Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel
Open accessAbstract
BACKGROUND: Approximately 5.1 million Israelis had been fully immunized against coronavirus disease 2019 (Covid-19) after receiving two doses of the BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) by May 31, 2021. After early reports of myocarditis during adverse events monitoring, the Israeli Ministry of Health initiated active surveillance. METHODS: We retrospectively reviewed data obtained from December 20, 2020, to May 31, 2021, regarding all cases of myocarditis and categorized the information using the Brighton Collaboration definition. We analyzed the occurrence of myocarditis by computing the risk difference for the comparison of the incidence after the first and second vaccine doses (21 days apart); by calculating the standardized incidence ratio of the observed-to-expected incidence within 21 days after the first dose and 30 days after the second dose, independent of certainty of diagnosis; and by calculating the rate ratio 30 days after the second dose as compared with unvaccinated persons. RESULTS: Among 304 persons with symptoms of myocarditis, 21 had received an alternative diagnosis. Of the remaining 283 cases, 142 occurred after receipt of the BNT162b2 vaccine; of these cases, 136 diagnoses were definitive or probable. The clinical presentation was judged to be mild in 129 recipients (95%); one fulminant case was fatal. The overall risk difference between the first and second doses was 1.76 per 100,000 persons (95% confidence interval [CI], 1.33 to 2.19), with the largest difference among male recipients between the ages of 16 and 19 years (difference, 13.73 per 100,000 persons; 95% CI, 8.11 to 19.46). As compared with the expected incidence based on historical data, the standardized incidence ratio was 5.34 (95% CI, 4.48 to 6.40) and was highest after the second dose in male recipients between the ages of 16 and 19 years (13.60; 95% CI, 9.30 to 19.20). The rate ratio 30 days after the second vaccine dose in fully vaccinated recipients, as compared with unvaccinated persons, was 2.35 (95% CI, 1.10 to 5.02); the rate ratio was again highest in male recipients between the ages of 16 and 19 years (8.96; 95% CI, 4.50 to 17.83), with a ratio of 1 in 6637. CONCLUSIONS: The incidence of myocarditis, although low, increased after the receipt of the BNT162b2 vaccine, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The BNT162b2 vaccine was associated with increased risk of myocarditis in Israeli participants, reaching a rate of approximately 3 events per 100,000 persons.
“However, the vaccine was associated with increased risk of myocarditis in Israeli participants, reaching a rate of approximately 3 events per 100,000 persons.398–400”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [399]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works
Haas, E. J., Angulo, F. J., McLaughlin, J. M., Anis, E., Singer, S. R., Khan, F., Brooks, N., Smaja, M., Mircus, G., Pan, K., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00947-8 · Cited by 1,564 · see citing works
Self-citationSafety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
Barda, N., Dagan, N., Ben-Shlomo, Y., Kepten, E., Waxman, J., Ohana, R., Hernán, M. A., Lipsitch, M., Kohane, I., Netzer, D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110475 · Cited by 1,027 · see citing works
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
Witberg, G., Barda, N., Hoss, S., Richter, I., Wiessman, M., Aviv, Y., Grinberg, T., Auster, O., Dagan, N., Balicer, R. D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110737 · Cited by 613 · see citing works
Mei, R., Raschi, E., Forcesi, E., Diemberger, I., Ponti, F. D., & Poluzzi, E. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.09.054 · Cited by 84 · see citing works
Surveillance Guidelines for Smallpox Vaccine (vaccinia) Adverse Reactions
Casey, C., Vellozzi, C. J., Mootrey, G. T., Chapman, L. E., McCauley, M. M., Roper, M. H., Damon, I. K., & Swerdlow, D. L. (2006) · PsycEXTRA Dataset · doi:10.1037/e506942006-001 · Cited by 58 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [7]Sahai H, Khurshid A. Statistics in epidemiology: methods, techniques, and applications. Boca Raton, FL: CRC Press, 1996.
Cited by
Sorted by citations
Oster, M. E., Shay, D. K., Su, J. R., Gee, J. M., Creech, C. B., Broder, K. R., Edwards, K. M., Soslow, J. H., Dendy, J. M., Schlaudecker, E. P., et al. (2022) · JAMA · doi:10.1001/jama.2021.24110 · Cited by 671 · see citing works
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar‐Hari, M., Watkinson, P., Khunti, K. K., Harnden, A., Coupland, C. A. C., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01630-0 · Cited by 641 · see citing works
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works
Covid-19 Vaccines — Immunity, Variants, Boosters
Barouch, D. H. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2206573 · Cited by 434 · see citing works
Gluckman, T. J., Bhave, N. M., Allen, L. A., Chung, E. H., Spatz, E. S., Ammirati, E., Baggish, A. L., Bozkurt, B., Cornwell, W. K., Harmon, K. G., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.003 · Cited by 419 · see citing works
Diagnosis and Treatment of Acute Myocarditis: A Review
Ammirati, E., & Moslehi, J. J. (2023) · JAMA · doi:10.1001/jama.2023.3371 · Cited by 379 · see citing works
SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study
Husby, A., Hansen, J. V., Fosbøl, E. L., Thiesson, E. M., Madsen, M., Thomsen, R. W., Sørensen, H. T., Andersen, M. T., Wohlfahrt, J., Gislason, G., et al. (2021) · BMJ · doi:10.1136/bmj-2021-068665 · Cited by 275 · see citing works
Ghattas, M., Dwivedi, G., Lavertu, M., & Alameh, M. (2021) · Vaccines · doi:10.3390/vaccines9121490 · Cited by 266 · see citing works
Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms
Heymans, S., & Cooper, L. T. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00662-w · Cited by 244 · see citing works
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar‐Hari, M., Watkinson, P., Khunti, K. K., Harnden, A., Coupland, C. A. C., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059970 · Cited by 238 · see citing works
Basso, C. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2114478 · Cited by 234 · see citing works
SARS-CoV-2 vaccination and myocarditis in a Nordic cohort study of 23 million residents
Karlstad, Ø., Hovi, P., Husby, A., Härkänen, T., Selmer, R. M., Pihlström, N., Hansen, J. V., Nohynek, H., Gunnes, N., Sundström, A., et al. (2022) · JAMA Cardiology · doi:10.1001/jamacardio.2022.0583 · Cited by 221 · see citing works
Chi, W.-Y., Li, Y.-D., Huang, H., Chan, T. E. H., Chow, S.-Y., Su, J.-H., Ferrall, L., Hung, C., & Wu, T. ‐. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00853-8 · Cited by 216 · see citing works
Truong, D. T., Dionne, A., Muniz, J. C., McHugh, K. E., Portman, M. A., Lambert, L. M., Thacker, D., Elias, M. D., Li, J. S., Toro-Salazar, O. H., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.056583 · Cited by 182 · see citing works
Wong, H., Hu, M., Zhou, C. K., Lloyd, P. C., Amend, K. L., Beachler, D. C., Secora, A. M., McMahill‐Walraven, C. N., Lu, Y., Wu, Y., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00791-7 · Cited by 169 · see citing works
Ling, R. R., Ramanathan, K. R., Tan, F. L., Tai, B. C., Somani, J., Fisher, D. A., & MacLaren, G. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00059-5 · Cited by 166 · see citing works
Heidecker, B., Dagan, N., Balicer, R., Eriksson, U., Rosano, G., Coats, A., Tschöpe, C., Kelle, S., Poland, G. A., Frustaci, A., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2669 · Cited by 159 · see citing works
Buchan, S. A., Seo, C. Y., Johnson, C., Alley, S., Kwong, J. C., Nasreen, S., Calzavara, A., Lu, D., Harris, T. M., Yu, K., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.18505 · Cited by 157 · see citing works
Pillay, J., Bialy, L., Gaudet, L., Wingert, A., Mackie, A. S., Paterson, D. I., & Hartling, L. (2022) · BMJ · doi:10.1136/bmj-2021-069445 · Cited by 147 · see citing works
Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus Vaccine
Lai, F. T. T., Li, X., Peng, K., Huang, L., Ip, P., Tong, X., Chui, C. S. L., Wan, E. Y. F., Wong, C. K. H., Chan, E. W., et al. (2022) · Annals of Internal Medicine · doi:10.7326/m21-3700 · Cited by 143 · see citing works
Cardiac involvement in the long-term implications of COVID-19
Satterfield, B. A., Bhatt, D. L., & Gersh, B. J. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00631-3 · Cited by 138 · see citing works
Should children be vaccinated against COVID-19?
Zimmermann, P., Pittet, L. F., Finn, A. H. R., Pollard, A. J., & Curtis, N. C. (2021) · Archives of Disease in Childhood · doi:10.1136/archdischild-2021-323040 · Cited by 125 · see citing works
Impact of COVID-19 on Cardiovascular Disease
Vosko, I., Zirlik, A., & Bugger, H. (2023) · Viruses · doi:10.3390/v15020508 · Cited by 129 · see citing works
Fazlollahi, A., Zahmatyar, M., Noori, M., Nejadghaderi, S. A., Sullman, M. J. M., Shekarriz‐Foumani, R., Kolahi, A., Singh, K., & Safiri, S. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2318 · Cited by 119 · see citing works
JCS 2023 Guideline on the Diagnosis and Treatment of Myocarditis
Nagai, T., Inomata, T., Kohno, T., Sato, T., Tada, A., Kubo, T., Nakamura, K., Oyama‐Manabe, N., Ikeda, Y., Fujino, T., et al. (2023) · Circulation Journal · doi:10.1253/circj.cj-22-0696 · Cited by 119 · see citing works
Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines
Vu, S. L., Bertrand, M., Jabagi, M.-J., Botton, J., Drouin, J., Baricault, B., Weill, A., Dray‐Spira, R., & Zureik, M. (2022) · Nature Communications · doi:10.1038/s41467-022-31401-5 · Cited by 111 · see citing works
Gender Differences in Adverse Events Following the Pfizer-BioNTech COVID-19 Vaccine
Green, M. S., Peer, V., Magid, A., HaGani, N., Anis, E., & Nitzan, D. (2022) · Vaccines · doi:10.3390/vaccines10020233 · Cited by 106 · see citing works
Self-citationThe Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
Siripanthong, B., Asatryan, B., Hanff, T. C., Chatha, S., Khanji, M. Y., Ricci, F., Muser, D., Ferrari, V. A., Nazarian, S., Santangeli, P., et al. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.10.011 · Cited by 102 · see citing works
Viral Myocarditis: Classification, Diagnosis, and Clinical Implications
Sozzi, F. B., Gherbesi, E., Faggiano, A., Gnan, E., Maruccio, A., Schiavone, M., Iacuzio, L., & Carugo, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.908663 · Cited by 105 · see citing works
Myocarditis in SARS-CoV-2 infection vs. COVID-19 vaccination: A systematic review and meta-analysis
Voleti, N., Reddy, S. P., & Ssentongo, P. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.951314 · Cited by 95 · see citing works
Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents
Mansanguan, S., Charunwatthana, P., Piyaphanee, W., Dechkhajorn, W., Poolcharoen, A., & Mansanguan, C. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7080196 · Cited by 83 · see citing works
IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination
Thurner, L., Kessel, C., Fadle, N., Regitz, E., Seidel, F., Kindermann, I., Lohse, S., Kos, I., Tschöpe, C., Kheiroddin, P., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmc2205667 · Cited by 83 · see citing works
Self-citationKwan, A. C., Ebinger, J. E., Wei, J., Le, C. N., Oft, J. R., Zabner, R., Teodorescu, D. L., Botting, P. G., Navarrette, J., Ouyang, D., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00177-8 · Cited by 80 · see citing works
Herrera, D., & Campos, G. D. L. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07262-0 · Cited by 71 · see citing works
Khan, N. A., Al-Thani, H. A. S., & El-Menyar, A. A. (2021) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2021.102246 · Cited by 72 · see citing works
Chen, L., Chua, G. T., Lu, L., Chan, B. P.-C., Wong, J. S. C., Chow, C. C. K., Yu, T.-C., Leung, A. S. Y., Lam, S.-Y., Wong, T.-W., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2035195 · Cited by 71 · see citing works
Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview
Shiravi, A. A., Ardekani, A., Sheikhbahaei, E., & Heshmat‐Ghahdarijani, K. (2021) · Cardiology and Therapy · doi:10.1007/s40119-021-00248-0 · Cited by 71 · see citing works
Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
Schwab, C., Domke, L. M., Hartmann, L., Stenzinger, A., Longerich, T., & Schirmacher, P. (2022) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02129-5 · Cited by 71 · see citing works
Myocarditis associated with COVID-19 vaccination
Buoninfante, A., Andeweg, A. C., Genov, G., & Cavaleri, M. (2024) · npj Vaccines · doi:10.1038/s41541-024-00893-1 · Cited by 76 · see citing works
Risk of Myocarditis and Pericarditis Following BNT162b2 and mRNA-1273 COVID-19 Vaccination
Goddard, K., Lewis, N., FIREMAN, B. H., Weintraub, E., Shimabukuro, T. T., Zerbo, O., Boyce, T. G., Oster, M. E., Hanson, K. E., Donahue, J. G., et al. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.07.007 · Cited by 70 · see citing works
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis
Krug, A., Stevenson, J., & Høeg, T. B. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13759 · Cited by 69 · see citing works
Lane, S., Yeomans, A., & Shakir, S. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059223 · Cited by 69 · see citing works
Cardiovascular Magnetic Resonance in Myocarditis
Polte, C. L., Bobbio, E., Bollano, E., Bergh, N., Polte, C., Himmelman, J., Lagerstrand, K. M., & Gao, S. A. (2022) · Diagnostics · doi:10.3390/diagnostics12020399 · Cited by 67 · see citing works
Ouldali, N., Bagheri, H., Salvo, F., Antona, D., Pariente, A., Leblanc, C., Tebacher, M., Micallef, J., Lévy, C., Cohen, R., et al. (2022) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2022.100393 · Cited by 66 · see citing works
Bardosh, K., Krug, A., Jamrozik, E., Lemmens, T., Keshavjee, S. A., Prasad, V. K., Makary, M., Baral, S., & Høeg, T. B. (2022) · Journal of Medical Ethics · doi:10.1136/jme-2022-108449 · Cited by 74 · see citing works
Makkar, S. K. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1675209 · Cited by 65 · see citing works
Myocarditis after BNT162b2 Vaccination in Israeli Adolescents
Mevorach, D., Anis, E., Cedar, N., Hasin, T., Bromberg, M., Goldberg, L., Parnasa, E., Dichtiar, R., Hershkovitz, Y., Ash, N., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmc2116999 · Cited by 62 · see citing works
Self-citationAutopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose
Gill, J. R., Tashjian, R., & Duncanson, E. (2022) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2021-0435-sa · Cited by 62 · see citing works
Sessa, F., Salerno, M., Esposito, M., Nunno, N. R. D., Zamboni, P., & Pomara, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245876 · Cited by 60 · see citing works
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines
Mouro, V., & Fischer, A. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00517-8 · Cited by 55 · see citing works
Lai, F. T. T., Chua, G. T., Chan, E. W. W., Huang, L., Kwan, M. Y. W., Ma, T., Qin, X. S., Chui, C. S. L., Li, X., Wan, E. Y. F., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2050952 · Cited by 57 · see citing works
Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
Ammirati, E., Bizzi, E., Veronese, G., Groh, M., Heyning, C. M. V. D., Lehtonen, J. Y. A., de Chambrun, M. P., Cereda, A. F., Picchi, C., Trotta, L., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.838564 · Cited by 59 · see citing works
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis
Lai, F. T. T., Chan, E. W. W., Huang, L., Cheung, C. L., Chui, C. S. L., Li, X., Wan, E. Y. F., Wong, C. K. H., Chan, E. W., Yiu, K. H., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.09.049 · Cited by 53 · see citing works
Safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents
Choe, Y. J., Yi, S., Hwang, I., Kim, J., Park, Y.-J., Cho, E., Jo, M., Lee, H., & Choi, E. H. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.12.044 · Cited by 49 · see citing works
Tsilingiris, D., Vallianou, N. G., Karampela, Ι., Liu, J., & Dalamaga, Μ. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100159 · Cited by 49 · see citing works
Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?
Cosentino, M., & Marino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810881 · Cited by 49 · see citing works
Gao, J., Feng, L., Li, Y., Lowe, S., Guo, Z., Bentley, R., Xie, C., Wu, B., Xie, P., Xia, W., et al. (2022) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2022.09.002 · Cited by 49 · see citing works
Ryan, F. J., Norton, T. S., McCafferty, C., Blake, S. J., Stevens, N. E., James, J., Eden, G. L., Tee, Y. C., Benson, S. C., Masavuli, M. G., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100971 · Cited by 51 · see citing works
Mouliou, D. S., & Dardiotis, E. (2022) · Diagnostics · doi:10.3390/diagnostics12071555 · Cited by 49 · see citing works
COVID ‐19 vaccine induced myocarditis in young males: A systematic review
Knudsen, B., & Prasad, V. K. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13947 · Cited by 48 · see citing works
Potential health risks of mRNA-based vaccine therapy: A hypothesis
Acevedo‐Whitehouse, K. A., & Bruno, R. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111015 · Cited by 54 · see citing works
Mahroum, N., Lavine, N., Ohayon, A., Seida, R., Alwani, A., Alrais, M., Zoubi, M., & Bragazzi, N. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872683 · Cited by 49 · see citing works
Fatima, M., Cheema, H. A., Khan, M. H. A., Shahid, H., Ali, M. S., Hassan, U., Murad, M. W., Rehman, M. A. U., & Farooq, H. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.103486 · Cited by 46 · see citing works
Wong, C. K. H., Lau, K. T. K., Xiong, X., Au, I. C. H., Lai, F. T. T., Wan, E. Y. F., Chui, C. S. L., Li, X., Chan, E. W., Gao, L., et al. (2022) · PLoS Medicine · doi:10.1371/journal.pmed.1004018 · Cited by 45 · see citing works
Alami, A., Krewski, D., Farhat, N., Mattison, D., Wilson, K., Gravel, C. A., Farrell, P. J., Crispo, J. A. G., Haddad, N., Perez-Lloret, S., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-065687 · Cited by 44 · see citing works
COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events
Giannotta, G., Murrone, A., & Giannotta, N. (2023) · Vaccines · doi:10.3390/vaccines11040747 · Cited by 43 · see citing works
SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity
Jaycox, J. R., Lucas, C. G. D. O., Yildirim, I. B., Dai, Y., Wang, E. Y., Monteiro, V. S., Lord, S. M., Carlin, J. S., Kita, M., Buckner, J. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36686-8 · Cited by 42 · see citing works
Ferreira, V. M., Plein, S., Wong, T. C., Tao, Q., Raisi‐Estabragh, Z., Jain, S., Han, Y., Ojha, V., Bluemke, D. A., Hanneman, K. A., et al. (2023) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-023-00933-0 · Cited by 42 · see citing works
Li, L., Honda-Okubo, Y., Baldwin, J., Bowen, R., Bielefeldt-Ohmann, H., & Petrovsky, N. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.04.041 · Cited by 38 · see citing works
Stowe, J., Miller, E., Andrews, N. J., & Whitaker, H. (2023) · PLoS Medicine · doi:10.1371/journal.pmed.1004245 · Cited by 42 · see citing works
Tomkins‐Netzer, O., Sar, S., Barnett‐Griness, O., Friedman, B., Shyriaieva, H., & Saliba, W. (2022) · Ophthalmology · doi:10.1016/j.ophtha.2022.05.015 · Cited by 41 · see citing works
Self-citationAnalysis of Myocarditis Among 252 Million mRNA-1273 Recipients Worldwide
Straus, W., Urdaneta, V., Esposito, D. B., Mansi, J. A., Sanz Rodriguez, C., Burton, P., & Vega, J. M. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciac446 · Cited by 41 · see citing works
Vaccination-Associated Myocarditis and Myocardial Injury
Altman, N. L., Berning, A. A., Mann, S., Quaife, R. A., Gill, E. A., Auerbach, S. R., Campbell, T., & Bristow, M. R. (2023) · Circulation Research · doi:10.1161/circresaha.122.321881 · Cited by 41 · see citing works
Stein, M., Ashkenazi‐Hoffnung, L., Greenberg, D., Dalal, I., Livni, G., Chapnick, G., Stein‐Zamir, C., Ashkenazi, S., Sagie, L. H., & Grossman, Z. (2022) · Vaccines · doi:10.3390/vaccines10010081 · Cited by 39 · see citing works
Husby, A., Gulseth, H. L., Hovi, P., Hansen, J. V., Pihlström, N., Gunnes, N., Härkänen, T., Dahl, J., Karlstad, Ø., Heliö, T. M., et al. (2023) · BMJ Medicine · doi:10.1136/bmjmed-2022-000373 · Cited by 38 · see citing works
Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England
Copland, E., Patone, M., Saatci, D., Handunnetthi, L., Hirst, J. A., Hunt, D. P. J., Mills, N. L., Moss, P. A. H., Sheikh, A., Coupland, C. A. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47745-z · Cited by 38 · see citing works
Myocarditis in Athletes Recovering from COVID-19: A Systematic Review and Meta-Analysis
Modica, G., Bianco, M., Sollazzo, F., Murro, E. D., Monti, R., Cammarano, M., Morra, L., Nifosì, F. M., Gervasi, S. F., Gravina, E. M., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074279 · Cited by 37 · see citing works
Myopericarditis After COVID-19 mRNA Vaccination Among Adolescents and Young Adults
Yasuhara, J., Masuda, K., Aikawa, T., Shirasu, T., Takagi, H., Lee, S., & Kuno, T. (2022) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2022.4768 · Cited by 38 · see citing works
A Case of Multisystem Inflammatory Syndrome in a 12-Year-old Male After COVID-19 mRNA Vaccine
Yalçınkaya, R., Öz, F. N., Polat, M., Uçan, B., Teke, T. A., Kaman, A., Özdem, S., Şen, Z. S., Cinni, R. G., & Tanir, G. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003432 · Cited by 36 · see citing works
The pathological maelstrom of COVID-19 and cardiovascular disease
Giacca, M., & Shah, A. M. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00029-5 · Cited by 36 · see citing works
Acute myocarditis caused by COVID-19 disease and following COVID-19 vaccination
Kornowski, R., & Witberg, G. (2022) · Open Heart · doi:10.1136/openhrt-2021-001957 · Cited by 35 · see citing works
COVID-19 mRNA vaccination and myocarditis or pericarditis
Husby, A., & Køber, L. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00842-x · Cited by 34 · see citing works
Innate and adaptive immunity in acute myocarditis
Golino, M., Harding, D., Buono, M. G. D., Fanti, S., MOHIDDIN, S. A., Toldo, S. A., Smyth, J. W., Sanna, T., Marelli‐Berg, F. M., & Abbate, A. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.131901 · Cited by 38 · see citing works
Wan, E. Y. F., Wang, Y., Chui, C. S. L., Mok, A. H. Y., Xu, W., Yan, V. K. C., Lai, F. T. T., Li, X., Wong, C. K. H., Chan, E. W., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00125-8 · Cited by 35 · see citing works
Information systems for vaccine safety surveillance
Buttery, J. P., & Clothier, H. J. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2100173 · Cited by 34 · see citing works
Cardiovascular complications of COVID-19 vaccines: A review of case-report and case-series studies
Paknahad, M. H., Yancheshmeh, F. B., & Soleimani, A. (2023) · Heart & Lung · doi:10.1016/j.hrtlng.2023.02.003 · Cited by 34 · see citing works
Myocarditis associated with COVID-19 and its vaccines - a systematic review
Rout, A., Suri, S. S., Vorla, M., & Kalra, D. K. (2022) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2022.10.004 · Cited by 34 · see citing works
Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records
Niesen, M. J. M., Pawlowski, C., O’Horo, J. C., Challener, D. W., Silvert, E., Donadio, G., Lenehan, P. J., Virk, A., Swift, M. D., Speicher, L. L., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.7038 · Cited by 32 · see citing works
Thuluva, S., Paradkar, V. M., Gunneri, S., Yerroju, V., Mogulla, R. R., Suneetha, P. V., Turaga, K., Kyasani, M., Manoharan, S. K., Adabala, S., et al. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.10.045 · Cited by 33 · see citing works
Cardiovascular Assessment up to One Year After COVID-19 Vaccine–Associated Myocarditis
Yu, C. K.-M., Tsao, S. S. L., Ng, C. W.-K., Chua, G. T., Chan, K.-L., Shi, J. J., Chan, Y. Y.-T., Ip, P., Kwan, M. Y. W., & Cheung, Y. (2023) · Circulation · doi:10.1161/circulationaha.123.064772 · Cited by 33 · see citing works
Ilonze, O. J., & Guglin, M. E. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10243-9 · Cited by 32 · see citing works
Xu, K., Fan, C., Han, Y., Dai, L., & Gao, G. F. (2022) · International Immunology · doi:10.1093/intimm/dxac031 · Cited by 31 · see citing works
Shibata, S., Kobayashi, K., Tanaka, M., Asayama, K., Yamamoto, E., Nakagami, H., Hoshide, S., Kishi, T., Matsumoto, C., Mogi, M., et al. (2022) · Hypertension Research · doi:10.1038/s41440-022-01134-5 · Cited by 32 · see citing works
Receipt of mRNA Vaccine against Covid-19 and Myocarditis
Caforio, A. L. P. (2021) · New England Journal of Medicine · doi:10.1056/nejme2116493 · Cited by 32 · see citing works
Overview of U.S. COVID-19 vaccine safety surveillance systems
Gee, J. M., Shimabukuro, T. T., Su, J. R., Shay, D. K., Ryan, M. A. K., Basavaraju, S. V., Broder, K. R., Clark, M. P. A., Creech, C. B., Cunningham, F. E., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.02.065 · Cited by 34 · see citing works
Attitudes of Poles towards the COVID-19 Vaccine Booster Dose: An Online Survey in Poland
Babicki, M., & Mastalerz–Migas, A. (2022) · Vaccines · doi:10.3390/vaccines10010068 · Cited by 31 · see citing works
Safety monitoring of COVID-19 vaccines in Japan
Yamaguchi, T., Iwagami, M., Ishiguro, C., Fujii, D., Yamamoto, N., Narisawa, M., Tsuboi, T., Umeda, H., Kinoshita, N., Iguchi, T., et al. (2022) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2022.100442 · Cited by 31 · see citing works
Naveed, Z., Li, J., Wilton, J., Spencer, M., Naus, M., García, H. A. V., Kwong, J. C., Rose, C., Otterstatter, M. C., & Janjua, N. Z. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.08.799 · Cited by 31 · see citing works
Real-life safety profile of mRNA vaccines for COVID-19: An analysis of VAERS database
Laurini, G. S., Montanaro, N., Broccoli, M., Bonaldo, G., & Motola, D. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.03.054 · Cited by 31 · see citing works
- Authors
- Mevorach, D., Anis, E., Cedar, N., Bromberg, M., Haas, E. J., Nadir, E., Olsha-Castell, S., Arad, D., Hasin, T., Levi, N., Asleh, R., Amir, O., Meir, K., Cohen, D., Dichtiar, R., Novick, D., Hershkovitz, Y., Dagan, R., Leitersdorf, I., Ben-Ami, R., Miskin, I., Saliba, W., Muhsen, K., Levi, Y., Green, M. S., Keinan-Boker, L., & Alroy-Preis, S.
- Affiliations
- Bar-Ilan University (IL)
- From the Department of Internal Medicine B, Division of Immunology–Rheumatology, and Wohl Institute for Translational Medicine (D.M.) and the Departments of Cardiology (R.A., O.A.), Pathology (K. Meir), and Radiology (D.C.), Hadassah Medical Center, Braun School of Public Health (E.A.), Jesselson Integrated Heart Center, Shaare Zedek Medical Center (T.H., N.L.), and the Department of Family Medicine (I.M.), Faculty of Medicine, Hebrew University of Jerusalem, the Divisions of Epidemiology (E.A., N.C., E.J.H., E.N.), Patient Safety (S.O.-C., D.A.), and Medicine (I.L.), Israeli Ministry of Health (M.B., R. Dichtiar, D.N., Y.H., Y.L., L.K.-B., S.A.-P.), and Clalit Health Services (E.N., I.M.), Jerusalem, Israel Center for Disease Control, and Azrieli Faculty of Medicine, Bar-Ilan University (O.A.), Ramat Gan, the Department of Epidemiology and Preventive Medicine, School of Public Health (M.B., K. Muhsen), and Tel Aviv Sourasky Medical Center (R.B.-A.), Tel Aviv University, Tel Aviv, Ben Gurion University of ...
- Corresponding author
- Alroy-Preis, Sharon
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-12-02
- Volume
- 385
- Issue
- 23
- Pages
- 2140-2149
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8531987
- OpenAlex
- W3204791524
- Cited by
- 599
- References
- 7
- Citations by year
- 2026: 29 · 2025: 39 · 2024: 84 · 2023: 125 · 2022: 280 · 2021: 41
- FWCI
- 88.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- New England Journal of Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- myocarditis, BNT162b2 mRNA vaccine, COVID-19 vaccination, vaccine adverse events, incidence, standardized incidence ratio, risk difference, second vaccine dose, young men, Israel, active surveillance, adverse event reporting, vaccine safety surveillance, COVID-19 mortality, SARS-CoV-2 variants, Omicron variant
- MeSH terms
- COVID-19, BNT162 Vaccine, Adolescent, Adult, Echocardiography, Female, Hospitalization, Humans, Israel, Male, Middle Aged, Myocarditis, Retrospective Studies, Comorbidity, Incidence, Age Distribution, Sex Distribution, Kaplan-Meier Estimate, Young Adult, Patient Acuity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
