after a ventricular arrhythmia
Hsu, J., Uratsu, C. S., Truman, A. F., Quesenberry, C. P., McDonald, K. M., Hlatky, M. A., & Selby, J. V. (2002) · American Heart Journal · doi:10.1067/mhj.2002.125497 · Cited by 22
Primary Prevention of Sudden Cardiac Death with Implantable Cardioverter Defibrillators: Lessons Learned From MADIT and MUSTT
Gold, M. R., & Nisam, S. (2000) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2000.tb07067.x · Cited by 22
Infrequent physician use of implantable cardioverter-defibrillators risks patient safety
Lyman, S., Sedrakyan, A., Do, H. T., Razzano, R. A., & Mushlin, A. I. (2011) · Heart · doi:10.1136/hrt.2011.226282 · Cited by 21
Comparison of 2 ambulatory patch ECG monitors: The benefit of the P-wave and signal clarity
Rho, R. W., Vossler, M. R., Blancher, S., & Poole, J. E. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.03.022 · Cited by 21
Sex Differences in Electrophysiology, Ventricular Tachyarrhythmia, Cardiac Arrest and Sudden Cardiac Death Following Acute Myocardial Infarction
Zaman, S. J., Deshmukh, T., Aslam, A., Martin, C., & Kovoor, P. (2019) · Heart Lung and Circulation · doi:10.1016/j.hlc.2019.07.017 · Cited by 21
Periodic Repolarization Dynamics Identifies ICD Responders in Nonischemic Cardiomyopathy: A DANISH Substudy
Boas, R., Sappler, N., von Stuelpnagel, L., Klemm, M., Dixen, U., Thune, J., Pehrson, S., Køber, L., Nielsen, J., Videbæk, L., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.056464 · Cited by 16
Genomics, heart failure and sudden cardiac death
Darbar, D. (2008) · Heart Failure Reviews · doi:10.1007/s10741-008-9095-9 · Cited by 21
Ventricular automaticity as a predictor of sudden death in ischaemic heart disease
Bastiaenen, R., Batchvarov, V., & Gallagher, M. M. (2011) · EP Europace · doi:10.1093/europace/eur342 · Cited by 21
“The number needed to treat to prevent one death was 3 over 5 years in MUSTT, 4 over 5 years in MADIT I, and 18 over 20 months in MADIT II.36,37,58 NSVT remains a significant predictor for appropriate ICD therapy in the primary prevention population.59 Electrophysiological study in implantable cardioverter defibrillato…”
BackgroundInfluential
Prediction of sudden cardiac death: next steps in pursuit of effective methodology
Stecker, E. C., & Chugh, S. S. (2011) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-010-9535-z · Cited by 21
“The first two, nonsustained ventricular tachycardia (VT) on ambulatory ECG and inducible VT during electrophysiology study, were effective in defining patients with severe ischemic cardiomyopathy who are at very high risk of SCD and benefit from an ICD [3, 4]; however, the SCD risk among patients without these markers…”
Background
Implantable Cardioverter Defibrillator Criteria for Primary and Secondary Prevention of Pediatric Sudden Cardiac Death
Berul, C. I. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02388.x · Cited by 21
Long‐Term Follow‐Up of Patients Supplied with Single‐Chamber or Dual‐Chamber Cardioverter Defibrillators
Kolb, C., Deisenhofer, I., Schmieder, S., Barthel, P., Zrenner, B., KARCH, M. R., & Schmitt, C. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00467.x · Cited by 20
Declining clinical benefit of ICD in heart failure patients: Temporal trend of mortality outcomes from randomized controlled trials
Disertori, M., Masè, M., Rigoni, M., Nollo, G., & Ravelli, F. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.06.001 · Cited by 21
The effects of gender on electrical therapies for the heart: physiology, epidemiology, and access to therapies
Boriani, G., Lorenzetti, S., Cerbai, E., Oreto, G., Bronzetti, G., Malavasi, V. L., Biffi, A., Padeletti, L., Botto, G., & Diemberger, I. (2017) · EP Europace · doi:10.1093/europace/eux068 · Cited by 21
Joint Shock/Death Risk Prediction Model for Patients Considering Implantable Cardioverter-Defibrillators
Reeder, H. T., Shen, C., Buxton, A. E., Haneuse, S., & Kramer, D. B. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.005675 · Cited by 21
Self-citation
Significance and Control of Cardiac Arrhythmias in Patients with Congestive Cardiac Failure
Singh, B. N. (2002) · Heart Failure Reviews · doi:10.1023/a:1020001912248 · Cited by 21
Implantable Cardiac Defibrillators
Peters, R. W., & Gold, M. R. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70319-9 · Cited by 21
MANAGEMENT OF ARRHYTHMIAS
Lampert, R., & Ezekowitz, M. D. (2000) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70030-6 · Cited by 21
Incidence and electrophysiological characteristics of spontaneous ventricular tachyarrhythmias in high risk coronary patients and prophylactic implantation of a defibrillator
Wolpert, C., Kuschyk, J., Aramin, N., Spehl, S., Streitner, F., Süselbeck, T., Schumacher, B., Haase, K. K., Schimpf, R., & Borggrefe, M. (2004) · Heart · doi:10.1136/hrt.2003.019042 · Cited by 21
Guideline for the management of heart failure caused by systolic dysfunction: Part I. Guideline development, etiology and diagnosis.
Chavey, W. E., Blaum, C. S., Bleske, B. E., Harrison, R. V., Kesterson, S. K., & Nicklas, J. M. (2001) · PubMed · Cited by 21
Prevention of Sudden Death in Patients With Coronary Artery Disease: Do Lipid‐Lowering Drugs Play a Role?
Sutter, J. D., Firsovaite, V., & Tavernier, R. (2002) · Preventive Cardiology · doi:10.1111/j.1520.037x.2002.00731.x · Cited by 21
Ischemia, metabolic disturbances, and arrhythmogenesis: Mechanisms and management
Ramaswamy, K., & Hamdan, M. H. (2000) · Critical Care Medicine · doi:10.1097/00003246-200010001-00007 · Cited by 21
“Patients with inducible arrhythmias benefit from an implantable cardioverterdefibrillator (15, 16).”
Background
Prevention of Sudden Death in Patients with Coronary Artery Disease
Aggarwal, A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004273421714 · Cited by 21
Global and Regional Functional Assessment of Ischemic Heart Disease with Cardiac MR Imaging
Collins, J. D. (2015) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2014.11.001 · Cited by 19
Role of Implantable Cardioverter Defibrillator in Heart Failure With Contemporary Medical Therapy
Butler, J., Talha, K. M., Aktaş, M. K., Zaręba, W., & Goldenberg, I. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.122.009634 · Cited by 20
Impact of late gadolinium enhancement extent, location, and pattern on ventricular tachycardia and major adverse cardiac events in patients with ischemic vs. non-ischemic cardiomyopathy
Tat, E., Ball, C., Camren, G. P., Wroblewski, I., Dajani, K. A., Goldberg, A., Kinno, M., Sanagala, T., Syed, M., Wilber, D. J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1026215 · Cited by 20
“(3) In patients with NICM, LGE extent, location (anterior, inferior and apical segment LGE), involvement of multiple LV walls, and mid-wall LGE pattern yielded prognostic significance for the prediction of worse outcomes.”
BackgroundMethodInfluential
Utilization rates of implantable cardioverter-defibrillators for primary prevention of sudden cardiac death: A 2012 calculation for a midwestern health referral region
Hoang, A., Shen, C., Zheng, J. J., Taylor, S., Groh, W. J., Rosenman, M. B., Buxton, A. E., & Chen, P. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.02.019 · Cited by 20
“1>2>3): (1) ICD implanted before the 12-month period [N=22] or unavailable confirmed date of original implant [N=1], (2) ICD for secondary prevention [N=1], or (3) ICD implanted despite last EF>0.”
Self-citation
Long‐Term Outcomes of Inducible Very Fast Ventricular Tachycardia (Cycle Length 200–250 ms) in Patients With Ischemic Cardiomyopathy
Kumar, S., Sivagangabalan, G., Choi, M.-C., EIPPER, V. E., Thiagalingam, A., & Kovoor, P. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01624.x · Cited by 20
Indications for internal cardioverter defibrillator implantation predict time to first shock and the modulating effect of β-blockers
Hreybe, H., Bedi, M., Ezzeddine, R., Barrington, W., Jain, S. K., Ngwu, O., & Saba, S. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.07.019 · Cited by 20
Ventricular arrhythmias: from the electrophysiology laboratory to clinical practice. Part II: potentially malignant and benign ventricular arrhythmias.
Gatzoulis, K. A., Archontakis, S., Dilaveris, P., Tsiachris, D., Αρσένος, Π., Sideris, S. K., & Stefanadis, C. (2012) · PubMed · Cited by 19
Risk of arrhythmic death in ischemic heart disease: a prospective, controlled, observer‐blind risk stratification over 10 years
Pezawas, T., Diedrich, A., Robertson, D., Winker, R., Richter, B., Wang, L. A., & Schmidinger, H. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12729 · Cited by 20
Current Therapeutic Options for Heart Failure in Elderly Patients
Guerra, F., Brambatti, M., Matassini, M. V., & Capucci, A. (2017) · BioMed Research International · doi:10.1155/2017/1483873 · Cited by 22
ASNC/SNMMI Model Coverage Policy: Myocardial sympathetic innervation imaging: Iodine-123 meta-iodobenzylguanidine (123I-mIBG)
Sciammarella, M. G., Gerson, M. C., Buxton, A. E., Bartley, S., Doukky, R., Merlino, D. A., Tandon, S., Thompson, R., & Travin, M. I. (2015) · Journal of Nuclear Cardiology · doi:10.1007/s12350-015-0202-8 · Cited by 20
Self-citation
Gender and Its Effect in Cardiovascular Pharmacotherapeutics: Recent Considerations
Sica, D. A., Wood, M. A., & Hess, M. (2005) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2005.04171.x · Cited by 20
Amiodarone Therapy in Patients Implanted With Cardioverter-Defibrillator for Life-Threatening Ventricular Arrhythmias
Satomi, K., Kurita, T., Takatsuki, S., Yokoyama, Y., Chinushi, M., Tsuboi, N., Nitta, T., Shoda, M., & Mitamura, H. (2006) · Circulation Journal · doi:10.1253/circj.70.977 · Cited by 20
Alzheimer?s disease: the impact of age-related changes in reproductive hormones
Atwood, C. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4380-4 · Cited by 22
New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias
Gambit, M. O. T. S. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00465-5 · Cited by 20
Cardiac arrhythmias in congestive heart failure
Kantharia, B. K. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.09.185 · Cited by 19
Association Between Comorbidities and Outcomes in Heart Failure Patients With and Without an Implantable Cardioverter‐Defibrillator for Primary Prevention
Khazanie, P., Hellkamp, A. S., Fonarow, G. C., Bhatt, D. L., Masoudi, F. A., Anstrom, K. J., Heidenreich, P. A., Yancy, C. W., Curtis, L. H., Hernandez, A. F., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002061 · Cited by 19
Arrhythmic risk stratification in ischemic, non-ischemic and hypertrophic cardiomyopathy: A two-step multifactorial, electrophysiology study inclusive approach
Αρσένος, Π., Gatzoulis, K. A., Tsiachris, D., Dilaveris, P., Sideris, S. K., Sotiropoulos, I., Archontakis, S., Antoniou, C. K., Kordalis, A., Skiadas, I., et al. (2022) · World Journal of Cardiology · doi:10.4330/wjc.v14.i3.139 · Cited by 19
Long‐Term Outcomes of Cardiovascular Implantable Electronic Devices in Patients with Staphylococcus aureus Bacteremia
Obeid, K. M., Szpunar, S. M., & Khatib, R. (2012) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2012.03438.x · Cited by 19
Arrhythmias in Structural Heart Disease
Gillespie, H. S., Lin, C. C. H., & Prutkin, J. M. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0510-7 · Cited by 18
Use and long-term outcomes of implantable cardioverter-defibrillators, 1990 to 2009
Bradshaw, P. J., Stobie, P. E., Briffa, T. G., & HOBBS, M. S. T. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.02.007 · Cited by 19
Fragmented QRS Predicts Cardiovascular Death of Patients With Structural Heart Disease and Inducible Ventricular Tachyarrhythmia
Hayashi, T., Fukamizu, S., Hojo, R., Komiyama, K., Tanabe, Y., Tejima, T., Nishizaki, M., Hiraoka, M., Ako, J., Momomura, S., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0335 · Cited by 19
“VT/VF storm (≥3 ICD shocks/24 h) 3 (10) 11 (15) 0.”
Significance of Inducible Very Fast Ventricular Tachycardia (Cycle Length 200–230 ms) After Early Reperfusion for ST-Segment–Elevation Myocardial Infarction
Zaman, S. J., Kumar, S., Sullivan, J., Narayan, A., Thiagalingam, A., Ross, D. L., & Kovoor, P. (2013) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000213 · Cited by 19
Native T1 value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction
Nakamori, S., Alakbarli, J., Bellm, S., Motiwala, S. R., Addae, G., Manning, W. J., & Nezafat, R. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25652 · Cited by 19
“The prophylactic use of primary prevention implantable cardioverter-defibrillator for reducing mortality due to ventricular arrhythmias is widely accepted in patients with heart failure and a low left ventricular ejection fraction (LVEF).(3,4) However, the importance of LV dysfunction as a pathogenic mechanism after M…”
Background
CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy international registry: Design and rationale of the DERIVATE study
Guaricci, A. I., Masci, P. G., Lorenzoni, V., Schwitter, J., & Pontone, G. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.03.043 · Cited by 19
Outcomes of elderly heart failure recipients of ICD and CRT
Grimm, W. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.10.007 · Cited by 19
Evidence-based analysis of risk factors for sudden cardiac death
Goldberger, J. J. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.11.007 · Cited by 19
Risk stratification of ischaemic patients with implantable cardioverter defibrillators by C-reactive protein and a multi-markers strategy: results of the CAMI-GUIDE study
Biasucci, L. M., Bellocci, F., Landolina, M., Rordorf, R., Vado, A., Menardi, E., Giubilato, G., Orazi, S., Sassara, M., Castro, A., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr487 · Cited by 19
Mode of Induction of Ventricular Tachycardia and Prognosis in Patients with Coronary Disease: The Multicenter UnSustained Tachycardia Trial (MUSTT)
Piccini, J. P., Hafley, G. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., Buxton, A. E., & for the MUSTT Investigators (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01469.x · Cited by 19
Self-citation
Forty Years of Invasive Clinical Electrophysiology
Wellens, H. J. J. (2008) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.108.770529 · Cited by 19
Implantable cardioverter defibrillators for primary prevention in patients with nonischemic cardiomyopathy: A systematic review and meta‐analysis
Akel, T., & Lafferty, J. (2017) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12253 · Cited by 19
Habitual Cocaine Use Is Associated with High Defibrillation Threshold During ICD Implantation
CHEN, J., Naseem, R. H., OBEL, O. A., & Joglar, J. A. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00834.x · Cited by 19
Role of Antiarrhythmic Therapy in Patients at Risk for Sudden Cardiac Death: An Evidence‐Based Review
Hilleman, D. E., & Bauman, J. L. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.6.556.34550 · Cited by 19
“Event rates in the MUSTT are shown in Table 2.(56) Two- and 5-year rates of cardiac arrest or death from arrhythmia in patients given no antiarrhythmic therapy were 18% and 32%, respectively.”
