Cited by 313Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Metformin for the Treatment of the Polycystic Ovary Syndrome

Nestler, John E.·2008·New England Journal of Medicine

DOI 10.1056/nejmct0707092

Open this paper in CoChat — free account

Abstract

A 23-year-old woman with the polycystic ovary syndrome presents for evaluation and possible treatment. She has a family history of diabetes, is obese, and has impaired glucose tolerance. Metformin therapy is recommended. Metformin increases insulin sensitivity and may reduce the risk of diabetes. In the polycystic ovary syndrome, long-term metformin treatment may increase ovulation, improve menstrual cyclicity, and reduce serum androgen levels.

Integrity signals

Registry

Crossref · 10.1056/nejmct0707092

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967
The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
Ramachandran, A., Snehalatha, C., Mary, S., Mukesh, B., Bhaskar, A. D., Vijay, V., & Indian Diabetes Prevention Programme (IDPP) (2006) · Diabetologia · doi:10.1007/s00125-005-0097-z · Cited by 1,881
Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study
Knochenhauer, E. S., Key, T. J., Kahsar-Miller, M., Waggoner, W., Boots, L. R., & Azziz, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5090 · Cited by 1,759
Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743
Metformin
Bailey, C. J., & Turner, R. C. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340906 · Cited by 1,726
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement Executive Summary
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000380842.14048.7e · Cited by 1,600

Flagged first, then by citations

Show all 60 references

1 of the 60 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

10.1210/jc.87.5.2013 · DOI · Paper page
10.1210/jc.87.2.742 · DOI
10.1210/jc.83.6.2001 · DOI · Paper page
2005, Endocr Pract, 11, 126

Sorted by citations

Items 201–300 of 313

Drugs frequently involved in inducing hypersensitivity reactions
Dragostin, I., Dragostin, O.-M., Lisă, E. L., Stefan, S. C., Zamfir, A. S., Diaconu, C., & Zamfir, C. L. (2020) · Drug and Chemical Toxicology · doi:10.1080/01480545.2020.1746331 · Cited by 4
The Mediterranean Way of Eating
Anderson, J. J. B., & Sparling, M. C. (2014) · CRC Press eBooks · doi:10.1201/b17032 · Cited by 7
A Narrative Review on Effects of Maternal Bariatric Surgery on Offspring
Pathak, M. M., Shekhar, K. V., & Meshram, R. J. (2023) · Cureus · doi:10.7759/cureus.48513 · Cited by 4
Role of Metformin in Polycystic Ovary Syndrome
Nowak, K., Nowak, K., Olejarz, Z., Drygała, Z., Wyrwał, J., Zielińska, Z., Słowik, M., Nieć, M., Gierlach, K., & Krasuska, M. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.52.009 · Cited by 5
Pre-extinction activation of hippocampal AMPK prevents fear renewal in mice.
Wang, C.-M., Zhang, Y.-F., Lin, Z.-Q., Cai, Y.-F., Fu, X.-Y., & Lin, Z.-H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105099 · Cited by 3
Polycystic Ovary Syndrome
Rosenblum, J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6845-6_16 · Cited by 4
Effects of physical activity in women with polycystic ovary syndrome: a systematic review and meta-analysis
Cavalcante, D. C. B., Scandolara, T. B., Kogure, G. S., Rodrigues, C. G., Verruma, C. G., de Moraes, M. O., dos Reis, R. M., Cavalcante, M. B., & Furtado, C. L. M. (2025) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.61622/rbgo/2025rbgo56 · Cited by 3
Comparative study on the use of myoinositol and metformin in the improvement of clinical symptoms and biochemical parameters in women with polycystic ovarian syndrome
Sangeereni, M., & Duraisingam, A. (2020) · International Journal of Clinical Obstetrics and Gynaecology · doi:10.33545/gynae.2020.v4.i6b.737 · Cited by 3
Impact of Cyproterone Acetate and Ethinylestradiol on Clomiphene Resistant PCOS Patient with High Serum AMH level
Banu, J., Ishrat, S., Deeba, F., Anowary, S., Alamgir, C. F., & Darmini, M. (2021) · Journal of Shaheed Suhrawardy Medical College · doi:10.3329/jssmc.v12i1.51617 · Cited by 3
Impact of Molecular Symmetry/Asymmetry on Insulin-Sensitizing Treatments for Type 2 Diabetes
Filisola-Villaseñor, J. G., Aranda-Barradas, M. E., Miranda-Castro, S. P., Mendieta‐Wejebe, J. E., Valdez-Guerrero, A. S., Castro, S. A. G., Castillo, M. M., Cach, F. T., & Álvarez-Almazán, S. (2022) · Symmetry · doi:10.3390/sym14061240 · Cited by 3
Aspectos nutricionais e manejo alimentar no controle da Síndrome do Ovário Policístico
Lima, C. M. A. D. M. E., Pinto, K. C. G., & Correia, V. M. F. (2022) · Research Society and Development · doi:10.33448/rsd-v11i9.31526 · Cited by 3
Effect of Gymnema sylvestre Extract on the Regulation of AMPK-GLUT4 Mediated Signaling Pathway on Insulin Resistance in a PCOS Rat Model
Balasubramanian, A., Ramalingam, K., & Pachiappan, S. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/29805 · Cited by 3
Review of Use of Drugs for Conditions Not Included in Product Characteristics
García-Sabina, A., Rey, R. R., & Martı́nez-Pacheco, R. (2011) · Farmacia Hospitalaria (English Edition) · doi:10.1016/j.farmae.2010.06.006 · Cited by 3
PCOS and metformin: from pharmacology to clinical use for women's health
Genazzani, A. D., Ricchieri, F., Prati, A., Chierchia, E., Rattighieri, E., Bosco, G., Despini, G., Campedelli, A., Farinetti, A., & Santagni, S. (2012) · IRIS UNIMORE (University of Modena and Reggio Emilia) · Cited by 3
Metabolische und reproduktionsmedizinische Aspekte des Polyzystischen Ovarsyndroms (PCOS)
Feichtinger, M., Linder, T., & Göbl, C. S. (2016) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-016-0439-0 · Cited by 3
Traitement du diabète en dehors de l'insuline
Blickle, J. (2011) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(11)48522-x · Cited by 3
The Effect of Administration of Metformin on BMI and Insulin Resistance in Patients with Polycystic Ovary Syndrome
Afroz, M. N. (2017) · Journal of Gynecology and Womens Health · doi:10.19080/jgwh.2017.06.555686 · Cited by 3
Combined N-Acetylcysteine and Clomiphene Citrate for Ovulation Induction in Polycystic Ovary Syndrome, a Double Blind Randomized Controlled Trial
Alalfy, M. (2019) · Austin Journal of Obstetrics and Gynecology · doi:10.26420/austinjobstetgynecol.1134.2019 · Cited by 3
PCOS Therapy
Stracquadanio, M., & Ciotta, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-16760-2_6 · Cited by 3
Treatment of infertility in women
Smith, C., Grimm, M., & Schwegel, M. (2012) · Pharmacy Today · doi:10.1016/s1042-0991(15)31824-7 · Cited by 3
Combined Clomiphene Citrate-Metformin Versus Letrozole-Metformin in Achieving Pregnancy among Women with Polycystic Ovary Syndrome
Shrivastava, U., Shrestha, S., & Dhakal, R. (2019) · Gynecology & Reproductive Health · doi:10.33425/2639-9342.1071 · Cited by 3
Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in RatPreprint
Hosseini, S. F., Khodaei, F., Hasansagha, Z., Khosravizadeh, H., Abdollahi, M., & Azaryan, E. (2023) · Preprints.org · doi:10.20944/preprints202304.0299.v1 · Cited by 3
A Complex Condition; Polycystic Ovary Syndrome (PCOS): A Review of its Recent Advanced Treatment
Wal, P., Saxena, B., Aziz, N., Pyne, C., Wal, A., & Rathore, S. (2023) · Current Women s Health Reviews · doi:10.2174/0115734048259334231020120628 · Cited by 2
Therapeutic potential of crystal-engineered berberine cocrystals ameliorates PCOS phenotypes via AMPK–IRS1/PI3K/Akt axis: An integrative computational and preclinical study
Kamalakannan, U., Surampudi, A. V. S. D., Racha, V., Amanchy, R., Jain, N., & Muralidharan, K. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.104937 · Cited by 2
New onset of alopecia in a young woman with end-stage renal disease
Pistrosch, F., Herbrig, K., Parmentier, S. B., & Gross, P. (2008) · Clinical Kidney Journal · doi:10.1093/ndtplus/sfn031 · Cited by 2
Insulin resistance and dysglycaemia in polycystic ovary syndrome patients
Dere, K. A. L., Prisca, D. A., Menin, M. M., Coulibaly, D., & Tiahou, G. G. (2021) · International Journal of Clinical Biochemistry and Research · doi:10.18231/j.ijcbr.2020.101 · Cited by 2
Effects of Lifestyle Modification on Pregnancy Success in Obese and Overweight Women with PCOS
Karkanaki, A. (2013) · Journal of Women s Health Care · doi:10.4172/2167-0420.1000125 · Cited by 2
Polycystic Ovary Syndrome and the Role of Metformin in Ovulation Induction
Fraga, F., Romeiro, G. A. C. S., de Sá, L. B. P. C., & Arbex, A. K. (2018) · Health · doi:10.4236/health.2018.105045 · Cited by 2
Biological basis of child health 7: growth, development and the reproductive system
Davies, K. M. (2020) · Nursing Children and Young People · doi:10.7748/ncyp.2020.e1308 · Cited by 2
Molecular regulation of polycystic ovary syndrome: altered gene expression levels in mouse models pretreatment and post-treatment
Tulay, P., Önal, T., & Vatansever, S. (2021) · Zygote · doi:10.1017/s0967199421000769 · Cited by 2
Effect of Metformin Therapy Over Hormone Profile in Newly Diagnosed Polycystic Ovary Syndrome –A Nine Months Randomized Controlled Trial
(2017) · American Research Journal of Endocrinology · doi:10.21694/2577-8412.17002 · Cited by 2
Polycystic Ovary Syndrome
Romualdi, D., Versace, V., Lanzone, A., & Longhi, E. V. (2023) · Springer eBooks · doi:10.1007/978-3-031-31307-3_16 · Cited by 2
Actions of androgens and estrogens in experimental models of cardiovascular disease
Fagman, J. B. (2010) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 2
Metformin in Polycystic Ovary Syndrome
Raskauskas, T. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmc080154 · Cited by 2
Acne
Melnik, B. C. (2011) · Wiley eBooks · doi:10.1002/9781444345384.ch79 · Cited by 2
Patient Criteria For Successful Induction of Ovulation By Clomiphene Citrate In Patients With Polycystic Ovary Syndrome
Ahmed, A. E. A. M., Elboghdady, A. A., & Ahmed, I. (2023) · Al-Azhar International Medical Journal /Al-Azhar International Medical Journal · doi:10.58675/2682-339x.2098 · Cited by 1
Alnustone ameliorates obesity and polycystic ovary syndrome by remodeling adipose metabolism via AMPK signaling
Qin, Y., Hu, S., Xu, Y., Lin, Z.-X., Liang, X., Liu, Y., Li, Y., Geng, C., Chen, X., Feng, X. H., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3220-8 · Cited by 1
Multimodal Therapy With Metformin, Inositol and Dietary Restriction Improves Insulin Resistance and Endocrine Outcomes in Women With Polyendocrine Metabolic Ovarian Syndrome: A Randomized Controlled Trial
Irfan, N. U. A., Saleem, S., & Irfan, A. (2026) · Clinical Endocrinology · doi:10.1111/cen.70188 · Cited by 2
Pharmacologic Approaches to Type 2 Diabetes and Obesity in Children and Adolescents
Pongsuwan, P. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-256-8_12 · Cited by 1
Hyperandrogenämie und Hyperandrogenismus
Keck, C. (2012) · gynäkologie + geburtshilfe · doi:10.1007/s15013-012-0258-3 · Cited by 1
Polycystic Ovary Syndrome and Hirsutism
Gibson, M., & Huddleston, H. G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0755-7.00546-7 · Cited by 1
Zaburzenia gospodarki węglowodanowej u kobiet z zespołem wielotorbielowatych jajników (PCOS)
Kuligowska-Jakubowska, M. (2012) · Cited by 1
Celebrating 50 years of Independence of Bangladesh
Soumendra, S. D. (2021) · International Journal of Pharma and Bio Sciences · doi:10.22376/ijpbs/ijlpr/sp15/oct/2021.1-27 · Cited by 1
Obesity, Dysmetabolic and Proinflammatory Milieu of Polycystic Ovary Syndrome
Morong, J. J., & González, F. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_9 · Cited by 1
Comparative Treatment between Sitagliptin vs. Metformin, Alone or In Combination, In Patients with Polycystic Ovarian Syndrome. A Clinical Entity with a High Risk of Developing Diabetes Mellitus and Gestational Diabetes
(2019) · doi:10.31038/edmj.2019341 · Cited by 1
ASPECTOS NUTRICIONAIS NA SINDROME DO OVÁRIO POLICÍSTICO
Nogueira, A. A., Vieira, S. A., Pena, Â. C., & Neumann, K. R. D. S. (2024) · Revista Saúde dos Vales · doi:10.61164/rsv.v3i1.2220 · Cited by 1
Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome
Lin, L.-T., Shen, H., & Wang, Y. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321380 · Cited by 2
The Risks of Cardiovascular Disease and Diabetes in the Polycystic Ovary Syndrome
Sharma, S. T., & Nestler, J. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-09718-3_10 · Cited by 1
Self-citation
Polycystic Ovary Syndrome in the Non-Gynaecological Practice – Can We Use a Common Medical Approach?
Petrnyi, G. (2012) · InTech eBooks · doi:10.5772/25983 · Cited by 1
Therapeutic Options for Management of Endometrial Hyperplasia: An Update
Chandra, V., Kim, J.-J., Benbrook, D. M., Dwivedi, A., & Rai, R. (2015) · Cited by 1
The Effect of Orlistat as an Adjuvant to Lifestyle Modification on Weight Loss in Polycystic Ovary Syndrome Patients:An Evidence-Based Case Report
Andre, N., Aristyo, K., Zhafira, A. S., Hanjani, R., Susantono, D. P., Ethelind, R., & Mirtha, L. T. (2017) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-0701011520 · Cited by 1
Effects of metformin on polycystic ovary syndrome: a randomized, double-blind, placebo-controlled study
Akhtar, N., Banu, H., Morshed, M. S., Sultana, T., Begum, A., & Hasanat, M. (2021) · IMC Journal of Medical Science · doi:10.3329/imcjms.v15i2.55808 · Cited by 3
The effect of chamomile on menstruation pattern and serum androgens in polycystic ovary syndrome
Heidary, M., Dokuhaki, S., Yazdanpanahi, Z., Dabbaghmanesh, M. H., Emamghoreishi, M., & Akbarzadeh, M. (2022) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/0975-6892.2022.00007.7 · Cited by 1
Endocrinology
Wilson, G., Mooradian, A. D., Alexandraki, I., & Samrai, G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1160-8.10035-1 · Cited by 1
Ovulation Induction
Mills, G., & Tulandi, T. (2022) · Springer eBooks · doi:10.1007/978-3-030-99596-6_16 · Cited by 1
Bruk av metformin ved polycystisk ovarie-syndrom
Carlsen, S. M. (2009) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.08.0663 · Cited by 1
Markers for Subclinical Atherosclerosis in Women with Polycystic Ovary Syndrome and Controls
Meyer, M. L. (2011) · D-Scholarship@Pitt (University of Pittsburgh)
Polycystic Ovarian Syndrome
Shoupe, D. (2010) · Wiley eBooks · doi:10.1002/9781444323030.ch93
PCOS from Conception to Menopause: A Review of Our Current Understanding
Durrant, L. W. M., & Yaklic, J. L. (2015) · Andrology & Gynecology Current Research · doi:10.4172/2327-4360.1000133
Metformina no tratamento da infertilidade na síndrome do ovário poliquístico
Moreira, A. R. D. S. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Appendix B: List of Excluded Studies
Wilt, T. J., Shamliyan, T., Shaukat, A., Taylor, B. C., MacDonald, R. H., Yuan, J., Johnson, J. R., Tacklind, J., Rutks, I. R., & Kane, R. L. (2008)
AMH – applications beyond IVF
Topolčan, O. (2013) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2012.11.006
Geschlechtsspezifische Aspekte bei Prä-Diabetes und Diabetes mellitus Typ 2
Göbl, C., Handisurya, A., & Kautzky‐Willer, A. (2009) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Ensaio clínico randomizado com uso de cloridrato de metformina nas doses de 1500mg e 1000mg dia em pacientes com Sindrome de Ovários Polícisticos
Angonese, N. T. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
ORIGINAL STUDY TREATMENT OF POLYCYSTIC OVARY SINDROME RETROSPECTIVE STUDY 2004-2010
Liliana, C., Pricop, M., & Popa, T. (2011)
Efecto del hiperandrogenismo sobre la fisiología uterina. Acción de la Metformina como tratamiento
Elia, E. M. (2011) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Evaluation of metformin treatment in patient with polycystic ovary syndrome in Kirkuk city
Mohammed, T., AL-Mandalawi, S., Sabah, I., Azzo, E., Gassan, I., & qadir, N. (2012) · Zanco Journal of Medical Sciences · doi:10.15218/zjms.2012.0009 · Cited by 1
“Hormonal Wedge Resection”: An Effective Treatment Method of Anovulatory Infertility Associated with Polycystic Ovary Syndrome
Siklósi, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-39540-1_11
Omega 3 Fatty Acids in the Treatment of Dyslipidemia
Goldberg, R. B. (2008)
Metformin: direct inhibition of rat ovarian theca-interstitial cell
Palaniappan, M., Peegel, H., & Kayampilly, P. P. (2012)
Usage of metformin in patients with type 2 diabetes mellitus
Huang, W. (2016) · UTAS Research Repository · doi:10.25959/23240615
Metformin and Prostate Cancer among Diabetic Men
Margel, D. (2014) · TSpace (University of Toronto)
Polycystic Ovarian Syndrome and Bariatric Surgery
Jonsson, A., Patel, L. Y., Singh, A., Davis, S. S., & Lin, E. (2017) · Bariatric Surgical Practice and Patient Care · doi:10.1089/bari.2017.29009.aj
External Validation of PCOS Questionnaire in Assessing Quality of Life in Females with PCOS Based on Lifestyle Changes with Therapeutic Measures like OC Pills and Metformin
Routray, P. (2017) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v5i12.84
Insulin-Sensitising Drugs
Palomba, S., Falbo, A. I., & Sala, G. B. L. (2018) · Springer eBooks · doi:10.1007/978-3-319-45534-1_11
Management of the metabolic syndrome and glucose intolerance in women with PCOS
Pasquali, R. (2013) · doi:10.2217/ebo.12.271
Appropriate use of metformin in early pregnancy: is there a role for first trimester use?
Panidis, D., & Τζιόμαλος, Κ. (2013) · doi:10.2217/ebo.12.187
Diagnostik, konservative und chirurgische Therapie des PCOS
Franz, M. B. (2018) · gynäkologie + geburtshilfe · doi:10.1007/s15013-018-1471-5
New pharmacological approaches in type 2 diabetes mellitus
Cusi, K. J. (2009) · Dialnet (Universidad de la Rioja) · doi:10.1016/b978-84-8086-683-5.50016-0
A comprehensive overview of role of combined myoinositol and D-chiroinositol (40:1 ratio) therapy in the management of PCOS
Malvi, A., Chaturvedi, A., Mehta, S. V., Sonkusare, K., & Dave, N. (2019) · The New Indian Journal of OBGYN · doi:10.21276/obgyn.2019.5.2.2
Comparison between Cabergoline and Coasting in Prevention of Ovarian Hyperstimulation Syndrome and their effect on Intracytoplasmic Sperm Injection Outcome
El-Garhy, I. M., Motaal, A. O. A., & Omr, M. G. (2018) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2018.11877
ROLE OF DIET IN THE MANAGEMENT OF POLYCYSTIC OVARIAN SYNDROME (PCOS).
MohdAli, Y., Bushra, A.-Q., Tanzim, B., & Mumbai., A. P. I. D. O. I. B. T. D. (2019) · doi:10.21474/ijar01/8870
Síndrome dos ovários policísticos e doença hepática gordurosa não alcóolica: o que sabemos?
Pinto, F. H. A. D. M., Nardelli, M. J., Elias, M. L. C., Santos, B. C., Couto, C. A., Rocha, A. L. L., & Faria, L. C. (2019) · Revista Médica de Minas Gerais · doi:10.5935/2238-3182.20190033
TRASTORNOS DE LA FERTILIDAD EN LA MUJER CON DIABETES TIPO 1 Y 2
Pomares, M. L., Martín, C. G., Maccio, N., Geller, M., Bertona, C., Migueles, J., Arinovich, B., Schindler, A., Garrido, N. P., Larreburo, S. V., et al. (2014) · Revista de la Sociedad Argentina de Diabetes · doi:10.47196/diab.v48i2.185
Clinical Evaluation of Antihyperglycemic Activity of Metformin in Treatment of Insulin Sensitivity in Polycystic Ovary Syndrome: A double Blind Placebo-Controlled Study
Casarini, E., Soyinka, I., & Vonkeff, C. (2017) · Endocrinology and Disorders · doi:10.31579/2640-1045/011
Reproductive endocrinology
Dhillo, W. S., Davies, M. C., Jayasena, C. N., & Seal, L. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198851899.003.0004
P
(2012) · Elsevier eBooks · doi:10.1016/b978-0-323-08373-7.00025-x
Asthma drugs in pregnacy and lactation
Truscott, J., Lim, A. S., Hussainy, S. Y., & Abramson, M. J. (2014) · Australian Prescriber · doi:10.18773/austprescr.2014.017
Reproductive endocrinology
Wass, J. A. H., Owen, K. R., & Turner, H. E. (2014) · doi:10.1093/med/9780199644438.003.0004
Acne
Perman, M. J., Melnik, B. C., & Lucky, A. W. (2019) · Wiley eBooks · doi:10.1002/9781119142812.ch68
Efficacy of metformin treatment in polycystic ovary syndrome
Jerenec, K., Samojlenko, M., Geršak, K., & Ferk, P. (2021) · Acta Medico-Biotechnica · doi:10.18690/actabiomed.87
A randomised double blind clinical study on effect between clomiphene citrate plus metformin and clomiphene citrate alone on induction of ovulation in women with polycystic ovarian syndrome
Chakraborty, A., Dwibedi, D., Das, C., & Ghosh, D. (2023) · Indian Journal of Obstetrics and Gynecology Research · doi:10.18231/j.ijogr.2023.041
Effects of Metformin on Fertility in Patients with Polycystic Ovary Syndrome: Overview of Systematic ReviewsPreprint
Oliveira, P. S., Uggioni, M. L. R., Colonetti, T., Balbinot, E. L., Marçal, F., Silveira, V., Rech, P., Macedo, A. C. L., Ceretta, L. B., Grande, A. J., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4781337
Exploring the Current Renews on Numerous Animal Models of PCOS: An Overview
Samreen, F., Mohapatra, L., Sushree, S., Deepak, M., & Tripathi Alok, S. (2024) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2024.v10i01.057
Combined Hormonal Contraceptives, Metformin or Both for Management of Polycystic Ovary Syndrome (COMET-PCOS): A Randomized ClinicalPreprint
Dokras, A., Coutifaris, C., Remaley, A. T., Mehta, N. N., Playford, M. P., Kunselman, A. R., Stetter, C. M., William, D., & Legro, R. S. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5236696
Pathophysiology, diagnostics and promising therapies of polycystic ovary syndrome: A systematic review of scientific literature
Soni, A., Parikh, M., & Gandhi, T. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22300-6.00013-9
The Role of Bariatric Surgery in the Treatment of Obese Women with Polycystic Ovary Syndrome
Söylemez, E. (2025) · Obstetrics and gynecology. · doi:10.5772/intechopen.1011572
CLINICAL PROFILE AND OUTCOMES OF PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME
Poonia, M. (2025) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.53555/6vtsz040
Recent Publications on Medications and Pharmacy
Sterling, J. A. (2008) · Hospital Pharmacy · doi:10.1310/hpj4312-1024
Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function
Johansson, J. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Authors: Nestler, J. E.
Affiliations: Virginia Commonwealth University (US)
Corresponding author: Nestler, John E.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-01-03
Volume: 358
Issue: 1
Pages: 47-54
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmct0707092
OpenAlex: W2100076759
Semantic Scholar: f4b14c6984a40041406cef4211cbef144350d0fb
Cited by: 313
References: 60
Citations by year: 2026: 12 · 2025: 9 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 10 · 2020: 12 · 2019: 14 · 2018: 19 · 2017: 17 · 2016: 13 · 2015: 19 · 2014: 19 · 2013: 26 · 2012: 27
FWCI: 3.62
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
VCU Scholars Compass (Virginia Commonwealth University) (submittedVersion)
Funders: U.S. Public Health Service (K24D040237)
Fogarty International Center (D43TW007692)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD035629)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: metformin, polycystic ovary syndrome, insulin sensitivity, impaired glucose tolerance, obesity, diabetes risk, ovulation, menstrual cyclicity, androgen reduction
MeSH terms: Adult, Female, Humans, Hypoglycemic Agents, Insulin Resistance, Cholesterol, LDL, Metformin, Obesity, Polycystic Ovary Syndrome, Triglycerides, Practice Guidelines as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metformin for the Treatment of the Polycystic Ovary Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks