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Cited by 861Multiple Sclerosis Research StudiesPolyomavirus and related diseasesPeripheral Neuropathies and Disorders

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

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Brex, Peter A., Ciccarelli, Olga, O'Riordan, Jonathon I., Sailer, Michael, Thompson, Alan J., Miller, David H.·2002·New England Journal of Medicine
DOI 10.1056/nejmoa011341
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Abstract

Background In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, changes in volume, and long-term disability. Methods Seventy-one patients in a serial MRI study of patients with isolated syndromes were reassessed after a mean of 14.1 years. Disability was measured with the use of Kurtzke's Expanded Disability Status Scale (EDSS; possible range, 0 to 10, with a higher score indicating a greater degree of disability). Results Clinically definite multiple sclerosis developed in 44 of the 50 patients (88 percent) with abnormal results on MRI at presentation and in 4 of 21 patients (19 percent) with normal results on MRI. The median EDSS score at follow-up for those with multiple sclerosis was 3.25 (range, 0 to 10); 31 percent had an EDSS score of 6 or more (including three patients whose deaths were due to multiple sclerosis). The EDSS score at 14 years correlated moderately with lesion volume on MRI at 5 years (r=0.60) and with the increase in lesion volume over the first 5 years (r=0.61). Conclusions In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance im…

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Research works printed but not linked: 2

  1. Molyneux PD, 1998, AJNR Am J Neuroradiol, 19, 1715
  2. Paty DW, 1993, Neurology, 43, 6627

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Metadata

Authors
Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H.
Affiliations
  • National Hospital for Neurology and Neurosurgery (GB)
  • Otto-von-Guericke-Universität Magdeburg (DE)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2002-01-17
Volume
346
Issue
3
Pages
158-164
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa011341
OpenAlex
W1966515383
Cited by
861
References
42
Citations by year
2026: 5 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 23 · 2018: 27 · 2017: 33 · 2016: 30 · 2015: 32 · 2014: 44 · 2013: 34 · 2012: 40
FWCI
36.73
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Multiple Sclerosis Society
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
multiple sclerosis, long-term disability, Expanded Disability Status Scale, optic neuritis, spinal cord syndromes, T2-weighted MRI, disease-modifying therapy, disease progression
MeSH terms
Adolescent, Adult, Brain, Brain Diseases, Brain Stem, Disability Evaluation, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Optic Neuritis, Spinal Cord Diseases

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