Cited by 861Multiple Sclerosis Research StudiesPolyomavirus and related diseasesPeripheral Neuropathies and Disorders

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

Open access

Brex, Peter A., Ciccarelli, Olga, O'Riordan, Jonathon I., Sailer, Michael, Thompson, Alan J., Miller, David H.·2002·New England Journal of Medicine

DOI 10.1056/nejmoa011341

Open this paper in CoChat — free account Open PDF

Abstract

Background In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, changes in volume, and long-term disability. Methods Seventy-one patients in a serial MRI study of patients with isolated syndromes were reassessed after a mean of 14.1 years. Disability was measured with the use of Kurtzke's Expanded Disability Status Scale (EDSS; possible range, 0 to 10, with a higher score indicating a greater degree of disability). Results Clinically definite multiple sclerosis developed in 44 of the 50 patients (88 percent) with abnormal results on MRI at presentation and in 4 of 21 patients (19 percent) with normal results on MRI. The median EDSS score at follow-up for those with multiple sclerosis was 3.25 (range, 0 to 10); 31 percent had an EDSS score of 6 or more (including three patients whose deaths were due to multiple sclerosis). The EDSS score at 14 years correlated moderately with lesion volume on MRI at 5 years (r=0.60) and with the increase in lesion volume over the first 5 years (r=0.61). Conclusions In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance im…

Integrity signals

Registry

Crossref · 10.1056/nejmoa011341

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Practical Statistics for Medical Research.
Walter, S., & Altman, D. G. (1992) · Biometrics · doi:10.2307/2532320 · Cited by 11,666
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Self-citation
Tests for comparing elements of a correlation matrix
Steiger, J. H. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.2.245 · Cited by 4,621
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,762

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 2

Molyneux PD, 1998, AJNR Am J Neuroradiol, 19, 1715
Paty DW, 1993, Neurology, 43, 6627

Sorted by citations

Items 401–500 of 858

MRI aspects of the ?inflammatory phase? of multiple sclerosis
Filippi, M., & Rocca, M. A. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0173-4 · Cited by 20
Predictive role of evoked potential examinations in patients with clinically isolated optic neuritis in light of the revised McDonald criteria
Simó, M., Barsi, P., & Arányi, Z. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458507085061 · Cited by 20
Genomics and proteomics: role in the management of multiple sclerosis
Kappos, L., Achtnichts, L., Dahlke, F., Kuhle, J., Naegelin, Y., Sandbrink, R., & Lindberg, R. (2005) · Journal of Neurology · doi:10.1007/s00415-005-2013-3 · Cited by 20
Multiple sclerosis disease-modifying therapies: adverse effect surveillance and management
Wingerchuk, D. M. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.3.333 · Cited by 20
Early MS treatment.
Tintoré, M. (2007) · PubMed · Cited by 20
Magnetic Resonance Imaging Surrogates of Multiple Sclerosis Pathology and Their Relationship to Central Nervous System Atrophy
Meier, D., Weiner, H. L., Khoury, S. J., & Guttmann, C. R. G. (2004) · Journal of Neuroimaging · doi:10.1177/1051228404266268 · Cited by 20
Current Immunological and Clinical Perspective on Vaccinations in Multiple Sclerosis Patients: Are They Safe after All?
Tsur, S. W., Zaher, E. A., Tsur, M., Kania, K., & Kalinowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083859 · Cited by 21
Effect of daclizumab high-yield process in patients with highly active relapsing-remitting multiple sclerosis
Giovannoni, G., Radue, E. W., Havrdová, E., Riester, K. A., Greenberg, S. J., Mehta, L. R., & Elkins, J. S. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7196-4 · Cited by 19
Recommendations for using and interpreting magnetic resonance imaging in multiple sclerosis
Rovira, À., Tintoré, M., Alvarez-Cermeño, J. C., Izquierdo, G., & Prieto, J. M. L. (2010) · Neurología (English Edition) · doi:10.1016/s2173-5808(10)70049-3 · Cited by 19
Conventional MR Imaging
Traboulsee, A. L., & Li, D. K. B. (2008) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2008.07.001 · Cited by 19
Spectrum of Microbial Sequences and a Bacterial Cell Wall Antigen in Primary Demyelination Brain Specimens Obtained from Living Patients
Kriesel, J. D., Bhetariya, P. J., Wang, Z., Renner, D. R., Palmer, C. A., & Fischer, K. F. (2019) · Scientific Reports · doi:10.1038/s41598-018-38198-8 · Cited by 21
Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study
Çınar, B. P., & Özakbaş, S. (2018) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.12667 · Cited by 19
Magnetic Resonance Imaging Advances in Multiple Sclerosis
Bakshi, R. (2005) · Journal of Neuroimaging · doi:10.1177/1051228405283362 · Cited by 19
Assessing treatment effects on axonal loss—evidence from MRI monitored clinical trials
Barkhof, F. (2004) · Journal of Neurology · doi:10.1007/s00415-004-1403-2 · Cited by 18
The Lesions of Multiple Sclerosis
Paty, D. W., & Arnold, D. L. (2002) · New England Journal of Medicine · doi:10.1056/nejm200201173460311 · Cited by 19
Magnetic Resonance Imaging in Multiple Sclerosis
Neema, M., Ceccarelli, A., Jackson, J. S., & Bakshi, R. (2012) · doi:10.1002/9781119963714.ch6 · Cited by 19
Neuropsychological Deficits but Not Coping Strategies Are Related to Physical Disability in Multiple Sclerosis
Haase, C. G., Lienemann, M., & Faustmann, P. M. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0759-6 · Cited by 18
Using MRI to make informed clinical decisions in multiple sclerosis care
Bermel, R. A., & Naismith, R. T. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000204 · Cited by 18
Evaluation of machine learning-based classification of clinical impairment and prediction of clinical worsening in multiple sclerosis
Noteboom, S., Seiler, M., Chien, C., Rane, R. P., Barkhof, F., Strijbis, E. M. M., Paul, F., Schoonheim, M. M., & Ritter, K. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12507-w · Cited by 19
The Prognostic Utility of MRI in Clinically Isolated Syndrome: A Literature Review
Odenthal, C., & Coulthard, A. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3954 · Cited by 18
Magnetic resonance imaging as a prognostic disability marker in clinically isolated syndrome: A systematic review
Rahn, A. C., Köpke, S., Stellmann, J., Schiffmann, I., Lukas, C., Chard, D., & Heesen, C. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13010 · Cited by 18
Disease activity impacts disability progression in primary progressive multiple sclerosis
Marrodán, M., Bensi, C., Pappolla, A., Rojas, J. I., Gaitán, M. I., Ysrraelit, M. C., Negrotto, L., Fiol, M., Patrucco, L., Cristiano, E., et al. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101892 · Cited by 18
Predicting disability worsening in relapsing and progressive multiple sclerosis
Simmons, S. B., Schippling, S., Giovannoni, G., & Ontaneda, D. (2021) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000928 · Cited by 18
Predictive value of motor evoked potentials in clinically isolated syndrome
Pallix-Guyot, M., Guennoc, A.-M., Blasco, H., de Toffol, B., Corcia, P., & Praline, J. (2011) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2011.01498.x · Cited by 18
Clinical isolated syndrome: A 3-year follow-up study in China
Liu, Y., Duan, Y., Yu, C., Qin, W., Chen, H., Dong, H., Ye, J., Butzkueven, H., & Li, K. (2011) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2011.05.013 · Cited by 18
Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis
Jeffery, D. (2004) · Neurology · doi:10.1212/wnl.63.12_suppl_6.s41 · Cited by 18
MRI in Multiple Sclerosis
Simon, J. H. (2005) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2005.01.012 · Cited by 17
Are Cerebrospinal Fluid Biomarkers Useful in Predicting the Prognosis of Multiple Sclerosis Patients?
Gajofatto, A., Bongianni, M., Zanusso, G., Benedetti, M. D., & Monaco, S. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12117960 · Cited by 17
Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist
Eckstein, C. P., & Bhatti, M. T. (2015) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2015.12.001 · Cited by 21
CSF levels of HoxB3 and YKL-40 may predict conversion from clinically isolated syndrome to relapsing remitting multiple sclerosis
Tamam, Y., Güneş, B., Akbayır, E., Kızılay, T., Karaaslan, Z., Koral, G., Düzel, B., Küçükali, C. İ., Gündüz, T., Kürtüncü, M., et al. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102697 · Cited by 17
Neuritis óptica inflamatoria
Ayuso, T., Aliseda, D., Ajuria, I., Zandio, B., Mayor, S., & Navarro, M. C. (2009) · Anales del Sistema Sanitario de Navarra · doi:10.4321/s1137-66272009000300011 · Cited by 17
Interleukin 18 Receptor 1 expression distinguishes patients with multiple sclerosis
Gillett, A., Hedreul, M. T., Khademi, M., Espinosa, A., Beyeen, A. D., Jagodic, M., Kockum, I. S., Harris, R. A., & Olsson, T. P. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510364634 · Cited by 16
Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions
Alpini, D. C., Berardino, F. D., Mattei, V., Caputo, D., Schalek, P., & Cesarani, A. (2012) · Audiology Research · doi:10.4081/audiores.2012.e9 · Cited by 17
Diagnosing MS: recent guidelines and future goals focusing on magnetic resonance imaging.
Jm, N., Korteweg, T., & Polman, C. H. (2007) · PubMed · Cited by 17
Immune-Mediated Myelopathies
Wingerchuk, D. M. (2018) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000582 · Cited by 16
Management of Optic Neuritis in Canada: Survey of Ophthalmologists and Neurologists
Atkins, E. J., Drews‐Botsch, C., Newman, N. J., Calvetti, O., Swanson, S., & Biousse, V. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s031716710000860x · Cited by 16
The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome
Ahlgren, C., Odén, A., Haghighi, S., Andersen, O., Bergström, T. B., & Lycke, J. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.04.002 · Cited by 16
Clinically isolated syndrome: the rationale for early treatment
Comı, G. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0772 · Cited by 16
Biomarkers as precursors of disability
Davillas, A., & Pudney, S. E. (2019) · Economics & Human Biology · doi:10.1016/j.ehb.2019.100814 · Cited by 16
The Influence of Immunomodulation on Psycho-Neuroimmunological Functions in Benign Multiple Sclerosis
Haase, C. G., Tinnefeld, M., & Faustmann, P. M. (2004) · NeuroImmunoModulation · doi:10.1159/000080146 · Cited by 16
Magnetic resonance-based techniques for the study and management of multiple sclerosis
Rovaris, M., Rocca, M. A., & Filippi, M. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.133 · Cited by 16
Long-term Brain Magnetic Resonance Imaging Changes After Optic Neuritis in Patients Without Clinically Definite Multiple Sclerosis
Optic Neuritis Study Group (2004) · Archives of Neurology · doi:10.1001/archneur.61.10.1538 · Cited by 16
The effect of interferon-beta1a on relapses and progression of disability in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis
Motamed, M. R., Najimi, N., & Fereshtehnejad, S. (2007) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2007.01.007 · Cited by 15
Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis
Otero‐Romero, S., Carbonell‐Mirabent, P., Midaglia, L. S., Rodas, M. I. Z., Galán, I., Cobo‐Calvo, Á., Río, J., Arrambide, G., Vidal‐Jordana, Á., Castilló, J., et al. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211053001 · Cited by 15
Clinically Isolated Syndrome and Early Relapsing Multiple Sclerosis
Metz, L. M. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000729 · Cited by 15
Autoimmune Myelopathies
Flanagan, E. P., Lennon, V. A., & Pittock, S. J. (2011) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000403795.20914.6c · Cited by 15
Disease-modifying agents in multiple sclerosis
O'Connor, P. W., & Oh, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00021-2 · Cited by 15
Update on Multiple Sclerosis
Simon, J. H. (2006) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2005.08.005 · Cited by 15
Can clinical outcomes be used to detect neuroprotection in multiple sclerosis?
Khan, O. (2007) · Neurology · doi:10.1212/01.wnl.0000275235.43506.d2 · Cited by 15
Volumetric reconstruction from printed films: Enabling 30 year longitudinal analysis in MR neuroimaging
Ebner, M., Chung, K. K., Prados, F., Cardoso, M. J., Chard, D., Vercauteren, T. K., & Sebastien Ourselin, A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.09.056 · Cited by 14
The clinical-radiological paradox in multiple sclerosis: myth or truth?
Hartmann, A., Noro, F., Bahia, P. R. V., Fontes-Dantas, F. L., Andreiuolo, R. F., Lopes, F. C. R., Pereira, V. C. S. R., Coutinho, R., de Araújo, A. D., Marchiori, E. D. S., et al. (2023) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0042-1758457 · Cited by 14
Molecular mimicry in neurological disease: what is the evidence?
Lee, S., & Levin, M. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7312-7 · Cited by 14
Food allergies are associated with increased disease activity in multiple sclerosis
Fakih, R., Diaz‐Cruz, C., Chua, A. S., Gonzalez, C. T., Healy, B. C., Sattarnezhad, N., Glanz, B. I., Weiner, H. L., & Chitnis, T. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319301 · Cited by 14
Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing–remitting multiple sclerosis
Wybrecht, D., Françoise Reuter, A., Zaaraoui, W., Faivre, A., Crespy, L., Rico, A., Irina Malikova, A., Sylviane Confort-gouny, A., Soulier, E., Cozzone, P. J., et al. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512442991 · Cited by 14
Predictive value of MRI findings in multiple sclerosis
Filippi, M. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00008-x · Cited by 14
Magnetic resonance imaging techniques to define and monitor tissue damage and repair in multiple sclerosis
Filippi, M., & Rocca, M. A. (2007) · Journal of Neurology · doi:10.1007/s00415-007-1010-0 · Cited by 14
Neuroimaging in multiple sclerosis
Traboulsee, A. L., Zhao, G., & Li, D. K. B. (2005) · Neurologic Clinics · doi:10.1016/j.ncl.2004.10.001 · Cited by 14
Evidence for the efficacy of interferon beta-1b in delaying the onset of clinically definite multiple sclerosis in individuals with clinically isolated syndrome
Freedman, M. S. (2014) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285614549554 · Cited by 13
Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis
Fleischer, V., Brummer, T., Muthuraman, M., Steffen, F., Heldt, M. B. O. T., Protopapa, M., Schraad, M., González‐Escamilla, G., Groppa, S., Bittner, S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1532660 · Cited by 13
Differential Diagnosis, Clinical Features, and Prognosis of Multiple Sclerosis
Olek, M. J. (2005) · Humana Press eBooks · doi:10.1385/1-59259-855-2:015 · Cited by 13
Predictive nature of IgM anti-α-glucose serum biomarker for relapse activity and EDSS progression in CIS patients: a BENEFIT study analysis
Freedman, M., Metzig, C., Kappos, L., Polman, C. H., Edan, G., Hartung, H.-P., Miller, D., Montalbán, X., Yarden, J., Spector, L., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511432327 · Cited by 13
Self-citation
Imaging biomarkers in multiple Sclerosis: From image analysis to population imaging
Barillot, C., Edan, G., & Commowick, O. (2016) · Medical Image Analysis · doi:10.1016/j.media.2016.06.017 · Cited by 13
Diffusion Tensor Magnetic Resonance Imaging in Patients with Multiple Sclerosis and its Relationship with Disability
TEMEL, Ş., Kekliğkoğlu, H. D., Vural, G., Denız, O., & Ercan, K. (2013) · The Neuroradiology Journal · doi:10.1177/197140091302600101 · Cited by 13
Clinical and Radiological Characteristics in Multiple Sclerosis Patients with Large Cavitary Lesions
Renard, D., Brochet, B., Vukusic, S., Edan, G., Deburghgraeve, V., Goizet, C., Dupuy, D., Touzé, E., Deschamps, R., Zephyr, H., et al. (2012) · European Neurology · doi:10.1159/000338476 · Cited by 13
Predicting Conversion to MS - The Role of a History Suggestive of Demyelination
Morrow, S. A., Fraser, J. A., Nicolle, D. A., & Kremenchutzky, M. (2010) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100010519 · Cited by 13
Serum IgG repertoire in clinically isolated syndrome predicts multiple sclerosis
Zéphir, H., Lefranc, D., Dubucquoi, S., Seze, J. D., Boron, L., Prin, L., & Vermersch, P. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458508101951 · Cited by 12
Neuroimaging in Multiple Sclerosis
Ali, E. N., & Buckle, G. J. (2008) · Neurologic Clinics · doi:10.1016/j.ncl.2008.09.012 · Cited by 13
Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal study
Rashid, W., Davies, G., Chard, D., Griffin, C., Altmann, D. R., Thompson, A. J., & Miller, D. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506070758 · Cited by 13
Self-citation
Multiple Sclerosis and Other Inflammatory Demyelinating Diseases of the Central Nervous System
Houtchens, M. K., LUBLIN, F. D., Miller, A., & Khoury, S. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0434-1.00079-7 · Cited by 13
Horizontal monocular saccadic failure: an unusual clinically isolated syndrome progressing to multiple sclerosis
Frohman, E. M., & Frohman, T. C. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms864oa · Cited by 13
The importance of long-term data in multiple sclerosis
Montalbán, X. (2006) · Journal of Neurology · doi:10.1007/s00415-006-6003-x · Cited by 13
Patients with clinically isolated syndromes suggestive of MS
Giovannoni, G., & Bever, C. T. (2003) · Neurology · doi:10.1212/wnl.60.1.6 · Cited by 13
Évènements neurologiques sous traitement par anti-TNF alpha
Cohen, M., Baldin, B., Thomas, P., & Lebrun‐Frénay, C. (2011) · Revue Neurologique · doi:10.1016/j.neurol.2011.06.005 · Cited by 12
A lag functional linear model for prediction of magnetization transfer ratio in multiple sclerosis lesions
Pomann, G., Staicu, A., Lobaton, E. J., Mejia, A. F., Dewey, B. E., Reich, D. S., Sweeney, E. M., & Shinohara, R. T. (2016) · The Annals of Applied Statistics · doi:10.1214/16-aoas981 · Cited by 12
Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage
Chen, Q., Hattori, T., Tomisato, H., Ohara, M., Hirata, K., Yokota, T., & Initiative, A. D. N. (2022) · Human Brain Mapping · doi:10.1002/hbm.26151 · Cited by 12
Conversion from radiologically isolated syndrome to multiple sclerosis.
Etemadifar, M., Janghorbani, M., Koushki, M. M., Etemadifar, F., & Fereidan-Esfahani, M. (2014) · Europe PMC (PubMed Central) · Cited by 12
New magnetic resonance imaging biomarkers for the diagnosis of multiple sclerosis
Filippi, M., & Rocca, M. A. (2012) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2012.657624 · Cited by 13
Multiple Sclerosis: Clinical Features, Pathophysiology, Neuroimaging and Future Therapies
Borazanci, A., Harris, M. K., Schwendimann, R. N., Gonzalez‐Toledo, E., Maghzi, A. H., Etemadifar, M., Alekseeva, N., Pinkston, J. B., Kelley, R. E., & Minagar, A. (2009) · Future Neurology · doi:10.2217/14796708.4.2.229 · Cited by 12
Intensity ratio to improve black hole assessment in multiple sclerosis
Adusumilli, G., Trinkaus, K. M., Sun, P., Lancia, S., Viox, J. D., Wen, J., Naismith, R. T., & Cross, A. H. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.11.020 · Cited by 12
Biomarkers of Multiple Sclerosis
Pastare, D., Bennour, M. R., Polunosika, E., & Karelis, G. (2019) · The Open Immunology Journal · doi:10.2174/1874226201909010001 · Cited by 13
Multiple sclerosis therapy: An update on recently finished trials
Kleinschnitz, C., Meuth, S. G., Stüve, O., Kieseier, B. C., & Wiendl, H. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0684-7 · Cited by 12
Retrospective comparison of the original and revised McDonald criteria in a general neurology practice in Ireland
McHugh, J. C., Galvin, P. L., & Murphy, R. P. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507081169 · Cited by 12
Validation of the Patient-Determined Disease Steps in ambulatory older adults with multiple sclerosis
Leavenworth, R. C., Wagshul, M. E., Motl, R. W., Foley, F. W., & Holtzer, R. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106391 · Cited by 11
Multiple sclerosis should be treated using a step-down strategy rather than a step-up strategy–NO
Naismith, R. T. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516644676 · Cited by 11
Magnetic Resonance Imaging as a Prognostic Disability Marker in Clinically Isolated Syndrome and Multiple Sclerosis: A Systematic Review and Meta-Analysis
AlTokhis, A. I., AlAmrani, A., Alotaibi, A., Podlasek, A., & Constantinescu, C. S. (2022) · Diagnostics · doi:10.3390/diagnostics12020270 · Cited by 11
Precision medicine for multiple sclerosis: an update of the available biomarkers and their use in therapeutic decision making
Valdeolivas, I. P., Zubizarreta, I., Martínez‐Lapiscina, E. H., & Villoslada, P. (2017) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2017.1393315 · Cited by 11
MRI in predicting conversion to multiple sclerosis within 1 year
Eran, A., García, M., Malouf, R., Bosak, N., Wagner, R., Ganelin‐Cohen, E., Artsy, E., Shifrin, A., & Rozenberg, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1042 · Cited by 11
Oxidative Status in Multiple Sclerosis and Off-Targets of Antioxidants: The Case of Edaravone
Agresti, C., Mechelli, R., Olla, S., Veroni, C., Eleuteri, C., Ristori, G., & Salvetti, M. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190124122752 · Cited by 11
Continuing Education
Carter, B. L., Rodby, R. A., Orland, B. I., Lewis, S. J., & Hunsicker, L. G. (2004) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2004.10.s5-a.s26 · Cited by 11
Multiple Sclerosis and Other Demyelinating Diseases
Soldan, S. S., Wu, G. F., Markowitz, C., & Kolson, D. L. (2008) · Springer eBooks · doi:10.1007/978-0-387-72573-4_18 · Cited by 11
CLINICAL FEATURES OF MULTIPLE SCLEROSIS
Miller, A., & Coyle, P. K. (2004) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000293634.15851.7d · Cited by 11
Radiologically isolated syndrome and clinically isolated syndrome
Niino, M., & Miyazaki, Y. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12346 · Cited by 11
A minimal unified model of disease trajectories captures hallmarks of multiple sclerosis
Kannan, V., Kiani, N. A., Piehl, F., & Tegner, J. N. (2017) · Mathematical Biosciences · doi:10.1016/j.mbs.2017.03.006 · Cited by 12
Optic disk hemorrhage in health and disease
Razeghinejad, R., & Nowroozzadeh, M. H. (2017) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2017.04.001 · Cited by 11
The curious incident of disability in multiple sclerosis trials
Coles, A. J. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70585-3 · Cited by 11
Multiple sclerosis and Alzheimer disease through the looking glass of MR imaging.
Frisoni, G. B., & Filippi, M. (2005) · PubMed Central · Cited by 11
MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS
Wolinsky, J. S. (2004) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000293629.92979.1f · Cited by 11
Predictors of short-term disease activity following a first clinical demyelinating event: analysis of the CHAMPS placebo groupy
CHAMPS Study Group (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms825oa · Cited by 11
Simultaneous lesion and neuroanatomy segmentation in Multiple Sclerosis using deep neural networksPreprint
McKinley, R., Wepfer, R., Aschwanden, F., Grunder, L., Muri, R., Rummel, C., Verma, R. K., Weisstanner, C., Reyes, M., Salmen, A., et al. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1901.07419 · Cited by 11
MRI features and disability in multiple sclerosis: A systematic review and meta-analysis
Nabizadeh, F., Zafari, R., Mohamadi, M., Maleki, T., Fallahi, M. S., & Rafiei, N. (2024) · Journal of Neuroradiology · doi:10.1016/j.neurad.2023.11.007 · Cited by 13

Authors: Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
Otto-von-Guericke-Universität Magdeburg (DE)
ORCID: Ciccarelli, Olga
Sailer, Michael
Thompson, Alan J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2002-01-17
Volume: 346
Issue: 3
Pages: 158-164
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa011341
OpenAlex: W1966515383
Cited by: 861
References: 42
Citations by year: 2026: 5 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 23 · 2018: 27 · 2017: 33 · 2016: 30 · 2015: 32 · 2014: 44 · 2013: 34 · 2012: 40
FWCI: 36.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Multiple Sclerosis Society
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: multiple sclerosis, long-term disability, Expanded Disability Status Scale, optic neuritis, spinal cord syndromes, T2-weighted MRI, disease-modifying therapy, disease progression
MeSH terms: Adolescent, Adult, Brain, Brain Diseases, Brain Stem, Disability Evaluation, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Optic Neuritis, Spinal Cord Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks