Cited by 48Cardiac electrophysiology and arrhythmiasCardiac Arrhythmias and TreatmentsHeart Rate Variability and Autonomic Control

Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?

Yusuf, Shamil, Camm, A. John·2003·Journal of Cardiovascular Pharmacology and Therapeutics

Abstract

A relatively novel group of drugs that inhibit the funny current in the sinus node pacemaker cells, the so-called specific bradycardic agents, are likely to play a significant role in the management of a wide range of cardiovascular disorders, including the sinus tachyarrhythmias. This comprehensive review initially provides an insight into these agents, their historical background, and their mechanism of action. It then discusses the differential diagnosis of the sinus tachyarrhythmias (normal sinus tachycardia, inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, and sinus node reentry tachycardia), elaborates on their pathophysiologic basis, and provides up-to-date evidence-based information on their optimum management. The specific bradycardic agents, by the very nature of their mode of action, may prove ideal therapies for the management of the sinus tachyarrhythmias, and this is explored at every stage.

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Crossref · 10.1177/107424840300800202

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135 of 135 references verified0 citation errors · 0 not checkable

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Authors
Yusuf, S., & Camm, A. J.
Affiliations
St George's, University of London (GB)
Venue
Journal of Cardiovascular Pharmacology and Therapeutics
Published
2003-06
Volume
8
Issue
2
Pages
89-105
ISSN
  • 1074-2484 (ISSN-L)
  • 1940-4034
OpenAlex
W2162354003
Cited by
48
References
135
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Pharmacology and Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, mechanism of action, differential diagnosis, arrhythmia management
MeSH terms
Ivabradine, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Benzazepines, Calcium Channel Blockers, Clonidine, Diagnosis, Differential, Humans, Phthalimides, Pyrimidines, Sinoatrial Node, Tachycardia, Sinus, Vasodilator Agents, Verapamil, Isoindoles

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