The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Widespread Distribution of Urinary Tract Infections Caused by a Multidrug-Resistant Escherichia coli Clonal Group
Open accessAbstract
BACKGROUND: The management of urinary tract infections is complicated by the increasing prevalence of antibiotic-resistant strains of Escherichia coli. We studied the clonal composition of E. coli isolates that were resistant to trimethoprim-sulfamethoxazole from women with community-acquired urinary tract infections. METHODS: Prospectively collected E. coli isolates from women with urinary tract infections in a university community in California were evaluated for antibiotic susceptibility, O:H serotype, DNA fingerprinting, pulsed-field gel electrophoretic pattern, and virulence factors. The prevalence and characteristics of an antibiotic-resistant clone were evaluated in this group of isolates and in those from comparison cohorts in Michigan and Minnesota. RESULTS: Fifty-five of the 255 E. coli isolates (22 percent) from the California cohort were resistant to trimethoprim-sulfamethoxazole as well as other antibiotics. There was a common pattern of DNA fingerprinting, suggesting that the isolates belonged to the same clonal group (clonal group A), in 28 of 55 isolates with trimethoprim-sulfamethoxazole resistance (51 percent) and in 2 of 50 randomly selected isolates that were susceptible to trimethoprim-sulfamethoxazole (4 percent, P<0.001). In addition, 11 of 29 resistant isolates (38 percent) from the Michigan cohort and 7 of 18 (39 percent) from the Minnesota cohort belonged to clonal group A. Most of the clonal group A isolates were serotype O11:H(nt) or O77:H(nt), with similar patterns of virulence factors, antibiotic susceptibility, and electrophoretic features. CONCLUSIONS: In three geographically diverse communities, a single clonal group accounted for nearly half of community-acquired urinary tract infections in women that were caused by E. coli strains with resistance to trimethoprim-sulfamethoxazole. The widespread distribution and high prevalence of E. coli clonal group A has major public health implications.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 15,041
Tenover, F. C., Arbeit, R. D., Goering, R. V., Mickelsen, P. A., Murray, B. E., Persing, D. H., & Swaminathan, B. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.9.2233-2239.1995 · Cited by 8,204
Versalovic, J., Koeuth, T., & Lupski, R. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.24.6823 · Cited by 3,249
Foxman, B., Barlow, R., D'Arcy, H., Gillespie, B., & Sobel, J. D. (2000) · Annals of Epidemiology · doi:10.1016/s1047-2797(00)00072-7 · Cited by 1,447
Self-citationVirulence factors in Escherichia coli urinary tract infection
Johnson, J. R. (1991) · Clinical Microbiology Reviews · doi:10.1128/cmr.4.1.80 · Cited by 1,290
Self-citationJohnson, J. R., & Stell, A. L. (2000) · The Journal of Infectious Diseases · doi:10.1086/315217 · Cited by 1,269
Self-citationDIAGNOSIS AND TREATMENT OF UNCOMPLICATED URINARY TRACT INFECTION
Hooton, T. M., & Stamm, W. E. (1997) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70373-1 · Cited by 751
Gupta, K. (1999) · JAMA · doi:10.1001/jama.281.8.736 · Cited by 609
Hulton, C. S. J., Higgins, C. F., & Sharp, P. M. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb00755.x · Cited by 578
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Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
Welch, R. A., Burland, V., Plunkett, G., Redford, P., Roesch, P., Rasko, D., Buckles, E. L., Liou, S.-R., Boutin, A., Hackett, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252529799 · Cited by 1,531
Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections
Anderson, G. G., Palermo, J. J., Schilling, J. D., Roth, R., Heuser, J., & Hultgren, S. J. (2003) · Science · doi:10.1126/science.1084550 · Cited by 1,161
Russo, T. A., & Johnson, J. R. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(03)00049-2 · Cited by 801
Self-citationOrigins and virulence mechanisms of uropathogenic Escherichia coli
Wiles, T. J., Kulesus, R. R., & Mulvey, M. A. (2008) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.03.007 · Cited by 606
Metadata
- Authors
- Manges, A. R., Johnson, J. R., Foxman, B., O'Bryan, T. T., Fullerton, K. E., & Riley, L. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-10-04
- Volume
- 345
- Issue
- 14
- Pages
- 1007-1013
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1964168847
- Cited by
- 531
- References
- 25
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Manges, A. R., Johnson, J. R., Foxman, B., O'Bryan, T. T., Fullerton, K. E., & Riley, L. W. (2001). Widespread Distribution of Urinary Tract Infections Caused by a Multidrug-Resistant Escherichia coli Clonal Group. New England Journal of Medicine. https://doi.org/10.1056/nejmoa011265
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