Gestational Perfluoroalkyl Substance Exposure and Body Mass index Trajectories over the First 12 Years of Life

Braun, Joseph M.; Eliot, Melissa; Papandonatos, George D.; Buckley, Jessie P.; Cecil, Kim M.; Kalkwarf, Heidi J.; Chen, Aimin; Eaton, Charles B.; Kelsey, Karl; Lanphear, Bruce P.; Yolton, Kimberly

doi:10.1038/s41366-020-00717-x

Cited by 67Per- and polyfluoroalkyl substances researchBirth, Development, and HealthEffects and risks of endocrine disrupting chemicals

Gestational Perfluoroalkyl Substance Exposure and Body Mass index Trajectories over the First 12 Years of Life

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Braun, Joseph M., Eliot, Melissa, Papandonatos, George D., Buckley, Jessie P., Cecil, Kim M., Kalkwarf, Heidi J., Chen, Aimin, Eaton, Charles B. +3 more·2021·International Journal of Obesity

DOI 10.1038/s41366-020-00717-xPMC PMC7755727

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Abstract

Background/objectives Gestational exposure to perfluoroalkyl substances (PFAS), a ubiquitous class of persistent endocrine disrupting chemicals, is associated with increased risk of obesity and cardiometabolic disease. However, it is unclear if gestational PFAS exposure is associated with adiposity trajectories related to adult obesity and cardiometabolic health.Subjects/methods We measured perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononaoic acid, and perfluorohexanesulfonic acid (PFHxS) concentrations in maternal serum collected between 16 weeks gestation and delivery in a cohort of 345 mother-child pairs in Cincinnati, OH (enrolled 2003-06). From age 4 weeks to 12 years, we measured weight and length or height up to eight times and calculated child body mass index (BMI) (1865 repeated measures). Using covariate-adjusted linear mixed models and splines to account for repeated BMI measures and nonlinear BMI patterns, respectively, we estimated the age/magnitude of infancy BMI zenith (~1 year) and childhood BMI nadir (~5 years), BMI accrual from 8 to 12 years, and BMI at age 12 years by PFAS terciles.Results BMI trajectories varied by PFOA concentrations (age × PFOA interaction p value = 0.03). Children born to women with higher PFOA concentrations had lower infancy and early childhood BMI, earlier BMI nadir, accelerating BMI gains in mid-childhood and adolescence, and higher BMI at age 12 years. Some of these associations were non-monotonic. PFOS and PFHxS were not associated with alterations in BMI trajectories, but were monotonically associated with lower BMI across infancy, childhood, and adolescence. Compared to children in the first PFOS tercile, those in the second (β: -0.83; 95% confidence interval (CI): -2.11, 0.51 kg/m 2), and third (β: -1.41; 95% CI: -2.65, -0.14 kg/m 2) had lower BMI at age 12 years.Conclusions These results suggest that gestational PFOA exposure may be associated with BMI trajectories related to adult obesity and cardiometabolic disease, while PFOS and PFHxS exposure is associated with lower BMI in the first 12 years of life.

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The impacts of PFAS on body weight are not consistent in the literature, with many studies reporting associations between PFAS exposure and increased body weight gain and metabolic syndrome-like phenotypes in human and rodent studies.
“the impacts of PFAS on body weight are not consistent in the literature, with many studies reporting associations between PFAS exposure and increased body weight gain and metabolic syndrome-like phenotypes in human and rodent studies”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Braun et al., 2021
The Introduction and Discussion report mixed findings on PFAS and adiposity, including increased adiposity in human studies and elevated body weight in rodent experiments. The cited paper does not clearly report metabolic syndrome-like phenotypes as a finding across both human and rodent PFAS studies; its discussion of metabolic syndrome concerns the later-life risks associated with BMI patterns. (LLM, conf=0.84)
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Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014) · JAMA · doi:10.1001/jama.2014.732 · Cited by 8,072 · see citing works
Childhood obesity: public-health crisis, common sense cure
Ebbeling, C. B., Pawlak, D. B., & Ludwig, D. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09678-2 · Cited by 2,980 · see citing works
Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
Childhood obesity: causes and consequences
Sahoo, K., Sahoo, B., Choudhury, A., Sofi, N. Y., Kumar, R., & Bhadoria, A. (2015) · Journal of Family Medicine and Primary Care · doi:10.4103/2249-4863.154628 · Cited by 1,790 · see citing works
Super Learner
van der Laan, M. J., Polley, E., & Hubbard, A. (2007) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1309 · Cited by 1,472 · see citing works
Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and Comparisons with NHANES 1999–2000
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247 · see citing works
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
Environmental chemicals in pregnant women in the United States: NHANES 2003–2004
Woodruff, T. J., Zota, A. R., & Schwartz, J. M. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002727 · Cited by 930 · see citing works
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta‐analysis
Llewellyn, A., Simmonds, M. C., Owen, C. G., & Woolacott, N. F. (2015) · Obesity Reviews · doi:10.1111/obr.12316 · Cited by 820 · see citing works
Acceleration of BMI in Early Childhood and Risk of Sustained Obesity
Geserick, M., Vogel, M., Gausche, R., Lipek, T., Spielau, U., Keller, E., Pfäffle, R. W., Kieß, W., & Körner, A. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803527 · Cited by 813 · see citing works
The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review
Park, M. H., Falconer, C., Viner, R., & Kinra, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01015.x · Cited by 739 · see citing works
Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α
Heuvel, J. P. V., Thompson, J. T., Frame, S. R., & Gillies, P. J. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl014 · Cited by 479 · see citing works
The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth
Johnson, P. I., Sutton, P., Atchley, D. S., Koustas, E., Lam, J., Sen, S., Robinson, K. A., Axelrad, D. A., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307893 · Cited by 449 · cited 3× · see citing works
“In multiple studies, higher serum PFOA concentrations during pregnancy have been associated with lower birth weight and reduced early childhood BMI [32, 33, 50], altered growth and excess adiposity during childhood and adolescence [35, 37, 38, 51], and excess adiposity in adulthood [36].”
Background
Developmental origins of chronic disease
Barker, D. J. (2012) · Public Health · doi:10.1016/j.puhe.2011.11.014 · Cited by 399 · see citing works
Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes
Bjerregaard, L. G., Jensen, B. W., Ängquist, L., Osler, M., Sørensen, T. I. A., & Baker, J. L. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1713231 · Cited by 392 · see citing works
Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: A prospective cohort study
Halldorsson, T. I., Rytter, D., Haug, L. S., Bech, B. H., Danielsen, I., Becher, G., Henriksen, T. B., & Olsen, S. F. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104034 · Cited by 353 · see citing works
The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth
Koustas, E., Lam, J., Sutton, P., Johnson, P. I., Atchley, D. S., Sen, S., Robinson, K. A., Axelrad, D. A., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307177 · Cited by 349 · see citing works
Environmental Obesogens: Mechanisms and Controversies
Heindel, J. J., & Blumberg, B. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021304 · Cited by 341 · see citing works
Prenatal origin of obesity and their complications: Gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia
Ornoy, A. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.05.002 · Cited by 317 · see citing works
Early markers of adult obesity: a review
Brisbois, T. D., Farmer, A. P., & McCargar, L. J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00965.x · Cited by 298 · see citing works
Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanoic Acid (PFOA) in Female CD-1 Mice: Low Doses Induce Elevated Serum Leptin and Insulin, and Overweight in Mid-life☆☆
Hines, E. P., White, S. S., Stanko, J. P., Gibbs-Flournoy, E. A., Lau, C., & Fenton, S. E. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.021 · Cited by 282 · see citing works
Super Learning: An Application to the Prediction of HIV-1 Drug Resistance
Sinisi, S. E., Polley, E. C., Petersen, M. L., Rhee, S., & van der Laan, M. J. (2007) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1240 · Cited by 238 · see citing works
Maternal Concentrations of Polyfluoroalkyl Compounds during Pregnancy and Fetal and Postnatal Growth in British Girls
Maisonet, M., Terrell, M. L., Mcgeehin, M., Christensen, K., Holmes, A. K., Calafat, A., & Marcus, M. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1003096 · Cited by 228 · see citing works
Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study
Braun, J. M., Chen, A.-M., Romano, M., Calafat, A., Webster, G. M., Yolton, K., & Lanphear, B. (2015) · Obesity · doi:10.1002/oby.21258 · Cited by 223 · see citing works
Self-citation
Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development
Abbott, B. D. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.10.001 · Cited by 218 · see citing works
Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)
Verner, M., Loccisano, A., Morken, N., Yoon, M., Wu, H., Mcdougall, R., Maisonet, M., Marcus, M., Kishi, R., Miyashita, C., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408837 · Cited by 210 · see citing works
Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian Health Measures Survey 2007–2013
Saravanabhavan, G., Werry, K., Walker, M., Haines, D. A., Malowany, M., & Khoury, C. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.10.006 · Cited by 210 · see citing works
Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans
Fletcher, T., Galloway, T. S., Melzer, D. R., Holcroft, P., Cipelli, R., Pilling, L. C., Mondal, D., Luster, M. I., & Harries, L. W. (2013) · Environment International · doi:10.1016/j.envint.2013.03.008 · Cited by 191 · see citing works
Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals
Kato, K., Basden, B. J., Needham, L. L., & Calafat, A. M. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.10.051 · Cited by 189 · see citing works
Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine-Disrupting Chemicals: A Review of Existing Approaches and New Alternatives
Lazarevic, N., Barnett, A. G., Sly, P. D., & Knibbs, L. D. (2019) · Environmental Health Perspectives · doi:10.1289/ehp2207 · Cited by 184 · see citing works
Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation
Bastos Sales, L., Kamstra, J. H., Cenijn, P. H., van Rijt, L. S., Hamers, T., & Legler, J. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.04.005 · Cited by 181 · see citing works
Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood
Mora, A. M., Oken, E., Rifas‐Shiman, S. L., Webster, T. F., Gillman, M. W., Calafat, A. M., Ye, X., & Sagiv, S. K. (2016) · Environmental Health Perspectives · doi:10.1289/ehp246 · Cited by 178 · see citing works
Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation
Taxvig, C., Dreisig, K., Boberg, J., Nellemann, C., Schelde, A. B., Pedersen, D. C., Boergesen, M., Mandrup, S., & Vinggaard, A. M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.03.021 · Cited by 174 · see citing works
Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study
Braun, J. M., Kalloo, G., Chen, A., Dietrich, K. N., Liddy-Hicks, S., Morgan, S., Xu, Y. Y., Yolton, K. A., & Lanphear, B. P. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw006 · Cited by 164 · see citing works
Self-citation
Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to perfluorooctane sulfonate
Lv, Z., Li, G., Li, Y., Ying, C., Chen, J., Chen, T. X., Wei, J., Lin, Y., Jiang, Y., Wang, Y., et al. (2011) · Environmental Toxicology · doi:10.1002/tox.20747 · Cited by 135 · see citing works
The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study
Werner, E. F., Braun, J. M., Yolton, K. A., Khoury, J. C., & Lanphear, B. P. (2015) · Environmental Health · doi:10.1186/s12940-015-0062-3 · Cited by 125 · see citing works
Self-citation
Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse
Abbott, B. D., Wolf, C. J., Das, K. P., ZEHR, R. D. J., Schmid, J. E., Lindstrom, A. B., Strynar, M. J., & Lau, C. S. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.05.061 · Cited by 124 · see citing works
The effects of perfluorinated chemicals on adipocyte differentiation in vitro
Watkins, A. M., Wood, C. R., Lin, M. T., & Abbott, B. D. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.10.020 · Cited by 116 · see citing works
Variability and predictors of serum perfluoroalkyl substance concentrations during pregnancy and early childhood
Kingsley, S. L., Eliot, M., Kelsey, K. T., Calafat, A. M., Ehrlich, S., Lanphear, B. P., Chen, A., & Braun, J. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.04.033 · Cited by 110 · see citing works
Self-citation
Prenatal Exposures to Perfluorinated Chemicals and Anthropometry at 7 Years of Age
Andersen, C. S., Fei, C., Gamborg, M., Nohr, E. A., Sørensen, T. I. A., & Olsen, J. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt057 · Cited by 108 · see citing works
Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances
Høyer, B. B., Ramlau‐Hansen, C. H., Vrijheid, M., Valvi, D., Pedersen, H. S., Zviezdai, V., Jönsson, B., Lindh, C. H., Bonde, J. ., & Toft, G. V. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408881 · Cited by 107 · see citing works
Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Manzano-Salgado, C. B., Casas, M., López-Espinosa, M.-J., Ballester, F., Íñiguez, C., Martinez, D. R., Romaguera, D., Fernández‐Barrés, S., Santa‐Marina, L., Basterretxea, M., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1330 · Cited by 100 · see citing works
Early life exposure to perfluoroalkyl substances (PFAS) and ADHD: a meta-analysis of nine European population-based studies
Forns, J., Verner, M.-A., Iszatt, N., Nowack, N., Bach, C. C., Vrijheid, M., Costa, O., Andiarena, A., Sovcikova, E., Høyer, B. B., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5444 · Cited by 99 · see citing works
How do changes in body mass index in infancy and childhood associate with cardiometabolic profile in adulthood? Findings from the Northern Finland Birth Cohort 1966 Study
Sovio, U., Kaakinen, M., Tzoulaki, I., Das, S., Ruokonen, A., Pouta, A., Al, H., Molitor, J., & Järvelin, M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.165 · Cited by 84 · see citing works
Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding
Romano, M. E., Xu, Y. Y., Calafat, A. M., Yolton, K. A., Chen, A., Webster, G. M., Eliot, M., Howard, C. R., Lanphear, B. P., & Braun, J. M. (2016) · Environmental Research · doi:10.1016/j.envres.2016.04.034 · Cited by 84 · see citing works
Self-citation
Patterns of body mass index milestones in early life and cardiometabolic risk in early adolescence
Aris, I. M., Rifas‐Shiman, S. L., Li, L., KLEINMAN, K. P., Coull, B. A., Gold, D. R., Hivert, M., Kramer, M. S., & Oken, E. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy286 · Cited by 75 · see citing works
Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study.
Kashino, I., Sasaki, S., Okada, E., Matsuura, H., Goudarzi, H., Miyashita, C., Okada, E., Ito, Y. M., Araki, A., & Kishi, R. (2020) · Environment International · doi:10.1016/j.envint.2019.105355 · Cited by 74 · see citing works
Prenatal Exposure to Perfluoroalkyl Substances: Infant Birth Weight and Early Life Growth
Shoaff, J., Papandonatos, G., Calafat, A., Chen, A.-M., Lanphear, B., Ehrlich, S., Kelsey, K., & Braun, J. (2018) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000010 · Cited by 73 · see citing works
Self-citation
Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
Braun, J. M., Buckley, J. P., Cecil, K. M., Chen, A., Kalkwarf, H. J., Lanphear, B. P., Xu, Y. Y., Woeste, A., & Yolton, K. A. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034838 · Cited by 73 · see citing works
Self-citation
Age at adiposity rebound: determinants and association with nutritional status and the metabolic syndrome at adulthood
Péneau, S., González-Carrascosa, R., Gusto, G., Goxe, D., Lantieri, O., Fezeu, L., Hercberg, S., & Rolland-Cachera, M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.39 · Cited by 72 · see citing works
Environmental Pollutants and Hydroxysteroid Dehydrogenases
Ye, L., Guo, J., & Ge, R. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800095-3.00013-4 · Cited by 67 · see citing works
Prenatal exposure to per- and polyfluoroalkyl substances and infant growth and adiposity: the Healthy Start Study
Starling, A., Adgate, J., Hamman, R., Kechris, K., Calafat, A., & Dabelea, D. (2019) · Environment International · doi:10.1016/j.envint.2019.104983 · Cited by 67 · see citing works
Perfluoroalkyl acid levels in first-time mothers in relation to offspring weight gain and growth.
