Cited by 2,489Cardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studiesCardiac Arrhythmias and Treatments

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A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

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Buxton, Alfred E., Lee, Kerry L., Fisher, John D., Josephson, Mark E., Prystowsky, Eric N., Hafley, Gail·1999·New England Journal of Medicine

DOI 10.1056/nejm199912163412503

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Abstract

BACKGROUND: Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death. METHODS: We conducted a randomized, controlled trial to test the hypothesis that electrophysiologically guided antiarrhythmic therapy would reduce the risk of sudden death among patients with coronary artery disease, a left ventricular ejection fraction of 40 percent or less, and asymptomatic, unsustained ventricular tachycardia. Patients in whom sustained ventricular tachyarrhythmias were induced by programmed stimulation were randomly assigned to receive either antiarrhythmic therapy, including drugs and implantable defibrillators, as indicated by the results of electrophysiologic testing, or no antiarrhythmic therapy. Angiotensin-converting-enzyme inhibitors and beta-adrenergic-blocking agents were administered if the patients could tolerate them. RESULTS: A total of 704 patients with inducible, sustained ventricular tachyarrhythmias were randomly assigned to treatment groups. Five-year Kaplan-Meier estimates of the incidence of the primary end point of cardiac arrest or death from arrhythmia were 25 percent among those receiving electrophysiologically guided therapy and 32 percent among the patients assigned to no antiarrhythmic therapy (relative risk, 0.73; 95 percent confidence interval, 0.53 to 0.99), representing a reduction in risk of 27 percent). The five-year estimates of overall mortality were 42 percent and 48 percent, respectively (relative risk, 0.80; 95 percent confidence interval, 0.64 to 1.01). The risk of cardiac arrest or death from arrhythmia among the patients who received treatment with defibrillators was significantly lower than that among the patients discharged without receiving defibrillator treatment (relative risk, 0.24; 95 percent confidence interval, 0.13 to 0.45; P<0.001). Neither the rate of cardiac arrest or death from arrhythmia nor the overall mortality rate was lower among the patients assigned to electrophysiologically guided therapy and treated with antiarrhythmic drugs than among the patients assigned to no antiarrhythmic therapy. CONCLUSIONS: Electrophysiologically guided antiarrhythmic therapy with implantable defibrillators, but not with antiarrhythmic drugs, reduces the risk of sudden death in high-risk patients with coronary disease.

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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
A Comparison of Antiarrhythmic-Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-Fatal Ventricular Arrhythmias
The AVID Investigators (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372202 · Cited by 3,221
Discrete Sequential Boundaries for Clinical Trials
Lan, K. K. G., & DeMets, D. L. (1983) · Biometrika · doi:10.2307/2336502 · Cited by 2,310
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
Julian, D. G., CAMM, A. J., Frangin, G., Janse, M. J., Munoz, A., Pj, S., & Simon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09145-3 · Cited by 1,100

Show all 34 references

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Left Ventricular Ejection Fraction for Sudden Death Risk Stratification and Guiding Implantable Cardioverter-defibrillators Implantation
Buxton, A. E., Ellison, K., Lorvidhaya, P., & Ziv, O. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181d9f49c · Cited by 46
Self-citation
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Richardson, T. D., Hale, L., Arteaga, C., Xu, M., Keebler, M., Schlendorf, K. H., Danter, M. R., Shah, A. S., Lindenfeld, J. M., & Ellis, C. R. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007748 · Cited by 46
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Steffen, M., Osborn, J. S., & Cutler, M. J. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.04.005 · Cited by 46
In Vivo Restoration of Myocardial Conduction With Carbon Nanotube Fibers
McCauley, M. D., Vitale, F., Yan, J. S., Young, C. C., Greet, B. D., Orecchioni, M., Perike, S., Elgalad, A., Coco, J. A., John, M. M., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007256 · Cited by 46
Cardiac Implantable Electronic Miniaturized and Micro Devices
Rav-Acha, M., Soifer, E., & Hasin, T. (2020) · Micromachines · doi:10.3390/mi11100902 · Cited by 46
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Butt, J. H., Nicolau, J. C., Verma, S., Docherty, K. F., Petrie, M. C., Inzucchi, S. E., Schou, M., Kosiborod, M., Langkilde, A. M., Martínez, F. A., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2124 · Cited by 51
The implantable cardioverter-defibrillator
Raj, S. R., & Sheldon, R. S. (2001) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2001.29146 · Cited by 46
The cost of implantable defibrillators: perceptions and reality
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Noninvasive risk stratification in postinfarction patients with severe left ventricular dysfunction and methodology of the MADIT II noninvasive electrocardiology substudy
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Heart Failure Devices
Kadish, A. H., & Mehra, M. R. (2005) · Circulation · doi:10.1161/circulationaha.104.481267 · Cited by 45
Implantable cardioverter defibrillator therapy activation for high risk patients with relatively well preserved left ventricular ejection fraction. Does it really work?
Gatzoulis, K. A., Tsiachris, D., Dilaveris, P., Archontakis, S., Αρσένος, Π., Vouliotis, A., Sideris, S. K., Trantalis, G., Kartsagoulis, E., Kallikazaros, I. E., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.04.005 · Cited by 45
“The LVEF used in clinical trials assessing the ICD for primary prevention of SCD ranged from less than 40% in MUSTT to less than 30% in MADIT II, while MADIT I and SCD-HeFT used LVEFs of less than 35% as entry criteria [2–5].”
Method
Mechanisms of ventricular arrhythmias in heart failure
Ebinger, M. W., Krishnan, S., & Schuger, C. D. (2005) · Current Heart Failure Reports · doi:10.1007/s11897-005-0018-y · Cited by 45
Modes and timing of death in 66 252 patients with non-ST-segment elevation acute coronary syndromes enrolled in 14 TIMI trials
Berg, D. D., Wiviott, S. D., D, E. B. M., Guo, J., Im, K., Kashani, A., Gibson, C. M., Cannon, C. P., Morrow, D. A., Bhatt, D. L., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy556 · Cited by 45
Kommentar zu den Leitlinien zur Diagnostik und Therapie von Synkopen—der Europäischen Gesellschaft für Kardiologie 2001 und dem Update 2004
Seidl, K., Schuchert, A., Tebbenjohanns, J., & Hartung, W. (2005) · Zeitschrift für Kardiologie · doi:10.1007/s00392-005-0230-5 · Cited by 43
“Bei negativem passivem Test ist zur pharmakologischen Provokation entweder intravenös Iso- proterenol/Isoprenalin oder sublingual Nitroglyzerin zu geben.”
BackgroundInfluential
Primary Prevention of Sudden Death With Implantable Defibrillator Therapy in Patients With Cardiac Disease
Exner, D. V., Klein, G. J., & Prystowsky, E. N. (2001) · Circulation · doi:10.1161/hc3801.096395 · Cited by 45
Self-citation
2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter‐defibrillator programming and testing
Wilkoff, B. L., Fauchier, L., Stiles, M. K., Morillo, C. A., Al‐Khatib, S. M., Almendral, J., Aguinaga, L., Berger, R. D., Cuesta, A., Daubert, J. P., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2015.12.001 · Cited by 44
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction (PROTECT-ICD): Trial Protocol, Background and Significance
Zaman, S. J., Taylor, A. J., Stiles, M. K., Chow, C. K., & Kovoor, P. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.04.007 · Cited by 44
“Electrophysiological study consistently predicts arrhythmic risk post-MI in clinical observational and randomised studies [11–18].”
BackgroundMethod
Systematic Review for the 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death
Kusumoto, F. M., Bailey, K. R., Chaouki, A. S., Deshmukh, A. J., Gautam, S., Kim, R. J., Kramer, D. B., Lambrakos, L. K., Nasser, N. H., & Sorajja, D. (2017) · Circulation · doi:10.1161/cir.0000000000000550 · Cited by 44
Primary Prophylaxis With the Implantable Cardioverter-Defibrillator
Gehi, A. K., Haas, D. C., & Fuster, V. (2005) · JAMA · doi:10.1001/jama.294.8.958 · Cited by 44
Is Inappropriate Implantable Defibrillator Shock Therapy Predictable?
Nanthakumar, K., Dorian, P., Paquette, M., Greene, M., Edwards, J., Heng, D., Noble, J., & Newman, D. (2003) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/a:1023973306742 · Cited by 44
Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
Pontone, G., Guaricci, A. I., Fusini, L., Baggiano, A., Guglielmo, M., Muscogiuri, G., Volpe, A., Abete, R., Aquaro, G. D., Barison, A., et al. (2023) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2023.03.015 · Cited by 43
Implantable Cardioverter Defibrillator Therapy in Patients with Prior Coronary Revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD‐HeFT)
Al‐Khatib, S. M., Hellkamp, A. S., Lee, K. L., Anderson, J., Poole, J. E., Mark, D. B., Bardy, G. H., & for the scd‐heft investigators (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01191.x · Cited by 43
Self-citation
New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials
Friedman, D. J., Al‐Khatib, S. M., Zeitler, E. P., Han, J., Bardy, G. H., Poole, J. E., Bigger, J. T., Buxton, A. E., Moss, A. J., Lee, K. L., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.06.002 · Cited by 43
Self-citation
Sex Disparities in Cardiovascular Device Evaluations
Ghare, M. I., Chandrasekhar, J., Mehran, R., Ng, V. G., Grines, C. L., & Lansky, A. J. (2019) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2018.10.048 · Cited by 43
The role of implantable cardioverter-defibrillators and sudden cardiac death prevention: indications, device selection, and outcome
Goldenberg, I., Huang, D. T.-C., & Nielsen, J. C. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz788 · Cited by 44
Prophylactic implantable cardioverter defibrillator trials: MUSTT, MADIT, and beyond
Prystowsky, E. N., & Nisam, S. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01205-4 · Cited by 43
Self-citation
Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction
Smilde, T. D. J., Hillege, H. L., Voors, A. A., Dunselman, P. H. J. M., & van Veldhuisen, D. J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.03.075 · Cited by 43
Psychological indices and phantom shocks in patients with ICD
Prudente, L. A., Reigle, J., Bourguignon, C. M., Haines, D. E., & Dimarco, J. (2006) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-006-9010-z · Cited by 43
Efficacy and Safety of ICD Therapy in a Population of Elderly Patients Treated with Optimal Background Medication
Duray, G. Z., Richter, S., Manegold, J. C., Israel, C. W., Grönefeld, G., & Hohnloser, S. H. (2005) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-006-5200-y · Cited by 43
Women and minorities are less likely to receive an implantable cardioverter defibrillator for primary prevention of sudden cardiac death
Mezu, U. L., Ch, I., Halder, I., London, B., & Saba, S. (2011) · EP Europace · doi:10.1093/europace/eur360 · Cited by 43
Cardiac arrhythmias: The quest for a cure
Wellens, H. J. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.080 · Cited by 48
Differences in inducibility and prognosis of in-hospital versus out-of-hospital identified nonsustained ventricular tachycardia in patients with coronary artery disease: Clinical and trial design implications
Pires, L. A., Lehmann, M. H., Buxton, A. E., Hafley, G. E., & Lee, K. L. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01482-6 · Cited by 42
“41%) received a defibrillator, which is consistent with the positive impact of a defibrillator, but not antiarrhythmic drug therapy in treated patients enrolled in MUSTT (9).”
MethodResultInfluentialSelf-citation
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.05.004 · Cited by 42
Self-citation
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Ng, J., Jacobson, J. T., Ng, J., Gordon, D., Lee, D. C., Carr, J., & Goldberger, J. J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.029 · Cited by 42
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Chung, M. K. (2014) · Cardiology Clinics · doi:10.1016/j.ccl.2013.11.002 · Cited by 42
Association Between Prophylactic Implantable Cardioverter-Defibrillators and Survival in Patients With Left Ventricular Ejection Fraction Between 30% and 35%
Al‐Khatib, S. M., Hellkamp, A. S., Fonarow, G. C., Mark, D. B., Curtis, L. H., Hernandez, A. F., Anstrom, K. J., Peterson, E. D., Sanders, G. D., Al‐Khalidi, H. R., et al. (2014) · JAMA · doi:10.1001/jama.2014.5310 · Cited by 42
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Sowell, L. V., Kuhl, E. A., Sears, S. F., Klodell, C. T., & CONTI, J. B. (2006) · Journal of Women s Health · doi:10.1089/jwh.2006.15.830 · Cited by 42
[Task Force on Sudden Cardiac Death, European Society of Cardiology. Summary of recommendations].
Priori, S. G., Aliot, E., Blomström‐Lundqvist, C., Bossaert, L. L., Breithardt, G., Brugada, P., Camm, A. J., Cappato, R., Cobbe, S. M., Mario, C. D., et al. (2002) · PubMed · Cited by 42
Right ventricular pacing is an independent predictor for ventricular tachycardia/ventricular fibrillation occurrence and heart failure events in patients with an implantable cardioverter-defibrillator
Gardiwal, A., Yu, H. H., Oswald, H., Luesebrink, U., Ludwig, A., Pichlmaier, A. M., Drexler, H., & Klein, G. (2008) · EP Europace · doi:10.1093/europace/eun019 · Cited by 42
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Moss, A. J., Daubert, J. P., & Zaręba, W. (2002) · Cardiac Electrophysiology Review · doi:10.1023/a:1021104929368 · Cited by 42
“A study reported in 1999 by the Multicenter Unsustained Tachycardia Trial (MUSTT) confirmed the MADIT findings [3].”
Result
Follow‐Up of CRT‐ICD: Implications for the Use of Remote Follow‐Up Systems. Data from the InSync ICD Italian Registry
Lunati, M., Gasparini, M., Santini, M., Landolina, M., Perego, G. B., Pappone, C., Marzegalli, M., ARGIOLAS, C., Murthy, A., Valsecchi, S., et al. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00923.x · Cited by 41
Fahreignung bei kardiovaskulären Erkrankungen
Klein, H. H., Krämer, A., Pieske, B. M., Trappe, H., & de Vries, H. (2010) · Der Kardiologe · doi:10.1007/s12181-010-0308-9 · Cited by 39
HRS/ACC/AHA Expert Consensus Statement on the Use of Implantable Cardioverter-Defibrillator Therapy in Patients Who Are Not Included or Not Well Represented in Clinical Trials
Kusumoto, F. M., Calkins, H. G., BOEHMER, J. P., Buxton, A. E., Chung, M. K., Gold, M. R., Hohnloser, S. H., Indik, J. H., Lee, R., Mehra, M. R., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.03.041 · Cited by 41
“Although EF was similar for all five trials, ranging from 0.23–0.30, 80% of patients in MUSTT had Class I or II heart failure symptoms, 70% of patients in MADIT II had Class I or II heart failure symptoms, and 67% of patients in MADIT and 100% of patients in SCD-HeFT had Class II or III heart failure symptoms.”
BackgroundMethodInfluentialSelf-citation
Impact of Implantable Cardioverter‐Defibrillator Recalls on Patients' Anxiety, Depression, and Quality of Life
Undavia, M. B., Goldstein, N. E., Cohen, P., Sinthawanarong, K., SINGSON, M., Bhutani, D., Munson, T., Gomes, J. A., Fischer, A., & Mehta, D. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01204.x · Cited by 41
Predictors of electrical storm recurrences in patients with implantable cardioverter-defibrillators
Streitner, F., Kuschyk, J., Veltmann, C., Mahl, E., Dietrich, C., Schimpf, R., Doesch, C., Streitner, I., Wolpert, C., & Borggrefe, M. (2010) · EP Europace · doi:10.1093/europace/euq428 · Cited by 41
Original Research: Deactivation of ICDs at the End of Life: A Systematic Review of Clinical Practices and Provider and Patient Attitudes
Russo, J. E. (2011) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000406411.49438.91 · Cited by 42
Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model
Weber, C., Neacsu, I., Krautz, B., Schlegel, P., Sauer, S. W., Raake, P. W. J., Ritterhoff, J., Jungmann, A., Remppis, A. B., Stangassinger, M., et al. (2013) · Gene Therapy · doi:10.1038/gt.2013.63 · Cited by 41
Absolute risk reduction in total mortality with implantable cardioverter defibrillators: analysis of primary and secondary prevention trial data to aid risk/benefit analysis
Betts, T. R., Sadarmin, P. P., Tomlinson, D. R., Rajappan, K., Wong, K. C., de Bono, J. P., & Bashir, Y. (2013) · EP Europace · doi:10.1093/europace/eus427 · Cited by 41
Finite element modeling of subcutaneous implantable defibrillator electrodes in an adult torso
Jolley, M. A., Stinstra, J. G., Tate, J. D., Pieper, S., MacLeod, R., Chu, L., Wang, P. J., & Triedman, J. K. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.01.030 · Cited by 41
Implantable cardioverter defibrillator shock reduction using new antitachycardia pacing therapies
Wathen, M. S. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.01.020 · Cited by 41
Sudden cardiac death: The role of risk stratification
Kusmirek, S., & Gold, M. R. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.01.024 · Cited by 41
Quality of Life and Psychological Impact of Implantable Cardioverter Defibrillators: Focus on Randomized Controlled Trial Data
McCready, M. J., & Exner, D. V. (2003) · Cardiac Electrophysiology Review · doi:10.1023/a:1023699225221 · Cited by 41
“ICD therapy is clearly effective in improving survival among patients at high risk for life-threatening arrhythmias [2–7].”
Background
Mortality and safety of catheter ablation for antiarrhythmic drug-refractory ventricular tachycardia in elderly patients with coronary artery disease
Inada, K., Roberts‐Thomson, K. C., Seiler, J., Steven, D., Tedrow, U. B., Koplan, B. A., & Stevenson, W. G. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.02.019 · Cited by 41
Patients treated with catheter ablation for ventricular tachycardia after an ICD shock have lower long-term rates of death and heart failure hospitalization than do patients treated with medical management only
Bunch, T. J., Weiss, J. P., Crandall, B. G., Day, J. D., May, H. T., Bair, T. L., Osborn, J. S., Mallender, C. D., Fischer, A., Brunner, K. J., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.12.014 · Cited by 41
Defibrillators
Al‐Khatib, S. M., Friedman, P. A., & Ellenbogen, K. A. (2016) · Circulation · doi:10.1161/circulationaha.116.021889 · Cited by 40
Electrophysiologic testing for diagnostic evaluation and risk stratification in patients with suspected cardiac sarcoidosis with preserved left and right ventricular systolic function
Zipse, M. M., Tzou, W. S., Schuller, J. L., Aleong, R. G., Varosy, P. D., TOMPKINS, C. M., Borne, R. T., Tumolo, A. Z., Sandhu, A., Kim, D., et al. (2019) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14058 · Cited by 40
Ability of microvolt T-wave alternans to modify risk assessment of ventricular tachyarrhythmic events: A meta-analysis
Gupta, A., Hoang, D. D., Karliner, L., Tice, J. A., Heidenreich, P. A., Wang, P. J., & Turakhia, M. P. (2012) · American Heart Journal · doi:10.1016/j.ahj.2011.11.021 · Cited by 39
Implantable Cardioverter Defibrillator Therapy for Prevention of Sudden Cardiac Death in Children in The Netherlands
HEERSCHE, J. H. M., Blom, N. A., van den Heuvel, F., BLANK, C., Reimer, A., Clur, S. B., Witsenburg, M., & ten Harkel, A. D. J. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02603.x · Cited by 39
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Sowell, L. V., Sears, S. F., Walker, R. L., Kuhl, E. A., & CONTI, J. B. (2007) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/01.hcr.0000265027.79649.6a · Cited by 39
Electrocardiographic predictors of mortality and sudden cardiac death in patients with end stage renal disease on hemodialysis
Waks, J. W., Tereshchenko, L. G., & Parekh, R. S. (2016) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2016.07.020 · Cited by 39
“Sudden cardiac death (SCD) accounts for approximately 25% of deaths in patients with end stage renal disease (ESRD), with an incidence of approximately 50 events per 1000 person-years [1].”
Background
Early Reperfusion Therapy Affects Inducibility, Cycle Length, and Occurrence of Ventricular Tachycardia Late After Myocardial Infarction
Piers, S. R. D., Wijnmaalen, A. P., Borleffs, C. J. W., van Taxis, C. F. B. V. H., Thijssen, J., van Rees, J. B., Cannegieter, S. C., Bax, J. J., Schalij, M. J., & Zeppenfeld, K. (2011) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.110.959213 · Cited by 39
Long-term outcomes of single-ventricle palliation for pulmonary atresia with intact ventricular septum: Fontan survivors remain at risk of late myocardial ischaemia and death†
Elias, P., Poh, C. L., du Plessis, K., Zannino, D., Rice, K., Radford, D. J., Bullock, A. M., Wheaton, G. R., Celermajer, D. S., & d’Udekem, Y. (2018) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezy038 · Cited by 39
“This indication was justified because this subgroup of patients had a 6% risk of sudden death within 5 years [24].”
