The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index; 1 of the 20 sources its claims cite were checked for support.
Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy
Open accessAbstract
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin-angiotensin system slows the progression of renal disease in patients with type 1 diabetes, but similar data are not available for patients with type 2, the most common form of diabetes. We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy. METHODS: A total of 1513 patients were enrolled in this randomized, double-blind study comparing losartan (50 to 100 mg once daily) with placebo, both taken in addition to conventional antihypertensive treatment (calcium-channel antagonists, diuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years. The primary outcome was the composite of a doubling of the base-line serum creatinine concentration, end-stage renal disease, or death. Secondary end points included a composite of morbidity and mortality from cardiovascular causes, proteinuria, and the rate of progression of renal disease. RESULTS: A total of 327 patients in the losartan group reached the primary end point, as compared with 359 in the placebo group (risk reduction, 16 percent; P=0.02). Losartan reduced the incidence of a doubling of the serum creatinine concentration (risk reduction, 25 percent; P=0.006) and end-stage renal disease (risk reduction, 28 percent; P=0.002) but had no effect on the rate of death. The benefit exceeded that attributable to changes in blood pressure. The composite of morbidity and mortality from cardiovascular causes was similar in the two groups, although the rate of first hospitalization for heart failure was significantly lower with losartan (risk reduction, 32 percent; P=0.005). The level of proteinuria declined by 35 percent with losartan (P<0.001 for the comparison with placebo). CONCLUSIONS: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
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In the paper
“In this regard, it should be noted that in related studies in patients with type 1 and type 2 diabetes, 1,28,29 the benefits of captopril or irbesartan were not tested in the presence of concurrent calcium-channel-antagonist therapy.”
What the sources say
- Not checked — no full text of the sourcecites [1] source
- Supportedcites [28] source
The Randomization and Treatment Plan states that calcium-channel blockers were discontinued before screening and excluded as additional antihypertensive treatment. Irbesartan and the calcium-channel blocker amlodipine were assigned as separate regimens, so this type 2 diabetes study did not test irbesartan's benefit with concurrent calcium-channel-blocker therapy. The captopril study in type 1 diabetes is covered by the sentence's other citations, not this source. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [29] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The level of proteinuria declined by 35 percent with losartan (P<0.001 for the comparison with placebo).”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Losartan also reduced the risk of end-stage renal disease by 28 percent (P=0.002)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“according to the per-protocol analysis, among the patients who continued to receive their assigned study treatment, losartan conferred a 22 percent reduction in the risk of the primary composite end point (P=0.008).”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We did find a significant difference in favor of losartan with regard to the rate of a first hospitalization for heart failure, a component of this secondary composite end point.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The risk of the combined end point of end-stage renal disease or death was 20 percent lower in the losartan group than in the placebo group (P=0.01)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In this population, losartan (plus conventional antihypertensive therapy) demonstrated excellent tolerability, similar to that of placebo (plus conventional antihypertensive therapy), as evidenced by the similar numbers of patients in the two groups in whom the study treatment was discontinued because of adverse events.”
Strength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Treatment with losartan resulted in a 16 percent reduction in the risk of the primary composite end point (P= 0.02)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Similarly, simultaneous therapy with calcium-channel antagonists did not detract from the beneficial effects of losartan, despite the recent controversy regarding the role of calcium-channel antagonists in the protection of the kidneys and the heart. 25-27”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Approximately one third of the patients had a fatal or nonfatal cardiovascular event (247 in the losartan group [32.9 percent] and 268 in the placebo group [35.2 percent]; risk reduction, 10 percent; P=0.26).”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- It may state two separate claims as one. 14
- Probably not a substantial claim. 16
- The quote only partly states this claim. 1
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There was a difference between the number of myocardial infarctions in the losartan group (50 patients [6.7 percent]) and the number in the placebo group (68 patients [8.9 percent]; risk reduction, 28 percent), but this difference was not statistically significant (P=0.08).”
Strength:plain· not yet calibratedn = 50Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“There was a small, time-averaged difference in the trough blood pressure between the losartan group”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Approximately 20 percent of the patients died, but there was no significant difference in mortality between the two groups (P=0.88).”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Losartan also led to an average reduction in the level of proteinuria (the urinary albumin-to-creatinine ratio) of 35 percent, whereas in the patients in the placebo group, the urinary albumin-to-creatinine ratio tended to increase (P<0.001 for the overall treatment effect) (Fig. 3).”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 95.9 mm Hg and 96.8 mm Hg, respectively [P=0.59]; pulse pressure, 66.7 mm Hg and 67 .4 mm Hg, respectively [P= 0.77]”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 99.1 mm Hg and 99.7 mm Hg, respectively [P= 0.38]; pulse pressure, 66.2 mm Hg and 67 .1 mm Hg, respectively [P=0.37]”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 100.9 mm Hg and 103.1 mm Hg, respectively [P<0.001]; pulse pressure, 67 .8 mm Hg and 69.8 mm Hg, respectively [P=0.05]”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences in the rates of most of the cardiovascular end points; the exception was the first hospitalization with heart failure (89 patients in the losartan group [11.9 percent], as compared with 127 in the placebo group [16.7 percent]), for which the risk was reduced by 32 percent (P=0.005)”
- Also stated in: § A BSTRACT · p. 1 · plain
“although the rate of first hospitalization for heart failure was significantly lower with losartan (risk reduction, 32 percent; P=0.005)”
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § A BSTRACT · p. 1 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At base line, 93.5 percent of the patients (92.3 percent in the losartan group and 94.6 percent in the placebo group) were receiving antihypertensive therapy.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The benefits of losartan were observed among our patients, many of whom were already receiving other therapies, such as aspirin, beta-blockers, and lipidlowering agents, as part of sound medical practice.”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Increased serum concentrations of creatinine or potassium led to the discontinuation of the study medication in 1.5 percent and 1.1 percent, respectively, of the patients in the losartan group, as compared with 1.2 percent and 0.5 percent of the patients in the placebo group.”
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Analyses of the primary and secondary end points were performed according to the intention-to-treat principle; we included data from all randomized patients (with the exception of three patients who were lost to follow-up), from the time of randomization through the date of study termination.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“An independent end-points committee whose members were unaware of the patients' treatment assignments reviewed the data to determine which patients had reached the end points.”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“More patients discontinued the study treatment in the placebo group (53.5 percent) than in the losartan group (46.5 percent).”
Strength:plain· not yet calibratedn = 1,513Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan Study was an investigator-initiated, multinational, double-blind, randomized, placebo-controlled study designed to evaluate the renoprotective effects of losartan in 1513 patients with type 2 diabetes and nephropathy.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Because one interim analysis used a stopping boundary that was based on an alpha spending function of the O'Brien-Fleming type, 10 a critical P value of 0.048 was required for the primary hypothesis.”
What the sources say
- Not checked — no full text of the sourcecites [10] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In a second, per-protocol analysis, we excluded patients who violated the criteria for inclusion and exclusion and censored patients' data 14 days after they permanently discontinued the study medication.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study protocol was approved by the institutional review board of each center, and all patients gave written informed consent.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the study was discontinued early (February 10, 2001) by a unanimous vote of the steering committee, whose members were unaware of the treatment assignments.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We cannot exclude the possibility that this small difference had a beneficial effect on the renal outcomes.”
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“The Heart Outcomes Prevention Evaluation (HOPE) Study 32 and its substudy of patients with diabetes, MICRO-HOPE, 20 showed benefits of angiotensin-I-converting enzyme inhibition in terms of the signs and symptoms of heart failure but failed to show significant differences in hospitalizations for heart failure.”
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Previous studies involving angiotensin-I-converting enzyme inhibitors have demonstrated beneficial effects on proteinuria but have not demonstrated the superiority of blockade of the renin-angiotensin system in slowing the progression to end-stage renal disease over nonblockade forms of therapy. 14-20”
What the sources say
- Not matchedcites [14] Walker WG, 1992, J Am Soc Nephrol
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [15] source
- Not checked — no full text of the sourcecites [16] source
- Not checked — no full text of the sourcecites [17] source
- Not checked — no full text of the sourcecites [18] source
- Not checked — no full text of the sourcecites [19] Estacio RO, 2000, Diabetes Care
- Not checked — no full text of the sourcecites [20] source
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, in the absence of a direct comparison between angiotensin-I-converting enzyme inhibitors and angiotensin II antagonists, any extrapolation from the results obtained with different classes of drugs is speculative at best.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We were able to determine the status of all patients (except for three patients in the losartan group who could not be contacted) with respect to dialysis, transplantation, and death.”
Strength:plain· not yet calibratedn = 3Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Subsequent hospitalizations for heart failure were not assessed.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, the Cox model accounts for the base-line level of proteinuria (which was a stratification factor) and the geographic region, as prespecified in the data analysis plan.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The difference results in part from the fact that the Cox regression model accounts for the time at risk - i.e., the longer average follow-up in the losartan group than in the placebo group.”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
The paper relies on this without support.
Diabetic nephropathy is the leading cause of end-stage renal disease.
“Diabetic nephropathy is the leading cause of end-stage renal disease.”
The paper relies on this without support.
Type 2 diabetes is the most common form of diabetes.
“type 2, the most common form of diabetes”
The paper relies on this without support.
Similar data on interruption of the renin-angiotensin system are not available for patients with type 2 diabetes.
“similar data are not available for patients with type 2, the most common form of diabetes”
The paper relies on this without support.
Postponing end-stage renal disease in patients with type 2 diabetes remains an elusive goal.
“postponing end-stage renal disease in patients with type 2 diabetes, the leading cause of chronic renal failure in many countries, remains an elusive goal”
The paper relies on this without support.
Type 2 diabetes is the leading cause of chronic renal failure in many countries.
“type 2 diabetes, the leading cause of chronic renal failure in many countries”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In the IDNT trial, treatment with irbesartan compared with placebo resulted in a 33% decrease in the risk of doubling of serum creatinine concentration and was associated with a nonsigni fi cant reduction in the incidence of kidney failure, which was independent of blood pressure.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [13]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Antihypertensive therapy reduces the risk of albuminuria (67)(68)(69)(70), and among people with type 1 or 2 diabetes with established CKD (eGFR <60 mL/min/1.73m 2 and UACR $300 mg/g creatinine), ACE inhibitor or ARB therapy reduces the risk of progression to ESKD (71)(72)(73)(74)(75)(76)(77)(78)(79)(80).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [71]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Treatment with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) has been shown to prevent major adverse kidney outcomes in people with diabetes, and these drugs are recommended by clinical practice guidelines for the treatment of people with type 2 diabetes who have, or are at high risk of, kidney disease.[4][5][6][7][8]”
From SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis (2019) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The only currently approved treatment for renoprotection in patients with type 2 diabetes is reninangiotensin system blockade, which was first shown to be effective 18 years ago.3,4”
From Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy (2019) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, a sustained ≥57% decrease in eGFR (equivalent to doubling of serum creatinine) was selected in FIDELITY because it is a classic outcome in diabetic nephropathy studies2 , 12–14 and is a more robust kidney failure surrogate outcome than a ≥40% decrease in eGFR, particularly when initial changes in eGFR occur.14 , 15”
From Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis (2022) · cites this paper as [13]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Antihypertensive therapy reduces the risk of albuminuria (68-71), and among people with type 1 or 2 diabetes with established CKD (eGFR <60 mL/min/1.73m 2 and UACR ≥300 mg/g creatinine), ACE inhibitor or ARB therapy reduces the risk of progression to kidney failure (72)(73)(74)(75)(76)(77)(78)(79)(80)(81).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“ACE inhibitors or ARBs are the preferred first-line agents for blood pressure treatment among people with diabetes, hypertension, eGFR <60 mL/min/1.73m 2 , and UACR ≥300 mg/g creatinine because of their proven benefits for prevention of CKD progression (72,73,75).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This recommendation is based on RCTs where findings demonstrated decreased risk of CKD progression, for which patients with albuminuria are at elevated risk, with a maximally dosed RAS inhibitor compared with placebo or an active antihypertensive drug comparator (42–44).”
From Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO) (2022) · cites this paper as [42]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In patients with diabetic kidney disease with increased levels of albuminuria, large placebo-controlled trials have shown that renin-angiotensin system (RAS) inhibitors,3–5 sodium-glucose cotransporter 2 (SGLT2) inhibitors,6,7 and the non-steroidal mineralocorticoid receptor antagonist finerenone8,9 all reduced the risk of progression to kidney failure.”
From Empagliflozin in Patients with Chronic Kidney Disease (2023) · cites this paper as [3]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In the IDNT trial, treatment with irbesartan compared with placebo resulted in a 33% decrease in the risk of doubling of serum creatinine concentration and was associated with a nonsigni fi cant reduction in the incidence of kidney failure, which was independent of blood pressure.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [13]
Experimental — accuracy not yet measuredIn the citing paper
“For many years, the only agents that had demonstrated benefit in slowing kidney disease progression were the renin angiotensin aldosterone system blockers of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) [11], [12], [13].”
From Glucagon-like peptide-1 receptor agonists in diabetic kidney disease: a review of their kidney and heart protection (2023) · cites this paper as [11]
In the citing paper
“ARBs (irbesartan/telmisartan) also slowed progression from microalbuminuria (albuminuria stage A2) to overt nephropathy.708,709”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [708]
In the citing paper
“Antagonism of the RAAS with ACE inhibitors or AngII receptor blockers also attenuates, but may not completely halt, the progression of kidney injury in patients with obesity, hypertension and T2DM67,68.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [67]
In the citing paper
“Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB)s improve endothelium-dependent vasodilation and reduce morbidity and mortality in heart failure and nephropathy, including diabetic nephropathy.218-221”
From The Vasculature in Prediabetes (2018) · cites this paper as [219]
In the citing paper
“Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB)s improve endothelium-dependent vasodilation and reduce morbidity and mortality in heart failure and nephropathy, including diabetic nephropathy.218-221”
From The Vasculature in Prediabetes (2018) · cites this paper as [219]
In the citing paper
“ARBs have also been shown to reduce the rate of progression from micro- to macroalbuminuria as well as ESRD in patients with type 2 diabetes (234–236).”
From Standards of Medical Care in Diabetes—2009 (2009) · cites this paper as [235]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Mean follow-up of 3.4 years is not 42 months
MinorAt 12 months per year, 3.4 years is 40.8 months, not 42 months. Forty-two months is 3.5 years.
Reported 42 · recomputed 40.8
“The mean follow-up time was 3.4 years (42 months).”
Patients with prior heart failure were both excluded and included
MinorThe eligibility criteria excluded anyone with a history of heart failure before enrollment, but the paper later says 88 patients had preexisting heart failure at randomization. This affects the description of the population used for the heart-failure analysis.
“who had any history of heart failure before enrollment.”
“There were 88 patients (44 in each group) who had preexisting heart failure at the time of randomization.”
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
Lewis, E. J., Hunsicker, L. G., Bain, R. P., & Rohde, R. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292004 · Cited by 5,394
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Flagged first, then by citations
Research works printed but not linked: 5
- Black HR, 1999, J Hypertens, 17, S3
- Levey AS, 2000, J Am Soc Nephrol, 11, 155A
- Walker WG, 1992, J Am Soc Nephrol, 3, 339
- Estacio RO, 2000, Diabetes Care, 23, B54
- Bauer JH, Reams GP. Antihypertensive drugs. In: Brenner BM, ed. The kidney. 6th ed. Philadelphia: W.B. Saunders, 2000:2253-97.
Cited by
Sorted by citations
Items 6,401–6,500 of 7,495
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Effect of Yoga and Aerobic Training on Bio Chemical Variables in Middle Aged Diabetic Patients
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Redón, J. (2010) · Springer eBooks · doi:10.1007/978-88-470-1463-3_25
Prevención de la enfermedad renal crónica II: medidas específicas
Abodovsky, M. A. (2009) · Medwave · doi:10.5867/medwave.2009.12.4305
Diagnostic and prognostic value of proteinuria in chronic renal diseases
Bakoush, O. (2004) · Lund University Publications (Lund University)
Influencia de la telemedicina en el control del paciente diabetico tipo 2
Muñoz, J. S. (2007) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
World Kidney Day 2011: protect your kidneys, save your heart
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The Organization of Diabetes Care: Western Pacific Region (China and Hong Kong as Examples)
Chan, J. C. N., & Cockram, C. S. (2003) · doi:10.1002/0470862092.d1105
Olmos, C. C. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Angiotensin-Il-receptor blockers and nephropathy in patients with type 2 diabetes.
Farquhar, D. (2001) · PubMed
Glomerulopatías secundarias a enfermedades metabólicas, hematológicas y conectivopatías
Gutiérrez, E., Muñoz, M. T., Sevillano, Á., Auñón, P., & Hernández, E. (2015) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2015.06.013
Telmisartan and enalapril in type 2 diabetes
Barnett, A. H. (2005) · The British Journal of Diabetes · doi:10.1177/14746514050050010501
Lasaridis, A. N., & Sarafidis, P. A. (2005) · Encyclopédie médico-chirurgicale. Néphrologie · doi:10.1016/j.emcnep.2005.09.001
Hypertension in the Older Patient: Practical Clinical Management
Ninomiya, T. (2012) · Clinical Medicine Reviews in Vascular Health · doi:10.4137/cmrvh.s5979
New Aspects of Renal Diseases-From Urine Checkup to Kidney Transplantation-1. Renal Screening Tests
Kusano, E., Murayama, N., Yasuhiro, A. N. D. O., et al. (2005) · Internal Medicine · doi:10.2169/internalmedicine.44.386
Challenges and opportunities in the development of therapeutics for chronic kidney disease
Shayman, J. A. (2014) · Translational research · doi:10.1016/j.trsl.2014.08.002
Forni, V., Wuerzner, G., Pruijm, M. T., & Burnier, M. (2010) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.08.008
Bomback, A. S., & Whaley‐Connell, A. T. (2011) · Diabetes Management · doi:10.2217/dmt.11.32
Sciarretta, S., Palano, F., Paneni, F., et al. (2008) · Current Hypertension Reviews · doi:10.2174/157340208786241291
Rodrguez, A. S., Ledesma, M. S., & Gonzlez, I. C. (2005) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0211-3449(05)73852-2
Angiotensin-Receptor Blockers for Renal Protection in Type 2 Diabetes
Ruggenenti, P. L., Macia, M. L., & Remuzzi, G. (2006) · Aging Health · doi:10.2217/1745509x.2.2.295
Self-citationVasavada, N., & Agarwal, R. (2009) · F1000 Medicine Reports · doi:10.3410/m1-47
Blockage of the renin-angiotensin system in peritoneal dialysis
Abensur, H. (2013) · Brazilian Journal of Nephrology · doi:10.5935/0101-2800.20130040
Reassessing guidelines for heart failure
Drexler, H., & Wollert, K. C. (2004) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2004.022
Rein et HTA chez le patient diabétique de type 2 : stratégies thérapeutiques
Halimi, J.-M. (2011) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(11)70056-6
Update in General Internal Medicine
Lucey, C. R., & Cole, C. A. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-5_part_1-200209030-00009
Complicaciones macrovasculares del paciente diab?tico. Pie diab?tico
Ledesma, M. S., Gonzlez, I. C., Garca, M. L. P., et al. (2008) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0211-3449(08)73214-4
Fármacos antihipertensivos en Atención Primaria
Morales‐Olivas, F. J. (2003) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(03)71360-9
Renal Ischemia as a Predictor of Cardiovascular Morbidity
Murphy, T. P. (2003) · Journal of Vascular and Interventional Radiology · doi:10.1016/s1051-0443(03)70144-4
BENEDICT: primary prevention of microalbuminuria in hypertensive type 2 diabetes
Vora, J. P., & Weston, C. F. M. (2006) · The British Journal of Diabetes · doi:10.1177/14746514060060020601
Medication among patients with type 1 diabetes and predialytic renal disease
Helve, J., Sund, R., Haapio, M., et al. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.12.010
Case Studies: Applying JNC-7 Treatment Guidelines
Kloner, R. A. (2007) · JAAPA · doi:10.1097/01720610-200711000-00010
Similarities and Differences between Angiotensin II Type 1 Receptor Antagonists
Corsini, A. (2004) · High Blood Pressure & Cardiovascular Prevention · doi:10.2165/00151642-200411030-00005
Angiotensin receptor blockers in hypertension and heart failure
Walthall, H. (2007) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2007.2.9.27210
Consuegra‐Sánchez, L., Sanchís, J., Núñez, J. E., Cascón, J. D., Villegas, M., & Picó, F. (2011) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2011.05.028
Volpe, M. (2009) · Hot Topics in Hypertension · doi:10.4147/hth-090700
Weir, M. (2015) · Journal of Indian College of Cardiology · doi:10.1016/j.jicc.2015.05.012
Angiotensin I convert ing enzyme inhibitors and angiotensin II receptor antagonists
de Jong, P. E. (2008) · Springer eBooks · doi:10.1007/978-0-387-84843-3_20
Dı́ez, J. (2009) · Revista Clínica Española · doi:10.1016/s0014-2565(09)73256-4
Clinical benefits from combination therapy in the treatment of hypertension
Fogari, R., & Zoppi, A. (2010) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2009.03.002
Nagai, T., Imamura, M., Shimizu, E., et al. (2006) · The Kitakanto Medical Journal · doi:10.2974/kmj.56.339
Optimal blood pressure targets in 2014 – Does the guideline recommendation match the evidence base?
Alviar, C. A., Bangalore, S., & Messerli, F. H. (2015) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2015.03.001
Coronel, F., Pérez-Flores, I., Salanova, L., et al. (2008) · Diálisis y Trasplante · doi:10.1016/s1886-2845(08)72169-6
Síndrome metabólico, enfermedad cardiovascular y medicina sexual
Navarro, N. C. (2008) · Revista Internacional de Andrología · doi:10.1016/s1698-031x(08)72568-8
Sien, C. C., de la Morena, J. S., & Urioste, L. M. R. (2002) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(02)71243-9
Inhibición y/o bloqueo del sistema renina-angiotensina
Puig, A. B. (2002) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(02)71226-9
What is diabetic renal disease?
Gallagher, H., & Andrews, P. (2002) · The British Journal of Diabetes · doi:10.1177/14746514020020020601
Caro, J. L. L., & Divisón, J. A. (2007) · Medicina de Familia SEMERGEN · doi:10.1016/s1138-3593(07)73882-0
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Passa (2003) · International Congress Series · doi:10.1016/s0531-5131(03)00146-8
González-Clemente, J. M., Giménez‐Palop, O., Caixàs, A., Barahona, M. J., Subías, D., Vilardell, C., Giménez‐Pérez, G., & Mauricio, D. (2005) · Medicina Clínica · doi:10.1157/13077140
Gómez-Fernández, P. (2004) · Revista Clínica Española · doi:10.1016/s0014-2565(04)71555-6
Value in hypertension treatment
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La pro-renina y su receptor. Papel de la inhibición directa de la renina
Gómez-Fernández, P., Nieto, J., & Robles, N. R. (2011) · Revista Española de Cardiología Suplementos · doi:10.1016/s1131-3587(11)14003-0
Castelao, A. M., Moreno, F. D. L., & Górriz, J. (2007) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0211-3449(07)74626-x
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Reply--PPAR agonists in diabetic nephropathy
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Remuzzi, G. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.07.009
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The challenge of managing hypertension in chronic renal disease
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Jain, P. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
Losartan for cardiovascular disease in patients with and without diabetes in the LIFE study
Bursztyn, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09073-6
Marín, R., Gorostidi, M., Navascués, R. A., & Melendreras, S. G. (2009) · Medicina Clínica · doi:10.1016/s0025-7753(09)70958-3
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Goicuria, E. C., & Meza, I. B. (2014) · Revista Clínica Escuela de Medicina UCR-HSJD · doi:10.15517/rc_ucr-hsjd.v4i7.17334
Taketa, K., Matsumura, T., Furukawa, N., & Araki, E. (2012) · Clinical Medicine Reviews in Vascular Health · doi:10.4137/cmrvh.s7434
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Valor pronóstico de la presión arterial en el paciente diabético
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Microalbuminuria y diabetes mellitus tipo 2. Áreas de incertidumbre
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Cattran, D. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0303
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Ichihara, K. B. A. A. (2010) · Clinical Medicine Reviews in Vascular Health · doi:10.4137/cmrvh.s5204
Tytus, R. H., Burgess, E. D., Maurer, J., & Vanjaka, A. (2013) · Clinical Drug Investigation · doi:10.1007/s40261-013-0092-y
de la Sierra, A. (2004) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(04)71459-2
Blood pressure drugs have no mortality benefit in diabetic patients
Vos, E., Rose, C. P., & Biron, P. (2009) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(09)70727-5
de la Figuera, M. (2004) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(04)71511-1
Role of mineralocorticoid receptor in diabetic vascular disease
Guo, C., Kherde, S., & Adler, G. K. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000216960.06010.4b
Aslam, & Uddin, I. (2010) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s6662
Dual angiotensin II blockade: a promise of enhanced renal protection?
Thurston, H. (2002) · Journal of Hypertension · doi:10.1097/00004872-200204000-00014
Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma
Tanemoto, M., Abe, M., Satoh, F., et al. (2007) · Clinical and Experimental Nephrology · doi:10.1007/s10157-007-0460-0
Treatment and Prevention of Diabetic Nephropathy in Caucasian and Asian Patients
Viberti, G. C. (2006) · International Journal of Pharmaceutical Medicine · doi:10.2165/00124363-200620010-00005
Woo, J. S., & Probstfield, J. L. (2009) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-009-0040-9
2. Importance of Early Detection and Diagnosis for Kidney Diseases
Iino, Y. (2005) · Internal Medicine · doi:10.2169/internalmedicine.44.388
Hundekari, S. T., & Shetty, S. (2011) · Journal of Indian College of Cardiology · doi:10.1016/s1561-8811(11)80025-8
Ancient terms of chronic renal failure: The key to ancient literature mining
Zhang, L., Li, Y., Zhu, D., et al. (2013) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm.2013.6732704
Metadata
- Authors
- Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S.
- Affiliations
- Brigham and Women's Hospital (US)
- The University of Melbourne (AU)
- Hennepin County Medical Center (US)
- Emory University (US)
- Mario Negri Institute for Pharmacological Research (IT)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-09-20
- Volume
- 345
- Issue
- 12
- Pages
- 861-869
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2056976690
- Semantic Scholar
- 842bf4da2a50ee13464536c9dfa502f4eb80c5f1
- Cited by
- 7,493
- References
- 37
- Citations by year
- 2026: 180 · 2025: 233 · 2024: 211 · 2023: 248 · 2022: 235 · 2021: 240 · 2020: 263 · 2019: 204 · 2018: 212 · 2017: 233 · 2016: 243 · 2015: 249 · 2014: 289 · 2013: 288 · 2012: 341
- FWCI
- 280.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- losartan, type 2 diabetes, diabetic nephropathy, angiotensin receptor blockers, renin-angiotensin system blockade, end-stage renal disease, kidney disease progression, proteinuria, cardiovascular morbidity and mortality, heart failure hospitalization, serum creatinine doubling, antihypertensive therapy
- MeSH terms
- Adult, Aged, Antihypertensive Agents, Cardiovascular Diseases, Creatine, Creatinine, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Humans, Hypertension, Kidney Failure, Chronic, Male, Middle Aged, Proteinuria, Disease Progression, Losartan, Angiotensin Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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