Gyllenhammar, I., Diderholm, B., Gustafsson, J., Berger, U., Ridefelt, P., Benskin, J. P., Lignell, S., Lampa, E., & Glynn, A. (2018) · Environment International · doi:10.1016/j.envint.2017.12.002 · Cited by 66 · see citing works
Perfluorobutanesulfonic acid (PFBS) potentiates adipogenesis of 3T3-L1 adipocytes
Qi, W., Clark, J. M., Timme‐Laragy, A. R., & Park, Y. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.031 · Cited by 66 · see citing works
Early life perfluorooctanoic acid (PFOA) exposure and overweight and obesity risk in adulthood in a community with elevated exposure
Barry, V., Darrow, L. A., Klein, M., Winquist, A. G., & Steenland, K. (2014) · Environmental Research · doi:10.1016/j.envres.2014.03.025 · Cited by 63 · see citing works
A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight
Braun, J. M., Daniels, J. L., Poole, C., Olshan, A. F., Hornung, R., Bernert, J. T., Xia, Y., Bearer, C. F., Barr, D. B., & Lanphear, B. P. (2010) · Environmental Health · doi:10.1186/1476-069x-9-53 · Cited by 63 · see citing works
Self-citation
Change in body mass index from childhood onwards and risk of adult cardiovascular disease,
Bjerregaard, L. G., Adelborg, K., & Baker, J. L. (2019) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2019.01.011 · Cited by 62 · see citing works
Modelling subject-specific childhood growth using linear mixed-effect models with cubic regression splines
Grajeda, L. M., Ivanescu, A. E., Saito, M., Crainiceanu, C. M., Jaganath, D., Gilman, R. H., Crabtree, J. E., Kelleher, D., Cabrera, L. Z., Cama, V. A., et al. (2016) · Emerging Themes in Epidemiology · doi:10.1186/s12982-015-0038-3 · Cited by 56 · see citing works
Infant body mass index peak and early childhood cardio-metabolic risk markers in a multi-ethnic Asian birth cohort
Aris, I. M., Bernard, J. Y., Chen, L., Tint, M. T., Pang, W. W., Lim, W. Y., Soh, S., Saw, S., Godfrey, K. M., Gluckman, P. D., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw232 · Cited by 55 · see citing works
The impact of prenatal perfluoroalkyl substances exposure on neonatal and child growth.
Chen, M.-H., Ng, S., Hsieh, C.-J., Lin, C.-C., Hsieh, W. S., & Chen, P.-C. (2017) · Science of the Total Environment · doi:10.1016/j.scitotenv.2017.06.273 · Cited by 55 · see citing works
Pre-, Perinatal, and Parental Predictors of Body Mass Index Trajectory Milestones
Aris, I. M., Rifas‐Shiman, S. L., Li, L., KLEINMAN, K. P., Coull, B. A., Gold, D. R., Hivert, M., Kramer, M. S., & Oken, E. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.05.041 · Cited by 54 · see citing works
Association of Childhood Body Mass Index and Change in Body Mass Index With First Adult Ischemic Stroke
Gjærde, L. K., Gamborg, M., Ängquist, L. H., Truelsen, T. C., Sørensen, T. I. A., & Baker, J. L. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.1627 · Cited by 45 · see citing works
Rate of change in body mass index at different ages during childhood and adult obesity risk
Zhang, T., Whelton, P. K., Xi, B., Krousel-Wood, M. A., Bazzano, L., He, J., Chen, W., & Li, S. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12513 · Cited by 35 · see citing works
Human biomonitoring reference values derived for persistent organic pollutants in blood plasma from the Canadian Health Measures Survey 2007–2011
Haines, D. A., Khoury, C., Saravanabhavan, G., Werry, K., Walker, M., & Malowany, M. (2017) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2017.03.004 · Cited by 30 · see citing works
Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study
Kingsley, S., Kelsey, K., Butler, R. A., Chen, A.-M., Eliot, M. N., Romano, M., Houseman, A., Koestler, D., Lanphear, B., Yolton, K., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.06.013 · Cited by 29 · see citing works
Self-citation
The cross‐sectional and prospective associations between sleep characteristics and adiposity in toddlers: Results from the GET UP! Study
Zhang, Z., Pereira, J. R., Sousa‐Sá, E., Okely, A. D., Feng, X., & Santos, R. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12557 · Cited by 27 · see citing works
Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study
Martinsson, M., Nielsen, C., Björk, J., Rylander, L., Malmqvist, E., Lindh, C. H., & Rignell‐Hydbom, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230137 · Cited by 26 · see citing works
Comparing BMI with skinfolds to estimate age at adiposity rebound and its associations with cardio-metabolic risk markers in adolescence
Gravio, C. D., Krishnaveni, G. V., Somashekara, R., Veena, S. R., Kumaran, K., Krishna, M., Karat, S. C., & Fall, C. H. D. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0144-8 · Cited by 18 · see citing works
Dynamic growth metrics for examining prenatal exposure impacts on child growth trajectories: Application to perfluorooctanoic acid (PFOA) and postnatal weight gain
Tanner, E. M., Bornehag, C., & Gennings, C. (2019) · Environmental Research · doi:10.1016/j.envres.2019.109044 · Cited by 14 · see citing works
10.1016/j.ynpm.2016.06.021
(2000) · Time to knit · doi:10.1016/j.ynpm.2016.06.021 · Cited by 7 · see citing works
Corrigendum to “The impact of prenatal Perfluoroalkyl substances exposure on neonatal and child growth” [Sci. Total Environ. 2017; 607–608:669–675]
Chen, M., Ng, S., Hsieh, C., Lin, C., Hsieh, W., & Chen, P. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.068 · Cited by 4 · see citing works