Method
Pacing in heart failure: the benefit of resynchronization.
Khaykin, Y., Saad, E., & Wilkoff, B. L. (2003) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.70.10.841 · Cited by 19
Comparison of ventricular arrhythmia burden, therapeutic interventions, and survival, in patients < 75 and patients >= 75 years of age treated with implantable cardioverter defibrillators
Ermiş, C., Zhu, A. X., VanHeel, L., Sakaguchi, R. N. S., Lurie, K. G., Lü, F., & Benditt, D. G. (2007) · EP Europace · doi:10.1093/europace/eum015 · Cited by 19
Sudden Cardiac Death
Antezano, E. S., & Hong, M. F. (2003) · Journal of Intensive Care Medicine · doi:10.1177/0885066603258140 · Cited by 19
Influence of gender on ICD implantation for primary and secondary prevention of sudden cardiac death
Davis, D. R., Tang, A., Lemery, R., Green, M. S., Gollob, M. H., & Birnie, D. H. (2006) · EP Europace · doi:10.1093/europace/eul123 · Cited by 19
Novel approaches to clinical trials: device-related infections
Califf, R. M., Fowler, V. G., Cabell, C. H., & Corey, G. R. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.12.031 · Cited by 19
Amino-Terminal Pro-Brain Natriuretic Peptide Predicts Ventricular Arrhythmogenesis in Patients With Ischemic Cardiomyopathy and Implantable Cardioverter-Defibrillators
Manios, E. G., Kallergis, E. M., KANOUPAKIS, E. M., Mavrakis, H. E., Kambouraki, D. C., Arfanakis, D. A., & Vardas, P. E. (2005) · CHEST Journal · doi:10.1378/chest.128.4.2604 · Cited by 19
ELECTROPHYSIOLOGY: Implantable cardioverter-defibrillators
Connelly, D. T. (2001) · Heart · doi:10.1136/heart.86.2.221 · Cited by 19
Interference of Electronic Apex Locators with Implantable Cardioverter Defibrillators
Idzahi, K., de Cock, C. C., Shemesh, H., & Brand, H. S. (2013) · Journal of Endodontics · doi:10.1016/j.joen.2013.07.027 · Cited by 18
“Pacemakers and ICDs are an effective treatment for life-threatening arrhythmias, and ICDs reducemortality caused by sudden cardiac death in high-risk patients (19).”
Background
Clinical significance of precedent asymptomatic non-sustained ventricular tachycardias on subsequent ICD interventions and heart failure hospitalization in primary prevention ICD patients
Makimoto, H., Zielke, S., Clasen, L., Lin, T., Gerguri, S., Müller, P., Schmidt, J., Bejinariu, A., Kurt, M. M., Brinkmeyer, C., et al. (2020) · European journal of medical research · doi:10.1186/s40001-020-0401-x · Cited by 18
Effect of ICD Therapies on Mortality in the OMNI Trial
Sun, S., Johnson, J. W., DeGroot, P., BROWN, M. L., & OBEL, O. A. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12860 · Cited by 18
Implantable Cardioverter-Defibrillator Therapy After Acute Myocardial Infarction
Goldberger, J. J., & PASSMAN, R. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.018 · Cited by 18
Sudden Cardiac Death Risk Stratification in Patients with Heart Failure
Lorvidhaya, P., Addo, K. N., Chodosh, A., Iyer, V., Lum, J. J., & Buxton, A. E. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2010.12.001 · Cited by 18
Self-citation
Wearable defibrillators in uninsured patients with newly diagnosed cardiomyopathy or recent revascularization in a community medical center
Mitrani, R. D., Mcardle, A., Slane, M., Cogan, J., & Myerburg, R. J. (2013) · American Heart Journal · doi:10.1016/j.ahj.2012.12.014 · Cited by 18
Risk stratification of ventricular arrhythmias in patients with systolic heart failure
Vest, R. N., & Gold, M. R. (2010) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283387a73 · Cited by 18
Clinical Reminders to Providers of Patients With Reduced Left Ventricular Ejection Fraction Increase Defibrillator Referral
Gupta, A., Gholami, P., Turakhia, M. P., Friday, K. J., & Heidenreich, P. A. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000753 · Cited by 18
Treatment of Arrhythmias and Use of Implantable Cardioverter-Defibrillators to Improve Survival in Elderly Patients with Cardiac Disease
Goldenberg, I., & Moss, A. J. (2007) · Heart Failure Clinics · doi:10.1016/j.hfc.2007.07.015 · Cited by 18
Arrhythmia issues in patients with renal disease
Kocheril, A. G. (2001) · Seminars in Nephrology · doi:10.1053/snep.2001.18379 · Cited by 18
Outcomes of patients with chronic kidney disease and implantable cardiac defibrillator: Primary versus secondary prevention
Hage, F. G., AlJaroudi, W., Aggarwal, H., Bhatia, V., Miller, J. M., Doppalapudi, H., Wazni, O. M., & Iskandrian, A. E. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.087 · Cited by 18
The incidence of implantable cardioverter defibrillator indications in patients admitted to all coronary care units in a single district
Plummer, C., JOHNIRVING, R., & McComb, J. M. (2005) · EP Europace · doi:10.1016/j.eupc.2005.01.006 · Cited by 18
“The time elapsed between infarction and randomisation was at least six months in 78% of patients recruited into MADIT and 88% in MADIT II, while 83% in MUSTT were at least one month post-MI.”
BackgroundInfluential
Evolution of the Implantable Cardioverter Defibrillator
Cannom, D. S., & Prystowsky, E. N. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.03689.x · Cited by 18
Self-citation
Myocardial Infarction in a Young Man due to a Hypoplastic Coronary Artery
Sim, D. S., Jeong, M. H., Choi, S., Yoon, N. S., Yoon, H. J., Moon, J. Y., Hong, Y. J., Kim, K. H., Park, H. W., Kim, J. H., et al. (2009) · Korean Circulation Journal · doi:10.4070/kcj.2009.39.4.163 · Cited by 18

Authors: Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G.
Affiliations: Brown University (US)
Duke University (US)
Albert Einstein College of Medicine (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Buxton, Alfred E.
Lee, Kerry L.
Fisher, John D.
Prystowsky, Eric N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-12-16
Volume: 341
Issue: 25
Pages: 1882-1890
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199912163412503
OpenAlex: W2313547185
Cited by: 2,489
References: 34
Citations by year: 2026: 20 · 2025: 36 · 2024: 23 · 2023: 34 · 2022: 44 · 2021: 41 · 2020: 51 · 2019: 54 · 2018: 54 · 2017: 92 · 2016: 75 · 2015: 87 · 2014: 95 · 2013: 114 · 2012: 122
FWCI: 70.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01hl045726-06)
National Heart, Lung, and Blood Institute (UO1HL45700, UO1-HL45726, U01HL045700)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: coronary artery disease, asymptomatic ventricular arrhythmia, implantable cardioverter-defibrillator, antiarrhythmic drugs, electrophysiologic testing, programmed electrical stimulation, cardiac arrest, all-cause mortality, left ventricular ejection fraction, ACE inhibitors, beta-blockers
MeSH terms: Aged, Anti-Arrhythmia Agents, Cardiac Pacing, Artificial, Coronary Disease, Electrophysiology, Female, Humans, Male, Middle Aged, Survival Analysis, Death, Sudden, Cardiac, Defibrillators, Implantable, Tachycardia, Ventricular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks