Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination
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Abstract
To evaluate the 8-month durability of humoral and cellular immune responses after Ad26.COV2.S Vaccination
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B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the WA1 strain.
“In multiple studies, B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the virus strain first described in January 2020 (Wuhan-Hu-1, spike also called WA1) (2–9).”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [8]
Most prior studies evaluated sera from vaccinated individuals soon after the first or second dose and had limited data on the durability of such responses.
“Most of these prior studies have evaluated sera from vaccinated individuals at time points soon after the first or second dose and have had limited data on the durability of such responses.”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [8]
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- Authors
- Barouch, D. H., Stephenson, K. E., Sadoff, J., Yu, J., Chang, A., Gebre, M., McMahan, K., Liu, J., Chandrashekar, A., Patel, S., Le Gars, M., de Groot, A. M., Heerwegh, D., Struyf, F., Douoguih, M., van Hoof, J., & Schuitemaker, H.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Janssen (Netherlands) (NL)
- Janssen Vaccines and Prevention, Leiden, the Netherlands
- Janssen (Belgium) (BE)
- Corresponding author
- Barouch, Dan H.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-09-02
- Volume
- 385
- Issue
- 10
- Pages
- 951-953
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8314733
- OpenAlex
- W3177895433
- Cited by
- 237
- References
- 5
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 22 · 2023: 35 · 2022: 110 · 2021: 45
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- New England Journal of Medicine (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nd)
- ImmPort
- Funders
- Musk Foundation
- Massachusetts Consortium on Pathogen Readiness
- Biomedical Advanced Research and Development Authority (HHSO100201700018C)
- National Cancer Institute (CA260476)
- Janssen Vaccines and Prevention
- Ragon Institute of MGH, MIT and Harvard
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- Ad26.COV2-S, SARS-CoV-2, COVID-19 vaccination, humoral immune response, cell-mediated immunity, vaccine durability, long-term immunity, adenovirus vector vaccine
- MeSH terms
- Immunogenicity, Vaccine, SARS-CoV-2, COVID-19 Vaccines, Ad26COVS1, Antibodies, Viral, Follow-Up Studies, Humans, Immunity, Cellular, T-Lymphocytes, Vaccination, Immunity, Humoral, Antibodies, Neutralizing
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