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A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166 · see citing works
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103 · see citing works
Early-life exposure to per- and poly-fluorinated alkyl substances and growth, adiposity, and puberty in children: a systematic review
Lee, Y. J., Jung, H. W., Kim, H. Y., Choi, Y.-J., & Lee, Y. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683297 · Cited by 96 · see citing works
Determinants of maternal and neonatal PFAS concentrations: a review
McAdam, J., & Bell, E. M. (2023) · Environmental Health · doi:10.1186/s12940-023-00992-x · Cited by 95 · see citing works
PFAS and Potential Adverse Effects on Bone and Adipose Tissue through Interactions with PPARγ
Kirk, A. B., Michelsen-Correa, S., Rosen, C., Martin, C. F., & Blumberg, B. (2021) · Endocrinology · doi:10.1210/endocr/bqab194 · Cited by 90 · see citing works
Associations of Gestational Perfluoroalkyl Substances Exposure with Early Childhood BMI z-Scores and Risk of Overweight/Obesity: Results from the ECHO Cohorts
Liu, Y., Wosu, A. C., Fleisch, A. F., Dunlop, A. L., Starling, A. P., Ferrara, A. M., Dabelea, D., Oken, E., Buckley, J. P., Chatzi, L., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11545 · Cited by 57 · see citing works
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PFAS Concentrations and Cardiometabolic Traits in Highly Exposed Children and Adolescents
Canova, C., Nisio, A. D., Barbieri, G., Russo, F., Fletcher, T., Batzella, E., Zuanna, T. D., & Pitter, G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182412881 · Cited by 55 · see citing works
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Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study
Buckley, J. P., Kuiper, J. R., Lanphear, B. P., Calafat, A. M., Cecil, K. M., Chen, A., Xu, Y. Y., Yolton, K. A., Kalkwarf, H. J., & Braun, J. M. (2021) · Environmental Health Perspectives · doi:10.1289/ehp9424 · Cited by 53 · see citing works
Self-citation
Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease
Massart, J., Begriche, K., Corlu, A., & Fromenty, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031062 · Cited by 46 · see citing works
Associations of Prenatal Per-and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16–20 Years of Age: Project Viva
Zhang, M., Rifas-Shiman, S. L., Aris, I. M., Fleisch, A. F., Lin, P.-I. D., Nichols, A. R., Oken, E., & Hivert, M.-F. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12597 · Cited by 45 · see citing works
Cerebral concentration and toxicity of endocrine disrupting chemicals: The implication of blood-brain interfaces
Denuzière, A., & Ghersi‐Egea, J. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.04.004 · Cited by 43 · see citing works
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study
Blomberg, A. J., Mortensen, J., Weihe, P., & Grandjean, P. (2022) · Environmental Health · doi:10.1186/s12940-022-00929-w · Cited by 33 · see citing works
Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort
Sevelsted, A., Gürdeniz, G., Rago, D., Pedersen, C., Lasky-Su, J., Checa, A., Zhang, P., Wheelock, C., Normann, S. S., Kristensen, D., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104236 · Cited by 30 · see citing works
Physical activity modifies the relation between gestational perfluorooctanoic acid exposure and adolescent cardiometabolic risk
Braun, J. M., Papandonatos, G. D., Li, N., Sears, C. G., Buckley, J. P., Cecil, K. M., Chen, A., Eaton, C. B., Kalkwarf, H. J., Kelsey, K. T., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114021 · Cited by 30 · see citing works
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Per- and polyfluoroalkyl substances in umbilical cord serum and body mass index trajectories from birth to age 10 years: Findings from a longitudinal birth cohort (SMBCS).
Dai, Y.-M., Zhang, J.-M., Wang, Z., Ding, J.-Y., Xu, S.-N., Zhang, B.-Y., Guo, J.-Q., Qi, X.-J., Chang, X.-L., Wu, C.-H., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108238 · Cited by 25 · see citing works
Association of maternal exposure to perfluoroalkyl and polyfluroalkyl substances with infant growth from birth to 12 months: A prospective cohort study
Zhang, Y., Pan, C., Ren, Y., Wang, Z., Luo, J., Ding, G., Vinturache, A., Wang, X., Shi, R., Ouyang, F., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151303 · Cited by 21 · see citing works
Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
Schillemans, T., Iszatt, N., Rémy, S., Schoeters, G. E. R., Fernández, M. F., D’Cruz, S. C., Desalegn, A. A., Haug, L. S., Lignell, S., Lindroos, A. K., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120566 · Cited by 21 · see citing works
Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes
Ku, M.-S., Pan, W., Huang, Y., Hsieh, W., Hsu, Y., Chen, P., & Liu, C.-Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119183 · Cited by 20 · see citing works
Gestational per- and polyfluoroalkyl substances exposure and infant body mass index trajectory in the New Hampshire Birth Cohort Study
Romano, M. E., Heggeseth, B., Gallagher, L. G., Botelho, J. C., Calafat, A. M., Gilbert‐Diamond, D., & Karagas, M. R. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114418 · Cited by 19 · see citing works
Untitled work
(2022) · PubMed · Cited by 17 · see citing works
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Associations between exposure to perfluoroalkyl substances and body fat evaluated by DXA and MRI in 109 adolescent boys
Thomsen, M. L., Henriksen, L. S., Tinggaard, J., Nielsen, F., Jensen, T. K., & Main, K. M. (2021) · Environmental Health · doi:10.1186/s12940-021-00758-3 · Cited by 17 · see citing works
Associations of Early Life Per- and Polyfluoroalkyl Substances (PFAS) Exposure with Body Mass Index and Risk of Overweight or Obesity at Age 2-18 Years: Mixture Analysis in the Prospective Boston Birth Cohort
Li, Z., Wang, G., Braun, J. M., Hong, X., Choi, G., O’Leary, S. P., Yu, C. H., Pearson, C., Adams, W. G., Fan, Z. (., et al. (2025) · Environment International · doi:10.1016/j.envint.2024.109206 · Cited by 16 · see citing works
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Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort
Kinkade, C. W., Rivera-Núñez, Z., Thurston, S., Kannan, K., Miller, R. K., Brunner, J., Wong, E., Groth, S. W., O'Connor, T., & Barrett, E. (2023) · Environmental Health · doi:10.1186/s12940-023-01009-3 · Cited by 14 · see citing works
Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study
Starling, A. P., Friedman, C., Boyle, K. E., Adgate, J. L., Glueck, D. H., Allshouse, W. B., Calafat, A. M., Bloemsma, L. D., & Dabelea, D. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01420-3 · Cited by 16 · see citing works
Evaluating Mixtures of Urinary Phthalate Metabolites and Serum Per-/Polyfluoroalkyl Substances in Relation to Adolescent Hair Cortisol: The HOME Study
Sears, C. G., Liu, Y., Lanphear, B. P., Buckley, J. P., Meyer, J. S., Xu, Y. Y., Chen, A., Yolton, K. A., & Braun, J. M. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad198 · Cited by 14 · see citing works
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Exposure to per- and polyfluoroalkyl substances and body composition in US adolescents aged 12-18 years: an analysis of data from the National Health and Nutrition Examination Surveys 2011-2018
Lin, L., Cai, L., Liu, Z., Gao, J., Zhou, Y., Zeng, X., Ou, Y., Dong, G., Dong, P., Wu, Q.-Z., et al. (2022) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2022.100009 · Cited by 14 · see citing works
Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years
Wang, H., Zhang, L., Wu, J., Wang, P., Li, Q., Sui, X., Xu, Y., Zhao, Y., Liu, Y., & Zhang, Y. (2023) · Eco-Environment & Health · doi:10.1016/j.eehl.2023.07.003 · Cited by 14 · see citing works
Estimating effects of longitudinal and cumulative exposure to PFAS mixtures on early adolescent body composition
Kuiper, J. R., Liu, S. H., Lanphear, B. P., Calafat, A. M., Cecil, K. M., Xu, Y. Y., Yolton, K. A., Kalkwarf, H. J., Chen, A., Braun, J. M., et al. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae014 · Cited by 14 · see citing works
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Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories
Cai, A., Portengen, L., Govarts, E., Martín, L. R., Schoeters, G. E. R., Legler, J., Vermeulen, R. C. H., Lenters, V. C., & Rémy, S. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137695 · Cited by 13 · see citing works
Maternal per- and poly-fluoroalkyl substances exposure and child adiposity measures: A birth cohort study
Song, X., Wu, J., Ji, H., Liang, H., Chen, Y., Yang, L., Yuan, W., Tu, X., & Miao, M. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114684 · Cited by 11 · see citing works
Dietary intake of potentially toxic elements and children's chemical exposure
Urbano, T., Zagnoli, F., Malavolti, M., Halldorsson, T. I., Vinceti, M., & Filippini, T. (2022) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2022.100393 · Cited by 10 · see citing works
Poly- and perfluoroalkyl substances (PFAS) in the first 1000 days reduce linear growth, lean body mass and bone mineral density at age 3 years
van Beijsterveldt, I. A. L. P., Dorrepaal, D. J., van Zelst, B. D., van den Berg, S. A. A., & Hokken‐Koelega, A. C. S. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.05.017 · Cited by 10 · see citing works
In utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles
Zeng, X., Chen, T., Cui, Y., Zhao, J., Chen, Q., Yu, Z., Zhang, Y., Han, L., Chen, Y., & Zhang, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161504 · Cited by 10 · see citing works
Prenatal PFAS exposure associates with DXA assessed markers of adiposity in 7-year-old children from the Odense Child Cohort
Beck, I. H., Grøntved, A., Palm, C. V. B., Batzella, E., Sigvaldsen, A., Dalgård, C., Jensen, R. C., Nielsen, C., Halldorsson, T. I., & Jensen, T. K. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121394 · Cited by 8 · see citing works
Prenatal Per‐ and Polyfluoroalkyl Substance Exposures and Longitudinal Blood Pressure Measurements in Children Aged 3 to 18 Years: Findings From a Racially and Ethnically Diverse US Birth Cohort
Li, Z., Wang, G., Hong, X., Brady, T. M., Pearson, C., Buckley, J. P., Wang, X., & Zhang, M. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039949 · Cited by 7 · see citing works
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Impact of gestational exposure to endocrine disrupting chemicals on pregnancy and birth outcomes
Padmanabhan, V., Moeller, J., & Puttabyatappa, M. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.04.004 · Cited by 7 · see citing works
Serum perfluoroalkyl substances and growth and development in US adolescents: a nationally representative cross-sectional study
Wang, Y.-F., Zhang, X.-R., & Zou, Y.-X. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-05136-4 · Cited by 6 · see citing works
Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study
Arzu, J. L., Kelsey, K. T., Papandonatos, G. D., Cecil, K. M., Chen, A., Langevin, S. M., Lanphear, B. P., Yolton, K. A., Buckley, J. P., & Braun, J. M. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01779-8 · Cited by 6 · see citing works
Self-citation
A prospective birth cohort study of maternal prenatal cigarette smoking assessed by self-report and biomarkers on childhood risk of overweight or obesity
Hou, W., Zhang, M., Ji, Y., Hong, X., Wang, G., Xu, R., Liang, L., Saria, S., & Ji, H. (2022) · Precision Nutrition · doi:10.1097/pn9.0000000000000017 · Cited by 5 · see citing works
19 F solid-state nuclear magnetic resonance as a tool to study the bioaccumulation of per- and polyfluoroalkyl substances in murine tissue samples
Neita, R., Kiefte, S., Adams, H. M., Mercer, G. V., Schneider, C., & Cahill, L. S. (2025) · Environmental Science Advances · doi:10.1039/d5va00220f · Cited by 4 · see citing works
The Role of Endocrine Disruptors in Childhood Obesity: Unraveling the Obesogens
Kapama, A., Stefanaki, C., Mastorakos, G. P., & Papagianni, M. (2025) · Hormone Research in Paediatrics · doi:10.1159/000545043 · Cited by 4 · see citing works
Association between Maternal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Growth Trajectories up to 4 Years of Age: The Japan Environment and Children’s Study
Yamamoto, M., Eguchi, A., Sakurai, K., Nakayama, S. F., Konno, Y., & Kamijima, M. (2025) · Environmental Science and Technology · doi:10.1021/acs.est.5c09583 · Cited by 4 · see citing works
Association between prenatal exposure to per- and polyfluoroalkyl substances and pubertal development in boys and girls in the Spanish INMA cohort
de Calle, S. L., Lertxundi, A., Alvarez, O., López-Espinosa, M.-J., Freire, C., Guxens, M., Schettgen, T., Bizec, B. L., Antignac, J., Vrijheid, M., et al. (2026) · Environmental Research · doi:10.1016/j.envres.2026.124095 · Cited by 4 · see citing works
“Effects of prenatal exposure to environmental pollutants on birth weight and child weight gain”
de Oliveira, A. P. N., de Figueiredo, N. D., Vieira, W. D. C., & Asmus, C. I. R. F. (2023) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2023.100512 · Cited by 4 · see citing works
Evaluating the association between longitudinal exposure to a PFAS mixture and adolescent cardiometabolic risk in the HOME Study
Fleury, E. S., Kuiper, J. R., Buckley, J. P., Papandonatos, G. D., Cecil, K. M., Chen, A., Eaton, C. B., Kalkwarf, H. J., Lanphear, B. P., Yolton, K. A., et al. (2024) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000289 · Cited by 5 · see citing works
Self-citation
Hidden link between endocrine-disrupting chemicals and pediatric obesity
Shin, M. W., & Kim, S.-H. (2024) · Korean Journal of Pediatrics · doi:10.3345/cep.2024.00556 · Cited by 4 · see citing works
Associations between prenatal exposure to PFAS and cardiometabolic health in preadolescents
Lejeune, N., Rouxel, E., Monfort, C., Tillaut, H., Rouget, F., Costet, N., Giton, F., Gaudreau, É., Lainé, F., Garlantézec, R., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120607 · Cited by 4 · see citing works
Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors
Fleury, E. S., Papandonatos, G. D., Manz, K. E., Pennell, K. D., Hall, A. M., Chen, A., Buckley, J. P., Yolton, K. A., Cecil, K. M., Lanphear, B. P., et al. (2025) · Pediatric Research · doi:10.1038/s41390-025-04322-4 · Cited by 2 · see citing works
Self-citation
Associations of the gut microbiome and cardiometabolic risk in adolescence: the HOME study
Arzu, J. L., Fleury, E. S., Cecil, K. M., Chen, A., Lanphear, B. P., Yolton, K. A., Buckley, J. P., Braun, J. M., & Laue, H. E. (2026) · BMC Medical Genomics · doi:10.1186/s12920-026-02359-w · Cited by 1 · see citing works
Self-citation
Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence
Hernandez‐Castro, I., Rifas‐Shiman, S. L., Smith, A. R., Lin, P. D., Fleisch, A. F., Gold, D. R., Zhang, M., Aris, I. M., Coull, B. A., Hivert, M., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c01336 · Cited by 1 · see citing works
Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectoriesPreprint
Cai, A., Portengen, L., Govarts, E., Martín, L. R., Schoeters, G. E. R., Legler, J., Vermeulen, R. C. H., Lenters, V. C., & Rémy, S. (2022) · medRxiv · doi:10.1101/2022.08.30.22279378 · Cited by 1 · see citing works
In-Utero Exposure to Cigarette Smoking on Child Long-Term Risk of Obesity: Concordance of Self-Report, Maternal and Cord Blood BiomarkersPreprint
Hou, W., Zhang, M., Ji, Y., Hong, X., Wang, G., Liang, L., Ji, H., Saria, S., & Wang, X. (2021) · Preprints.org · doi:10.20944/preprints202110.0296.v1
Additional file 4 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949736
Additional file 3 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949733
Additional file 8 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949748
Additional file 5 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949739
Additional file 6 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949742
