The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Antithyroid Drugs
Abstract
Antithyroid drugs, which have been available for more than half a century, are important in the management of hyperthyroidism, particularly in patients with Graves' disease, who have a high response rate. Since the responses of patients vary and these agents have potentially serious side effects, a working knowledge of their complex pharmacology is required. This review article considers recent pharmacologic and clinical data related to the use of these compounds.
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In the citing paper
“Some patients may develop a transient increase in thyroid hormones after RAI [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“ATDs are associated with a variety of side effects that include rare but potentially life-threatening complications [4,115,116] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“Hepatocellular disease is rarely reported during MMI treatment [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“However, this approach is not generally recommended because it has been shown to result in a higher rate of ATD side effects (109,119).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“since remission rates are highest in persons with mild disease (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“MMI and PTU both appear in breast milk in only small concentrations, and studies of breastfed infants of mothers taking ATDs have demonstrated normal thyroid function and subsequent normal intellectual development (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“Both MMI and PTU are effective therapies of hyperthyroidism in the majority of patients, and the major effect of both drugs is interaction with thyroid peroxidase-catalyzed thyroid hormone production (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
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Metadata
- Authors
- Cooper, D. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Cooper, David S.
- ORCID
- Cooper, David S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-03
- Volume
- 352
- Issue
- 9
- Pages
- 905-917
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4243225672
- Cited by
- 1,008
- References
- 123
- Citations by year
- 2026: 35 · 2025: 36 · 2024: 51 · 2023: 50 · 2022: 45 · 2021: 52 · 2020: 62 · 2019: 38 · 2018: 62 · 2017: 51 · 2016: 66 · 2015: 51 · 2014: 48 · 2013: 56 · 2012: 49
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Keywords
- antithyroid drugs, hyperthyroidism, Graves' disease, adverse effects, drug response
- MeSH terms
- Agranulocytosis, Algorithms, Female, Graves Disease, Humans, Hyperthyroidism, Methimazole, Pregnancy, Pregnancy Complications, Propylthiouracil, Antithyroid Agents, Thyroid Gland, Thyrotoxicosis, Thyroxine, Triiodothyronine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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