Background
Sex Disparities in Sudden Cardiac Death
Butters, A., Arnott, C. G., Sweeting, J., Winkel, B. G., Semsarian, C., & Ingles, J. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.009834 · Cited by 39
Implications of Arrhythmias and Prevention of Sudden Death in Hypertrophic Cardiomyopathy
Adabağ, S., & Maron, B. J. (2007) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2007.00157.x · Cited by 40
Clinical course and long-term follow-up of patients receiving implantable cardioverter-defibrillators
Tandri, H. S., Griffith, L. S. C., Tang, T., Nasir, K., Zardkoohi, O., Reddy, C. V., Capps, M., Calkins, H. G., & Donahue, J. K. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.03.027 · Cited by 39
Differences in Presentation, Diagnosis and Management of Heart Failure in Women. A Scientific Statement of the Heart Failure Association of the ESC
Rosano, G. M. C., Stolfo, D., Anderson, L., Abdelhamid, M., Adamo, M., Bauersachs, J., Bayés‐Genís, A., Böhm, M., Chioncel, O. D., Filippatos, G. S., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3284 · Cited by 48
Cardiac Implanted Electronic Device‐Related Infective Endocarditis: Clinical Features, Management, and Outcomes of 80 Consecutive Patients
Kim, D. H., Tate, J. A., DRESEN, W. F., Papa, F., Bloch, K. C., Kalams, S. A., Ellis, C. R., Baker, M., Lenihan, D. J., & Mendes, L. A. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12452 · Cited by 38
Incidência de choques e qualidade de vida em jovens com cardioversor-desfibrilador implantável
Costa, R., da Silva, K. R., Mendonça, R. C., Nishioka, S., de Siqueira, S. F., Tamaki, W. T., Crevelari, E. S., Moreira, L. F. P., & Filho, M. M. (2007) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2007000300002 · Cited by 38
Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
Piccini, J. P., Al‐Khatib, S. M., Hellkamp, A. S., Anstrom, K. J., Poole, J. E., Mark, D. B., Lee, K. L., & Bardy, G. H. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.11.033 · Cited by 38
Self-citation
Primary Prevention Implantable Cardioverter Defibrillator Recipients: The Need for Defibrillator Back-Up After an Event-Free First Battery Service-Life
van Welsenes, G. H., van Rees, J. B., Thijssen, J., Trines, S. A. I. P., van Erven, L., Schalij, M. J., & Borleffs, C. J. W. (2011) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2011.02134.x · Cited by 38
Sex-related similarities and differences in responses to heart failure therapies
Chyou, J. Y., Qin, H., Butler, J., Voors, A. A., & Lam, C. S. P. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-00996-1 · Cited by 39
“In landmark studies of the efficacy and indication for ICD therapies for primary prevention in patients with HFrEF, women comprised only 10–29% of the study populations 117–123 (Table 2).”
The effect of duration of follow-up and presence of competing risk on lifespan-gain from implantable cardioverter defibrillator therapy: who benefits the most?
Raphael, C. E., Finegold, J. A., Barron, A., Whinnett, Z. I., Mayet, J., Linde, C. M., Cleland, J. G. F., Levy, W. C., & Francis, D. P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv102 · Cited by 37
Arrhythmic sudden cardiac death: substrate, mechanisms and current risk stratification strategies for the post-myocardial infarction patient.
Αρσένος, Π., Gatzoulis, K. A., Dilaveris, P., Manis, G., Tsiachris, D., Archontakis, S., Vouliotis, A.-I., Vouliotis, A. H., Sideris, S. K., & Stefanadis, C. (2013) · PubMed · Cited by 36
Rationale, design, and baseline characteristics of the DANish randomized, controlled, multicenter study to assess the efficacy of Implantable cardioverter defibrillators in patients with non-ischemic Systolic Heart failure on mortality (DANISH)
Thune, J. J., Pehrson, S. M., Nielsen, J. C., Haarbo, J., Videbæk, L. M., Korup, E., Jensen, G. V. H., Hildebrandt, P. R., Steffensen, F. H., Bruun, N. E., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.06.016 · Cited by 37
Cardiac Arrhythmias in the Elderly
Gupta, A. K., Maheshwari, A., Tresch, D. D., & Thakur, R. K. (2002) · Cardiac Electrophysiology Review · doi:10.1023/a:1017963928016 · Cited by 36
Noninvasive Risk Stratification for Sudden Death: Signal-Averaged Electrocardiography, Nonsustained Ventricular Tachycardia, Heart Rate Variability, Baroreflex Sensitivity, and QRS Duration
Steín, K. M. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.10.001 · Cited by 37
Effectiveness of Cardiac Resynchronization Therapy in Mild Congestive Heart Failure: Systematic Review and Meta-Analysis of Randomized Trials
Lubitz, S. A., Leong‐Sit, P., Fine, N. M., Kramer, D. B., Singh, J. P., & Ellinor, P. T. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq029 · Cited by 37
Cost-effectiveness of implantable cardioverter defibrillators in patients ≥65 years of age
Sanders, G. D., Kong, M. H., Al‐Khatib, S. M., & Peterson, E. D. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.04.021 · Cited by 37
Reconstructive surgery of postinfarction left ventricular aneurysms: techniques and unsolved problems
Mukaddirov, M. M., Demaria, R., Perrault, L. P., Frapier, J.-M., & Albat, B. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2008.03.061 · Cited by 37
Effect of elevated heart rate preceding the onset of ventricular tachycardia on antitachycardia pacing effectiveness in patients with implantable cardioverter defibrillators
Kouakam, C., Lauwerier, B., Klug, D., Jarwe, M., Marquié, C., Lacroix, D., & Kacet, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00459-4 · Cited by 37
Prepulses Reduce the Pain of Cutaneous Electrical Shocks
Blumenthal, T. D., Burnett, T. T., & Swerdlow, C. D. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200103000-00012 · Cited by 37
Device therapy for heart failure
BOEHMER, J. P. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03380-5 · Cited by 37
Development of the Implantable Cardioverter-Defibrillator
Maron, B. J., Estes, N. A. M., Rowin, E. J., Maron, M. S., & Reynolds, M. R. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.04.056 · Cited by 36
Left ventricular sphericity independently predicts appropriate implantable cardioverter-defibrillator therapy
Levine, Y. C., Matos, J. D., Rosenberg, M. A., Manning, W. J., Josephson, M. E., & Buxton, A. E. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.09.022 · Cited by 36
Self-citation
Usefulness of Sleep-Disordered Breathing to Predict Occurrence of Appropriate and Inappropriate Implantable-Cardioverter Defibrillator Therapy in Patients With Implantable Cardioverter-Defibrillator for Primary Prevention of Sudden Cardiac Death
Kreuz, J., Skowasch, D., Horlbeck, F., Atzinger, C., SCHRICKEL, J. W., Lorenzen, H., Nickenig, G., & SCHWAB, J. O. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.01.277 · Cited by 36
Effect of cardiac resynchronization therapy and implantable cardioverter defibrillator on quality of life in patients with heart failure: a meta-analysis
Chen, S., Yin, Y., & Krucoff, M. W. (2012) · EP Europace · doi:10.1093/europace/eus168 · Cited by 36
Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators
Seegers, J., Conen, D., Jung, K., Bergau, L., Dorenkamp, M., Lüthje, L., Sohns, C., Sossalla, S. T., Fischer, T. H., Hasenfuss, G. P., et al. (2015) · EP Europace · doi:10.1093/europace/euv361 · Cited by 36
Sudden Death Risk-Stratification in 2018–2019: The Old and the New
Zaman, S. J., Goldberger, J. J., & Kovoor, P. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.08.027 · Cited by 36
Recommendations for the use of electrophysiological study: Update 2018
Mureşan, L., Cismaru, G. L., Martins, R. P., Bataglia, A., Roşu, R., Puiu, M., Guşetu, G., Mada, R. O., Muresan, C., Ispas, D. R., et al. (2018) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2018.09.002 · Cited by 37
