The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index; 4 of the 10 sources its claims cite were checked for support.
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
Open accessAbstract
BACKGROUND: Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR T-cell toxic effects in patients with relapsed and refractory multiple myeloma. METHODS: CAR-positive (CAR+) T cells. The primary end point was an overall response (partial response or better); a key secondary end point was a complete response or better (comprising complete and stringent complete responses). RESULTS: nucleated cells) was confirmed in 33 patients, representing 26% of all 128 patients who were treated and 79% of the 42 patients who had a complete response or better. The median progression-free survival was 8.8 months (95% confidence interval, 5.6 to 11.6). Common toxic effects among the 128 treated patients included neutropenia in 117 patients (91%), anemia in 89 (70%), and thrombocytopenia in 81 (63%). Cytokine release syndrome was reported in 107 patients (84%), including 7 (5%) who had events of grade 3 or higher. Neurotoxic effects developed in 23 patients (18%) and were of grade 3 in 4 patients (3%); no neurotoxic effects higher than grade 3 occurred. Cellular kinetic analysis confirmed CAR+ T cells in 29 of 49 patients (59%) at 6 months and 4 of 11 patients (36%) at 12 months after infusion. CONCLUSIONS: Ide-cel induced responses in a majority of heavily pretreated patients with refractory and relapsed myeloma; MRD-negative status was achieved in 26% of treated patients. Almost all patients had grade 3 or 4 toxic effects, most commonly hematologic toxic effects and cytokine release syndrome. (Funded by bluebird bio and Celgene, a Bristol-Myers Squibb company; KarMMa ClinicalTrials.gov number, NCT03361748.).
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Claims the paper makes
4 of 10 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“The B-cell maturation antigen (BCMA)-directed CAR T cell idecabtagene vicleucel (ide-cel, also called bb2121) showed promising efficacy in a phase 1 study involving patients with relapsed or refractory myeloma.11”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > D
What the sources say
- Supportedcites [11] 11. Raje N, Berdeja J, Lin Y, et al. Anti- BCMA CAR T-cell therapy bb2121 in re- lapsed or refractory multiple myeloma. N Engl J Med 2019; 380: 1726-37. source
The Methods identify bb2121 as an anti-BCMA CAR T-cell therapy studied in a phase 1 trial involving patients with relapsed or refractory multiple myeloma. The Discussion reports an 85% clinical response rate, supporting the characterization of its efficacy as promising. (LLM, conf=0.94)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These efficacy results compare favorably with results in similarly heavily pretreated patients with relapsed or refractory myeloma treated with two recently approved regimens, selinexor plus dexamethasone and belantamab mafodotin (median progression-free survival, 3.7 months and 2.9 months, respectively).5,17”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Supportedcites [5] 5. Chari A, Vogl DT, Gavriatopoulou M, et al. Oral selinexor-dexamethasone for triple-class refractory multiple myeloma. N Engl J Med 2019; 381: 727-38. source
The Methods and Discussion describe patients with triple-class refractory myeloma who were heavily pretreated, with a median of seven previous regimens. The Efficacy section reports median progression-free survival of 3.7 months with selinexor plus dexamethasone. This citation supports the selinexor result; the separate belantamab result is not attributed to this paper. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [17] 17. Lonial S, Lee HC, Badros A, et al. Belan- tamab mafodotin for relapsed or refracto- ry multiple myeloma (DREAMM-2): a two- arm, randomised, open-label, phase 2 study. Lancet Oncol 2020; 21: 207-21. source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: Cross-trial comparisons of progression-free survival between the KarMMa study and trials of selinexor plus dexamethasone or belantamab mafodotin are valid.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Observed toxic effects were consistent with those in previous reports.11”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Partly supportedcites [11] 11. Raje N, Berdeja J, Lin Y, et al. Anti- BCMA CAR T-cell therapy bb2121 in re- lapsed or refractory multiple myeloma. N Engl J Med 2019; 380: 1726-37. sourceExperimental — accuracy not yet measured
The Results (Safety; page unavailable) document the observed toxic effects. The Discussion compares them with previous studies, but reports a lower incidence of severe cytokine release syndrome with bb2121 and cautions that cross-study comparisons are complicated. It does not establish that the toxic effects were generally consistent with previous reports. (LLM, conf=0.82)
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Duration of undetectable sBCMA correlated with response duration, and clearance of sBCMA at month 2 was associated with longer progression-free survival (Fig. S5E and S5F).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Figure 2 (facing page). Progression-free Survival, Duration of Response, and Overall Survival.
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“with peak levels higher in patients having cytokine release syndrome of grade 3 or higher (Fig. S6).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a somewhat higher frequency and somewhat greater depth of response were observed at the 450 × 10 6 dose (response in 81% of the pa-tients and complete response or better in 39%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At baseline, 110 of 112 tumor samples (98%) expressed BCMA, with 109 having at least 50% BCMA-positive plasma cells, and all the patients had detectable levels of sBCMA.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Figure 2 (facing page). Progression-free Survival, Duration of Response, and Overall Survival.
Strength:plain· not yet calibratedn = 112Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A response was observed in 73% of the treated patients, and a complete response or better was observed in 33%;”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Baseline cytokine levels were not associated with higher-grade cytokine release syndrome or neurotoxic effects.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“with an incidence of response to bridging therapy of 4%”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- Probably not a substantial claim. 12
- It may state two separate claims as one. 32
- The quote only partly states this claim. 1
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In contrast, CD19 epitope loss is reported to be a relatively common escape mechanism after treatment with CD19-directed CAR T-cell therapy, especially in patients with acute leukemia.18,19”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Partly supportedcites [18] 18. Cheng J, Zhao L, Zhang Y, et al. Un- derstanding the mechanisms of resis- tance to CAR T-cell therapy in malignan- cies. Front Oncol 2019; 9: 1237. sourceExperimental — accuracy not yet measured
The Tumor Factors section reports that loss of the targeted CD19 epitope enabled escape after anti-CD19 CAR T-cell therapy in relapsed B-ALL. It also reports that target-antigen-negative relapse accounts for approximately 9–25% of B-ALL relapses, but does not establish that epitope loss specifically is relatively common or more common in acute leukemia than in other malignancies. (LLM, conf=0.82)
- Not checked — no full text of the sourcecites [19] 19. Badar T, Shah NN. Chimeric antigen receptor T cell therapy for acute lympho- blastic leukemia. Curr Treat Options On- col 2020; 21: 16. source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Among patients with persistent grade 3 or 4 neutropenia (52 patients) or thrombocytopenia (62 patients) 1 month after infusion, the median time to recovery to grade 2 or lower was 1.9 months (range, 1.2 to 5.6) and 2.1 months (range, 1.2 to 13.8), respectively”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 52Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimated median progression-free survival was 8.8 months overall (95% CI, 5.6 to 11.6), 12.1 months (95% CI, 8.8 to 12.3) at the 450 × 10 6 dose, and 20.2 months (95% CI, 12.3 to could not be estimated) in patients having a complete or stringent complete response”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The 128 treated patients had received a median of 6 previous antimyeloma regimens (range, 3 to 16), and 120 (94%) had received previous autologous hematopoietic stem-cell transplants (Table 1).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Patients
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although high interpatient variability was observed at all doses, upper quartiles of exposure (area under the curve of the transgene level from time of dose to 28 days [AUC 0-28 days ]) were observed more frequently at the 450 × 10 6 dose (Fig. 3B).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Among treated patients, 5 were positive for antidrug antibodies before infusion.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Baseline sBCMA levels were elevated in treated patients and de-creased rapidly after infusion in patients who had a response, with nadir values achieved within 3 months (Fig. 3A and Fig. S5B and S5C).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Neurotoxic effects developed in 23 patients (18%) and were of grade 3 in 4 patients (3%); no neurotoxic effects higher than grade 3 occurred.”
