Cited by 1,898Thermoregulation and physiological responsesHeat shock proteins researchThermal Regulation in Medicine

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Heat Stroke

Bouchama, Abderrezak, Knochel, James P.·2002·New England Journal of Medicine

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Abstract

Knowledge of the molecular and cellular events in heat stroke has advanced steadily during the past decade. It is now known that heat stroke is associated with injury to multiple tissues and organs as a result not only of the cytotoxic effect of heat, but also of the inflammatory and coagulation responses of the patient. Altered expression of heat-shock proteins may also have a role in the pathogenesis of heat stroke. This article reviews current understanding of the pathophysiology of heat stroke and advances in therapy.

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Authors: Bouchama, A., & Knochel, J. P.
Affiliations: King Faisal Specialist Hospital & Research Centre (SA)
ORCID: Bouchama, Abderrezak
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2002-06-20
Volume: 346
Issue: 25
Pages: 1978-1988
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra011089
OpenAlex: W4229653650
Cited by: 1,898
References: 80
Citations by year: 2026: 130 · 2025: 115 · 2024: 97 · 2023: 109 · 2022: 103 · 2021: 106 · 2020: 107 · 2019: 91 · 2018: 91 · 2017: 90 · 2016: 81 · 2015: 100 · 2014: 95 · 2013: 73 · 2012: 67
FWCI: 4.26
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords: heatstroke, pathophysiology, heat shock proteins, cytotoxicity, inflammation, coagulation, tissue damage
MeSH terms: Acute-Phase Reaction, Animals, Blood Coagulation, Body Temperature Regulation, Central Nervous System Diseases, Endothelium, Vascular, Fever, Heat-Shock Proteins, Humans, Multiple Organ Failure, Incidence, Cytokines, Heat Stress Disorders, Heat Stroke

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