Reducing the Risk of Sudden Death in Heart Failure With β-Blockers
Adamson, P. B., & Gilbert, E. M. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.213 · Cited by 36
Sudden Cardiac Death
Myerburg, R. J., Interian, A., Simmons, J. D., & Castellanos, A. (2004) · Elsevier eBooks · doi:10.1016/b0-7216-0323-8/50081-6 · Cited by 36
Addendum to “Personal and Public Safety Issues Related to Arrhythmias that May Affect Consciousness: Implications for Regulation and Physician Recommendations: A Medical/Scientific Statement from the American Heart Association and the North American Society of Pacing and Electrophysiology”
Epstein, A. E., Baessler, C. A., Curtis, A. B., Estes, N. A. M., Gersh, B. J., Grubb, B., & Mitchell, L. B. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.01.015 · Cited by 34
Arrhythmia and Death Following Percutaneous Revascularization in Ischemic Left Ventricular Dysfunction: Prespecified Analyses From the REVIVED-BCIS2 Trial
Perera, D., Morgan, H., Ryan, M. J., Dodd, M., Clayton, T. C., O’Kane, P. D., Greenwood, J. P., Walsh, S. J., Weerackody, R. P., McDiarmid, A. K., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.065300 · Cited by 35
Extracting Versus Abandoning Sterile Pacemaker and Defibrillator Leads
Rijal, S., Shah, R. U., & Saba, S. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.01.537 · Cited by 35
Correlation of Noninvasive Electrocardiography with Invasive Electrophysiology in Syncope of Unknown Origin: Implications from a Large Syncope Database
Gatzoulis, K. A., Karystinos, G., Gialernios, T. P., Sotiropoulos, H., Synetos, A. G., Dilaveris, P., Sideris, S. K., Kalikazaros, I., Olshansky, B., & Stefanadis, C. (2009) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2009.00286.x · Cited by 35
Safety of a Single Successful Conversion of Ventricular Fibrillation Before the Implantation of Cardioverter Defibrillators
Gold, M. R., Breiter, D. J., Leman, R. B., Rashba, E. J., Shorofsky, S. R., & Hahn, S. J. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00077.x · Cited by 35
Electrical storm in patients with biventricular implantable cardioverter defibrillator: Incidence, predictors, and prognostic implications
Gasparini, M., Lunati, M., Landolina, M., Santini, M., Padeletti, L., Perego, G. B., Vincenti, A., Curnis, A., Carboni, A., Denaro, A., et al. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.06.035 · Cited by 35
Sex-related differences in patients' responses to heart failure therapy
Barsheshet, A., brenyo, A. J., Goldenberg, I., & Moss, A. J. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.10 · Cited by 35
The ethical and legal implications of deactivating an implantable cardioverter-defibrillator in a patient with terminal cancer
England, R., England, T. J., & Coggon, J. (2007) · Journal of Medical Ethics · doi:10.1136/jme.2006.017657 · Cited by 35

Authors: Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G.
Affiliations: Brown University (US)
Duke University (US)
Albert Einstein College of Medicine (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Buxton, Alfred E.
Lee, Kerry L.
Fisher, John D.
Prystowsky, Eric N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-12-16
Volume: 341
Issue: 25
Pages: 1882-1890
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199912163412503
OpenAlex: W2313547185
Cited by: 2,489
References: 34
Citations by year: 2026: 20 · 2025: 36 · 2024: 23 · 2023: 34 · 2022: 44 · 2021: 41 · 2020: 51 · 2019: 54 · 2018: 54 · 2017: 92 · 2016: 75 · 2015: 87 · 2014: 95 · 2013: 114 · 2012: 122
FWCI: 70.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01hl045726-06)
National Heart, Lung, and Blood Institute (UO1HL45700, UO1-HL45726, U01HL045700)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: coronary artery disease, asymptomatic ventricular arrhythmia, implantable cardioverter-defibrillator, antiarrhythmic drugs, electrophysiologic testing, programmed electrical stimulation, cardiac arrest, all-cause mortality, left ventricular ejection fraction, ACE inhibitors, beta-blockers
MeSH terms: Aged, Anti-Arrhythmia Agents, Cardiac Pacing, Artificial, Coronary Disease, Electrophysiology, Female, Humans, Male, Middle Aged, Survival Analysis, Death, Sudden, Cardiac, Defibrillators, Implantable, Tachycardia, Ventricular

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A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

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