Additional file 7 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949745
Additional file 9 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949754
Additional file 1 of Associations between exposure to perfluoroalkyl substances and body fat evaluated by DXA and MRI in 109 adolescent boys
Thomsen, M. L., Henriksen, L. S., Tinggaard, J., Nielsen, F., Jensen, T. K., & Main, K. M. (2021) · Figshare · doi:10.6084/m9.figshare.14880498
Additional file 1 of Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort
Kinkade, C. W., Rivera‐Núñez, Z., Thurston, S. W., Kannan, K., Miller, R. K., Brunner, J., Wong, E., Groth, S. W., O’Connor, T. G., & Barrett, E. S. (2023) · Figshare · doi:10.6084/m9.figshare.24076931
Additional file 1 of Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study
Blomberg, A. J., Mortensen, J., Weihe, P., & Grandjean, P. (2022) · Figshare · doi:10.6084/m9.figshare.21591032
Additional file 2 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949727
Additional file 1 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
Frigerio, G., Ferrari, C. M., & Fustinoni, S. (2023) · Figshare · doi:10.6084/m9.figshare.23949724
Associations of maternal PFAS exposure with offspring growth trajectories from birth to age 2 years
Yang, L., Bai, L., Wang, X., Xi, J., Liu, Y., Zou, X., Miao, M., Yan, W., Yuan, W., Ji, H., et al. (2026) · Environment International · doi:10.1016/j.envint.2026.110392
Revealing the Link Between Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Stroke: A Comprehensive Epidemiological and Network Toxicology Perspective
Li, S.-S., Yang, Z.-S., Tian, X., Wu, Y.-D., Song, J.-K., Wang, W.-L., Tang, Z.-L., & Wang, J.-B. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10157-0

Prenatal Perfluorooctanoic Acid Exposure is Associated with Childhood Adiposity Trajectories
Braun, J. M., Eliot, M., Papandonatos, G. D., Buckley, J. P., Cecil, K. M., Chen, A., Kelsey, K. T., Lanphear, B. P., Eaton, C. B., & Yolton, K. A. (2020) · ISEE Conference Abstracts · doi:10.1289/isee.2020.virtual.p-0839
Self-citation
Associations of Gestational Perfluoroalkyl Substances Exposure with Early Childhood BMI z-Scores and Risk of Overweight/Obesity: Results from the ECHO Cohorts
Liu, Y., Wosu, A. C., Fleisch, A. F., Dunlop, A. L., Starling, A. P., Ferrara, A. M., Dabelea, D., Oken, E., Buckley, J. P., Chatzi, L., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11545 · Cited by 57 · see citing works
Self-citation
Per- and polyfluoroalkyl substances in umbilical cord serum and body mass index trajectories from birth to age 10 years: Findings from a longitudinal birth cohort (SMBCS).
Dai, Y.-M., Zhang, J.-M., Wang, Z., Ding, J.-Y., Xu, S.-N., Zhang, B.-Y., Guo, J.-Q., Qi, X.-J., Chang, X.-L., Wu, C.-H., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108238 · Cited by 25 · see citing works
Association between gestational PFAS exposure and Children's adiposity in a diverse population
Bloom, M. S., Commodore, S., Ferguson, P. L., Neelon, B., Pearce, J. L., Baumer, A., Newman, R., Grobman, W. A., Tita, A., Roberts, J. R., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111820 · Cited by 59 · see citing works
Umbilical cord serum concentrations of perfluorooctane sulfonate, perfluorooctanoic acid, and the body mass index changes from birth to 5 1/2 years of age
Horikoshi, T., Nishimura, T., Nomura, Y., Iwabuchi, T., Itoh, H., Takizawa, T., & Tsuchiya, K. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-99174-3 · Cited by 23 · see citing works

Authors: Braun, J. M., Eliot, M., Papandonatos, G. D., Buckley, J. P., Cecil, K. M., Kalkwarf, H. J., Chen, A., Eaton, C. B., Kelsey, K., Lanphear, B. P., & Yolton, K.
Affiliations: Brown University (US)
Johns Hopkins University (US)
Cincinnati Children's Hospital Medical Center (US)
University of Pennsylvania (US)
Simon Fraser University (CA)
Corresponding author: Braun, Joseph M.
ORCID: Braun, Joseph M.
Eliot, Melissa
Papandonatos, George D.
Buckley, Jessie P.
Cecil, Kim M.
Kalkwarf, Heidi J.
Chen, Aimin
Eaton, Charles B.
Kelsey, Karl
Lanphear, Bruce P.
Yolton, Kimberly
Venue: International Journal of Obesity
Publisher: Springer Science and Business Media LLC
Published: 2020-11-18
Volume: 45
Issue: 1
Pages: 25-35
ISSN: 0307-0565 (ISSN-L)
1476-5497
DOI: 10.1038/s41366-020-00717-x
PMC: PMC7755727
OpenAlex: W3099995528
Cited by: 67
References: 72
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 23 · 2022: 16 · 2021: 10
FWCI: 4.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: International Journal of Obesity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (R01ES030078, R01ES020349, R01ES027224, R01ES014575, P30ES006096, L40 ES032257, P01ES011261, R01ES025214, R01ES028277, P30ES013508)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: prenatal exposure, body mass index trajectories, childhood obesity, perfluorooctanoic acid, PFOS, PFHxS, perfluorononanoic acid, endocrine disruptors, maternal serum, cardiometabolic risk
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Environmental Pollutants, Female, Fluorocarbons, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Pregnancy, Prenatal Exposure Delayed Effects, Body Mass Index, Young Adult

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Gestational Perfluoroalkyl Substance Exposure and Body Mass index Trajectories over the First 12 Years of Life

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