The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Antithyroid Drugs
Abstract
Antithyroid drugs, which have been available for more than half a century, are important in the management of hyperthyroidism, particularly in patients with Graves' disease, who have a high response rate. Since the responses of patients vary and these agents have potentially serious side effects, a working knowledge of their complex pharmacology is required. This review article considers recent pharmacologic and clinical data related to the use of these compounds.
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In the citing paper
“Some patients may develop a transient increase in thyroid hormones after RAI [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“ATDs are associated with a variety of side effects that include rare but potentially life-threatening complications [4,115,116] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“Hepatocellular disease is rarely reported during MMI treatment [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“However, this approach is not generally recommended because it has been shown to result in a higher rate of ATD side effects (109,119).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“since remission rates are highest in persons with mild disease (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“MMI and PTU both appear in breast milk in only small concentrations, and studies of breastfed infants of mothers taking ATDs have demonstrated normal thyroid function and subsequent normal intellectual development (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“Both MMI and PTU are effective therapies of hyperthyroidism in the majority of patients, and the major effect of both drugs is interaction with thyroid peroxidase-catalyzed thyroid hormone production (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
Citations
Cites
The Transfer of Drugs and Other Chemicals Into Human Milk
Committee on Drugs (2001) · Pediatrics · doi:10.1542/peds.108.3.776 · Cited by 1,256
Occurrence of Ophthalmopathy after Treatment for Graves' Hyperthyroidism
Tallstedt, L., Lundell, G., Tørring, O., Wallin, G., Ljunggren, J.-G., Blomgren, H., & Taube, A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199206253262603 · Cited by 521
Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism
Singer, P. A. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520340064038 · Cited by 427
Liver transplantation for acute liver failure from drug induced liver injury in the United States
Russo, M. W., Galanko, J. A., Shrestha, R., Fried, M. W., & Watkins, P. (2004) · Liver Transplantation · doi:10.1002/lt.20204 · Cited by 393
Wartofsky, L., Glinoer, D., Solomon, B. L., Nagataki, S., Lagasse, R., Nagayama, Y., & Izumi, M. (1991) · Thyroid · doi:10.1089/thy.1991.1.129 · Cited by 374
Cooper, D. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411223112106 · Cited by 323
Self-citationTörring, O., Tallstedt, L., Wallin, G., Lundell, G. E. F., Ljunggren, J. ‐., Taube, A., Sääf, M., & Hamberger, B. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768863 · Cited by 311
VITTI, P., RAGO, T., CHIOVATO, L., PALLINI, S., SANTINI, F., FIORE, E., ROCCHI, R., MARTINO, E., & PINCHERA, A. (1997) · Thyroid · doi:10.1089/thy.1997.7.369 · Cited by 293
Carbimazole and the Autoimmune Response in Graves' Disease
McGregor, A. M., Petersen, M. M., McLachlan, S. M., Rooke, P., Smith, B. R., & Hall, R. (1980) · New England Journal of Medicine · doi:10.1056/nejm198008073030603 · Cited by 274
Current Trends in the Management of Graves' Disease*
Solomon, B. L., Glinoer, D., Lagasse, R., & Wartofsky, L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1518 · Cited by 266
Research works printed but not linked: 18
- Taurog A. Hormone synthesis and secretion. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid: a fundamental and clinical text. Philadelphia: Lippincott-Raven, 1996:47-80.
- 10.1210/jc.81.8.2976 · DOI
- Wilson R, 1988, Clin Exp Immunol, 73, 312
- 10.1001/archinte.147.4.785 · DOI
- 10.1210/jc.81.8.2986 · DOI
- 10.1210/jc.86.8.3488 · DOI
- 10.1210/jc.76.6.1516 · DOI
- 10.1210/jc.80.8.2470 · DOI
- Abraham P, 2004, Cochrane Database Syst Rev, 2, CD003420
- 10.1210/jc.81.9.3283 · DOI
- Ducornet B, 1988, Ann Med Interne (Paris), 139, 410
- 10.1210/jc.82.6.1727 · DOI
- Parker WA, 1982, Clin Pharm, 1, 471
- 10.1210/jc.84.1.13 · DOI
- Waldhauser L, 1991, Drug Metab Dispos, 19, 354
- 10.1210/jc.85.11.4270 · DOI · Paper page
- 10.1210/jc.82.9.3099 · DOI
- Junik R, 1989, Endokrynol Pol, 40, 307
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
Self-citationThe Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Self-citationBahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098
Self-citation2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism
Kahaly, G. J., Bartalena, L., Hegedüs, L., Leenhardt, L., Poppe, K. G., & Pearce, S. H. S. (2018) · European Thyroid Journal · doi:10.1159/000490384 · Cited by 1,025
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898
Self-citationDe Leo, S., Lee, S. Y., & Braverman, L. E. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00278-6 · Cited by 883
Brent, G. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp0801880 · Cited by 592
Davies, T. F., Andersen, S., Latif, R., Nagayama, Y., Barbesino, G., Brito, M., Eckstein, A. K., Stagnaro‐Green, A., & Kahaly, G. J. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0184-y · Cited by 421
Thyrotoxicosis and Thyroid Storm
Nayak, B. M., & Burman, K. D. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.008 · Cited by 392
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Burch, H. B., Burman, K. D., & Cooper, D. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2802 · Cited by 346
Self-citationBiondi, B., Bartalena, L., Cooper, D. S., Hegedüs, L., Laurberg, P., & Kahaly, G. J. (2015) · European Thyroid Journal · doi:10.1159/000438750 · Cited by 323
Self-citationCooper, D. S., & Laurberg, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70086-x · Cited by 310
Self-citationDiagnosis and management of Graves disease: a global overview
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Ross, D. S. (2011) · New England Journal of Medicine · doi:10.1056/nejmct1007101 · Cited by 286
Diagnosis and classification of Graves' disease
Menconi, F., Marcocci, C., & Marinò, M. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.013 · Cited by 285
Chiha, M., Samarasinghe, S., & Kabaker, A. S. (2013) · Journal of Intensive Care Medicine · doi:10.1177/0885066613498053 · Cited by 262
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Abraham, P., Avenell, A., McGeoch, S. C., Clark, L. F., & Bevan, J. S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003420.pub4 · Cited by 249
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Kahaly, G. J. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa646 · Cited by 237
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Biondi, B., & Kahaly, G. J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.105 · Cited by 230
Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones
Mondal, S., Raja, K., Schweizer, U., & Mugesh, G. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601116 · Cited by 220
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Cooper, D. S., & Rivkees, S. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0850 · Cited by 212
Self-citationWalter, M. A., Briel, M., Christ-Crain, M., Bonnema, S. J., Connell, J., Cooper, D. S., Bucher, H. C., Müller-Brand, J., & Müller, B. (2007) · BMJ · doi:10.1136/bmj.39114.670150.be · Cited by 202
Self-citationAntithyroid Drugs and Their Analogues: Synthesis, Structure, and Mechanism of Action
Manna, D., Roy, G., & Mugesh, G. (2013) · Accounts of Chemical Research · doi:10.1021/ar4001229 · Cited by 189
Pendergraft, W. F., & Niles, J. L. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000014 · Cited by 183
Analysis of 754 Cases of Antithyroid Drug-Induced Agranulocytosis Over 30 Years in Japan
Nakamura, H., Miyauchi, A., Miyawaki, N., & Imagawa, J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2569 · Cited by 180
Hyperthyroidism and Thyrotoxicosis
Devereaux, D. C., & Tewelde, S. Z. (2014) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2013.12.001 · Cited by 166
Fassi, D. E., Nielsen, C. H., Bonnema, S. J., Hasselbalch, H. C., & Hegedűs, L. D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2388 · Cited by 160
An Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine
Rivkees, S. A., & Dinauer, C. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1239 · Cited by 158
Schmutzler, C., Gotthardt, I., Hofmann, P. J., Radović, B., Kovács, G. L., Stemmler, L., Nobis, I., Bacinski, A., Mentrup, B., Ambrugger, P., et al. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9369 · Cited by 153
Jena, B. K., & Raj, C. R. (2008) · Chemistry of Materials · doi:10.1021/cm7019608 · Cited by 142
Pillaiyar, T., Meenakshisundaram, S., Manickam, M., & Sankaranarayanan, M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112275 · Cited by 140
Ending Propylthiouracil-Induced Liver Failure in Children
Rivkees, S. A., & Mattison, D. R. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0809750 · Cited by 140
Iddah, M. A., & Macharia, B. (2013) · ISRN Endocrinology · doi:10.1155/2013/509764 · Cited by 138
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Mai, S., Marquetand, P., & González, L. (2016) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6b00616 · Cited by 139
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Yamakawa, H., Kato, T., Noh, J. Y., Yuasa, S., Kawamura, A., Fukuda, K., & Aizawa, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.606931 · Cited by 137
Biondi, B., & Cooper, D. S. (2018) · New England Journal of Medicine · doi:10.1056/nejmcp1709318 · Cited by 135
Self-citationPropylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use
Rivkees, S. A., & Mattison, D. R. (2009) · International Journal of Pediatric Endocrinology · doi:10.1155/2009/132041 · Cited by 135
Liu, C., Zhang, X., Deng, J., Hecker, M., Al-Khedhairy, A. A., Giesy, J. P., & Zhou, B. (2010) · Environmental Science & Technology · doi:10.1021/es102659p · Cited by 135
Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection
Kuśmierek, K., Chwatko, G., Głowacki, R., & Bald, E. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.03.038 · Cited by 134
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Fini, J., Mével, S. L., Turque, N., Palmier, K., Zalko, D., Cravedi, J., & DEMENEIX, B. A. (2007) · Environmental Science & Technology · doi:10.1021/es0704129 · Cited by 132
Zimmerman, M. T., Bayse, C. A., Ramoutar, R. R., & Brumaghim, J. L. (2014) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2014.12.020 · Cited by 132
Schmutzler, C., Bacinski, A., Gotthardt, I., Huhne, K., Ambrugger, P., Klammer, H., Schlecht, C., Hoang‐Vu, C., Grüters, A., Wuttke, W., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1280 · Cited by 130
Coco, G., Dal Pra, C., Presotto, F., Albergoni, M. P., Canova, C., Pedini, B., Zanchetta, R., Chen, S., Furmaniak, J., Rees Smith, B., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0860 · Cited by 127
Antithyroid drug therapy: 70 years later
Burch, H. B., & Cooper, D. S. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0678 · Cited by 126
Self-citationSex differences and genomics in autoimmune diseases
Amur, S., Parekh, A., & Mummaneni, P. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.12.001 · Cited by 129
Kuśmierek, K., Chwatko, G., Głowacki, R., Kubalczyk, P., & Bald, E. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.10.035 · Cited by 122
Davies, M. J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107685 · Cited by 119
Graves disease: latest understanding of pathogenesis and treatment options
Lanzolla, G., Marinò, M., & Menconi, F. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01016-5 · Cited by 125
Epidemiology, management and outcomes of Graves’ disease—real life data
Hussain, Y. S., Hookham, J., Allahabadia, A., & Balasubramanian, S. P. (2017) · Endocrine · doi:10.1007/s12020-017-1306-5 · Cited by 118
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Azizi, F., & Malboosbaf, R. (2017) · Thyroid · doi:10.1089/thy.2016.0652 · Cited by 114
Diagnosis and management of thyrotoxicosis
Pearce, E. N. (2006) · BMJ · doi:10.1136/bmj.332.7554.1369 · Cited by 114
Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening
Friedman, K. P., Hedge, J. M., Rotroff, D. M., Hornung, M. W., Crofton, K. M., & Simmons, S. O. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400310w · Cited by 114
Emiliano, A. B., Governale, L. A., Parks, M. A., & Cooper, D. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2752 · Cited by 110
Self-citationRotondi, M., Cappelli, C., Pirali, B., Pirola, I., Magri, F., Fonte, R., Castellano, M., Rosei, E. A., & Chiovato, L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0966 · Cited by 109
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Andersen, S. L., Olsen, J., Wu, C. S., & Laurberg, P. (2014) · Thyroid · doi:10.1089/thy.2014.0150 · Cited by 108
Chen, P., Shih, S., Wang, P., Lin, Y., Chu, C., Lin, J., Chen, S., Chang, C.-C., Huang, T., Tsai, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms8633 · Cited by 105
Acute and emergency care for thyrotoxicosis and thyroid storm
Idrose, A. M. (2015) · Acute Medicine & Surgery · doi:10.1002/ams2.104 · Cited by 100
Villagelin, D., Romaldini, J. H., dos Santos, R. B., Milkos, A. B. B. P., & Ward, L. S. (2015) · Thyroid · doi:10.1089/thy.2015.0195 · Cited by 100
Roy, G., Das, D., & Mugesh, G. (2006) · Inorganica Chimica Acta · doi:10.1016/j.ica.2006.07.052 · Cited by 98
Antithyroid Drugs and Congenital Malformations
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Adverse Events Associated with Methimazole Therapy of Graves' Disease in Children
Rivkees, S. A., Stephenson, K., & Dinauer, C. (2010) · International Journal of Pediatric Endocrinology · doi:10.1155/2010/176970 · Cited by 95
Graves’ hyperthyroidism in pregnancy: a clinical review
Nguyen, C. T., Sasso, E. B., Barton, L., & Mestman, J. H. (2018) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-018-0054-7 · Cited by 94
Hallberg, P., Eriksson, N., Ibáñez, L., Bondon‐Guitton, E., Kreutz, R. H., Carvajal, A., Lucena, M. I., Ponce, E. S., Molokhia, M., Martin, J. J., et al. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)00113-3 · Cited by 94
Fassi, D. E., Banga, J. P., Gilbert, J. A., Padoa, C. J., Hegedűs, L. D., & Nielsen, C. H. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.09.007 · Cited by 92
Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use
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Sundaresh, V., Brito, J. P., Thapa, P., Bahn, R. S., & Stan, M. N. (2017) · Thyroid · doi:10.1089/thy.2016.0343 · Cited by 93
Pemphigus: Associations and management guidelines: Facts and controversies
Ruocco, E., Wolf, R., Ruocco, V., Brunetti, G., Romano, F., & Schiavo, A. L. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.01.005 · Cited by 89
Mazza, E., Carlini, M., Flecchia, D., Blatto, A., Zuccarini, O., Gamba, S., Beninati, S., & Messina, M. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346433 · Cited by 88
Shibutani, M., Woo, G., Fujimoto, H., Saegusa, Y., Takahashi, M., Inoue, K., Hirose, M., & Nishikawa, A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.04.011 · Cited by 88
Amjadi, M., Hallaj, T., Asadollahi, H., Song, Z., de Frutos, M., & Hildebrandt, N. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.01.003 · Cited by 88
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
Chen, M., Gao, Y., Guo, X., & Zhao, M. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.108 · Cited by 88
Laurberg, P., Berman, D. C., Andersen, S., & Pedersen, I. B. (2011) · Thyroid · doi:10.1089/thy.2011.0039 · Cited by 87
Moore, S., Jaeschke, H., Kleinau, G., Neumann, S., Costanzi, S., Jiang, J., Childress, J., Raaka, B. M., Colson, A. O., Paschke, R., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060247s · Cited by 83
Effects of the Antithyroid Agent Propylthiouracil in a Partial Life Cycle Assay with Zebrafish
van der Ven, L. T. M., van den Brandhof, E., Vos, J. H., Power, D. M., & Wester, P. W. (2005) · Environmental Science & Technology · doi:10.1021/es050972c · Cited by 81
Chen, C., Xirasagar, S., Lin, C.-C., Wang, L., Kou, Y. R., & Lin, H.-C. (2011) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2011.03019.x · Cited by 81
Moon, J. H., & Yi, K. H. (2013) · Endocrinology and Metabolism · doi:10.3803/enm.2013.28.4.275 · Cited by 79
Chaalal, A., Poirier, R., Blum, D. L., Laroche, S., & Enderlin, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1111-z · Cited by 80
Controversies in the management of Graves’ disease in children
Rivkees, S. A. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0477-x · Cited by 77
Gessl, A., Lemmens‐Gruber, R., & Kautzky‐Willer, A. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_17 · Cited by 79
Treatment of Graves' Hyperthyroidism: Evidence-Based and Emerging Modalities
Hegedűs, L. D. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.01.009 · Cited by 77
Maternal transfer of methimazole and effects on thyroid hormone availability in embryonic tissues
Herck, S. L. J. V., Geysens, S., Bald, E., Chwatko, G., Delezie, E., Dianati, E., Ahmed, R. G., & Darras, V. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0089 · Cited by 75
Bartalena, L., Chiovato, L., & Vitti, P. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0505-x · Cited by 75
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Weber, K. J., Solórzano, C. C., Lee, J. K., Gaffud, M. J., & Prinz, R. A. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2005.10.043 · Cited by 76
Predictors of long-term remission in patients with Graves’ disease: a single center experience
Anagnostis, P. G., Adamidou, F., Pοlyzos, S. A., Katergari, S., Karathanasi, E. M., Zouli, C., Panagiotou, A., & Kita, M. D. (2013) · Endocrine · doi:10.1007/s12020-013-9895-0 · Cited by 74
Benign Thyroid Disease: What Is the Role of Nuclear Medicine?
Sarkar, S. D. (2006) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2006.03.006 · Cited by 74
Saxena, P., Hamri, G. C., Folcher, M., Zulewski, H., & Fussenegger, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514383113 · Cited by 76
Iodide transport: implications for health and disease
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Metadata
- Authors
- Cooper, D. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Cooper, David S.
- ORCID
- Cooper, David S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-03
- Volume
- 352
- Issue
- 9
- Pages
- 905-917
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4243225672
- Cited by
- 1,008
- References
- 123
- Citations by year
- 2026: 35 · 2025: 36 · 2024: 51 · 2023: 50 · 2022: 45 · 2021: 52 · 2020: 62 · 2019: 38 · 2018: 62 · 2017: 51 · 2016: 66 · 2015: 51 · 2014: 48 · 2013: 56 · 2012: 49
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Keywords
- antithyroid drugs, hyperthyroidism, Graves' disease, adverse effects, drug response
- MeSH terms
- Agranulocytosis, Algorithms, Female, Graves Disease, Humans, Hyperthyroidism, Methimazole, Pregnancy, Pregnancy Complications, Propylthiouracil, Antithyroid Agents, Thyroid Gland, Thyrotoxicosis, Thyroxine, Triiodothyronine
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