Cited by 861Multiple Sclerosis Research StudiesPolyomavirus and related diseasesPeripheral Neuropathies and Disorders

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

Open access

Brex, Peter A., Ciccarelli, Olga, O'Riordan, Jonathon I., Sailer, Michael, Thompson, Alan J., Miller, David H.·2002·New England Journal of Medicine

DOI 10.1056/nejmoa011341

Open this paper in CoChat — free account Open PDF

Abstract

Background In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, changes in volume, and long-term disability. Methods Seventy-one patients in a serial MRI study of patients with isolated syndromes were reassessed after a mean of 14.1 years. Disability was measured with the use of Kurtzke's Expanded Disability Status Scale (EDSS; possible range, 0 to 10, with a higher score indicating a greater degree of disability). Results Clinically definite multiple sclerosis developed in 44 of the 50 patients (88 percent) with abnormal results on MRI at presentation and in 4 of 21 patients (19 percent) with normal results on MRI. The median EDSS score at follow-up for those with multiple sclerosis was 3.25 (range, 0 to 10); 31 percent had an EDSS score of 6 or more (including three patients whose deaths were due to multiple sclerosis). The EDSS score at 14 years correlated moderately with lesion volume on MRI at 5 years (r=0.60) and with the increase in lesion volume over the first 5 years (r=0.61). Conclusions In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance im…

Integrity signals

Registry

Crossref · 10.1056/nejmoa011341

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Practical Statistics for Medical Research.
Walter, S., & Altman, D. G. (1992) · Biometrics · doi:10.2307/2532320 · Cited by 11,666
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Self-citation
Tests for comparing elements of a correlation matrix
Steiger, J. H. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.2.245 · Cited by 4,621
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,762

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 2

Molyneux PD, 1998, AJNR Am J Neuroradiol, 19, 1715
Paty DW, 1993, Neurology, 43, 6627

