Cited by 238SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinationsAnimal Virus Infections Studies

Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination

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Barouch, Dan H., Stephenson, Kathryn E., Sadoff, Jerald, Yu, Jingyou, Chang, Aiquan, Gebre, Makda, McMahan, Katherine, Liu, Jinyan +9 more·2021·New England Journal of Medicine

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Abstract

To evaluate the 8-month durability of humoral and cellular immune responses after Ad26.COV2.S Vaccination

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Crossref · 10.1056/nejmc2108829

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  • B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the WA1 strain.

    “In multiple studies, B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the virus strain first described in January 2020 (Wuhan-Hu-1, spike also called WA1) (2–9).”
  • Most prior studies evaluated sera from vaccinated individuals soon after the first or second dose and had limited data on the durability of such responses.

    “Most of these prior studies have evaluated sera from vaccinated individuals at time points soon after the first or second dose and have had limited data on the durability of such responses.”

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Authors
Barouch, D. H., Stephenson, K. E., Sadoff, J., Yu, J., Chang, A., Gebre, M., McMahan, K., Liu, J., Chandrashekar, A., Patel, S., Le Gars, M., de Groot, A. M., Heerwegh, D., Struyf, F., Douoguih, M., van Hoof, J., & Schuitemaker, H.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Janssen (Netherlands) (NL)
  • Janssen Vaccines and Prevention, Leiden, the Netherlands
  • Janssen (Belgium) (BE)
Corresponding author
Barouch, Dan H.
Venue
New England Journal of Medicine
Published
2021-09-02
Volume
385
Issue
10
Pages
951-953
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W3177895433
Cited by
237
References
5
Citations by year
2026: 8 · 2025: 17 · 2024: 22 · 2023: 35 · 2022: 110 · 2021: 45
FWCI
16.93
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • medRxiv (acceptedVersion, cc-by-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion, cc-by-nd)
  • ImmPort
Funders
  • Musk Foundation
  • Massachusetts Consortium on Pathogen Readiness
  • Biomedical Advanced Research and Development Authority (HHSO100201700018C)
  • National Cancer Institute (CA260476)
  • Janssen Vaccines and Prevention
  • Ragon Institute of MGH, MIT and Harvard
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
Ad26.COV2-S, SARS-CoV-2, COVID-19 vaccination, humoral immune response, cell-mediated immunity, vaccine durability, long-term immunity, adenovirus vector vaccine
MeSH terms
Immunogenicity, Vaccine, SARS-CoV-2, COVID-19 Vaccines, Ad26COVS1, Antibodies, Viral, Follow-Up Studies, Humans, Immunity, Cellular, T-Lymphocytes, Vaccination, Immunity, Humoral, Antibodies, Neutralizing

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