The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Heat Stroke
Abstract
Knowledge of the molecular and cellular events in heat stroke has advanced steadily during the past decade. It is now known that heat stroke is associated with injury to multiple tissues and organs as a result not only of the cytotoxic effect of heat, but also of the inflammatory and coagulation responses of the patient. Altered expression of heat-shock proteins may also have a role in the pathogenesis of heat stroke. This article reviews current understanding of the pathophysiology of heat stroke and advances in therapy.
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“Severe CBT deviations (<33 °C or >40 °C) can even have life-threatening consequences3.”
From Increased core body temperature in astronauts during long-duration space missions (2017) · cites this paper as [3]
Citations
Cites
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Cited by
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Mora, C., Dousset, B., Caldwell, I. R., Powell, F. E., Geronimo, R. C., Bielecki, C. R., Counsell, C. W. W., Dietrich, B. S., Johnston, E. T., Louis, L. V., et al. (2017) · Nature Climate Change · doi:10.1038/nclimate3322 · Cited by 1,746
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Metadata
- Authors
- Bouchama, A., & Knochel, J. P.
- Affiliations
- King Faisal Specialist Hospital & Research Centre (SA)
- ORCID
- Bouchama, Abderrezak
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-06-20
- Volume
- 346
- Issue
- 25
- Pages
- 1978-1988
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4229653650
- Cited by
- 1,898
- References
- 80
- Citations by year
- 2026: 130 · 2025: 115 · 2024: 97 · 2023: 109 · 2022: 103 · 2021: 106 · 2020: 107 · 2019: 91 · 2018: 91 · 2017: 90 · 2016: 81 · 2015: 100 · 2014: 95 · 2013: 73 · 2012: 67
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- heatstroke, pathophysiology, heat shock proteins, cytotoxicity, inflammation, coagulation, tissue damage
- MeSH terms
- Acute-Phase Reaction, Animals, Blood Coagulation, Body Temperature Regulation, Central Nervous System Diseases, Endothelium, Vascular, Fever, Heat-Shock Proteins, Humans, Multiple Organ Failure, Incidence, Cytokines, Heat Stress Disorders, Heat Stroke
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