Sorted by citations

Items 501–600 of 858

Documento de consenso de LACTRIMS para el tratamiento farmacológico de la esclerosis múltiple y sus variantes clínicas
Herrera, P. A., Nogales-Gaete, J., Rivera, V. M., Cristiano, E., de Bedolla, F. H. D., Gatti, C. O., Alvarenga, R. M. P., Tenembaum, S. N., & Múl, G. D. E. D. E. M. G. D. E. D. E. (2012) · Revista de Neurología · doi:10.33588/rn.5512.2012306 · Cited by 10
An Approach to Comparing Accuracies of Two Flair MR Sequences in the Detection of Multiple Sclerosis Lesions in the Brain in the Absence of Gold Standard
Bilello, M., Suri, N., Krejza, J., Woo, J. H., Bagley, L. J., Mamourian, A. C., Vossough, A., Chen, J. Y., Millian, B. R., Mulderink, T. A., et al. (2010) · Academic Radiology · doi:10.1016/j.acra.2010.01.019 · Cited by 10
Longitudinal assessment of clinically isolated syndrome with diffusion tensor imaging and volumetric MRI
Kolasa, M., Hakulinen, U., Helminen, M., Hagman, S., Raunio, M., Rossi, M. E., Brander, A., Dastidar, P., & Elovaara, I. (2014) · Clinical Imaging · doi:10.1016/j.clinimag.2014.10.014 · Cited by 10
Imaging of Optic Neuropathy and Chiasmal Syndromes
Tantiwongkosi, B., & Mafee, M. F. (2015) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2015.05.004 · Cited by 10
Magnetic resonance imaging and treatment effects of multiple sclerosis therapeutics
Leist, T. P., & Marks, S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c98011 · Cited by 10
Imaging Markers for Monitoring Disease Activity in Multiple Sclerosis
Suthiphosuwan, S., Kim, D. D., Bharatha, A., & Oh, J. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0453-6 · Cited by 10
Diffusion Tensor Group Tractography of the Corpus Callosum in Clinically Isolated Syndrome
Lin, F., Yu, C., Liu, Y., Li, K., & Lei, H. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2273 · Cited by 11
B-cell function in CNS inflammatory demyelinating disease: a complexity of roles and a wealth of possibilities
Fillatreau, S., & Anderton, S. M. (2007) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.3.4.565 · Cited by 11
Current and Future Directions in MS Management: Key Considerations for Managed Care Pharmacists
Lipsy, R. J., Schapiro, R. T., & Prostko, C. R. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.s9.1 · Cited by 10
Multiple Sclerosis and the Spinal Cord
Sheremata, W. A., & Tornes, L. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.09.007 · Cited by 10
MRI findings in benign multiple sclerosis are variable
Pittock, S. J., Noseworthy, J. H., & Rodriguez, M. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0276-y · Cited by 10
MR-based technology for in vivo detection, characterization, and quantification of pathology of relapsing-remitting multiple sclerosis.
Rovaris, M., & Filippi, M. (2002) · PubMed · Cited by 10
Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy
Meier, D., Weiner, H., Khoury, S. J., & Guttmann, C. (2004) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2004.tb00278.x · Cited by 22
Multiple Sclerosis
Filippi, M., & Rocca, M. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-38621-4_1 · Cited by 12
The Barcelona baseline risk score to predict long-term prognosis after a first demyelinating event: a prospective observational study
Tur, C., Carbonell‐Mirabent, P., Otero‐Romero, S., Cobo‐Calvo, Á., Arévalo, M. J., Ariño, H., Arrambide, G., Auger, C., Carvajal, R., Castilló, J., et al. (2025) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2025.101302 · Cited by 10
When to Initiate Disease-Modifying Drugs for Relapsing Remitting Multiple Sclerosis in Adults?
Alkhawajah, M. M., & Oger, J. J.-F. (2011) · Multiple Sclerosis International · doi:10.1155/2011/724871 · Cited by 9
Early MRI activity predicts treatment nonresponse with intramuscular interferon beta-1a in clinically isolated syndrome
Kinkel, R. P., Simon, J. H., O'Connor, P. W., Hyde, R., & Pace, A. (2014) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2014.08.003 · Cited by 8
Imaging of Central Nervous System Demyelinating Disorders
Balashov, K. E. (2016) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000373 · Cited by 9
Nonlesional diffusely abnormal appearing white matter in clinically isolated syndrome: Prevalence, association with clinical and MRI features, and risk for conversion to multiple sclerosis
Holmes, R. D., Vavasour, I. M., Greenfield, J., Zhao, G., Lee, J. S., Moore, G. R. W., Tam, R. C., Metz, L. M., Trablousee, A., Li, D. K. B., et al. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12900 · Cited by 8