- Also stated in: § Table 1. (Continued.) · plain
“Investigator-identified neurotoxic effects were reported in 23 patients (18%), of whom 4 (3%) had grade 3 events; no grade 4 or 5 neu-rotoxic effects were observed”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Table 1. (Continued.) · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The median time to first response was 1.0 month (range, 0.5 to 8.8); the median time to a complete response or better was 2.8 months (range, 1.0 to 11.8).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, neurotoxic effects of any grade were reported in 0 of 4 patients, 12 of 70 patients (17%), and 11 of 54 patients (20%), respectively, with grade 3 events in 0 patients, 1 patient (1%), and 3 patients (6%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 54Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Antidrug antibodies had no effect on the incidence of response or of complete response or better and had no noticeable effect on progression-free survival.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The absence of a detectable effect of antidrug antibodies on efficacy is not due to insufficient statistical power.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimated median overall survival was 19.4 months (95% CI, 18.2 to could not be estimated), with an overall survival of 78% at 12 months (Fig. 2D).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Exposures were higher in patients who had a response than in those who did not (Fig. S5A), and higher exposure was associated with deeper response and longer progression-free survival (Fig. 3C and 3D).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Achievement of undetectable sBCMA levels increased with depth of response (17 of 27 pa-”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe quote only partly states this claim.
- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, cytokine release syndrome of any grade was observed in 2 of 4 patients (50%), 53 of 70 patients (76%), and 52 of 54 patients (96%), respectively, with cytokine release syndrome of grade 3 or higher observed in 0 patients, 4 patients (6%), and 3 patients (6%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimate for median duration of response was 10.7 months (95% CI, 9.0 to 11.3) overall and 11.3 months (95% CI, 10.3 to 11.4) at the 450 × 10 6 dose”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cytokine release syndrome was reported in 107 patients (84%), including 7 (5%) who had events of grade 3 or higher.”
- Also stated in: § Table 1. (Continued.) · plain
“Cytokine release syndrome occurred in 107 patients (84%) and was mostly of grade 1 or 2 (Table 2 and Table S10).Five patients (4%) had grade 3 cytokine release syndrome, 1 (<1%) had grade 4, and 1 (<1%) had grade 5 (300 × 10 6 dose level).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Table 1. (Continued.) · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Infections occurred in 88 patients (69%) and were of grade 3 or 4 in 28 (22%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 88Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“including many with a high tumor burden, high-risk cytogenetic abnormalities, and extramedullary disease.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Common toxic effects among the 128 treated patients included neutropenia in 117 patients (91%), anemia in 89 (70%), and thrombocytopenia in 81 (63%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After disease progression, 28 patients were retreated with ide-cel (Table S4).Six patients (21%) had a second response, with durations of response ranging from 1.9 to 6.8 months; all the patients who had a response were retreated at a dose higher than their initial dose.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Most grade 3 or 4 events were hematologic toxic effects, including neutropenia in 114 patients (89%), anemia in 77 (60%), and thrombocytopenia in 67 (52%), and were at least partially related to the lymphodepleting chemotherapy administered before ide-cel infusion.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 114Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A total of 44 treated patients (34%) died during the study, with most deaths (27) attributed by the investigator to complications of myeloma progression (Table S12).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 44Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Levels of proinflammatory markers, including cytokines, ferritin, and C-reactive protein, increased early after ide-cel infusion and decreased by month 1”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The response duration increased with the depth of response; the median response duration was 4.5 months (95% CI, 2.9 to 6.7), 10.4 months (95% CI, 5.1 to 11.3), and 19.0 months (95% CI, 11.3 to could not be estimated) in patients having a best response of partial response (27 patients), very good partial response (25 patients), and complete or stringent complete response (42 patients),”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At the target doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, a response was observed in 2 of 4 patients (50%), in 48 of 70 patients (69%), and in 44 of 54 patients (81%), respectively, and a complete response or better was observed in 1 of 4 patients (25%), in 20 of 70 patients (29%), and in 21 of 54 patients (39%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Five patients (4%) died after 6 months from unrelated adverse events, and an additional 8 patients (6%) died after disease progression.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 5Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Minimal residual disease (MRD)-negative status (<10 -5 nucleated cells) was confirmed in 33 patients, representing 26% of all 128 patients who were treated and 79% of the 42 patients who had a complete response or better.”
- Also stated in: § Efficacy · plain
“Of the 42 patients with a complete or stringent complete response, 33 (79%) also had MRDnegative status at a sensitivity level of 10 -5 , corresponding to 26% (95% CI, 19 to 34) of the treated population; the remaining 9 patients (21%) could not be evaluated for MRD”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 33Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Efficacy · plain
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“High-grade hematologic toxic effects were common but transient.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The fact that MRDnegative responses occurred in approximately a quarter of the patients highlights the depth of response induced by ide-cel.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: MRD negativity at a sensitivity of 10^-5 is a valid measure of depth of response and clinical benefit.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study protocol was approved by local or independent institutional review boards or ethics committees at participating sites.All the patients provided written informed consent.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Oversight
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Nearly all tumors expressed BCMA, a finding that supports the use of ide-cel in relapsed and refractory myeloma without restriction based on tumor BCMA expression.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: BCMA expression is required for ide-cel efficacy, so lack of tumor BCMA expression would limit its use.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The primary efficacy analysis was performed in the population of patients treated with ide-cel (128 patients).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Between December 13, 2017, and November 13, 2018, a total of 140 patients were enrolled and underwent leukapheresis, of whom 128 received ide-cel infusions.Twelve patients discontinued the study before ide-cel infusion (including 1 patient who discontinued after unsuccessful manufacture of the CAR T-cell product)”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Patients
Strength:plain· not yet calibratedn = 140Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study was designed by the authors in conjunction with the sponsors and conducted in accordance with the International Council for Harmonisation guidelines for Good Clinical Practice and the principles of the Declaration of Helsinki.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Oversight
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The sample size for the primary end point (overall response) was based on a onesample binomial test with normal approximation, under the assumption of 15% dropout between the time of enrollment and ide-cel treatment.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Statistical tests were not performed on subgroup analyses.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The primary end point was an overall response (partial response or better), defined according to IMWG Uniform Response Criteria for Multiple Myeloma 12 as assessed by an independent review committee.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“MRD negativity was evaluated in bone marrow aspirates by next-generation sequencing (clonoSEQ, Adaptive Biotechnologies) with a minimum cutoff of 10 -5 nucleated cells.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The actual doses delivered were within 20% of the target doses.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Design and Patients
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Adverse events were graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), version 4.03.Cytokine release syndrome was graded according to published criteria (Table S2).14”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper relies on this without support.
Soluble BCMA is a serum-based universal marker of myeloma burden.
“Soluble BCMA was assessed as a serum-based universal marker of myeloma burden.”
The paper relies on this without support.
Cross-trial comparisons of progression-free survival between the KarMMa study and trials of selinexor plus dexamethasone or belantamab mafodotin are valid.
“These efficacy results compare favorably with results in similarly heavily pretreated patients with relapsed or refractory myeloma treated with two recently approved regimens, selinexor plus dexamethasone and belantamab mafodotin (median progression-free survival, 3.7 months and 2.9 months, respectively).5,17”
The paper relies on this without support.
MRD negativity at a sensitivity of 10^-5 is a valid measure of depth of response and clinical benefit.
“The fact that MRDnegative responses occurred in approximately a quarter of the patients highlights the depth of response induced by ide-cel.”
The paper relies on this without support.
BCMA expression is required for ide-cel efficacy, so lack of tumor BCMA expression would limit its use.
“Nearly all tumors expressed BCMA, a finding that supports the use of ide-cel in relapsed and refractory myeloma without restriction based on tumor BCMA expression.”
The paper relies on this without support.
The absence of a detectable effect of antidrug antibodies on efficacy is not due to insufficient statistical power.
“Antidrug antibodies had no effect on the incidence of response or of complete response or better and had no noticeable effect on progression-free survival.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) are newly approved CAR-T products targeting BCMA that are active in relapsed refractory myeloma.89,90”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Safety of ide-cel remained consistent with the IA, with no parkinsonism, Guillain-Barré syndrome, or SPMs of T-cell origin reported. 13”
From Ide-cel vs standard regimens in triple-class-exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses. (2024) · cites this paper as [18]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Common side effects such as CRS and immune effector cell-associated neurotoxicity syndrome (ICANS) were mostly low grade, indicating manageable toxicity.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The median duration of response (mDOR) was 11 months in patients achieving CR and 19 months in those achieving stringent complete response (sCR).”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A number of BCMA-directed therapies, including belantamab mafodotin, idecabtagene vicleucel (ide-cel), ciltacabtagene autoleucel (cilta-cel) and teclistamab, have shown efficacy in clinical trials and are approved for the treatment of relapsed or refractory multiple myeloma4–9.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Median DOR and PFS were 10.7 months and 8.8 months, respectively, for ide-cel, and were both not reached for cilta-cel5,6.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Although follow-up is still ongoing, among patients with ≥CR, DOR and PFS at 15 months with elranatamab were comparable to those observed with other BCMA-targeted T-cell-redirecting therapies, suggesting similar outcomes once a deep response is achieved5,24,25.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“High response rates have been reported with the BCMA chimeric antigen receptor (CAR) T-cell therapies, ide-cel and cilta-cel, with responses reported in 73% and 97% of treated patients, respectively.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In comparison to other BCMA-targeted T-cell-redirecting therapies, the rate of hematologic AEs with elranatamab was similar or lower after a similar follow-up4–6.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“CAR-T therapy requires that patients have access to specialized care centers and can wait the minimum 4-week period for production, which can result in attrition rates of approximately 10 to 15%,6-8”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [6]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Among 128 patients with relapsed refractory myeloma treated on a phase II trial, ide-cel was associated with a response rate of 73%.89 Thirty three percent of patients had a complete response or better. The median PFS was 8.8 months.”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
The cited source says what the claim attributes to it.
In the citing paper
“Cytokine release syndrome was seen in 84%, and 5% were grade 3 or higher. Neurotoxicity was seen in 18%, and was grade 3 in 3%.”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
The cited source says what the claim attributes to it.
In the citing paper
“Chimeric antigen receptor (CAR) T-cell therapy has shown promising ef fi cacy in patients with TCE R/RMM. 13-21”
From Ide-cel vs standard regimens in triple-class-exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses. (2024) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“In the KarMMa study involving 128 patients with RRMM, the overall response rate (ORR) to a single infusion of Abecma was 73%, with a complete response (CR) rate of 33%.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
The cited source says what the claim attributes to it.
In the citing paper
“Abecma has demonstrated the ability to induce rapid, deep, and long-lasting remissions with just one infusion, providing a new and effective personalized therapy option for MM patients [227, 243, 258, 259].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
The cited source says what the claim attributes to it.
In the citing paper
“In contrast, higher-grade cytokine release syndrome and neurotoxic events have been described after CAR-T administration in patients with multiple myeloma.6,8”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [6]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Similarly, patients with advanced disease stage (R-ISS stage III) have consistently shown poorer outcomes irrespective of the therapy received4–6,19–22.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“Recently approved therapies such as selinexor, 9 belantamab mafodotin, 10 idecabtagene vicleucel, 11 and ciltacabtagene autoleucel 12 have had clinical benefit in patients with relapsed or refractory multiple myeloma.”
From Talquetamab, a T-Cell–Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma (2022) · cites this paper as [11]
Citations
Cites
Kumar, S., Paiva, B., Anderson, K. C., Durie, B., Landgren, O., Moreau, P., Munshi, N., Lonial, S., Bladé, J., Mateos, M.-V., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30206-6 · Cited by 3,061
Self-citationCurrent concepts in the diagnosis and management of cytokine release syndrome.
Lee, D. W., Gardner, R., Porter, D. L., Louis, C. U., Ahmed, N., Jensen, M., Grupp, S. A., & Mackall, C. L. (2014) · Blood · doi:10.1182/blood-2014-05-552729 · Cited by 2,806
Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma.
Raje, N., Berdeja, J., Lin, Y., Siegel, D., Jagannath, S., Madduri, D., Liedtke, M., Rosenblatt, J., Maus, M. V., Turka, A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1817226 · Cited by 1,730
Self-citationLonial, S., Lee, H. C., Badros, A., Trudel, S., Nooka, A. K., Chari, A., Abdallah, A.-O., Callander, N., Lendvai, N., Sborov, D., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30788-0 · Cited by 812
Self-citationOral selinexor-dexamethasone for triple-class refractory multiple myeloma.
Chari, A., Vogl, D. T., Gavriatopoulou, M., Nooka, A. K., Yee, A. J., Huff, C. A., Moreau, P., Dingli, D., Cole, C., Lonial, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1903455 · Cited by 666
Self-citationOutcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy.
Gandhi, U. H., Cornell, R. F., Lakshman, A., Gahvari, Z. J., McGehee, E., Jagosky, M. H., Gupta, R., Varnado, W., Fiala, M. A., Chhabra, S., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0435-7 · Cited by 616
Friedman, K. M., Garrett, T. E., Evans, J. W., Horton, H. M., Latimer, H. J., Seidel, S. L., Horvath, C. J., & Morgan, R. A. (2018) · Human Gene Therapy · doi:10.1089/hum.2018.001 · Cited by 205
Treatment of relapsed and refractory multiple myeloma
Sonneveld, P., & Broijl, A. (2016) · Haematologica · doi:10.3324/haematol.2015.129189 · Cited by 181
CAR T-cell therapy in hematologic malignancies: a voyage in progress.
Holstein, S. A., & Lunning, M. A. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1674 · Cited by 172
Understanding the mechanisms of resistance to CAR T-cell therapy in malignancies.
Cheng, J., Zhao, L., Zhang, Y., Qin, Y., Guan, Y., Zhang, T., Liu, C., & Zhou, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01237 · Cited by 153
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Comparison of FACS and PCR for Detection of BCMA-CAR-T Cells
Reichman, A., Kunz, A. B., Joedicke, J. J., Höpken, U. E., Keib, A., Neuber, B., Sedloev, D. N., Wang, L., Jiang, G., Hückelhoven‐Krauss, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020903 · Cited by 21
“Even though initial response rates to ide-cel and other BCMA-targeting CAR-T-cell products are impressive, these responses are not durable for most patients as reflected by a median PFS of less than 10 months, as observed within the KarMMa trial [14], which clearly demonstrates the need for further improvement.”
BackgroundMethodResultInfluentialDong, R., Wang, Y., Lin, Y., Sun, X., Xing, C., Zhang, Y., Wang, H., Dai, L., Kang, Y., & Jiang, S. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3814 · Cited by 20
“21037/atm-22-3814 Introduction Chimeric antigen receptor (CAR)-T cells have shown promising efficacy for the treatment of relapsed/refractory (r/r) hematologic malignancies, including acute lymphoblastic leukemia (ALL) (1,2), non-Hodgkin lymphoma (NHL) (3-6), and multiple myeloma (MM) (7,8).”
Self-citationCell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
Doglio, M., Crossland, R. E., Alho, A. C., Penack, O., Dickinson, A. M., Stary, G., de Lacerda, J. F., Eißner, G., & Inngjerdingen, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1045168 · Cited by 20
“Anti-BCMA CAR-T cells can efficiently kill plasma cells and they have been employed for the treatment of patients with multiple myeloma with encouraging results (27).”
BackgroundChimeric antigen receptor T-cell therapy for multiple myeloma
Wang, Z., Chen, C., Wang, L., Jia, Y., & Qin, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050522 · Cited by 21
“For example, a recent study pointed out that BCMA-negative was suspected in 3 of 71 patients at disease progression (94).”
BackgroundChakraborty, R., Darido, C., Liu, F., Maselko, M., & Ranganathan, S. (2023) · Cancers · doi:10.3390/cancers15030852 · Cited by 20
“Idecabtagene vicleucel (target antigen B cell maturation antigen) was used to treat relapsed or refractory multiple myeloma, with 33% complete response among the treated patients [22].”
MethodRaje, N. S., Mateos, M., Iida, S., & Reece, D. E. (2023) · Blood Cancer Journal · doi:10.1038/s41408-023-00804-y · Cited by 20
“4 months at a target dose of 150 to 450 × 10(6) CAR T cells [70].”
BackgroundSelf-citationTalbot, A., Bobin, A., Tabone, L., Lambert, J., Boccaccio, C., Deal, C., Petillon, M., Allangba, O. T., Agapé, P., Arnautou, P., et al. (2023) · Haematologica · doi:10.3324/haematol.2022.281772 · Cited by 20
Self-citationZafar, A., Huang, C., Lo, M., Arora, S., Chung, A., Wong, S. W. K., Wolf, J. L., Martin, T. G., Shah, N. D., & Banerjee, R. K. (2023) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.05.016 · Cited by 20
Self-citationClonal Myeloid Dysplasia Following CAR T-Cell Therapy: Chicken or the Egg?
Vainstein, V., Avni, B., Grisariu, S., Kfir-Erenfeld, S., Asherie, N., Nachmias, B., Auman, S., Saban, R., Zimran, E., Assayag, M., et al. (2023) · Cancers · doi:10.3390/cancers15133471 · Cited by 21
“Waitlist mortality” is high for myeloma patients with limited access to BCMA therapy
Ahmed, N., Wesson, W., Mushtaq, M. U., Bansal, R., Abdelhakim, H., Bromert, S., Appenfeller, A., Ghazal, B. A., Singh, A. K., Abhyankar, S., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1206715 · Cited by 23
“This appears to be better than the KarMMa data, where 12 (9%) patients did not receive the infusion after leukapheresis (4).”
BackgroundMethodInfluentialConditional Control of Universal CAR T Cells by Cleavable OFF-Switch Adaptors
Kvorjak, M., Ruffo, E., Tivon, Y., So, V., Parikh, A. B., Deiters, A., & Lohmueller, J. J. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00320 · Cited by 24
Teclistamab‐cqyv in multiple myeloma
Martino, E. A., Bruzzese, A., Labanca, C., Mendicino, F., Lucia, E., Olivito, V., Neri, A., Morabito, F., Vigna, E., & Gentile, M. (2023) · European Journal Of Haematology · doi:10.1111/ejh.14121 · Cited by 22
“Indeed, Teclistamab-cqyv, Idecabtagene vicleucel, 44 and Iltacabtagene auto-leucel 45 and neurotoxicity (3% vs. 18%).”
Einsele, H., Moreau, P., Bahlis, N. J., Bhutani, M., Vincent, L., Karlin, L., Perrot, A., Goldschmidt, H., van de Donk, N. W. C. J., Ocio, E. M., et al. (2024) · Advances in Therapy · doi:10.1007/s12325-024-02797-x · Cited by 20
Self-citationOliver‐Caldés, A., Español‐Rego, M., Zabaleta, A., González‐Calle, V., Velázquez, S. N., Inogés, S., de Cerio, A. L.-D., Cabañas, V., López‐Muñoz, N., Rodríguez‐Otero, P., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3759 · Cited by 21
Kalariya, N. M., Hildebrandt, M. A. T., Hansen, D. K., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013540 · Cited by 20
“10,16 A recently published single-center study also found globally comparable safety and ef fi cacy outcomes between younger (aged 70 years) and older (aged ≥ 70 years) patients with MM who received BCMA-directed CART therapy.”
Immunotherapy in Multiple Myeloma—Time for a Second Major Paradigm Shift
Mohan, M., Hari, P., & Dhakal, B. (2021) · JCO Oncology Practice · doi:10.1200/op.21.00032 · Cited by 21
Keller, A., Reiman, L. T., de Acha, O. P., Parzych, S. E., Forsberg, P. A., Kim, P., Bisht, K., Wang, H., de Velde, H. V., & Sherbenou, D. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0434 · Cited by 14
Bailén, R., Iacoboni, G., Delgado, J., López-Corral, L., Hernani-Morales, R., Ortíz-Maldonado, V., Guerreiro, M., Caballero, A., Domínguez, M. L. G., Sánchez-Pina, J., et al. (2024) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2024.06.022 · Cited by 24
Neurotoxic complications of chimeric antigen receptor (CAR) T-cell therapy
Vonberg, F. W., Malik, I., O'Reilly, M. A., Hyare, H., Carr, A. S., & Roddie, C. (2025) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-333924 · Cited by 23
Ho, M., Paruzzo, L., Noll, J. H., Stella, F., Devi, P., Ndeupen, S., Day, Y. A., Chen, G. M., Cohen, I., Ramírez-Fernández, Á., et al. (2026) · Nature Medicine · doi:10.1038/s41591-025-04121-8 · Cited by 21
Biavati, L., Huff, C. A., Ferguson, A. K., Sidorski, A., Stevens, M. A., Rudraraju, L., Zucchinetti, C., Ali, S. A., Imus, P. H., Gocke, C. B., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1916 · Cited by 20
“This is most clearly demonstrated in the recent BCMA CAR-T cell data showing that patients achieving a CR ultimately relapsed with disease (53) with earlier data from this same trial showing only a delayed relapse, but not durable remission, in patients that achievedMRD negativity.”
ResultNovel systemic treatment approaches for metastatic pancreatic cancer
Dorman, K., Heinemann, V., Kobold, S., von Bergwelt‐Baildon, M., & Boeck, S. H. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2037552 · Cited by 19
Mu, W., Long, X., Cai, H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.803693 · Cited by 19
Preclinical evaluation and structural optimization of anti-BCMA CAR to target multiple myeloma
Harush, O., Asherie, N., Kfir‐Erenfeld, S., Adler, G., Barliya, T., Assayag, M., Gatt, M. E., Stepensky, P., & Cohen, C. J. (2022) · Haematologica · doi:10.3324/haematol.2021.280169 · Cited by 18
Chimeric Antigen Receptor Based Cellular Therapy for Treatment Of T-Cell Malignancies
Polgárová, K., Otáhal, P., Šálek, C., & Pytlík, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.876758 · Cited by 19
“BCMA-directed treatment for multi-resistant multiple myeloma is also available (56).”
BackgroundTherapeutics to harness the immune microenvironment in multiple myeloma
Ignatz-Hoover, J. J., & Driscoll, J. J. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.23 · Cited by 21
Wang, X., Qi, Y., Li, H., Liu, F., Cao, J., Chen, W., Wang, Y., Qi, K., Yan, Z., Zhu, F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943004 · Cited by 19
“‡High-risk cytogenetics: presence of del(17p) and/or translocation t (4, 14) and/or translocation t (14, 16).”
BackgroundMultiplexed engineering and precision gene editing in cellular immunotherapy
Biederstädt, A., Manzar, G. S., & Daher, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1063303 · Cited by 19
“The promise of CAR-T cell therapy has primarily been realized through CD19directed therapies against B cell malignancies (2–6), and more recently through BCMA-directed therapies against multiple myeloma (7, 8), for which there are several commercial products now available.”
Background30 Years of Improved Survival in Non-Transplant-Eligible Newly Diagnosed Multiple Myeloma
Chacon, A., Leleu, X., & Bobin, A. (2023) · Cancers · doi:10.3390/cancers15071929 · Cited by 16
“Ide-cel was evaluated in the phase two KarMMA study [23] (Table 2).”
MethodTargeting BCMA in Multiple Myeloma: Advances in Antibody-Drug Conjugate Therapy
Xing, L., Liu, Y., & Liu, J. (2023) · Cancers · doi:10.3390/cancers15082240 · Cited by 19
Liu, R., Lv, Y., Hong, F., Zhao, W., Lei, B., Liu, J., Zhang, W., He, A., & Wang, F. (2023) · Hematological Oncology · doi:10.1002/hon.3155 · Cited by 19
Localized immunomodulation technologies to enable cellular and organoid transplantation
Nash, A., Lokhorst, N., & Omid Veiseh, A. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.05.008 · Cited by 18
Wachsmann, T. L. A., Meeuwsen, M. H., Remst, D. F. G., Buchner, K., Wouters, A. K., Hagedoorn, R. S., Falkenburg, J. H. F., & Heemskerk, M. H. M. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010410 · Cited by 22
New insights into the stemness of adoptively transferred T cells by γc family cytokines
Luo, M., Gong, W., Zhang, Y., Li, H., Ma, D., Wu, K., Gao, Q., & Fang, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01354-3 · Cited by 21
Gong, Z., Umoru, G., Monge, J., Shah, N. N., Mohyuddin, G. R., Radhakrishnan, S. V., Chakraborty, R., Rasche, L., Schinke, C., D’Souza, A., et al. (2024) · Blood Cancer Journal · doi:10.1038/s41408-024-01023-9 · Cited by 19
Self-citationLiang, E. C., Rejeski, K., Fei, T., Albittar, A. A., Huang, J. J., Portuguese, A. J., Wu, Q. V., Raj, S. S., Subklewe, M. S., Shouval, R., et al. (2024) · Bone Marrow Transplantation · doi:10.1038/s41409-024-02278-3 · Cited by 19
The evolving status of immunotherapies in multiple myeloma: the future role of bispecific antibodies
Swan, D., Routledge, D. J. M., & Harrison, S. J. (2021) · British Journal of Haematology · doi:10.1111/bjh.17805 · Cited by 19
“The median PFS was 8 8 months, 84% had CRS, of which 5% was Grade ≥3.(118,119) Based on these results, Ide-cel was granted FDA approval in March 2021.”
BackgroundManagement of Adverse Events and Supportive Therapy in Relapsed/Refractory Multiple Myeloma
Pozzi, S., Bari, A., Pecherstorfer, M., & Vallet, S. (2021) · Cancers · doi:10.3390/cancers13194978 · Cited by 20
Equitable access to cell and gene therapies in South Africa: opportunities and hurdles
Hendricks, C. L., Alessandrini, M., & Pepper, M. S. (2022) · Gene Therapy · doi:10.1038/s41434-021-00309-y · Cited by 20
“AntiCD19 and anti-B-cell maturation antigen CAR T-cells have been shown to be effective against relapsed/refractory B-cell malignancies [3, 4] and multiple myeloma [5], respectively, which has led to recent approvals by regulators (Table 1) [6].”
BackgroundShouval, R., Goldman, A., Flynn, J. R., El‐Moghraby, A., Rehman, M., Devlin, S. M., Corona, M., Landego, I., Lin, R. J., Scordo, M., et al. (2024) · British Journal of Haematology · doi:10.1111/bjh.19497 · Cited by 19
Impact of clonal hematopoiesis on clinical outcomes to BCMA CAR-T in multiple myeloma
Gustine, J. N., Branagan, A. R., Cirstea, D. D., Rexha, F., Han, R., Yee, A. J., Maus, M. V., Frigault, M. J., & Raje, N. S. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025015981 · Cited by 22
Self-citationManagement of Cytokine Release Syndrome (CRS) following CAR T-cell therapy: a comprehensive review
Zhang, Y., & Han, W. (2025) · Clinical Cancer Bulletin · doi:10.1007/s44272-025-00044-0 · Cited by 25
Petri, K., D’Ippolito, E., Künkele, A., Koehl, U., Busch, D. H., Einsele, H., & Hudecek, M. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01072-4 · Cited by 28
Self-citationXu, X., & Su, S.-H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1630569 · Cited by 19
“Since the 2017 FDA approval of tisagenlecleucel ® ( fi rst-in-class CD19-CAR T cell therapy for refractory acute lymphoblastic leukemia) (11), six CD19-CAR T cell products have been licensed for the treatment of B-cell malignancies and plasma cell dyscrasias (12, 13).”
Roads and detours for CAR T cell therapy in autoimmune diseases
Avouac, J., Barzel, A., Caiati, D., Davis, R. S., Gottschalk, S. M., Grieshaber‐Bouyer, R., Mao, X., Prak, E. T. L., Radic, M. Z., Scherlinger, M., et al. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01349-4 · Cited by 25
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CAR-T-Cell Therapy: Present Progress and Future strategies
Abbasi, M. H., Riaz, A., Khawar, M. B., Farooq, A., Majid, A., & Sheikh, N. (2022) · Biomedical Research and Therapy · doi:10.15419/bmrat.v9i2.726 · Cited by 18
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Therapy Resistant Gastroenteropancreatic Neuroendocrine Tumors
McClellan, K. V., Chen, E. Y.-S., Kardosh, A., Lopez, C. D., Rivero, J. D., Mallak, N., Rocha, F. G., Koethe, Y., Pommier, R. F., Mittra, E., et al. (2022) · Cancers · doi:10.3390/cancers14194769 · Cited by 20
Yuti, P., Wutti‐in, Y., Sawasdee, N., Kongkhla, K., Phanthaphol, N., Choomee, K., Chieochansin, T., Panya, A., Junking, M., Yenchitsomanus, P., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109442 · Cited by 19
Kim, S., Park, C. I., Lee, S., Choi, H. R., & Kim, C. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1062365 · Cited by 17
“For example, chimeric antigen receptor-T (CAR-T) cells exhibited a high proportion of complete responses against B cell malignancies (1, 2) and multiple myeloma (3).”
BackgroundSun, W., Liang, A., Huang, H., & Huang, X.-J. (2023) · Haematologica · doi:10.3324/haematol.2022.282316 · Cited by 18
Challenges and optimal strategies of CAR T therapy for hematological malignancies
Zhang, Y., Yang, X., Dang, X., Zhu, Z., Qian, W., Liang, A., & Han, W. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002476 · Cited by 19
“In addition, recent studies have shown that CD4-positive T cells are decisive for maintaining the long-term ef fi cacy of CAR T products [113] ; therefore, increasing the proportion of CD4-positive cells is one of the strategies to overcome CAR T cell exhaustion.”
Martin, Y. S., Franz, J. K., Agha, M., & Lazarus, H. (2023) · Blood reviews · doi:10.1016/j.blre.2023.101095 · Cited by 18
Costa, B. A., Mouhieddine, T. H., Ortiz, R. J., & Richter, J. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104040 · Cited by 18
O’Neill, C. A., & van de Donk, N. W. C. J. (2023) · eJHaem · doi:10.1002/jha2.729 · Cited by 17
“8months in patients with a median of 6 prior lines of therapy [10].”
BackgroundMartin, T. G., Madduri, D., Pacaud, L. B., & Usmani, S. Z. (2023) · Future Oncology · doi:10.2217/fon-2022-1317 · Cited by 20
Self-citationThomas, C., Ailawadhi, S., Popat, R., Kleinman, D. M., Ross, M., Gorsh, B., Mulnick, S., O’Neill, A., Paka, P., Hanna, M., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1271657 · Cited by 19
“The treatment combinations considered in the performance review included belantamab mafodotin (21, 22); idecabtagene vicleucel (23); melflufen and dexamethasone (24); selinexor and dexamethasone (25); pomalidomide and dexamethasone (26); carfilzomib and dexamethasone (27); isatuximab, pomalidomide…”
BackgroundSeckinger, A., Majocchi, S., Moine, V., Nouveau, L., Hoang, N., Daubeuf, B., Ravn, U., Plèche, N., Calloud, S., Broyer, L., et al. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01516-3 · Cited by 18
Breakthroughs in Cancer Immunotherapy: An Overview of T Cell, NK Cell, Mφ, and DC-Based Treatments
Lee, S., & Kim, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417634 · Cited by 18
Sodji, Q., Forsberg, M., Cappabianca, D., Kerr, C., Sarko, L. E., Shea, A., Adam, D., Eickhoff, J., Ong, I. M., Hernandez, R. T., et al. (2023) · Cancers · doi:10.3390/cancers16010191 · Cited by 12
“CAR targeting CD19 or B cell maturation antigen (BCMA) are FDA approved for the of relapsed/refractory B cell lymphoma/leukemia and multiple myeloma, following high rates of complete responses during clinical trials [3–10].”
BackgroundInfluentialHartley-Brown, M. A., Mo, C. C., Nadeem, O., Midha, S., Laubach, J. P., & Richardson, P. G. G. (2024) · Cancers · doi:10.3390/cancers16061166 · Cited by 22
“…early in the RRMM treatment algorithm [4,16,19–21], including the chimeric antigen receptor (CAR) T-cell therapies idecabtagene vicleucel (ide-cel) [22,23] and ciltacabtagene autoleucel (cilta-cel) [24,25]; the bispecific antibodies/T-cell engagers teclistamab [26], talquetamab [27], and…”
BackgroundAddressing platelet insecurity – A national call to action
Gehrie, E. A., Young, P. P., Basavaraju, S. V., et al. (2024) · Transfusion · doi:10.1111/trf.17987 · Cited by 18
Fu, B., Liu, R., Gao, G., Lin, Z., & He, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433774 · Cited by 20
“It is noting that all the patients who had a response were retreated with a higher dose than their initial dose (62).”
BackgroundIkeda, D., Aikawa, S., Misono, C., et al. (2024) · Blood · doi:10.1182/blood.2024026028 · Cited by 18
How Can We Engineer CAR T Cells to Overcome Resistance?
Glover, M., Avraamides, S., & Maher, J. F. (2021) · Biologics · doi:10.2147/btt.s252568 · Cited by 19
Toxicities associated with adoptive cellular therapies
Hansen, D. K., Dam, M., & Faramand, R. G. (2021) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2021.101287 · Cited by 18
Mohty, R., & Gauthier, J. (2021) · Bone Marrow Transplantation · doi:10.1038/s41409-021-01420-9 · Cited by 20
Beinfeld, M. T., Lee, S., McQueen, B., Fluetsch, N., Pearson, S. D., & Ollendorf, D. A. (2021) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2021.27.9.1315 · Cited by 17
Immunotherapy of Multiple Myeloma: Promise and Challenges
Abramson, H. N. (2021) · ImmunoTargets and Therapy · doi:10.2147/itt.s306103 · Cited by 19
Bozic, B., Rutner, J., Zheng, C., Ruckser, R., Selimi, F., Racz, K., Köcher, M., Tatzreiter, G., & Sebesta, C. (2021) · Cancers · doi:10.3390/cancers13205036 · Cited by 17
“Nearly all patients exhibited grade three or four toxic effects, most commonly haematologic toxic effects and cytokine release syndrome [47].”
BackgroundShah, N. D., Mojebi, A., Ayers, D., Cope, S. F., Dhanasiri, S., Davies, F. E., Hari, P., Patel, P. J., Hege, K. M., & Dhanda, D. S. (2022) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2022-0045 · Cited by 19
Self-citationMoreau, P., Mateos, M., García, M. E. G., Einsele, H., Stefano, V. D., Karlin, L., Lindsey-Hill, J., Besemer, B., Vincent, L., Kirkpatrick, S., et al. (2023) · Advances in Therapy · doi:10.1007/s12325-023-02738-0 · Cited by 18
Self-citationHarfmann, M., Schröder, T., Głów, D., Jung, M., Uhde, A., Kröger, N. M., Horn, S., Riecken, K., Fehse, B., & Ayuk, F. A. (2024) · Cancers · doi:10.3390/cancers16020334 · Cited by 17
Caillot, L., Sleiman, E., Lafon, I., et al. (2024) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2024.03.003 · Cited by 17
Perrot, A., Delimpasi, S., Spanoudakis, E., Frølund, U. C., Belotti, A., Oriol, A., Moreau, P., McFadden, I., Xia, Q., Arora, M., et al. (2024) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2024.2322030 · Cited by 17
Self-citationLong-term follow-up of BCMA CAR-T cell therapy in patients with relapsed/refractory multiple myeloma
Jin, C., Chen, R., Fu, S., Zhang, M., Teng, Y., Yang, T., Song, F., Feng, J., Hong, R., Cui, J., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010687 · Cited by 22
Dima, D., Vazquez-Martinez, M. A., Davis, J. A., Goel, U., Afrough, A., Sannareddy, A., Pasvolsky, O., Razzo, B. M., Banerjee, R. K., Khouri, J., et al. (2025) · Blood Cancer Journal · doi:10.1038/s41408-025-01314-9 · Cited by 18
Self-citationCAR T cell persistence in cancer
Mueller, K. P., Grenier, J. M., & Weber, E. W. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.08.014 · Cited by 22
van de Donk, N. W. C. J., Moreau, P., Miguel, J. F. S., Mateos, M., Dimopoulos, M. A., Zweegman, S., Gay, F., Engelhardt, M., Mina, R., Zamagni, E., et al. (2025) · HemaSphere · doi:10.1002/hem3.70260 · Cited by 20
“6, 16, relapse after CAR T ‐ cell therapy can be effectively treated with ( Besides approval status and reimbursement policies, the choice between belamaf and BsAbs is influenced by differences in safety profile (ocular toxicity with belamaf, infections with BCMA ‐ targeting BsAbs, and oral…”
InfluentialSelf-citationEnabling CAR-T cells for solid tumors: Rage against the suppressive tumor microenvironment
Antoñana-Vildosola, A., Zanetti, S. R., & Palazón, A. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.03.004 · Cited by 17
Byun, J. M., Min, C., Kım, K., Bang, S., Lee, J., Kim, J. S., Yoon, S., & Koh, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01374-5 · Cited by 17
“While it is true that ide-cel and cilta-cel is the current go-to option for the treatment of adult patients with RR MM following 4 or more prior lines of therapy [30, 31], the production turnaround time of median 1 month calls for adequate bridging therapy.”
BackgroundEEG-based grading of immune effector cell-associated neurotoxicity syndrome
Jones, D. K., Eckhardt, C. A., Sun, H., Tesh, R. A., Malik, P., Quadri, S. A., Firme, M. S., van Sleuwen, M., Jain, A., Fan, Z., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24010-1 · Cited by 20
Lipe, B. C., & Renaud, T. M. (2022) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552221140320 · Cited by 17
“In the phase 2 KarMMa study (NCT03361748) of idecabtagene vicleucel, CRS was reported in 107 (84%) of 128 patients, one of whom was administered siltuximab for these symptoms.(20) In the phase 1/2 EVOLVE study (NCT03430011), 55 (89%) of 62 patients who were treated with orvacabtagene autoleucel developed CRS and 8 (13…”
MethodDelforge, M., Rodríguez‐Otero, P., Shah, N. D., et al. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107074 · Cited by 17
Self-citationWu, W., Ding, S., Mingming, Z., Zhou, Y., Sun, X., Zhao, Z., Yang, Y., Hu, Y., & Dong, H. (2023) · Journal of Medical Economics · doi:10.1080/13696998.2023.2207742 · Cited by 22
“Although Ide-cel and Cilta-cel achieved a high complete response (CR) rate in heavily pre-treated populations, the disease progressed or relapsed soon after achieving responses in a certain proportion of patients, and some patients had no responses to anti-BCMA CAR T cells at all 12,13 .”
BackgroundCurrent and potential roles of immuno-PET/-SPECT in CAR T-cell therapy
Mulgaonkar, A., Udayakumar, D., Yang, Y., Harris, S. F., Öz, O. K., Geethakumari, P. R., & Sun, X. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1199146 · Cited by 18
“Two CAR T-cell therapies targeting the B-cell maturation antigen (BCMA), idecabtagene vicleucel (idecel, Abecma R© , BMS) (24) and ciltacabtagene autoleucel (ciltacel, Carvykti R© , Janssen) (25), have been approved in R/R multiple myeloma.”
BackgroundRational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy
Lorenzini, T., Cadilha, B. L., Obeck, H., Benmebarek, M.-R., Märkl, F., Michaelides, S., Strzalkowski, T., Briukhovetska, D., Müller, P. J., Nandi, S., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02332-9 · Cited by 17
Elranatamab: a new promising BispAb in multiple myeloma treatment
Grosicki, S., Bednarczyk, M., & Kociszewska, K. (2023) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2023.2236303 · Cited by 17
“This therapy showed frequent, deep, and durable responses in TCE patients with RRMM in the pivotal, phase 2 KarMMa trial [6].”
BackgroundWu, J. F., & Dhakal, B. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01479-5 · Cited by 18
van der Schans, J. J., Wang, Z., van Arkel, J., van Schaik, T., Katsarou, A., Ruiter, R., Baardemans, T., Yuan, H., de Bruijn, J., Zweegman, S., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0132 · Cited by 17
Outcomes of Autologous Stem Cell Transplantation in Patients with Ultra-High-Risk Multiple Myeloma
Pasvolsky, O., Ghanem, S., Milton, D. R., Masood, A., Tanner, M. R., Bashir, Q., Srour, S. A., Saini, N., Lin, P. Y., Ramdial, J., et al. (2023) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.08.031 · Cited by 17
Yamamoto, C., Minakata, D., Yokoyama, D., Furuki, S., Noguchi, A., Koyama, S., Oyama, T., Murahashi, R., Nakashima, H., Ikeda, T., et al. (2023) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.10.001 · Cited by 21
Novel Immunotherapies and Combinations: The Future Landscape of Multiple Myeloma Treatment
Morè, S., Corvatta, L., Manieri, V. M., Morsia, E., Poloni, A., & Offidani, M. (2023) · Pharmaceuticals · doi:10.3390/ph16111628 · Cited by 19
“Similarly, real world USA experiences about ide-cel confirmed good ORR and outcomes in populations not always eligible in KARMMA trials [83,84].”
BackgroundCurrent use of CAR T cells to treat multiple myeloma
Firestone, R., & Mailankody, S. (2023) · Hematology · doi:10.1182/hematology.2023000434 · Cited by 18
Kim, S. J., Yoon, S. E., & Kim, W. S. (2024) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.0388 · Cited by 19
Kitawi, R. C., Ledger, S., Kelleher, A. D., & Ahlenstiel, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052771 · Cited by 18
“Supplementary Table S1 gives a summary of gene and cell products that have been approved so far by different regulatory authorities [ 2– 34 ].”
BackgroundImmune status and selection of patients for immunotherapy in myeloma: a proposal
Dhodapkar, M. V. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023011242 · Cited by 21
“3,4 In spite of high rates of remission, including measurable residual disease (MRD) negativity, patients with MM remain at risk of ongoing relapse.”
BackgroundUpdates on CAR T cell therapy in multiple myeloma
Nasiri, F., Asaadi, Y., Mirzadeh, F., Abdolahi, S., Molaei, S., Piri‐Gavgani, S., & Rahbarizadeh, F. (2024) · Biomarker Research · doi:10.1186/s40364-024-00634-5 · Cited by 20
“However, despite the prolonged responses of ide-cel and cilta-cel in some patients, a significant number of them eventually face relapse, typically with a response duration of approximately 8.6 months and 34.9 months, respectively [8–13].”
BackgroundInfluentialRNA-loaded nanoparticles for the treatment of hematological cancers
Garbayo, E., Moukhtari, S. H. E., Rodríguez‐Nogales, C., Agirre, X., Rodríguez-Madoz, J. R., Rodríguez-Márquez, P., Prósper, F., Couvreur, P., & Blanco‐Prieto, M. J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115448 · Cited by 19
Metadata
- Authors
- Munshi, N. C., Anderson, L. D., Shah, N., Madduri, D., Berdeja, J., Lonial, S., Raje, N., Lin, Y., Siegel, D., Oriol, A., Moreau, P., Yakoub-Agha, I., Delforge, M., Cavo, M., Einsele, H., Goldschmidt, H., Weisel, K., Rambaldi, A., Reece, D., Petrocca, F., Massaro, M., Connarn, J. N., Kaiser, S., Patel, P., Huang, L., Campbell, T. B., Hege, K., & San-Miguel, J.
- Affiliations
- Harvard University (US)
- Mayo Clinic (US)
- Hackensack University Medical Center (US)
- From the Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute (N.C.M.), the Veterans Affairs Boston Healthcare System, Harvard Medical School (N.C.M.), and Massachusetts General Hospital (N.R.), Boston, and bluebird bio, Cambridge (F.P., M.M.) — all in Massachusetts; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas (L.D.A.); the University of California, San Francisco, San Francisco (N.S.); Icahn School of Medicine at Mount Sinai, New York ...
- ORCID
- Munshi, Nikhil C.
- Anderson, Larry D.
- Shah, Nina
- Madduri, Deepu
- Berdeja, Jesús
- Lonial, Sagar
- Raje, Noopur
- Lin, Yi
- Siegel, David
- Oriol, Albert
- Moreau, Philippe
- Yakoub-Agha, Ibrahim
- Delforge, Michel
- Einsele, Hermann
- Goldschmidt, Hartmut
- Weisel, Katja
- Rambaldi, Alessandro
- Reece, Donna
- Petrocca, Fabio
- Connarn, Jamie N.
- Kaiser, Shari
- Patel, Payal
- Huang, Liping
- Campbell, Timothy B.
- Hege, Kristen
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-02-25
- Volume
- 384
- Issue
- 8
- Pages
- 705-716
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3133229959
- Semantic Scholar
- fd96e2f87dff7d1153a17b78b56fbbab69cb714e
- Cited by
- 2,560
- References
- 17
- Citations by year
- 2026: 411 · 2025: 486 · 2024: 540 · 2023: 493 · 2022: 436 · 2021: 186
- FWCI
- 150.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- idecabtagene vicleucel, CAR T-cell therapy, relapsed/refractory multiple myeloma, BCMA, minimal residual disease, cytokine release syndrome, neurotoxicity, CAR T cell persistence, progression-free survival, complete response, neutropenia, anemia, thrombocytopenia, chimeric antigen receptor T cells
- MeSH terms
- Receptors, Chimeric Antigen, Progression-Free Survival, Cytokine Release Syndrome, Adult, Aged, Female, Hematologic Diseases, Humans, Male, Middle Aged, Multiple Myeloma, Recurrence, Biomarkers, Immunotherapy, Adoptive, Drug Resistance, Neoplasm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-11, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-11 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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