The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Autoantibodies to Ganglionic Acetylcholine Receptors in Autoimmune Autonomic Neuropathies
Open accessAbstract
BACKGROUND: Idiopathic autonomic neuropathy is a severe, subacute disorder with a presumed autoimmune basis. It is indistinguishable from the subacute autonomic neuropathy that may accompany lung cancer or other tumors. Autoantibodies specific for nicotinic acetylcholine receptors in the autonomic ganglia are potentially pathogenic and may serve as serologic markers of various forms of autoimmune autonomic neuropathy. METHODS: We tested serum from 157 patients with a variety of types of dysautonomia. Immunoprecipitation assays with iodine-125-labeled epibatidine and solubilized human neuroblastoma acetylcholine receptors were used to detect autoantibodies that bound to or blocked ganglionic receptors. RESULTS: Ganglionic-receptor-binding antibodies were found in 19 of 46 patients with idiopathic or paraneoplastic autonomic neuropathy (41 percent), in 6 of 67 patients with postural tachycardia syndrome, idiopathic gastrointestinal dysmotility, or diabetic autonomic neuropathy (9 percent), and in none of 44 patients with other autonomic disorders. High levels of the binding antibodies correlated with more severe autonomic dysfunction (including the presence of tonic pupils). Levels of these antibodies decreased in patients who had clinical improvement. All seven patients with ganglionic-receptor-blocking antibodies had ganglionic-receptor-binding antibodies and had idiopathic or paraneoplastic autonomic neuropathy. CONCLUSIONS: Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptors identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia. The positive correlation between high levels of ganglionic-receptor antibodies and the severity of autonomic dysfunction suggests that the antibodies have a pathogenic role in these types of neuropathy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Seropositivity for antiganglionic acetylcholine receptor antibodies is the serological hallmark of autoimmune autonomic ganglionopathy.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [433]
The cited source says what the claim attributes to it.
In the citing paper
“Other antibodies, including ganglionic acetylcholine receptor antibodies and CRMP-5 (CV2), have also been associated with enteric dysmotility in paraneoplastic/autoimmune contexts (Blackburn et al., 2019; Vernino et al., 2000), and neuropathologic studies show that some patients have more extensive involvement (Sodhi et al., 1989).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Vernino et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oosterhuis, H. (1997) · Cited by 2,397
Drachman, D. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302507 · Cited by 1,146
A Neurological Syndrome Associated with Orthostatic Hypotension: A Clinical-Pathologic Study
SHY, G. M. (1960) · A.M.A. Archives of Neurology · doi:10.1001/archneur.1960.03840110025004 · Cited by 743
Calcium-Channel Antibodies in the Lambert–Eaton Syndrome and Other Paraneoplastic Syndromes
Lennon, V. A., Kryzer, T. J., Griesmann, G. E., O’Suilleabhain, P. E., Windebank, A. J., Woppmann, A., Miljanich, G. P., & Lambert, E. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506013322203 · Cited by 595
Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548
Lucchinetti, C. F., Kimmel, D. W., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.3.652 · Cited by 499
Self-citationComposite Autonomic Scoring Scale for Laboratory Quantification of Generalized Autonomic Failure
Low, P. A. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60631-4 · Cited by 466
Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases
Yu, Z., & Lennon, V. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901213400311 · Cited by 431
Bradbury, S., & EGGLESTON, C. (1925) · American Heart Journal · doi:10.1016/s0002-8703(25)90007-5 · Cited by 373
Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia
Hart, I. K., Waters, C. T., Vincent, A. C., Newland, C., Beeson, D., Pongs, O., Morris, C. S., & Newsom–Davis, J. (1997) · Annals of Neurology · doi:10.1002/ana.410410215 · Cited by 314
Research works printed but not linked: 4
- Khurana RK. Paraneoplastic autonomic dysfunction. In: Low PA, ed. Clinical autonomic disorders: evaluation and management. 2nd ed. Philadelphia: Lippincott-Raven, 1997:545-54.
- Low PA, McLeod JG. Autonomic neuropathies. In: Low PA, ed. Clinical autonomic disorders: evaluation and management. 2nd ed. Philadelphia: Lippincott-Raven, 1997:463-86.
- Bohnen NI, 1997, Neurology, 48, A131
- Gerzanich V, 1995, Mol Pharmacol, 48, 774
Cited by
Sorted by citations
Items 101–200 of 674
Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS)
Tani, H., Singer, W., McPhee, B. R., Opfer-Gehrking, T. L., Haruma, K., Kajiyama, G., & Low, P. A. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00205-8 · Cited by 71
Self-citationDistal sudomotor findings in postural tachycardia syndrome
Peltier, A. C., Garland, E., Raj, S. R., Sato, K., Black, B., Song, Y., Wang, L., Biaggioni, I., Diedrich, A., & Robertson, D. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-009-0045-y · Cited by 70
Peripheral Demyelinating Diseases: From Biology to Translational Medicine
Kamil, K., Yazid, M. D., Idrus, R. B. H., Das, S., & Kumar, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00087 · Cited by 75
Postural tachycardia syndrome: current perspectives
Wells, R. M., Spurrier, A. J., Linz, D., Gallagher, C., Mahajan, R., Sanders, P., Page, A. J., & Lau, D. H. (2017) · Vascular Health and Risk Management · doi:10.2147/vhrm.s127393 · Cited by 70
Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire
Adler, B. L., Russell, J. W., Hummers, L. K., & McMahan, Z. H. (2018) · The Journal of Rheumatology · doi:10.3899/jrheum.170868 · Cited by 69
Buckley, C. J., & Vincent, A. C. (2005) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0033 · Cited by 70
Grubb, B. P., KOSINSKI, D. J., & Kanjwal, Y. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00155.x · Cited by 69
Myasthenic crisis: Clinical features, complications and mortality
Murthy, J., Meena, A., Chowdary, G., & Naryanan, J. (2005) · Neurology India · doi:10.4103/0028-3886.15050 · Cited by 68
Neural Autoantibody Profile of Primary Achalasia
Kraichely, R. E., Farrugia, G., Pittock, S. J., Castell, D. O., & Lennon, V. A. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0838-9 · Cited by 68
Bladder dysfunction in peripheral neuropathies
Burakgazi, A. Z., Alsowaity, B., Burakgazi, Z. A., Ünal, D., & Kelly, J. J. (2011) · Muscle & Nerve · doi:10.1002/mus.22178 · Cited by 66
The clinical approach to autonomic failure in neurological disorders
Benarroch, E. E. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.88 · Cited by 71
Kaur, D., Tiwana, H., Stino, A. M., & Sandroni, P. (2020) · Muscle & Nerve · doi:10.1002/mus.27048 · Cited by 65
From smoking to lung cancer: the CHRNA5/A3/B4 connection
Improgo, M. R., Scofield, M. D., Tapper, A. R., & Gardner, P. D. (2010) · Oncogene · doi:10.1038/onc.2010.256 · Cited by 67
Pupil Abnormalities in Selected Autonomic Neuropathies
Bremner, F., & Smith, S. (2006) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000235564.50518.1b · Cited by 65
Neurologic Autoimmunity in the Era of Checkpoint Inhibitor Cancer Immunotherapy
Ζεκερίδου, Α., & Lennon, V. A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.02.003 · Cited by 65
Other autonomic neuropathies associated with ganglionic antibody
Sandroni, P., & Low, P. A. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.10.022 · Cited by 63
Diseases of the peripheral nerves
Katona, I., & Weis, J. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00031-6 · Cited by 64
Golden, E. P., & Vernino, S. A. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00611-1 · Cited by 64
Postural Tachycardia Syndrome in Children and Adolescents
Jarjour, I. T. (2013) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2013.01.001 · Cited by 61
Antibody titers predict clinical features of autoimmune autonomic ganglionopathy
Gibbons, C. H., & Freeman, R. L. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.11.013 · Cited by 62
Sinmaz, N., Nguyen, T. T.-T. N., Tea, F., Dale, R. C., & Brilot, F. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0678-4 · Cited by 62
Parkinsonism in viral, paraneoplastic, and autoimmune diseases
Xing, F., Marsili, L., & Truong, D. D. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120014 · Cited by 62
Acetylcholinesterase Inhibition in Patients With Orthostatic Intolerance
Singer, W., Opfer-Gehrking, T. L., Nickander, K. K., Hines, S. M., & Low, P. A. (2006) · Journal of Clinical Neurophysiology · doi:10.1097/01.wnp.0000229946.01494.4c · Cited by 60
Koike, H., & Sobue, G. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52902-2.00041-2 · Cited by 58
Graus, F., & Dalmau, J. O. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328364c020 · Cited by 59
BENEZET‐MAZUECOS, J., RUBIO, J. M., FARRÉ, J., QUIÑONES, M. Á., SANCHEZ‐BORQUE, P., & MACÍA, E. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12118 · Cited by 55
Diagnosis and Management of Paraneoplastic Neurologic Disorders
Rosenfeld, M. R., & Dalmau, J. O. (2013) · Current Treatment Options in Oncology · doi:10.1007/s11864-013-0249-1 · Cited by 56
Li, Y., Jammoul, A., Mente, K., Li, J., Shields, R. W., Vernino, S. A., & Rae-Grant, A. D. (2014) · Muscle & Nerve · doi:10.1002/mus.24559 · Cited by 56
Enteric Autoantibodies and Gut Motility Disorders
Kashyap, P., & Farrugia, G. (2008) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2008.02.005 · Cited by 52
Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system
Melzer, N., Meuth, S. G., & Wiendl, H. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6657-5 · Cited by 52
Syncope in Children and Adolescents
Kanjwal, K., & Calkins, H. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.008 · Cited by 52
Immunotherapy for autoimmune autonomic ganglionopathy
Iodice, V., Kimpinski, K., Vernino, S. A., Sandroni, P., & Low, P. A. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.11.001 · Cited by 52
Autonomic Peripheral Neuropathy
Freeman, R. L. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.01.001 · Cited by 51
Autoimmune and Paraneoplastic Channelopathies
Vernino, S. A. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.01.007 · Cited by 50
Autonomic dysfunction: Diagnosis and management
Rafanelli, M., Walsh, K., Hamdan, M. H., & Buyan‐Dent, L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00008-x · Cited by 49
Autoantibodies in patients with gut motility disorders and enteric neuropathy
Törnblom, H., Lang, B., Clover, L. M., Knowles, C. H., Vincent, A. C., & Lindberg, G. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701396216 · Cited by 49
Spectrum of diabetic neuropathies
Sasaki, H., Kawamura, N., Dyck, P. J. B., Dyck, P. J. B., Kihara, M., & Low, P. A. (2020) · Diabetology International · doi:10.1007/s13340-019-00424-7 · Cited by 56
Rueda‐Ruzafa, L., Cedillo, J. L., & Hone, A. J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031189 · Cited by 51
Yu, X., Stavrakis, S., Hill, M. A., Huang, S., Reim, S., Li, H., Khan, M., Hamlett, S., Cunningham, M. W., & Kem, D. C. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.10.003 · Cited by 50
Goldstein, D. S., Holmes, C. S., Dendi, R., Li, S., Brentzel, S., & Vernino, S. A. (2002) · Clinical Autonomic Research · doi:10.1007/s10286-002-0020-3 · Cited by 49
Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?
Yusuf, S., & Camm, A. J. (2003) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840300800202 · Cited by 48
Paraneoplastic Neurological Syndromes And Onconeural Antibodies: Clinical And Immunological Aspects
Storstein, A. M., & Vedeler, C. A. (2007) · Advances in clinical chemistry · doi:10.1016/s0065-2423(07)44005-7 · Cited by 47
Disorders of Peripheral Nerves
Harati, Y., & Bosch, E. P. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7525-3.50118-7 · Cited by 46
Sudomotor dysfunction in autoimmune autonomic ganglionopathy
Kimpinski, K., Iodice, V., Sandroni, P., Fealey, R. D., Vernino, S. A., & Low, P. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bf995f · Cited by 46
Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab
Imrich, R., Vernino, S. A., Eldadah, B. A., Holmes, C. S., & Goldstein, D. S. (2009) · Clinical Autonomic Research · doi:10.1007/s10286-009-0012-7 · Cited by 44
Autoimmune autonomic disorders
McKeon, A. B., & Benarroch, E. E. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63432-0.00022-0 · Cited by 46
Autonomic “myasthenia”: the case for an autoimmune pathogenesis
Drachman, D. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18180 · Cited by 44
Viallard, J., Vincent, A. C., Moreau, J., Parrens, M., Pellegrin, J., & Ellie, E. (2005) · European Neurology · doi:10.1159/000084300 · Cited by 43
Anti-neuronal autoantibodies: Current diagnostic challenges
Probst, C., Saschenbrecker, S., Stoecker, W., & Komorowski, L. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2013.12.001 · Cited by 42
Recent advances in autoimmune autonomic ganglionopathy
Winston, N., & Vernino, S. A. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833d4c7f · Cited by 42
Wang, N., Orr‐Urtreger, A., Chapman, J., Rabinowitz, R., & Korczyn, A. D. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.3.574 · Cited by 42
Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?
Garland, E. M., & Robertson, D. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00922-6 · Cited by 40
Kanjwal, K., Saeed, B., Karabin, B., Kanjwal, Y., & Grubb, B. P. (2011) · Cardiology Journal · doi:10.5603/cj.2011.0008 · Cited by 46
Wang, X.-L., Ling, T.-Y., Charlesworth, M. C., Figueroa, J. J., Low, P., Shen, W.-K., & Lee, H.-C. (2013) · Translational Research · doi:10.1016/j.trsl.2013.03.002 · Cited by 41
Self-citationSeronegative autoimmune autonomic neuropathy: a distinct clinical entity
Golden, E. P., Bryarly, M. A., & Vernino, S. A. (2017) · Clinical Autonomic Research · doi:10.1007/s10286-017-0493-8 · Cited by 41
Nakane, S., Mukaino, A., Higuchi, O., Maeda, Y., Takamatsu, K., Yamakawa, M., Watari, M., Tawara, N., Nakahara, K., Kawakami, A., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102403 · Cited by 41
Autoimmune autonomic ganglionopathy with late-onset encephalopathy
Baker, S. K., Morillo, C. A., & Vernino, S. A. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.10.016 · Cited by 42
Tellioğlu, T., & Robertson, D. (2001) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399401003878 · Cited by 41
Update on Paraneoplastic Neurologic Disorders
Rosenfeld, M. R., & Dalmau, J. O. (2010) · The Oncologist · doi:10.1634/theoncologist.2010-0001 · Cited by 40
Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management
Arnold, A. C., Ng, J., Lei, L. Y., & Raj, S. R. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.09.008 · Cited by 42
Kanjwal, K., George, A., Figueredo, V. M., & Grubb, B. P. (2014) · Journal of Cardiovascular Medicine · doi:10.2459/01.jcm.0000446386.01100.35 · Cited by 39
Mukaino, A., Nakane, S., Higuchi, O., Nakamura, H., Miyagi, T., Shiroma, K., Tokashiki, T., Fuseya, Y., Ochi, K., Umeda, M., et al. (2016) · Modern Rheumatology · doi:10.3109/14397595.2016.1147404 · Cited by 36
Kondo, T., Inoue, H., Usui, T., Mimori, T., Tomimoto, H., Vernino, S. A., & Takahashi, R. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.12.002 · Cited by 39
Peripherin-IgG association with neurologic and endocrine autoimmunity
Chamberlain, J. L., Pittock, S. J., Oprescu, A.-M., Dege, C., Apiwattanakul, M., Kryzer, T. J., & Lennon, V. A. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.12.004 · Cited by 39
Autoimmune Autonomic Ganglionopathy With Reversible Cognitive Impairment
Centi, J. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.2372 · Cited by 39
Low, P. A. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200210000-00011 · Cited by 39
Confounders of Vasovagal Syncope
Nwazue, V. C., & Raj, S. R. (2012) · Cardiology Clinics · doi:10.1016/j.ccl.2012.09.003 · Cited by 39
Low iron storage and mild anemia in postural tachycardia syndrome in adolescents
Jarjour, I. T., & Jarjour, L. K. (2013) · Clinical Autonomic Research · doi:10.1007/s10286-013-0198-6 · Cited by 38
Autonomic paraneoplastic neurological syndromes
Lorusso, L., Hart, I. K., Ferrari, D., Ngonga, G. K., Gasparetto, C., & Ricevuti, G. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.10.003 · Cited by 38
Autoimmunoreactive IgGs from patients with postural orthostatic tachycardia syndrome
Wang, X.-L., Chai, Q., Charlesworth, M., Figueroa, J. J., Low, P., Shen, W., & Lee, H.-C. (2012) · PROTEOMICS - Clinical Applications · doi:10.1002/prca.201200049 · Cited by 34
Autoimmune Channelopathies of the Nervous System
Kleopa, K. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911796557966 · Cited by 36
Supine plasma NE predicts the pressor response to droxidopa in neurogenic orthostatic hypotension
Palma, J., Norcliffe‐Kaufmann, L., Martinez, J., & Kaufmann, H. (2018) · Neurology · doi:10.1212/wnl.0000000000006369 · Cited by 36
Dysautonomia and autonomic neuropathies
O’Brien, D. P., & Johnson, G. C. (2002) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(03)00087-1 · Cited by 36
Autoimmunity in Complex‐Regional Pain Syndrome
Blaes, F., Tschernatsch, M., Bräu, M. E., Matz, O., SCHMITZ, K., Nascimento, D. S. M., Kaps, M., & Birklein, F. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.018 · Cited by 36
Autoimmune Autonomic Disorders
Vernino, S. A. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000812 · Cited by 35
Transient loss of consciousness and syncope
Bassetti, C. L. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00013-8 · Cited by 37
Endothelial NO Synthase Polymorphisms and Postural Tachycardia Syndrome
Garland, E. M., Winker, R., Williams, S. M., Jiang, L., Stanton, K., Byrne, D. W., Biaggioni, I., Cascorbi, I., Phillips, J. A., Harris, P. A., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000185462.08685.da · Cited by 36
Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy
Koay, S., Vichayanrat, E., Bremner, F., Panicker, J. N., Lang, B., Lunn, M. P., Watson, L. P. E., Ingle, G. T., Hagen, E. M., McNamara, P., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26018 · Cited by 35
Surgery for head and neck skin tumors in the elderly
Dhiwakar, M., Khan, N. A., & McClymont, L. G. (2007) · Head & Neck · doi:10.1002/hed.20605 · Cited by 34
Hendrickson, J. E., Hendrickson, E. T., Gehrie, E. A., Sidhu, D., Wallukat, G., Schimke, I., & Tormey, C. A. (2015) · Journal of Clinical Apheresis · doi:10.1002/jca.21407 · Cited by 33
Wang, Z., Low, P. A., & Vernino, S. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.016 · Cited by 34
Anti-ganglionic AChR antibodies in Japanese patients with motility disorders
Mukaino, A., Minami, H., Isomoto, H., Hamamoto, H., Ihara, E., Maeda, Y., Higuchi, O., Okanishi, T., Kokudo, Y., Deguchi, K., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1477-8 · Cited by 34
Autoimmune autonomic ganglionopathy: an update on diagnosis and treatment
Nakane, S., Mukaino, A., Higuchi, O., Watari, M., Maeda, Y., Yamakawa, M., Nakahara, K., Takamatsu, K., Matsuo, H., & Ando, Y. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1540304 · Cited by 34
CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations
Mann, N., Kause, F., Henze, E. K., Gharpure, A., Shril, S., Connaughton, D. M., Nakayama, M., Klämbt, V., Majmundar, A. J., Wu, C. W., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.10.004 · Cited by 33
Lung cancer-induced paraneoplastic syndromes
Yeung, S. J., Habra, M. A., & Thosani, S. (2011) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328347bdba · Cited by 33
Park, K., Cha, S.-K., Kim, M.-J., Kim, D.-R., Jeong, S.-W., Lee, J.-W., & Kong, I. D. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0086-1 · Cited by 33
Kanjwal, K., Sheikh, M. A., Karabin, B. L., Kanjwal, Y., & Grubb, B. P. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02994.x · Cited by 33
Postinfectious gastroparesis related to autonomic failure: a case report
Lobrano, A., Blanchard, K., ABELL, T., Minocha, A., Boone, W., Wyatt‐Ashmead, J., Fratkin, J. F., Subramony, C., Wee, A., Nardo, G. D., et al. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00728.x · Cited by 33
Antibodies to Neuronal Structures
Vinik, A. I., Anandacoomaraswamy, D., & Ullal, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.2067 · Cited by 33
Muppidi, S., & Vernino, S. A. (2014) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000455876.53309.ec · Cited by 32
Mittermayer, F., Schaller, G., Pleiner, J., Vychytil, A., Sunder–Plassmann, G., Hörl, W. H., & Wolzt, M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004121109 · Cited by 31
Disautonomia: Uma Condição Esquecida – Parte 1
Rocha, E. A., Mehta, N., Távora‐Mehta, M. Z. P., Roncari, C. F., Cidrão, A. A. D. L., & Elías, J. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20200420 · Cited by 36
Paraneoplastic neuromuscular disorders
Sharp, L., & Vernino, S. A. (2012) · Muscle & Nerve · doi:10.1002/mus.23502 · Cited by 32
Orthostatic Heart Rate and Blood Pressure in Adolescents: Reference Ranges
Skinner, J. E., Driscoll, S. W., Porter, C.-B. J., Brands, C. K., Pianosi, P. T., Kuntz, N. L., Nelson, D. E., Burkhardt, B. E. U., Bryant, S. C., & Fischer, P. R. (2010) · Journal of Child Neurology · doi:10.1177/0883073809359539 · Cited by 31
Chronic autoimmune autonomic neuropathy responsive to immunosuppressive therapy
Modoni, A., Massimiliano Mirabella, A., Madia, F., Sanna, T., Lanza, G. A., Tonali, P., & Silvestri, G. (2007) · Neurology · doi:10.1212/01.wnl.0000251194.82212.75 · Cited by 31
Deciphering the sinus tachycardias
Yusuf, S., & Camm, A. J. (2005) · Clinical Cardiology · doi:10.1002/clc.4960280603 · Cited by 30
Autonomic Dysfunction in Rheumatic Diseases
Straub, R. H., Baerwald, C., Wahle, M., & Jänig, W. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.09.002 · Cited by 29
Mathew, S. T., Po, S. S., & Thadani, U. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2017.10.004 · Cited by 29
Basilisco, G., Marchi, M., & Coletta, M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14715 · Cited by 29
Extra-autonomic manifestations in autoimmune autonomic ganglionopathy: a Japanese survey
Nakane, S., Mukaino, A., Maeda, Y., Higuchi, O., Matsuo, H., & Ando, Y. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314707 · Cited by 29
Metadata
- Authors
- Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A.
- Affiliations
- Mayo Clinic (US)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-09-21
- Volume
- 343
- Issue
- 12
- Pages
- 847-855
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341201500
- Cited by
- 674
- References
- 34
- Citations by year
- 2026: 16 · 2025: 10 · 2024: 33 · 2023: 20 · 2022: 26 · 2021: 36 · 2020: 28 · 2019: 30 · 2018: 32 · 2017: 24 · 2016: 21 · 2015: 21 · 2014: 19 · 2013: 31 · 2012: 27
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
- Keywords
- autoantibodies, postural orthostatic tachycardia syndrome, diabetic autonomic neuropathy, gastrointestinal motility disorders, autonomic dysfunction, serological markers, epibatidine, tonic pupil
- MeSH terms
- Adult, Aged, Autoantibodies, Autoimmune Diseases, Autonomic Nervous System Diseases, Diabetic Neuropathies, Female, Follow-Up Studies, Ganglia, Autonomic, Humans, Male, Middle Aged, Receptors, Nicotinic, Sensitivity and Specificity, Severity of Illness Index, Sweating, Paraneoplastic Syndromes, Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
