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Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia
Open accessAbstract
BACKGROUND: Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined. METHODS: We studied a cohort of 221 children with high-risk B-cell-progenitor ALL with the use of single-nucleotide-polymorphism microarrays, transcriptional profiling, and resequencing of samples obtained at diagnosis. Children with known very-high-risk ALL subtypes (i.e., BCR-ABL1-positive ALL, hypodiploid ALL, and ALL in infants) were excluded from this cohort. A copy-number abnormality was identified as a predictor of poor outcome, and it was then tested in an independent validation cohort of 258 patients with B-cell-progenitor ALL. RESULTS: More than 50 recurring copy-number abnormalities were identified, most commonly involving genes that encode regulators of B-cell development (in 66.8% of patients in the original cohort); PAX5 was involved in 31.7% and IKZF1 in 28.6% of patients. Using copy-number abnormalities, we identified a predictor of poor outcome that was validated in the independent validation cohort. This predictor was strongly associated with alteration of IKZF1, a gene that encodes the lymphoid transcription factor IKAROS. The gene-expression signature of the group of patients with a poor outcome revealed increased expression of hematopoietic stem-cell genes and reduced expression of B-cell-lineage genes, and it was similar to the signature of BCR-ABL1-positive ALL, another high-risk subtype of ALL with a high frequency of IKZF1 deletion. CONCLUSIONS: Genetic alteration of IKZF1 is associated with a very poor outcome in B-cell-progenitor ALL.
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“In mice, both Ikzf1 and Ikzf3 are required for normal T cell development and maintenance of mature T cell populations88,89”
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Mullighan, C. G., Goorha, S., Radtke, I., Miller, C. B., Coustan‐Smith, E., Dalton, J., Girtman, K., Mathew, S., Ma, J., Pounds, S. B., et al. (2007) · Nature · doi:10.1038/nature05690 · Cited by 1,777
Self-citationPui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Self-citationBCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature · doi:10.1038/nature06866 · Cited by 1,072
Self-citationThe ikaros gene is required for the development of all lymphoid lineages
Georgopoulos, K., Bigby, M., Wang, J.-H., Molnar, A., Wu, P., Winandy, S., & Sharpe, A. (1994) · Cell · doi:10.1016/0092-8674(94)90407-3 · Cited by 985
Borowitz, M. J., Devidas, M., Hunger, S. P., Bowman, W. P., Carroll, A. J., Carroll, W. L., Linda, S. B., Martin, P. L., Pullen, D. J., Viswanatha, D. S., et al. (2008) · Blood · doi:10.1182/blood-2008-01-132837 · Cited by 841
Self-citationPrediction by Supervised Principal Components
Bair, E., Hastie, T. J., Paul, D., & Tibshirani, R. J. (2006) · Journal of the American Statistical Association · doi:10.1198/016214505000000628 · Cited by 824
Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
Mullighan, C. G., Phillips, L. A., Su, X., Ma, J., Miller, C. B., Shurtleff, S. A., & Downing, J. R. (2008) · Science · doi:10.1126/science.1164266 · Cited by 806
Self-citationOn testing the significance of sets of genes
Efron, B., & Tibshirani, R. J. (2007) · The Annals of Applied Statistics · doi:10.1214/07-aoas101 · Cited by 785
Semi-Supervised Methods to Predict Patient Survival from Gene Expression Data
Bair, E., & Tibshirani, R. J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020108 · Cited by 749
Flagged first, then by citations
Research works printed but not linked: 3
- Shuster JJ, 1999, Cancer Res Ther Control, 9, 101
- Pui CH, 2006, Ann Hematol, 85, 88
- Mirebeau D, 2006, Haematologica, 91, 881
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Liu, Y., Easton, J., Shao, Y., Maciaszek, J., Wang, Z., Wilkinson, M. R., McCastlain, K., Edmonson, M., Pounds, S. B., Shi, L., et al. (2017) · Nature Genetics · doi:10.1038/ng.3909 · Cited by 918
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Self-citationHarvey, R. C., Mullighan, C. G., Chen, I., Wharton, W., Mikhail, F. M., Carroll, A. J., Kang, H., Liu, W., Dobbin, K. K., Smith, M. A., et al. (2010) · Blood · doi:10.1182/blood-2009-09-245944 · Cited by 568
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Self-citationBattle, A., Mostafavi, S., Zhu, X., Potash, J. B., Weissman, M. M., McCormick, C., Haudenschild, C. D., Beckman, K. B., Shi, J., Mei, R., et al. (2014) · Genome Research · doi:10.1101/gr.155192.113 · Cited by 547
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Self-citationPapaemmanuil, E., Hosking, F. J., Vijayakrishnan, J., Price, A., Olver, B. D., Sheridan, E., Kinsey, S. E., Lightfoot, T. J., Roman, E., Irving, J. A. E., et al. (2009) · Nature Genetics · doi:10.1038/ng.430 · Cited by 498
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Self-citationMoorman, A. V., Ensor, H., Richards, S. M., Chilton, L., Schwab, C. J., Kinsey, S. E., Vora, A. J., Mitchell, C., & Harrison, C. J. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70066-8 · Cited by 390
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Self-citationThe genomic landscape of pediatric acute lymphoblastic leukemia
Brady, S. W., Roberts, K. G., Gu, Z., Shi, L. G., Pounds, S. B., Pei, D., Cheng, C., Dai, Y. E., Devidas, M., Qu, C., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01159-z · Cited by 413
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Self-citationPieters, R., de Groot‐Kruseman, H., van der Velden, V., Fiocco, M. F., van den Berg, H., de Bont, E., Egeler, R. M., Hoogerbrugge, P. M., Kaspers, G. J. L., van der Schoot, C. E., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.6364 · Cited by 366
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Self-citationDhédin, N., Huynh, A., Maury, S., Tabrizi, R., Beldjord, K., Asnafi, V., Thomas, X., Chevallier, P., Nguyen, S., Coiteux, V., et al. (2015) · Blood · doi:10.1182/blood-2014-09-599894 · Cited by 271
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Kuiper, R. P., Waanders, E., van der Velden, V. H. J., van Reijmersdal, S. V., Venkatachalam, R., Scheijen, B., Sonneveld, E., van Dongen, J. J. M., Veerman, A. J. P., van Leeuwen, F. N., et al. (2010) · Leukemia · doi:10.1038/leu.2010.87 · Cited by 266
Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience
Holstein, S. A., & McCarthy, P. L. (2017) · Drugs · doi:10.1007/s40265-017-0689-1 · Cited by 263
Roberts, K. G., Pei, D., Campana, D., Payne-Turner, D., Li, Y., Cheng, C., Sandlund, J. T., Jeha, S., Easton, J. B., Becksfort, J. B., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.4105 · Cited by 256
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Inaba, H., & Pui, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091926 · Cited by 268
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Mullighan, C. G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61203 · Cited by 247
Self-citationNg, S. Y., Yoshida, T., Zhang, J., & Georgopoulos, K. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.014 · Cited by 258
Self-citationChen, I., Harvey, R. C., Mullighan, C. G., Gastier, J. M., Wharton, W., Kang, H., Borowitz, M. J., Camitta, B. M., Carroll, A. J., Devidas, M., et al. (2012) · Blood · doi:10.1182/blood-2011-11-394221 · Cited by 244
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Kuehn, H. S., Boisson, B., Cunningham‐Rundles, C., Reichenbach, J., Stray‐Pedersen, A., Gelfand, E. W., Maffucci, P., Pierce, K. R., Abbott, J. K., Voelkerding, K. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1512234 · Cited by 244
The Philadelphia chromosome in leukemogenesis
Kang, Z.-J., Liu, Y.-F., Xu, L.-Z., Long, Z., Huang, D. A., Yang, Y., Liu, B., Feng, J.-X., Pan, Y.-J., Yan, J., et al. (2016) · 癌症：英文版 · doi:10.1186/s40880-016-0108-0 · Cited by 249
Clinical Implications of the Cancer Genome
MacConaill, L. E., & Garraway, L. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.4944 · Cited by 234
Xu, H. Y., Yang, W., Pérez-Andreu, V., Devidas, M., Fan, Y., Cheng, C., Pei, D., Scheet, P. A., Burchard, E. G., Eng, C. S., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt042 · Cited by 233
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Self-citationBrown, P. A., Inaba, H., Annesley, C., Beck, J. C., Colace, S. I., Dallas, M. H., DeSantes, K. B., Kelly, K. M., Kitko, C. L., Lacayo, N. J., et al. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.0001 · Cited by 229
Newman, S., Nakitandwe, J., Kesserwan, C. A., Azzato, E. M., Wheeler, D. A., Rusch, M., Shurtleff, S. A., Hedges, D. J., Hamilton, K. V., Foy, S. G., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1631 · Cited by 226
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Chiaretti, S., Zini, G., & Bassan, R. (2014) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2014.073 · Cited by 218
Challenging issues in pediatric oncology
Pui, C., Gajjar, A. J., Kane, J. R., Qaddoumi, I. A., & Pappo, A. S. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.95 · Cited by 220
Self-citationMoorman, A. V., Enshaei, A., Schwab, C. J., Wade, R. L., Chilton, L., Elliott, A., Richardson, S., Hancock, J. P., Kinsey, S. E., Mitchell, C., et al. (2014) · Blood · doi:10.1182/blood-2014-03-562918 · Cited by 214
Weston, B. W., Hayden, M. A., Roberts, K. G., Bowyer, S., Hsu, J. H., Fedoriw, Y. D., Rao, K. W., & Mullighan, C. G. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.6770 · Cited by 212
Self-citationMoorman, A. V. (2016) · Haematologica · doi:10.3324/haematol.2015.141101 · Cited by 210
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML
Krivtsov, A. V., Figueroa, M. E., Sinha, A. U., Stubbs, M. C., Feng, Z., Valk, P. J. M., Delwel, R., Döhner, K., Bullinger, L., Kung, A. L., et al. (2013) · Leukemia · doi:10.1038/leu.2012.363 · Cited by 203
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Churchman, M. L., Low, J. A., Qu, C., Paietta, E. M., Kasper, L. H., Chang, Y., Payne-Turner, D., Althoff, M. J., Song, G., Chen, S.-C., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.07.016 · Cited by 203
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Churchman, M. L., Qian, M., Kronnie, G. T., Zhang, R., Yang, W., Zhang, H., Lana, T., Tedrick, P., Baskin, R., Verbist, K., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.021 · Cited by 213
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Schwickert, T. A., Tagoh, H., Gültekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., et al. (2014) · Nature Immunology · doi:10.1038/ni.2828 · Cited by 201
Moorman, A. V. (2012) · Blood Reviews · doi:10.1016/j.blre.2012.01.001 · Cited by 206
Pagliaro, L., Chen, S., Herranz, D., Mecucci, C., Harrison, C. J., Mullighan, C. G., Zhang, M., Zhu, C. H., Boissel, N., Winter, S. S., et al. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00525-x · Cited by 202
Self-citationOnciu, M. M. (2009) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2009.04.009 · Cited by 196
Kang, H., Chen, I., Wilson, C. S., Bedrick, E. J., Harvey, R. C., Atlas, S. R., Devidas, M., Mullighan, C. G., Wang, X., Murphy, M. H., et al. (2009) · Blood · doi:10.1182/blood-2009-05-218560 · Cited by 196
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Bert, S. A., Robinson, M. D., Strbenac, D., Statham, A. L., Song, J. Z., Hulf, T., Sutherland, R. L., Coolen, M. W., Stirzaker, C., & Clark, S. J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.11.006 · Cited by 200
Minimal Residual Disease in Acute Lymphoblastic Leukemia
Campana, D. (2010) · Hematology · doi:10.1182/asheducation-2010.1.7 · Cited by 193
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Roberts, K. G. (2018) · Hematology · doi:10.1182/asheducation-2018.1.137 · Cited by 204
Hogan, L. E., Meyer, J. A., Yang, J. J. J., Wang, J., Wong, N. C., Yang, W., Condos, G. J., Hunger, S. P., Raetz, E. A., Saffery, R., et al. (2011) · Blood · doi:10.1182/blood-2011-04-345595 · Cited by 189
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Witkowski, M. T., Dolgalev, I., Evensen, N. A., Ma, C., Chambers, T. M., Roberts, K. G., Sreeram, S., Dai, Y., Tikhonova, A. N., Lasry, A., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.04.015 · Cited by 200
Self-citation
Metadata
- Authors
- Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., Harvey, R. C., Chen, I.-M., Clifford, R. J., Carroll, W. L., Reaman, G., Bowman, W. P., Devidas, M., Gerhard, D. S., Yang, W., Relling, M. V., Shurtleff, S. A., Campana, D., Borowitz, M. J., Pui, C.-H., Smith, M., Hunger, S. P., Willman, C. L., & Downing, J. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- National Institutes of Health (US)
- UNM Comprehensive Cancer Center (US)
- New York University (US)
- Children's National (US)
- Cook Children's Medical Center (US)
- University of Florida Health (US)
- Children's Hospital Colorado (US)
- ORCID
- Mullighan, Charles G.
- Su, Xiaoping
- Zhang, Jinghui
- Radtke, Ina
- Ma, Jing
- Liu, Wei
- Cheng, Cheng
- Schulman, Brenda A.
- Harvey, Richard C.
- Chen, I-Ming
- Clifford, Robert J.
- Carroll, William L.
- Reaman, Gregory
- Bowman, W. Paul
- Devidas, Meenakshi
- Yang, Wenjian
- Relling, Mary V.
- Campana, Dario
- Pui, Ching-Hon
- Smith, Malcolm
- Hunger, Stephen P.
- Willman, Cheryl L.
- Downing, James R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-01-29
- Volume
- 360
- Issue
- 5
- Pages
- 470-480
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC2674612
- OpenAlex
- W2040329520
- Cited by
- 1,422
- References
- 37
- Citations by year
- 2026: 30 · 2025: 50 · 2024: 66 · 2023: 90 · 2022: 66 · 2021: 103 · 2020: 92 · 2019: 69 · 2018: 74 · 2017: 105 · 2016: 96 · 2015: 101 · 2014: 84 · 2013: 90 · 2012: 98
- FWCI
- 101.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (N01C012400, 21765)
- National Cancer Institute (CA 098543, R01CA086011, U10CA098413, U01CA157937, R01 CA86011, U10CA098543, U01CA114762, CA114762, P30CA021765)
- National Institute of General Medical Sciences (U01 GM61393, U01GM061374, U01-GM-61374, U01GM061393)
- Topics
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- IKZF1 deletion, acute lymphoblastic leukemia, pediatric leukemia, copy number abnormalities, prognosis, PAX5, Ikaros, B cell development, gene expression signatures, relapse
- MeSH terms
- B-Lymphocytes, Child, DNA Mutational Analysis, Genotype, Hematopoietic Stem Cells, Humans, Prognosis, Recurrence, Cohort Studies, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Trans-Activators, Gene Expression, Treatment Outcome, Gene Deletion, Drug Resistance, Neoplasm, Mutation, Missense, Gene Expression Profiling, Ikaros Transcription Factor, PAX5 Transcription Factor
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