Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes
Open accessAbstract
BACKGROUND: Childhood overweight is associated with an increased risk of type 2 diabetes in adulthood. We investigated whether remission of overweight before early adulthood reduces this risk. METHODS: We conducted a study involving 62,565 Danish men whose weights and heights had been measured at 7 and 13 years of age and in early adulthood (17 to 26 years of age). Overweight was defined in accordance with Centers for Disease Control and Prevention criteria. Data on type 2 diabetes status (at age ≥30 years, 6710 persons) were obtained from a national health registry. RESULTS: Overweight at 7 years of age (3373 of 62,565 men; 5.4%), 13 years of age (3418 of 62,565; 5.5%), or early adulthood (5108 of 62,565; 8.2%) was positively associated with the risk of type 2 diabetes; associations were stronger at older ages at overweight and at younger ages at diagnosis of type 2 diabetes. Men who had had remission of overweight before the age of 13 years had a risk of having type 2 diabetes diagnosed at 30 to 60 years of age that was similar to that among men who had never been overweight (hazard ratio, 0.96; 95% confidence interval [CI], 0.75 to 1.21). As compared with men who had never been overweight, men who had been overweight at 7 and 13 years of age but not during early adulthood had a higher risk of type 2 diabetes (hazard ratio, 1.47; 95% CI, 1.10 to 1.98), but their risk was lower than that among men with persistent overweight (hazard ratio [persistently overweight vs. never overweight], 4.14; 95% CI, 3.57 to 4.79). An increase in body-mass index between 7 years of age and early adulthood was associated with an increased risk of type 2 diabetes, even among men whose weight had been normal at 7 years of age. CONCLUSIONS: Childhood overweight at 7 years of age was associated with increased risks of adult type 2 diabetes only if it continued until puberty or later ages. (Funded by the European Union.).
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Remitting from overweight by late adolescence can reduce the risk of type 2 diabetes.
“A 2018 study has shown that remitting from overweight by late adolescence can reduce the risk of type 2 diabetes.152”
From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [152]
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Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries
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Lessons Learned From 10 Years of Preschool Intervention for Health Promotion
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Vascular Ageing in Youth: A Call to Action
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Uric Acid Is Elevated in Children With Obesity and Decreases After Weight Loss
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Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes
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Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
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BMI Change During Puberty Is an Important Determinant of Adult Type 2 Diabetes Risk in Men
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Self-citationAdiposity Metabolic Consequences for Adolescent Bone Health
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Early puberty and risk for type 2 diabetes in men
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Self-citationChild-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
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Self-citationLife-Course Implications of Pediatric Risk Factors for Cardiovascular Disease
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Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
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Cardiovascular Imaging in Obesity
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Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice
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2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis
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- Authors
- Bjerregaard, L. G., Jensen, B. W., Ängquist, L., Osler, M., Sørensen, T. I. A., & Baker, J. L.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-04-05
- Volume
- 378
- Issue
- 14
- Pages
- 1302-1312
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2796382035
- Cited by
- 392
- References
- 33
- Citations by year
- 2026: 29 · 2025: 43 · 2024: 43 · 2023: 53 · 2022: 52 · 2021: 50 · 2020: 55 · 2019: 36 · 2018: 31
- FWCI
- 41.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Horizon 2020 Framework Programme (633595)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- childhood overweight, type 2 diabetes, early adulthood, body mass index, puberty, men, diabetes risk
- MeSH terms
- Adolescent, Adult, Child, Diabetes Mellitus, Type 2, Humans, Intelligence Tests, Male, Middle Aged, Risk Factors, Weight Gain, Body Mass Index, Overweight, Young Adult, Pediatric Obesity
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