The DOI matches its Crossref record, with a small difference in title or year; 34 of the 35 references it cites were found in a registry or an index.
Estrogen plus Progestin and the Risk of Coronary Heart Disease
Open accessAbstract
BACKGROUND: Recent randomized clinical trials have suggested that estrogen plus progestin does not confer cardiac protection and may increase the risk of coronary heart disease (CHD). In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI). METHODS: The WHI included a randomized primary-prevention trial of estrogen plus progestin in 16,608 postmenopausal women who were 50 to 79 years of age at base line. Participants were randomly assigned to receive conjugated equine estrogens (0.625 mg per day) plus medroxyprogesterone acetate (2.5 mg per day) or placebo. The primary efficacy outcome of the trial was CHD (nonfatal myocardial infarction or death due to CHD). RESULTS: After a mean follow-up of 5.2 years (planned duration, 8.5 years), the data and safety monitoring board recommended terminating the estrogen-plus-progestin trial because the overall risks exceeded the benefits. Combined hormone therapy was associated with a hazard ratio for CHD of 1.24 (nominal 95 percent confidence interval, 1.00 to 1.54; 95 percent confidence interval after adjustment for sequential monitoring, 0.97 to 1.60). The elevation in risk was most apparent at one year (hazard ratio, 1.81 [95 percent confidence interval, 1.09 to 3.01]). Although higher base-line levels of low-density lipoprotein cholesterol were associated with an excess risk of CHD among women who received hormone therapy, higher base-line levels of C-reactive protein, other biomarkers, and other clinical characteristics did not significantly modify the treatment-related risk of CHD. CONCLUSIONS: Estrogen plus progestin does not confer cardiac protection and may increase the risk of CHD among generally healthy postmenopausal women, especially during the first year after the initiation of hormone use. This treatment should not be prescribed for the prevention of cardiovascular disease.
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“Although there have been no placebo-controlled trials in children, observational studies have suggested that early treatment can reduce LDL-C burden, improve endothelial function, substantially attenuate the development of atherosclerosis, and improve coronary outcomes [369-371].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [371]
In the citing paper
“Although there have been no placebo-controlled trials in children, observational studies have suggested that early treatment can reduce LDL-C burden, improve endothelial function, substantially attenuate the development of atherosclerosis, and improve coronary outcomes [369-371].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [371]
In the citing paper
“Although there have been no placebo-controlled trials in children, observational studies have suggested that early treatment can reduce LDL-C burden, improve endothelial function, substantially attenuate the development of atherosclerosis, and improve coronary outcomes [369-371].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [371]
In the citing paper
“Although there have been no placebo-controlled trials in children, observational studies have suggested that early treatment can reduce LDL-C burden, improve endothelial function, substantially attenuate the development of atherosclerosis, and improve coronary outcomes [369-371].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [371]
In the citing paper
“Oestrogen replacement therapy, despite some favourable effects on the lipid profile, has not been demonstrated to reduce CV risk and cannot be recommended for CV prevention in women.166”
From ESC/EAS Guidelines for the management of dyslipidaemias (2011) · cites this paper as [166]
In the citing paper
“Oestrogen replacement therapy, despite some favourable effects on the lipid profile, has not been demonstrated to reduce CV risk and cannot be recommended for CVD prevention in women. 318”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [318]
In the citing paper
“and the higher palatability and acceptance of MeDiets in comparison with low-fat diets 17,18 lend support to our hypothesis.”
From Cohort Profile: Design and methods of the PREDIMED study (2012) · cites this paper as [18]
In the citing paper
“Oestrogen replacement therapy, despite some favourable effects on the lipid profile, has not been demonstrated to reduce CV risk and cannot be recommended for CVD prevention in women.318”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [318]
In the citing paper
“however, hormone replacement therapy does not consistently restore BP, suggesting additional regulatory mechanisms [ 177 ].”
From Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications (2026) · cites this paper as [177]
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Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Hulley, S. (1998) · JAMA · doi:10.1001/jama.280.7.605 · Cited by 6,216
The Protective Effects of Estrogen on the Cardiovascular System
Mendelsohn, M. E., & Karas, R. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402306 · Cited by 3,119
Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698
Design of the Women’s Health Initiative Clinical Trial and Observational Study
The Women’s Health Initiative Study Group (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)00078-0 · Cited by 2,580
Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women
Grady, D., Rubin, S. M., Petitti, D. B., Fox, C. S., Black, D. M., Ettinger, B. B., Ernster, V. L., & Cummings, S. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-1016 · Cited by 2,329
Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy
Grady, D. G., Herrington, D. M., Bittner, V., Blumenthal, R. S., Davidson, M., Hlatky, M. A., Hsia, J. A., Hulley, S. B., Herd, A. J., Khan, S. S., et al. (2002) · JAMA · doi:10.1001/jama.288.1.49 · Cited by 1,921
Self-citationEffect of Statin Therapy on C-Reactive Protein Levels
Albert, M. A., Danielson, E., Rifai, N., Ridker, P. M., & for the PRINCE Investigators (2001) · JAMA · doi:10.1001/jama.286.1.64 · Cited by 1,644
Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis
Herrington, D. M., Reboussin, D. M., Brosnihan, K. B., Sharp, P. C., Shumaker, S. A., Snyder, T. E., Furberg, C. D., Kowalchuk, G. J., Stuckey, T. D., Rogers, W. J., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008243430801 · Cited by 1,242
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Gencel, V. B., Benjamin, M. M., Bahou, S. N., & Khalil, R. A. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712798995020 · Cited by 134
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol
Guo, Y., Zhao, M., Bo, T., Ma, S., Yuan, Z., Chen, W., He, Z., Hou, X. H., Liu, J., Zhang, Z., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0123-6 · Cited by 132
Nelson, H. D., Walker, M., Zakher, B., & Mitchell, J. P. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-2-201207170-00466 · Cited by 132
An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology
Rybaczyk, L. A., Bashaw, M. J., Pathak, D. R., Moody, S. M., Gilders, R. M., & Holzschu, D. L. (2005) · BMC Women s Health · doi:10.1186/1472-6874-5-12 · Cited by 128
Frei-Kleiner, S., Schaffner, W., Rahlfs, V. W., Bodmer, C., & Birkhäuser, M. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.10.003 · Cited by 127
Pelzer, T., Arias-Loza, P.-A., Hu, K., Bayer, B., Dienesch, C., Calvillo, L., Couse, J. F., Korach, K. S., Neyses, L., & Ertl, G. (2005) · Circulation · doi:10.1161/01.cir.0000159262.18512.46 · Cited by 128
Women-Specific Factors to Consider in Risk, Diagnosis and Treatment of Cardiovascular Disease
Harvey, R. E., Coffman, K. E., & Miller, V. M. (2015) · Women s Health · doi:10.2217/whe.14.64 · Cited by 124
Sex and haemodynamics in pulmonary arterial hypertension
Ventetuolo, C. E., Praestgaard, A. H., Palevsky, H. I., Klinger, J. R., Halpern, S. D., & Kawut, S. M. (2013) · European Respiratory Journal · doi:10.1183/09031936.00027613 · Cited by 124
Sex hormones, aging and cardiometabolic syndrome
Faulkner, J., & de Chantemèle, E. J. B. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0246-6 · Cited by 124
Optimising health after early menopause
Mishra, G. D., Davies, M. C., Hillman, S., Chung, H., Roy, S., Maclaran, K., & Hickey, M. (2024) · The Lancet · doi:10.1016/s0140-6736(23)02800-3 · Cited by 132
Mendelsohn, M. E., & Karas, R. H. (2007) · New England Journal of Medicine · doi:10.1056/nejme078072 · Cited by 123
Acute Myocardial Infarction During Pregnancy and the Puerperium in the United States
Smilowitz, N. R., Gupta, N., Guo, Y., Zhong, J., Weinberg, C. R., Reynolds, H. R., & Bangalore, S. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.04.019 · Cited by 122
Sex differences in non-obstructive coronary artery disease
Waheed, N., Elias‐Smale, S. E., Malas, W., Maas, A. H. E. M., Sedlak, T., Tremmel, J. A., & Mehta, P. K. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa001 · Cited by 126
Update in Hormone Therapy Use in Menopause
Taylor, H. S., & Manson, J. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0536 · Cited by 121
Self-citationSex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors
Clegg, D. J., Hevener, A. L., Moreau, K. L., Morselli, E., Criollo, A., Pelt, R. E. V., & Vieira‐Potter, V. J. (2017) · Endocrinology · doi:10.1210/en.2016-1677 · Cited by 126
Hormone therapy and risk of myocardial infarction: a national register study
Løkkegaard, E., Andreasen, A. H., Jacobsen, R. K., Nielsen, L. H., Agger, C., & Lidegaard, Ø. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn408 · Cited by 120
White, W. B., Hanes, V., Chauhan, V., & Pitt, B. (2006) · Hypertension · doi:10.1161/01.hyp.0000232179.60442.84 · Cited by 119
The Women's Health Initiative trial and related studies: 10 years later: A clinician's view
Gurney, E. P., Nachtigall, M. J., Nachtigall, L. E., & Naftolin, F. N. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.009 · Cited by 125
Where Are We 10 Years After the Women's Health Initiative?
Lobo, R. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4070 · Cited by 123
Mix, T.-C. H., Brenner, R. M., Cooper, M. E., de Zeeuw, D., Ivanovich, P. T., Levey, A. S., McGill, J. B., McMurray, J. J. V., Parfrey, P. S., Parving, H., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.09.047 · Cited by 119
Beyond BMI: the need for new guidelines governing the use of bariatric and metabolic surgery
Cummings, D. E., & COHEN, R. V. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70198-0 · Cited by 120
Hormone replacement therapy – where are we now?
Langer, R. D., Hodis, H. N., Løbo, R. A., & Allison, M. (2021) · Climacteric · doi:10.1080/13697137.2020.1851183 · Cited by 118
Vitamin D and Cardiovascular Disease
Nemerovski, C. W., Dorsch, M. P., Simpson, R. U., Bone, H. G., Aaronson, K. D., & Bleske, B. E. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.6.691 · Cited by 118
Zhao, L., O’Neill, K. E., & Brinton, R. D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.009 · Cited by 120
Correlates of Peripheral Blood Mitochondrial DNA Content in a General Population
Knez, J., Winckelmans, E., Plusquin, M., Thijs, L., Cauwenberghs, N., Gu, Y., Staessen, J. A., Nawrot, T. S., & Kuznetsova, T. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv175 · Cited by 121
Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens
Jiang, Y., Gong, P., Madak‐Erdogan, Z., Martin, T. A., Jeyakumar, M., Carlson, K. E., Khan, I. A., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-234617 · Cited by 116
Batulan, Z., Venu, V. K. P., Li, Y., Koumbadinga, G. A., Alvarez-Olmedo, D., Shi, C., & O’Brien, E. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00285 · Cited by 120
Effects of soy isoflavones on endothelial function in healthy postmenopausal women
Colacurci, N., Chiàntera, A., Fornaro, F., de Novellis, V., Manzella, D., Arciello, A., Chiàntera, V., Improta, L., & Paolisso, G. (2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000147017.23173.5b · Cited by 116
Gender determinants of cardiovascular risk factors and diseases
Mercuro, G. G., Deidda, M., Piras, A., Dessalvi, C. C., Maffei, S., & Rosano, G. M. C. (2010) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32833178ed · Cited by 114
Neuroprotection and Estrogen Receptors
Simpkins, J. W., Singh, M., Brock, C., & Etgen, A. M. (2012) · Neuroendocrinology · doi:10.1159/000338409 · Cited by 114
Dietel, M., Lewis, M. A., & Shapiro, S. (2005) · Human Reproduction · doi:10.1093/humrep/dei043 · Cited by 114
Endogenous Postmenopausal Hormones and Serum Lipids: The Atherosclerosis Risk in Communities Study
Mudali, S., Dobs, A. S., Ding, J., Cauley, J. A., Szklo, M., & Golden, S. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0744 · Cited by 115
The Women's Health Initiative: Lessons Learned
Prentice, R. L., & Anderson, G. L. (2008) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.29.020907.090947 · Cited by 114
Guo, J. P., Nikolic, D. S., Chadwick, L. R., Pauli, G. F., & van Breemen, R. B. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.008250 · Cited by 113
Multimarker Prediction of Coronary Heart Disease Risk
Kim, H. C., Greenland, P., Rossouw, J. E., Manson, J. E., Cochrane, B. B., Lasser, N. L., Limacher, M. C., Lloyd‐Jones, D. M., Margolis, K. L., & Robinson, J. G. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.047 · Cited by 113
Self-citationLiu, D., Homan, L. L., & Dillon, J. S. (2004) · Endocrinology · doi:10.1210/en.2004-0102 · Cited by 112
Iron Stores and Vascular Function in Voluntary Blood Donors
Zheng, H., Cable, R. G., Spencer, B. R., Votto, N., & Katz, S. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000174126.28201.61 · Cited by 112
Toh, S., Hernández–Dı́az, S., Logan, R., Rossouw, J. E., & Hernán, M. Á. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-4-201002160-00005 · Cited by 111
Self-citationTiming and Duration of Menopausal Hormone Treatment May Affect Cardiovascular Outcomes
Harman, S. M., Vittinghoff, E., Brinton, E. A., Budoff, M. J., Cedars, M. I., Løbo, R. A., Merriam, G. R., Miller, V. M., Naftolin, F. N., Pal, L., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.09.021 · Cited by 114
Measuring Hot Flashes: Summary of a National Institutes of Health Workshop
Miller, H. G., & Li, R. M. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.6.777 · Cited by 111
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Moyer, V. A., & Butler, M. (2004) · Pediatrics · doi:10.1542/peds.2004-1076 · Cited by 109
Gender differences in risk factors for coronary heart disease
Tan, Y. Y., Herber-Gast, G.-C. M., & van der Schouw, Y. T. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.09.023 · Cited by 109
Gierach, G. L., Johnson, B. D., Merz, C. N. B., Kelsey, S. F., Bittner, V., Olson, M. B., Shaw, L. J., Mankad, S. V., Pepine, C. J., Reís, S. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.099 · Cited by 109
Lipoprotein(a), Hormone Replacement Therapy, and Risk of Future Cardiovascular Events
Danik, J. S., Rifai, N., Buring, J. E., & Ridker, P. M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.009 · Cited by 111
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Pinkerton, J. V., Guico‐Pabia, C. J., & Taylor, H. S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.061 · Cited by 108
Lindsey, S. H., Carver, K. A., Prossnitz, E. R., & Chappell, M. C. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182135f1c · Cited by 107
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Lønning, P. E., & Eikesdal, H. P. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0099 · Cited by 111
Collins, P. D., Mosca, L. J., Geiger, M. J., Grady, D. G., Kornitzer, M., Amewou-Atisso, M. G., Effron, M. B., Dowsett, S. A., Barrett-Connor, E. L., & Wenger, N. K. (2009) · Circulation · doi:10.1161/circulationaha.108.817577 · Cited by 107
White, W. B., Pitt, B., Preston, R. A., & Hanes, V. (2005) · Circulation · doi:10.1161/circulationaha.104.501502 · Cited by 107
Demer, L. L., Hsu, J. J., & Tintut, Y. (2018) · Circulation Research · doi:10.1161/circresaha.118.311585 · Cited by 106
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Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26130 · Cited by 105
Soumerai, S., Starr, D., & Majumdar, S. (2015) · Preventing Chronic Disease · doi:10.5888/pcd12.150187 · Cited by 103
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Sliwa, K. S., & Böhm, M. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu012 · Cited by 105
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Du, X. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.027 · Cited by 104
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Choi, H. K., Nguyen, U., Niu, J., Danaei, G., & Zhang, Y. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.36 · Cited by 103
Kim, K. H., Kang, K., Kim, D., Kim, H. J., Yoon, H.-M., Lee, J., Jeong, J. C., Lee, M. S., Jung, H. J., & Choi, S. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181bfac3b · Cited by 102
Khaodhiar, L., Ricciotti, H. A., Li, L., Pan, W., Schickel, M., Zhou, J., & Blackburn, G. L. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31805c035b · Cited by 102
Sitruk-Ware, R. L. (2004) · Drugs & Aging · doi:10.2165/00002512-200421130-00004 · Cited by 102
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Sierksma, A., Sarkola, T., Eriksson, C. J. P., van der Gaag, M. S., Grobbee, D. E., & Hendriks, H. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000125356.70824.81 · Cited by 100
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Link, J. C., Chen, X., Prien, C., Borja, M. S., Hammerson, B., Oda, M. N., Arnold, A. P., & Reue, K. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305460 · Cited by 97
Sherwood, A., Bower, J. K., McFetridge-Durdle, J., Blumenthal, J. A., Newby, L. K., & Hinderliter, A. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145383 · Cited by 97
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Metadata
- Authors
- Manson, J. E., Hsia, J., Johnson, K. C., Rossouw, J. E., Assaf, A. R., Lasser, N. L., Trevisan, M., Black, H. R., Heckbert, S. R., Detrano, R., Strickland, O. L., Wong, N. D., Crouse, J. R., Stein, E., & Cushman, M.
- Affiliations
- Brigham and Women's Hospital (US)
- George Washington University (US)
- University of Tennessee Health Science Center (US)
- National Heart, Lung, and Blood Institute (US)
- Memorial Hospital of Rhode Island (US)
- Rutgers New Jersey Medical School (US)
- University at Buffalo, State University of New York (US)
- Rush University Medical Center (US)
- University of Washington (US)
- University of California, Los Angeles (US)
- Emory University (US)
- University of California, Irvine (US)
- Wake Forest University (US)
- University of Vermont (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-08-07
- Volume
- 349
- Issue
- 6
- Pages
- 523-534
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1981922048
- Cited by
- 2,065
- References
- 35
- Citations by year
- 2026: 32 · 2025: 43 · 2024: 34 · 2023: 32 · 2022: 33 · 2021: 43 · 2020: 51 · 2019: 48 · 2018: 51 · 2017: 59 · 2016: 42 · 2015: 67 · 2014: 73 · 2013: 109 · 2012: 99
- FWCI
- 123.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- estrogen plus progestin, coronary artery disease, hormone replacement therapy, Women's Health Initiative, postmenopausal women, conjugated equine estrogens, medroxyprogesterone acetate, myocardial infarction, cardiovascular risk, LDL cholesterol, C-reactive protein, trial termination
- MeSH terms
- Aged, Coronary Disease, Double-Blind Method, Drug Combinations, Estrogens, Conjugated (USP), Female, Follow-Up Studies, Heart Diseases, Humans, Middle Aged, Myocardial Infarction, Risk Factors, Proportional Hazards Models, Case-Control Studies, Treatment Outcome, Medroxyprogesterone Acetate, Postmenopause, Hormone Replacement Therapy, Progesterone Congeners
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