Cited by 2,641Clostridium difficile and Clostridium perfringens researchInfection Control in HealthcareAntimicrobial Resistance in Staphylococcus

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Burden of Clostridium difficile Infection in the United States

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Lessa, Fernanda C., Mu, Yi, Bamberg, Wendy M., Beldavs, Zintars G., Dumyati, Ghinwa K., Dunn, John R., Farley, Monica M., Holzbauer, Stacy M., Meek, James I., Phipps, Erin C., Wilson, Lucy E., Winston, Lisa G., Cohen, Jessica A., Limbago, Brandi M., Fridkin, Scott K., Gerding, Dale N., McDonald, L. Clifford·2015·New England Journal of Medicine

DOI 10.1056/nejmoa1408913PMC PMC10966662

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Abstract

BACKGROUND: The magnitude and scope of Clostridium difficile infection in the United States continue to evolve. METHODS: In 2011, we performed active population- and laboratory-based surveillance across 10 geographic areas in the United States to identify cases of C. difficile infection (stool specimens positive for C. difficile on either toxin or molecular assay in residents ≥ 1 year of age). Cases were classified as community-associated or health care-associated. In a sample of cases of C. difficile infection, specimens were cultured and isolates underwent molecular typing. We used regression models to calculate estimates of national incidence and total number of infections, first recurrences, and deaths within 30 days after the diagnosis of C. difficile infection. RESULTS: A total of 15,461 cases of C. difficile infection were identified in the 10 geographic areas; 65.8% were health care-associated, but only 24.2% had onset during hospitalization. After adjustment for predictors of disease incidence, the estimated number of incident C. difficile infections in the United States was 453,000 (95% confidence interval [CI], 397,100 to 508,500). The incidence was estimated to be higher among females (rate ratio, 1.26; 95% CI, 1.25 to 1.27), whites (rate ratio, 1.72; 95% CI, 1.56 to 2.0), and persons 65 years of age or older (rate ratio, 8.65; 95% CI, 8.16 to 9.31). The estimated number of first recurrences of C. difficile infection was 83,000 (95% CI, 57,000 to 108,900), and the estimated number of deaths was 29,300 (95% CI, 16,500 to 42,100). The North American pulsed-field gel electrophoresis type 1 (NAP1) strain was more prevalent among health care-associated infections than among community-associated infections (30.7% vs. 18.8%, P<0.001). CONCLUSIONS: C. difficile was responsible for almost half a million infections and was associated with approximately 29,000 deaths in 2011. (Funded by the Centers for Disease Control and Prevention.).

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Planche, T., Davies, K., Coen, P. G., Finney, J. M., Monahan, I. M., Morris, K. A., O’Connor, L., Oakley, S. J., Pope, C. F., Wren, M. W. D., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70200-7 · Cited by 436

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2005, MMWR Morb Mortal Wkly Rep, 54, 1201
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2014, Fed Regist, 79, 10524
2011, Fed Regist, 76, 51476

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Kelly, C. R., Yen, E. F., Grinspan, A. M., Kahn, S. A., Atreja, A., Lewis, J. D., Moore, T. A., Rubin, D. T., Kim, A. M., Serra, S. M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.038 · Cited by 227
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Kang, J. D., Myers, C. J., Harris, S. C., Kakiyama, G., Lee, I., Yun, B., Matsuzaki, K., Furukawa, M., Min, H., Bajaj, J. S., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.10.003 · Cited by 211
Enterococci enhance Clostridioides difficile pathogenesis
Smith, A. B., Jenior, M. L., Keenan, O., Hart, J. L., Specker, J. T., Abbas, A. A., Rangel, P. C., Di, C., Green, J., Bustin, K. A., et al. (2022) · Nature · doi:10.1038/s41586-022-05438-x · Cited by 210
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Patients at Increased Risk for Recurrence
Gerding, D. N., Kelly, C. P., Rahav, G., Lee, C., Dubberke, E. R., Kumar, P. N., Yacyshyn, B., Kao, D. H., Eves, K. A., Ellison, M. C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy171 · Cited by 204
Self-citation
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Seekatz, A. M., Theriot, C. M., Rao, K. K., Chang, Y., Freeman, A. E., Kao, J. Y., & Young, V. B. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2018.04.001 · Cited by 197
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Orenstein, R., Dubberke, E., Hardi, R., Ray, A., Mullane, K., Pardi, D. S., & Ramesh, M. S. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ938 · Cited by 197
Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
Fletcher, J. R., Pike, C. M., Parsons, R., Rivera, A. J., Foley, M. H., McLaren, M. R., Montgomery, S. A., & Theriot, C. M. (2021) · Nature Communications · doi:10.1038/s41467-020-20746-4 · Cited by 186
Fecal microbiota transplant in severe and severe-complicatedClostridium difficile: A promising treatment approach
Fischer, M., Sipe, B. W., Cheng, Y., Phelps, E. L., Rogers, N. A., Sagi, S. V., Bohm, M. E., Xu, H., & Kassam, Z. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1273998 · Cited by 195
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
Cowardin, C. A., Buonomo, E. L., Saleh, M. M., Wilson, M. G., Burgess, S. L., Kuehne, S. A., Schwan, C., Eichhoff, A. M., Koch‐Nolte, F., Lyras, D., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.108 · Cited by 186
Risk factors for Clostridium difficile infections – an overview of the evidence base and challenges in data synthesis
Eze, P., Balsells, E., Kyaw, M. H., & Nair, H. (2017) · Journal of Global Health · doi:10.7189/jogh.07.010417 · Cited by 186
The burden of CDI in the United States: a multifactorial challenge
Feuerstadt, P., Theriault, N., & Tillotson, G. (2023) · BMC Infectious Diseases · doi:10.1186/s12879-023-08096-0 · Cited by 193
Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection
Youngster, I., Mahabamunuge, J., Systrom, H. K., Sauk, J. S., Khalili, H., Levin, J., Kaplan, J. L., & Hohmann, E. L. (2016) · BMC Medicine · doi:10.1186/s12916-016-0680-9 · Cited by 194
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Fay, K. T., Ford, M. L., & Coopersmith, C. M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.005 · Cited by 196
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Zhang, T., Yang, Y., Liang, Y., Jiao, X., & Zhao, C. (2018) · Nutrients · doi:10.3390/nu10081055 · Cited by 190
Disruption of the gut ecosystem by antibiotics.
Yoon, M. Y., & Yoon, S. S. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.1.4 · Cited by 175
Increasing Incidence of Multiply Recurrent Clostridium difficile Infection in the United States
Ma, G. K., Brensinger, C. M., Wu, Q., & Lewis, J. D. (2017) · Annals of Internal Medicine · doi:10.7326/m16-2733 · Cited by 175
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Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis
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McGovern, B., Ford, C. B., Henn, M. R., Pardi, D. S., Khanna, S., Hohmann, E. L., O’Brien, E. J., Desjardins, C. A., Bernardo, P., Wortman, J. R., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa387 · Cited by 165
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Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach
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Authors: Lessa, F. C., Mu, Y., Bamberg, W. M., Beldavs, Z. G., Dumyati, G. K., Dunn, J. R., Farley, M. M., Holzbauer, S. M., Meek, J. I., Phipps, E. C., Wilson, L. E., Winston, L. G., Cohen, J. A., Limbago, B. M., Fridkin, S. K., Gerding, D. N., & McDonald, L. C.
Affiliations: National Center for Emerging and Zoonotic Infectious Diseases (US)
Colorado Department of Public Health and Environment (US)
Oregon Health Authority (US)
University of Rochester Medicine (US)
Tennessee Department of Health (US)
Emory University (US)
Office of Readiness and Response (US)
Yale University (US)
University of New Mexico (US)
Maryland Department of Health (US)
University of California, San Francisco (US)
Loyola University Chicago (US)
ORCID: Lessa, Fernanda C.
Mu, Yi
Bamberg, Wendy M.
Dumyati, Ghinwa K.
Dunn, John R.
Farley, Monica M.
Holzbauer, Stacy M.
Meek, James I.
Phipps, Erin C.
Wilson, Lucy E.
Fridkin, Scott K.
Gerding, Dale N.
McDonald, L. Clifford
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2015-02-26
Volume: 372
Issue: 9
Pages: 825-834
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1408913
PMC: PMC10966662
OpenAlex: W2071054182
Cited by: 2,641
References: 44
Citations by year: 2026: 94 · 2025: 111 · 2024: 120 · 2023: 150 · 2022: 176 · 2021: 225 · 2020: 328 · 2019: 382 · 2018: 356 · 2017: 323 · 2016: 262 · 2015: 108
FWCI: 270.42
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: New England Journal of Medicine (publishedVersion, other-oa)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Maryland Shared Open Access Repository (USMAI Consortium) (submittedVersion, public-domain)
eScholarship (California Digital Library) (submittedVersion)
Digital Repository at the University of Maryland (University of Maryland College Park) (public-domain)
Funders: National Institutes of Health (CC999999)
Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: Clostridium difficile infection, incidence, nosocomial infections, community-associated infections, recurrence, mortality, NAP1 strain, molecular typing, pulsed-field gel electrophoresis
MeSH terms: Adolescent, Adult, Aged, Child, Child, Preschool, Clostridium Infections, Cross Infection, Female, Humans, Infant, Male, Middle Aged, Population Surveillance, Recurrence, United States, Bacterial Typing Techniques, Incidence, Clostridioides difficile, Electrophoresis, Gel, Pulsed-Field, Age Distribution, Sex Distribution

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