Corneal axonal loss as an imaging biomarker of neurodegeneration in multiple sclerosis: a longitudinal study
Petropoulos, I. N., Al‐Shibani, F., Bitirgen, G., Ponirakis, G., Khan, A., Gad, H., Mahfoud, Z. R., Altarawneh, H. N., Rehman, M. H., John, K., et al. (2023) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864221118731 · Cited by 9
Lesiones incidentales desmielinizantes en resonancia magnética: estudio de 11 casos con seguimiento clinicorradiológico y revisión de la bibliografía
Marcos, A. S., Mitjana, R., Castilló, J., Edo, M. C., Horga, A., Tintoré, M., Río, J., Auger, C., Rovira, À., & Montalbán, X. (2010) · Revista de Neurología · doi:10.33588/rn.5103.2010259 · Cited by 9
Neuropathies optiques
Biousse, V. (2005) · Revue Neurologique · doi:10.1016/s0035-3787(05)85086-6 · Cited by 9
Relationship between the extent of T2 lesions and the onset of secondary progression in multiple sclerosis
Mostert, J. P., de Groot, J. C., Ramsaransing, G. S. M., Koch, M. W., & Keyser, J. D. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01915.x · Cited by 9
A web-based decision support tool for prognosis simulation in multiple sclerosis
Veloso, M. (2014) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2014.04.005 · Cited by 9
Optic neuritis incidence is increased in spring months in patients with asymptomatic demyelinating lesions
Balashov, K. E., Pal, G. D., & Rosenberg, M. L. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458509355070 · Cited by 9
Radiologically isolated syndrome: watchful waiting vs. active treatment
Alshamrani, F., Alnajashi, H. A., & Freedman, M. S. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1259568 · Cited by 9
Biomarkers and surrogate outcomes in neurodegenerative disease: Lessons from multiple sclerosis
Miller, D. H. (2004) · Neurotherapeutics · doi:10.1007/bf03206612 · Cited by 9
Self-citation
Polyregional and hemispheric syndromes: a study of these uncommon first attacks in a CIS cohort
Pelayo, R., Tintoré, M., Rovira, À., Río, J., Nos, C., Grivé, E., Téllez, N., Comabella, M., & Montalbán, X. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506074178 · Cited by 9
The pros and cons of early treatment of relapsing forms of multiple sclerosis
Montalbán, X. (2004) · Journal of Neurology · doi:10.1007/s00415-004-1406-z · Cited by 9
Defining Multiple Sclerosis Treatment Response With Magnetic Resonance Imaging
Giacomini, P. S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.529 · Cited by 9
Is multiple sclerosis still a clinical diagnosis?
Simon, J. H., & Thompson, A. J. (2003) · Neurology · doi:10.1212/wnl.61.5.596 · Cited by 9
Self-citation
Gadolinium‐Enhancing Lesions Lead to Decreases in White Matter Tract Fractional Anisotropy in Multiple Sclerosis
Chiang, G. C.-Y., Pinto, S., Comunale, J. P., & Gauthier, S. A. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12309 · Cited by 8
White matter changes measured by multi-component MR Fingerprinting in multiple sclerosis
Nagtegaal, M. A., Hermann, I., Weingärtner, S., Martínez‐Heras, E., Solana, E., Llufriú, S., Gass, A., Poot, D. H. J., van Osch, M. J. P., Vos, F. M., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103528 · Cited by 8
A Radiomic “Warning Sign” of Progression on Brain MRI in Individuals with MS
Kelly, B. S., Mathur, P., McGuinness, G., Dillon, H., Lee, E. H., Yeom, K. W., Lawlor, A., & Killeen, R. P. (2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.a8104 · Cited by 8
What do we currently know about the clinically isolated syndrome suggestive of multiple sclerosis? An update
Grzegorski, T., & Losy, J. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0084 · Cited by 9
Intrathecal Immunoglobulin G Synthesis and Brain Injury by Quantitative MRI in Multiple Sclerosis
Brandão, C. O., Ruocco, H. H., Farias, A. S., Oliveira, C., Cendes, F., Damasceno, B. P., & dos Santos, L. M. B. (2006) · NeuroImmunoModulation · doi:10.1159/000096091 · Cited by 8
Immunotherapies in Neurologic Disorders
Graves, D. F., & Vernino, S. A. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.05.001 · Cited by 8
What makes a prognostic biomarker in CNS diseases: strategies for targeted biomarker discovery? Part 2: chronic progressive and relapsing disease
Kühle, J., & Petzold, A. (2011) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2011.592184 · Cited by 8
Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results
Nielsen, J., Moraal, B., Polman, C. H., Poppe, P. A., Vos, M. D., Freedman, M. S., Kappos, L., Barkhof, F., Bauer, L., Pohl, C., et al. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506074684 · Cited by 8
MRI utility in the detection of disease activity in clinically stable patients with multiple sclerosis: a retrospective analysis of a community based cohort
COHAN, S. L., Chen, C., Baraban, E., Stuchiner, T. L., & Grote, L. (2016) · BMC Neurology · doi:10.1186/s12883-016-0699-8 · Cited by 8
The Level of Testosterone, Vitamin D, and Irregular Menstruation More Important than Omega-3 in Non-Symptomatic Women Will Define the Fate of Multiple Scleroses in Future
Tavakol, S., Shakibapour, S., & Bidgoli, S. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0325-1 · Cited by 8
Visual Loss
Pineles, S. L., & Balcer, L. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-34044-1.00005-5 · Cited by 8
Optic neuritis associated to treatment with infliximab
Landais, A. F., & Fanhan, R. (2016) · La Presse Médicale · doi:10.1016/j.lpm.2016.11.020 · Cited by 8
Multiple sclerosis
Hawker, K., & Frohman, E. M. (2004) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(03)00123-4 · Cited by 8
Diagnosis and disease modifying treatments in multiple sclerosis
Zajicek, J. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.031294 · Cited by 8
10 Most Commonly Asked Questions About Cerebrospinal Fluid Characteristics in Demyelinating Disorders of the Central Nervous System
Mehling, M., Kühle, J., & Regeniter, A. (2008) · The Neurologist · doi:10.1097/nrl.0b013e31815ac523 · Cited by 8
Understanding the types of multiple sclerosis and prognostic indicators
Talbot, P. R. (2010) · British Journal of Neuroscience Nursing · doi:10.12968/bjnn.2010.6.4.47791 · Cited by 8
MS treatment: New perspectives
Comı, G., & Martino, G. (2005) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2005.11.011 · Cited by 8
Assessing Treatment Effects on Axonal Loss - Evidence from MRI Monitored Clinical Trials
Barkhof, F. (2005) · Rivista di Neuroradiologia · doi:10.1177/197140090501800410 · Cited by 8
Developmental Disorders of the Nervous System
Sarnat, H. B., & Flores‐Sarnat, L. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7525-3.50102-3 · Cited by 8
Multiple Sclerosis Disease Evolution Assessment in Brain MRI Lesions Based on Texture and Multi-Scale Amplitude Modulation-Frequency Modulation (AM-FM) Features
Loizou, C. P., Fotso, K., Nicolaou, A., Pantzaris, M., Pattichis, M. S., & Pattichis, C. S. (2023) · IEEE Access · doi:10.1109/access.2023.3260982 · Cited by 8
Atypical myelitis in patients with multiple sclerosis: Characterization and comparison with typical multiple sclerosis and neuromyelitis optica spectrum disorders
Bigaut, K., Lambert, C., Kremer, L. D., Lebrun‐Frénay, C., Cohen, M., Ciron, J., Bourre, B., Créange, A., Kerschen, P., Montcuquet, A., et al. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520906995 · Cited by 7
Conventional MRI Techniques in Multiple Sclerosis
Traboulsee, A. L., Li, D. K. B., Zhao, G., & Paty, D. W. (2005) · Springer eBooks · doi:10.1007/3-540-27644-0_14 · Cited by 7
Stellenwert der Uveitis im Rahmen demyelinisierender Erkrankungen des Zentralnervensystems
Beyer, A.-M., Rosche, B., Pleyer, U., & Wandinger, K.-P. (2007) · Der Nervenarzt · doi:10.1007/s00115-007-2297-x · Cited by 7
Patients’ Stratification and Correlation of Brain Magnetic Resonance Imaging Parameters with Disability Progression in Multiple Sclerosis
Vaněčková, M., Seidl, Z., Krásenský, J., Havrdová, E., Horáková, D., Doležal, O., Burgetová, A., & Mašek, M. (2009) · European Neurology · doi:10.1159/000206852 · Cited by 7
Is it clinically relevant to repair focal multiple sclerosis lesions?
Comı, G. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.09.001 · Cited by 7
Does cerebrospinal fluid analysis add predictive value to magnetic resonance imaging for long term irreversible disability in patients with early multiple sclerosis?
Moroso, A., Deloire, M. S. A., Ruet, A., Ouallet, J., Casey, R., & Brochet, B. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.04.044 · Cited by 7
Relapsing Acute Disseminated Encephalomyelitis in Children: Further Evaluation of the Diagnosis
Dündar, N. O., Anlar, B., Güven, A., Serdaroğlu, A., & Yarar, Ç. (2010) · Journal of Child Neurology · doi:10.1177/0883073810369260 · Cited by 7
Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis
Chen, J., Zhu, L., He, L., Lu, Z., Chen, X., & Fang, S. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3635 · Cited by 7
Prognostic value of oligoclonal IgG bands in Japanese clinically isolated syndrome converting to clinically definite multiple sclerosis
Kinoshita, M., Daifu, M., Tanaka, K., & Tanaka, M. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.03.010 · Cited by 7
Updates and Controversies in the Management of Acute Optic Neuritis
Meltzer, E. I., & Prasad, S. (2018) · Asia-Pacific Journal of Ophthalmology · doi:10.22608/apo.2018108 · Cited by 7
Cognitive Event-Related Potentials–The P300 Wave Is a Prognostic Factor of Long-Term Disability Progression in Patients With Multiple Sclerosis
Szilasiová, J., Rosenberger, J., Mikula, P., Vitková, M., Fedičová, M., & Gdovinová, Z. (2020) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000788 · Cited by 7
Early MRI outcomes in participants with a first clinical demyelinating event at risk of multiple sclerosis in the ORACLE-MS study
Freedman, M. S., Coyle, P. K., Comi, G., Scarberry, S., Damian, D., Hyvert, Y., Dangond, F., Galazka, A. R., Jack, D. L., Lebson, L. A., et al. (2021) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217321990852 · Cited by 7
New developments in the treatment of optic neuritis
Jenkins, T. M. (2010) · Eye and Brain · doi:10.2147/eb.s8386 · Cited by 7
Role of Magnetic Resonance Imaging in the Diagnosis and Prognosis of Multiple Sclerosis
Zivadinov, R., & Bakshi, R. (2005) · Humana Press eBooks · doi:10.1385/1-59259-855-2:055 · Cited by 7
The puzzle of multiple sclerosis: gray matter finds its place
Calabrese, M., Rinaldi, F., Poretto, V., & Gallo, P. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.143 · Cited by 7
Management of Relapsing-Remitting Multiple Sclerosis
Lyseng-Williamson, K. A., & Plosker, G. L. (2002) · Disease Management & Health Outcomes · doi:10.2165/00115677-200210050-00004 · Cited by 7
A Spatio-Temporal Model for Longitudinal Image-on-Image Regression
Hazra, A., Reich, B. J., Reich, D. S., Shinohara, R. T., & Staicu, A. (2017) · Statistics in Biosciences · doi:10.1007/s12561-017-9206-z · Cited by 7
Interferon‐β for multiple sclerosis: Long‐term benefits?
Rudick, R. A., & Cutter, G. (2007) · Annals of Neurology · doi:10.1002/ana.21119 · Cited by 7
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI
Shin, H., Kim, W., Lee, J. H., Lee, H., Nam, Y., Kim, J., Li, X., van Zijl, P. C. M., Calabresi, P. A., Lee, J., et al. (2025) · NeuroImage Clinical · doi:10.1016/j.nicl.2025.103748 · Cited by 8
Sex hormone therapy in Multiple Sclerosis: A systematic review of randomized clinical trials
Shayestehfar, M., Salari, M., Karimi, S., Vosough, M., Memari, A. H., & Nabavi, S. M. (2024) · Journal of Central Nervous System Disease · doi:10.1177/11795735231223411 · Cited by 6
Dissemination in time as a requirement for diagnosis of multiple sclerosis: Time for a change?
Miller, A. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241233999 · Cited by 7
Recent Developments in the Early Diagnosis and Management of Multiple Sclerosis
Ross, A. P., & Thrower, B. W. (2010) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3181f8a5d0 · Cited by 6
Clinically isolated syndrome and multiple sclerosis in children: a single center study
Bektaş, G., Özkan, M. U., Yıldız, E. P., Uzunhan, T. A., Sencer, S., Aydınli̇, N., Çalışkan, M., & Özmen, M. (2020) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2020.02.010 · Cited by 6
Evaluating the Role of Corticosteroid Pulse Therapy in Patients With Secondary Progressive Multiple Sclerosis Receiving Mitoxantrone: A Double Blind Randomized Controlled Clinical Trial
Rahimdel, A., Zeinali, A., & Mellat, A. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.30618 · Cited by 6
INFECTIOUS AND INFLAMMATORY MYELOPATHIES
Wingerchuk, D. M. (2008) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000324123.16947.3c · Cited by 6
The clinical usefulness of routine MRI assessment.
Arnold, D. L., & Stone, L. (2011) · PubMed · Cited by 6
Krankheitsverlauf und Prognose
Flachenecker, P., & Zettl, U. K. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22083-8.00007-9 · Cited by 5
Tissue damage detected by quantitative gradient echo MRI correlates with clinical progression in non-relapsing progressive MS
Xiang, B., Brier, M. R., Kanthamneni, M., Wen, J., Snyder, A. Z., Yablonskiy, D. A., & Cross, A. H. (2022) · Multiple Sclerosis Journal · doi:10.1177/13524585211073761 · Cited by 6
Emerging oral immunomodulating agents – focus on teriflunomide for the treatment of multiple sclerosis
Allington, D. R., Rivey, M., & Nwankwo, E. (2012) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s29022 · Cited by 6
New treatment measurements for treatment effects on relapses and progression
Tintoré, M., & Sastre‐Garriga, J. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.08.036 · Cited by 6
The relevance of Neuroimaging Findings to Physical Disability in Multiple Sclerosis
Göçmen, R. (2018) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.23409 · Cited by 6
Clinical multiple sclerosis occurs at one end of a spectrum of CNS pathology: A modified threshold liability model leads to new ways of thinking about the cause of clinical multiple sclerosis
Haegert, D. G. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.03.009 · Cited by 6
DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF MULTIPLE SCLEROSIS
Cree, B. (2010) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000389932.38919.c7 · Cited by 6
Use of Imaging in Multiple Sclerosis
Filippi, M., Rocca, M. A., Arnold, D. L., Bakshi, R., Barkhof, F., Stefano, N. D., Fazekas, F., Frohman, E. M., Miller, D., & Wolinsky, J. S. (2010) · Wiley eBooks · doi:10.1002/9781444328394.ch3 · Cited by 5
Self-citation
BENEFIT 8-year results provide further support for the long-term value of early treatment of multiple sclerosis
Fujihara, K. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306720 · Cited by 6
Efficacy and safety of subcutaneous interferon-β-1a in patients with a first demyelinating event and early multiple sclerosis
Freedman, M. S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.924496 · Cited by 5
Clinically isolated syndrome: prognostic markers for conversion to multiple sclerosis and initiation of disease-modifying therapy
Kohriyama, T. (2011) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.51.179 · Cited by 5
Benign multiple sclerosis: Some recent ideas
Dawson, D. M. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0001-6 · Cited by 5
Interferon β in Multiple Sclerosis
Gross, R., & LUBLIN, F. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801914-6.00016-7 · Cited by 5
Multiple Sklerose
Ziemssen, T., Wilhelm, H., & Ziemssen, F. (2006) · Der Ophthalmologe · doi:10.1007/s00347-006-1368-x · Cited by 5
Neuroimaging in Multiple Sclerosis
Andreadou, E. (2012) · InTech eBooks · doi:10.5772/24069 · Cited by 5
Update on Multiple Sclerosis
Simon, J. H. (2006) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2006.06.008 · Cited by 5
Optimizing Outcomes in Multiple Sclerosis – A Consensus Initiative
Coyle, P. K., Arnason, B. G. W., Hurwitz, B. J., & LUBLIN, F. D. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458508101134 · Cited by 5
The place of MRI in monitoring the individual MS patient
Arnold, D. L. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.11.023 · Cited by 5
Diagnostic biomarkers in multiple sclerosis
Kuenz, B., Deisenhammer, F., Berger, T., & Reindl, M. (2007) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.1.2.225 · Cited by 5
Evaluation of the 2005 McDonald MRI criteria for dissemination in space in Afro‐Caribbean patients with clinically isolated syndromes
Chausson, N., Olindo, S., Signaté, A., Smadja, D., & Cabre, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02691.x · Cited by 5
Imaging of multiple sclerosis: Role in neurotherapeutics
Bakshi, R., Minagar, A., Jaisani, Z., & Wolinsky, J. S. (2005) · Neurotherapeutics · doi:10.1007/bf03206672 · Cited by 5
Inflammation and Axon Degeneration
Perry, V. H. (2005) · Elsevier eBooks · doi:10.1016/b978-012738761-1/50018-3 · Cited by 5
Sample size estimates for determining treatment effects in high-risk patients with early relapsing-remitting multiple sclerosis
Scott, T. F. M., Schramke, C. J., & Cutter, G. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms910oa · Cited by 5

Authors: Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
Otto-von-Guericke-Universität Magdeburg (DE)
ORCID: Ciccarelli, Olga
Sailer, Michael
Thompson, Alan J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2002-01-17
Volume: 346
Issue: 3
Pages: 158-164
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa011341
OpenAlex: W1966515383
Cited by: 861
References: 42
Citations by year: 2026: 5 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 23 · 2018: 27 · 2017: 33 · 2016: 30 · 2015: 32 · 2014: 44 · 2013: 34 · 2012: 40
FWCI: 36.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Multiple Sclerosis Society
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: multiple sclerosis, long-term disability, Expanded Disability Status Scale, optic neuritis, spinal cord syndromes, T2-weighted MRI, disease-modifying therapy, disease progression
MeSH terms: Adolescent, Adult, Brain, Brain Diseases, Brain Stem, Disability Evaluation, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Optic Neuritis, Spinal Cord Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks