The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Antithyroid Drugs
Abstract
Antithyroid drugs, which have been available for more than half a century, are important in the management of hyperthyroidism, particularly in patients with Graves' disease, who have a high response rate. Since the responses of patients vary and these agents have potentially serious side effects, a working knowledge of their complex pharmacology is required. This review article considers recent pharmacologic and clinical data related to the use of these compounds.
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In the citing paper
“Some patients may develop a transient increase in thyroid hormones after RAI [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“ATDs are associated with a variety of side effects that include rare but potentially life-threatening complications [4,115,116] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“Hepatocellular disease is rarely reported during MMI treatment [115, 117] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [115]
In the citing paper
“However, this approach is not generally recommended because it has been shown to result in a higher rate of ATD side effects (109,119).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“since remission rates are highest in persons with mild disease (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“MMI and PTU both appear in breast milk in only small concentrations, and studies of breastfed infants of mothers taking ATDs have demonstrated normal thyroid function and subsequent normal intellectual development (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
In the citing paper
“Both MMI and PTU are effective therapies of hyperthyroidism in the majority of patients, and the major effect of both drugs is interaction with thyroid peroxidase-catalyzed thyroid hormone production (109).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [109]
Citations
Cites
The Transfer of Drugs and Other Chemicals Into Human Milk
Committee on Drugs (2001) · Pediatrics · doi:10.1542/peds.108.3.776 · Cited by 1,256
Occurrence of Ophthalmopathy after Treatment for Graves' Hyperthyroidism
Tallstedt, L., Lundell, G., Tørring, O., Wallin, G., Ljunggren, J.-G., Blomgren, H., & Taube, A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199206253262603 · Cited by 521
Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism
Singer, P. A. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520340064038 · Cited by 427
Liver transplantation for acute liver failure from drug induced liver injury in the United States
Russo, M. W., Galanko, J. A., Shrestha, R., Fried, M. W., & Watkins, P. (2004) · Liver Transplantation · doi:10.1002/lt.20204 · Cited by 393
Wartofsky, L., Glinoer, D., Solomon, B. L., Nagataki, S., Lagasse, R., Nagayama, Y., & Izumi, M. (1991) · Thyroid · doi:10.1089/thy.1991.1.129 · Cited by 374
Cooper, D. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411223112106 · Cited by 323
Self-citationTörring, O., Tallstedt, L., Wallin, G., Lundell, G. E. F., Ljunggren, J. ‐., Taube, A., Sääf, M., & Hamberger, B. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768863 · Cited by 311
VITTI, P., RAGO, T., CHIOVATO, L., PALLINI, S., SANTINI, F., FIORE, E., ROCCHI, R., MARTINO, E., & PINCHERA, A. (1997) · Thyroid · doi:10.1089/thy.1997.7.369 · Cited by 293
Carbimazole and the Autoimmune Response in Graves' Disease
McGregor, A. M., Petersen, M. M., McLachlan, S. M., Rooke, P., Smith, B. R., & Hall, R. (1980) · New England Journal of Medicine · doi:10.1056/nejm198008073030603 · Cited by 274
Current Trends in the Management of Graves' Disease*
Solomon, B. L., Glinoer, D., Lagasse, R., & Wartofsky, L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1518 · Cited by 266
Antithyroid Drug Therapy for Graves' Disease during Pregnancy
Momotani, N., Noh, J., Oyanagi, H., Ishikawa, N., & Ito, K. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607033150104 · Cited by 261
MATERNAL HYPERTHYROIDISM AND CONGENITAL MALFORMATION IN THE OFFSPRING
Momotani, N., Ito, K., Hamada, N., Ban, Y., NISHIKAWA, Y., & Mimura, T. (1984) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1984.tb00119.x · Cited by 238
SINGER, P. A. (1995) · JAMA · doi:10.1001/jama.273.10.808 · Cited by 235
The Use of Antithyroid Drugs in Pregnancy and Lactation
Mandel, S. J., & Cooper, D. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7573 · Cited by 234
Self-citationVanderpump, M. P. J., Ahlquist, J., Franklyn, J., & Clayton, R. (1996) · BMJ · doi:10.1136/bmj.313.7056.539 · Cited by 233
A comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancy
Wing, D. A., Millar, L. K., Koonings, P. P., Montoro, M. N., & Mestman, J. H. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70390-6 · Cited by 218
Administration of Thyroxine in Treated Graves' Disease
Hashizume, K., Ichikawa, K., Sakurai, A., Suzuki, S., Takeda, T., Kobayashi, M., Miyamoto, T., Arai, M., & Nagasawa, T. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104043241403 · Cited by 214
Adverse effects of prenatal methimazole exposure
Gianantonio, E. D., Schaefer, C., Mastroiacovo, P. P., Cournot, M. P., Benedicenti, F., Reuvers, M., Occupati, B., Robert, E., Bellemin, B., Addis, A., et al. (2001) · Teratology · doi:10.1002/tera.1072 · Cited by 204
Aggravation of Thyrotoxicosis in Early Pregnancy and after Delivery in Graves' Disease*
Amino, N., Tanizawa, O., MORI, H., Iwatani, Y., Yamada, T., Kurachi, K., Kumahara, Y., & Miyai, K. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-1-108 · Cited by 204
Allannic, H., Fauchet, R., Orgiazzi, J., Orgiazzi, A., GENETET, B., LORCY, Y., GUERRIER, A. M. L., Delambre, C., & Derennes, V. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-3-675 · Cited by 192
Feldt‐Rasmussen, U., Schleusener, H., & Carayon, P. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.1.8288723 · Cited by 184
REINWEIN, D., Benker, G., Lazarus, J. H., & Alexander, W. D. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501160 · Cited by 181
Methimazole and Propylthiouracil Equally Cross the Perfused Human Term Placental Lobule
Mortimer, R. H., Cannell, G. R., Addison, R. S., Johnson, L. P., Roberts, M. S., & Bernus, I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4210 · Cited by 175
Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents
Wood, L. C., & Ingbar, S. H. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109601 · Cited by 173
Salvi, M., Girasole, G., Pedrazzoni, M., Passeri, M., Giuliani, N., Minelli, R., Braverman, L. E., & Roti, E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768861 · Cited by 166
Schleusener, H., Schwander, J., Fischer, C., Holle, R., Holl, G., Badenhoop, K. W. J., Hensen, J., Finke, R., Bogner, U., Mayr, W. R., et al. (1989) · European Journal of Endocrinology · doi:10.1530/acta.0.1200689 · Cited by 161
Neonatal Thyroid Function after Propylthiouracil Therapy for Maternal Graves' Disease
Cheron, R. G., Kaplan, M. M., Larsen, P. R., Selenkow, H. A., & Crigler, J. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198102263040907 · Cited by 160
Review of Antithyroid Drug Use During Pregnancy and Report of a Case of Aplasia Cutis
Mandel, S. J., Brent, G. A., & Larsen, P. R. (1994) · Thyroid · doi:10.1089/thy.1994.4.129 · Cited by 150
Fifty Years of Experience with Propylthiouracil-Associated Hepatotoxicity: What Have We Learned?
Williams, K. V., Nayak, S., Becker, D. J., Reyes, J., & Burmeister, L. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.4011 · Cited by 143
Andrade, V. A., Gross, J. L., & Maia, A. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7707 · Cited by 143
Cooper, D. (2003) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2003-030185 · Cited by 142
Self-citationMethimazole Pharmacology in Man: Studies Using a Newly Developed Radioimmunoassay for Methimazole*
Cooper, D. S., Bode, H. H., Nath, B. J., SAXE, V. C., Maloof, F., & Ridgway, E. C. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-3-473 · Cited by 141
Self-citationHepatic Injury during Propylthiouracil Therapy in Patients with Hyperthyroidism: A Cohort Study
Liaw, Y., Huang, M.-J., Fan, K.-D., Li, K.-L., Wu, S.-S., & Chen, T.-J. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-6-199303150-00005 · Cited by 136
McIver, B., Rae, P., Beckett, G. J., Wilkinson, E., Gold, A., & Toft, A. D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601253340403 · Cited by 135
Davidson, B., Soodak, M., Neary, J. T., Strout, H. V., Kieffer, J. D., MOVER, H., & Maloof, F. (1978) · Endocrinology · doi:10.1210/endo-103-3-871 · Cited by 135
Nedrebo, B., Holm, P., Uhlving, S., Sorheim, J., Skeie, S., Eide, G., Husebye, E., Lien, E., & Aanderud, S. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470583 · Cited by 132
TENG, C. S., & YEUNG, R. T. T. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-1-144 · Cited by 131
Tötterman, T. H., Karlsson, F. A., Bengtsson, M., & Mendel-Hartvig, I. (1987) · New England Journal of Medicine · doi:10.1056/nejm198701013160104 · Cited by 131
Fukata, S., Kuma, K., & Sugawara, M. (1999) · Thyroid · doi:10.1089/thy.1999.9.29 · Cited by 129
Insulin Autoimmune Syndrome (Hirata Disease): Clinical Features and Epidemiology in Japan
Uchigata, Y., Eguchi, Y., Takayama-Hasumi, S., & Omori, Y. (1994) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(94)90040-x · Cited by 127
Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK
Pearce, S. H. S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02135.x · Cited by 120
Drug‐induced agranulocytosis: prognostic factors in a series of 168 episodes
Julià, A., Olona, M., Bueno, J., Revilla, E., Rosselló-Urgell, J., Petit, J., Morey, M., Flores, A., Font, L., & Maciá, J. (1991) · British Journal of Haematology · doi:10.1111/j.1365-2141.1991.tb08042.x · Cited by 117
Antithyroid drugs and Graves' disease — prospective randomized assessment of long‐term treatment
Maugendre, D., Gatel, A., Campion, L., Massart, C., Guilhem, I., LORCY, Y., Lescouarc’h, J., Herry, J. Y., & Allannic, H. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00629.x · Cited by 116
Tajiri, J., & Noguchi, S. (2004) · Thyroid · doi:10.1089/105072504323150787 · Cited by 116
Intrathyroidal Concentrations of Methimazole in Patients with Graves’ Disease*
Jansson, R., Dahlberg, P. A., Johansson, H., & Lindström, B. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-1-129 · Cited by 110
Gunton, J., Stiel, J. N., Caterson, R. J., & McElduff, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.0013 · Cited by 109
Benker, G., REINWEIN, D., Kahaly, G., Tegler, L., Alexander, W. D., Faßbinder, J., & Hirche, H. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00554.x · Cited by 108
Schott, M., Morgenthaler, N. G., Fritzen, R., Feldkamp, J., Willenberg, H. S., Scherbaum, W. A., & Seissler, J. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-814217 · Cited by 104
The Side Effects of Antithyroid Drugs
Cooper, D. S. (1999) · The Endocrinologist · doi:10.1097/00019616-199911000-00008 · Cited by 102
Self-citationSato, H., Hattori, M., Fujieda, M., Sugihara, S., Inomata, H., Hoshi, M., & Miyamoto, S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.7000 · Cited by 102
ANTITHYROID DRUGS FOR THE TREATMENT OF HYPERTHYROIDISM CAUSED BY GRAVES' DISEASE
Cooper, D. S. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70308-x · Cited by 101
Self-citationLjunggren, J., Törring, O., Wallin, G., Taube, A., Tallstedt, L., Hamberger, B., & Lundell, G. E. F. (1998) · Thyroid · doi:10.1089/thy.1998.8.653 · Cited by 101
Fibbe, W. E., Claas, F. H. J., van der Star, W., Meyboom, R. H. B., Meyboom, R. H. B., & Falkenburg, J. H. F. (1986) · British Journal of Haematology · doi:10.1111/j.1365-2141.1986.tb04130.x · Cited by 100
Braga, M., Walpert, N., Burch, H. B., Solomon, B. L., & Cooper, D. S. (2002) · Thyroid · doi:10.1089/105072502753522365 · Cited by 96
Self-citationMomotani, N. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3633 · Cited by 96
Thyroid function in wholly breast‐feeding infants whose mothers take high doses of propylthiouracil
Momotani, N., Yamashita, R., Makino, F., Noh, J. Y., Ishikawa, N., Ito, K., & Ito, K. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01078.x · Cited by 94
Diagnosis and Management of Graves' Disease in Pregnancy
Hamburger, J. I. (1992) · Thyroid · doi:10.1089/thy.1992.2.219 · Cited by 94
Messer, P. M., Hauffa, B. P., Olbricht, T., Benker, G., Kotulla, P., & REINWEIN, D. (1990) · European Journal of Endocrinology · doi:10.1530/acta.0.1230311 · Cited by 92
Hedley, A. J., Young, R. E., JONES, S. J., Alexander, W. D., Bewsher, P. D., & SCOTTISH AUTOMATED FOLLOW‐UP REGISTER GROUP (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb01244.x · Cited by 91
Bonnema, S. J., Bennedbæk, F. N., Veje, A., Marving, J., & Hegedűs, L. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0247 · Cited by 90
Sera, N., Ashizawa, K., Ando, T., Abe, Y., Ide, A., Usa, T., Tominaga, T., Ejima, E., Yokoyama, N., & Eguchi, K. (2000) · Thyroid · doi:10.1089/thy.2000.10.595 · Cited by 89
Harper, L., Chin, L. S., Daykin, J., Allahabadia, A., Heward, J. M., Gough, S. C. L., Savage, C. O. S., & Franklyn, J. A. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02029.x · Cited by 88
Feldt-Rasmussen, U. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.1.98 · Cited by 88
GARDNER, D. F., Cruikshank, D. P., Hays, P. M., & Cooper, D. S. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-1-217 · Cited by 84
Self-citationIntellectual capacity of subjects exposed to methimazole or propylthiouracil in utero
Eisenstein, Z., Weiss, M., Katz, Y., & Bank, H. (1992) · European Journal of Pediatrics · doi:10.1007/bf01957719 · Cited by 83
Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections
Sheng, W. (1999) · QJM · doi:10.1093/qjmed/92.8.455 · Cited by 83
The Use of Antithyroid Drugs in Pregnancy and Lactation
Mandel, S. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.6.2354 · Cited by 81
Michelangeli, V. P., Poon, C., TAFT, J., Newnham, H. H., Topliss, D. J., & Colman, P. G. (1998) · Thyroid · doi:10.1089/thy.1998.8.119 · Cited by 78
COOPER, D. S., SAXE, V. C., MESKELL, M., MALOOF, F., & RIDGWAY, E. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-101 · Cited by 76
Self-citationHaematopoietic growth factor in antithyroid-drug-induced agranulocytosis
Andrès, E. (2001) · QJM · doi:10.1093/qjmed/94.8.423 · Cited by 73
dos Santos, R. B., Romaldini, J. H., & Ward, L. S. (2004) · Thyroid · doi:10.1089/1050725041517093 · Cited by 73
Methimazole: An Alternative Route of Administration*
NABIL, N., Miner, D. J., & AMATRUDAf, J. M. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-180 · Cited by 70
García-Mayor, R. V., Páramo, C., Cano, R. L., Méndez, L. F. P., Galofré, J. C., & Andrade, A. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348811 · Cited by 69
Fukao, A., Takamatsu, J., Murakami, Y., Sakane, S., Miyauchi, A., Kuma, K., Hayashi, S., & Hanafusa, T. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01625.x · Cited by 68
Long-term Antithyroid Treatment in Hyperthyroidism
Slingerland, D. W. (1979) · JAMA · doi:10.1001/jama.1979.03300220020015 · Cited by 67
Volpe, R. J. (2001) · Current Pharmaceutical Design · doi:10.2174/1381612013397898 · Cited by 66
Liver Tests in Hyperthyroidism: Effect of Antithyroid Therapy
Gürlek, A., Çobankara, V., & Bayraktar, M. (1997) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199704000-00013 · Cited by 65
Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole.
Arab, D. M., Malatjalian, D. A., & Rittmaster, R. S. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714072 · Cited by 65
NICHOLAS, W. C., FISCHER, R. G., STEVENSON, R. A., & BASS, J. D. (1995) · Southern Medical Journal · doi:10.1097/00007611-199509000-00018 · Cited by 64
Azizi, F., Bahrainian, M., Khamseh, M. E., & Khoshniat, M. (2003) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2003.16.9.1239 · Cited by 59
Akamizu, T., Ozaki, S., Hiratani, H., Uesugi, H., Sobajima, J., Hataya, Y., Kanamoto, N., Saijo, M., Hattori, Y., Moriyama, K., et al. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01720.x · Cited by 58
Marchant, B., Alexander, W. D., Robertson, J. W. K., & Lazarus, J. H. (1971) · Metabolism · doi:10.1016/0026-0495(71)90021-7 · Cited by 57
Berglund, J., Christensen, S. B., Dymling, J. ‐., & Hallengren, B. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00371.x · Cited by 57
Granulocyte Colony-Stimulating Factor Treatment of Antithyroid Drug-Induced Granulocytopenia
Tajiri, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410040073011 · Cited by 55
Cho, B. Y., Shong, M. H., Yl, K. H., Lee, H. K., Koh, C., & Mln, H. K. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02269.x · Cited by 51
Mitsiades, N., Poulaki, V., Tseleni-Balafouta, S., Chrousos, G. P., & Koutras, D. A. (2000) · Thyroid · doi:10.1089/thy.2000.10.527 · Cited by 49
Gumá, M., Salinas, I., Reverter, J. L., Roca, J., Roc, M. V., Juan, M., & Olivé, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021383 · Cited by 48
Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism
Homsanit, M., Sriussadaporn, S., Vannasaeng, S., Peerapatdit, T., Nitiyanant, W., & Vichayanrat, A. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01239.x · Cited by 48
Rittmaster, R. S., Zwicker, H., Abbott, E., Douglas, R. D., Givner, M. L., Gupta, M. K., Lehmann, L., Reddy, S. S. K., Salisbury, S. R., Shlossberg, A. H., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784084 · Cited by 48
He, C.-T., Hsieh, A.-T., Pei, D., Hung, Y.-J., Wu, L.-Y., Yang, T., Lian, W., Huang, W.-S., & Kuo, S.-W. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02032.x · Cited by 47
The antithyroid arthritis syndrome reviewed
Shabtai, R., Shapiro, M., Orenstein, D., Taragan, R., & Shenkman, L. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780270216 · Cited by 46
Thyroid function in breast-fed infants whose mothers take high doses of methimazole
Azizi, F., & Hedayati, M. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03345489 · Cited by 44
Pharmacokinetic Properties and Bioavailability of Methimazole
Jansson, R., Lindström, B., & Dahlberg, P. A. (1985) · Clinical Pharmacokinetics · doi:10.2165/00003088-198510050-00006 · Cited by 44
A Simple Test for Selecting the Thioamide Schedule in Thyrotoxicosis
Barnes, H. V., & Bledsoe, T. J. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-2-250 · Cited by 42
A comparison of 20 or 40 mg per day of carbimazole in the initial treatment of hyperthyroidism
Page, S. R., Sheard, C. E., Herbert, M., Hopton, M., & Jeffcoate, W. J. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.00800.x · Cited by 41
KALLNER, G., Vitols, S., & Ljunggren, J. ‐. (1996) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1996.489827000.x · Cited by 38
Jongjaroenprasert, W., Akarawut, W., Chantasart, D., Chailurkit, L., & Rajatanavin, R. (2002) · Thyroid · doi:10.1089/105072502320288500 · Cited by 37
Influence of methimazole on murine thyroiditis. Evidence for immunosuppression in vivo.
Davies, T. F., Weiss, I. A., & Gerber, M. A. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111225 · Cited by 35
Short‐term treatment of Graves' disease with methimazole in high versus low doses
Jorde, R., Ytre-Arne, K., Störmer, J., & Sundsfjord, J. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00914.x · Cited by 35
Grebe, S. K. G., Feek, C. M., Ford, H. C., Fagerström, J. N., Cordwell, D. P., DeLaHunt, J., & Toomath, R. J. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00446.x · Cited by 35
Acute pancreatitis and parotitis induced by methimazole in a patient with Graves' disease
Taguchi, M., Yokota, M., Koyano, H. M., Endo, Y., & Ozawa, Y. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00888.x · Cited by 34
Propylthiouracil-induced agranulocytosis: An unusual presentation and a possible mechanism
Toth, E. L., Mant, M. J., Shivji, S., & Ginsberg, J. (1988) · The American Journal of Medicine · doi:10.1016/s0002-9343(88)80251-1 · Cited by 34
An anti‐neutrophil antibody associated with a propylthiouracil‐induced lupus‐like syndrome
Berkman, E. M., ORLIN, J. B., & Wolfsdorf, J. I. (1983) · Transfusion · doi:10.1046/j.1537-2995.1983.23283172851.x · Cited by 33
Antithyroid Drugs Inhibit In Vivo HLA-DR Expression in Thyroid Follicular Cells in Graves' Disease
Zantut‐Wittmann, D. E., Tambascia, M. A., Trevisan, M. A. D. S., Pinto, G. A., & Vassallo, J. (2001) · Thyroid · doi:10.1089/105072501750302886 · Cited by 33
Treatment of hyperthyroidism with a small single daily dose of methimazole
Mashio, Y., Beniko, M., Ikota, A., Mizumoto, H., & KUNITA, H. (1988) · European Journal of Endocrinology · doi:10.1530/acta.0.1190139 · Cited by 33
Tajiri, J., Noguchi, S., & Murakami, N. (1997) · Thyroid · doi:10.1089/thy.1997.7.575 · Cited by 30
Meyer‐Geßner, M., Benker, G., Olbricht, T., WINDECK, R., Cissewski, K., Reiners, C., & REINWEIN, D. (2008) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-2008-1066570 · Cited by 29
Fulminant Hepatic Failure Associated with Propylthiouracil
Ruiz, J. K., Rossi, G. V., Vallejos, H. A., Brenet, R. W., Lopez, I. B., & Escribano, A. A. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1a408 · Cited by 29
Paschke, R., Vogg, M., Kristoferitsch, R., Aktuna, D., Wawschinek, O., Eber, O., & Usadel, K. H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.8.7629244 · Cited by 28
Pfeilschifter, J., & Ziegler, R. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360081 · Cited by 27
Werner, R. S., Romaldini, J. H., Farah, C. S., WERNER, M. C., & Bromberg, N. (1991) · Thyroid · doi:10.1089/thy.1991.1.293 · Cited by 25
DEPRESSED NATURAL KILLER ACTIVITY IN GRAVES' DISEASE AND DURING ANTITHYROID MEDICATION
Wang, P., LUO, S., Huang, B., Lin, J., & Mj, H. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb03657.x · Cited by 25
Sonnet, E., Massart, C., Gibassier, J., Allannic, H., & Maugendre, D. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343586 · Cited by 23
McCRUDEN, D. C., HILDITCH, T. E., CONNELL, J. M. C., McLELLAN, A. R., ROBERTSON, J., & ALEXANDER, W. D. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb03636.x · Cited by 21
Do higher doses of carbimazole improve remission in Graves' disease?
Wilson, R., Buchanan, L., Fraser, W. D., McKillop, J. H., & Thomson, J. A. (1996) · QJM · doi:10.1093/qjmed/89.5.381 · Cited by 21
Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole
Arab, D. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.4.1083 · Cited by 21
Nakazato, N., Yoshida, K., Mori, K., KISO, Y., SAYAMA, N., Tani, J., Nakagawa, Y., & Ito, S. (1999) · Thyroid · doi:10.1089/thy.1999.9.775 · Cited by 20
Increased serum interleukin‐1bT during treatment of zhyperthyroidism with antithyroid drugs
Tsatsoulis, A. A., Vlachoyiannopoulos, P. G., Dalekos, G. Ν., Johnson, E., & Moutsopoulos, H. Μ. (1995) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1995.tb01981.x · Cited by 20
Granulocyte colony-stimulating factor treatment of antithyroid drug-induced granulocytopenia
Tajiri, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.4.509 · Cited by 20
Hernández, J. J. C., López, A., Ciudad, J., Mories, M. T., Miralles-García, J. M., & Orfao, A. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1550491 · Cited by 18
PROPYLTHIOURACIL-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS
Horton, R., Sheppard, M. C., & Emery, P. E. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90696-x · Cited by 17
Pharmacology of Propylthiouracil in Thyrotoxicosis and Chronic Renal Failure
Cooper, D. S. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370040167029 · Cited by 17
Self-citationReinhardt, W., Appel, M. C., Alex, S., Yang, Y.-N., & Braverman, L. E. (1989) · Journal of Endocrinological Investigation · doi:10.1007/bf03350760 · Cited by 16
Hegedűs, L. D., Hansen, J. M., Bech, K., Kampmann, J. P., Jensen, K., Andersen, E., Hansen, P., Karstrup, S., & Bliddal, H. (1984) · European Journal of Endocrinology · doi:10.1530/acta.0.1070482 · Cited by 16
Kinetics of Propylthiouracil in the Elderly
Kampmann, J. P., Mortensen, H. B., Bach, B., Waldorff, S., Kristensen, M. B., & Hansen, J. (1979) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1979.tb00727.x · Cited by 15
Long-term antithyroid treatment in hyperthyroidism
Slingerland, D. W. (1979) · JAMA · doi:10.1001/jama.242.22.2408 · Cited by 12
Hoffman, W. H., & Miceli, J. N. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457669 · Cited by 7
Determination of free propylthiouracil clearance and single sample prediction of steady state
Giles, H. G., Roberts, E. A., Orrego, H., & Sellers, E. M. (1982) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1982.tb04684.x · Cited by 4
Excessive blood loss during operation in the patient treated with propylthiouracil
Ikeda, S., & Schweiss, J. F. (1982) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03009412 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 18
- Taurog A. Hormone synthesis and secretion. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid: a fundamental and clinical text. Philadelphia: Lippincott-Raven, 1996:47-80.
- 10.1210/jc.81.8.2976 · DOI
- Wilson R, 1988, Clin Exp Immunol, 73, 312
- 10.1001/archinte.147.4.785 · DOI
- 10.1210/jc.81.8.2986 · DOI
- 10.1210/jc.86.8.3488 · DOI
- 10.1210/jc.76.6.1516 · DOI
- 10.1210/jc.80.8.2470 · DOI
- Abraham P, 2004, Cochrane Database Syst Rev, 2, CD003420
- 10.1210/jc.81.9.3283 · DOI
- Ducornet B, 1988, Ann Med Interne (Paris), 139, 410
- 10.1210/jc.82.6.1727 · DOI
- Parker WA, 1982, Clin Pharm, 1, 471
- 10.1210/jc.84.1.13 · DOI
- Waldhauser L, 1991, Drug Metab Dispos, 19, 354
- 10.1210/jc.85.11.4270 · DOI · Paper page
- 10.1210/jc.82.9.3099 · DOI
- Junik R, 1989, Endokrynol Pol, 40, 307
Cited by
Sorted by citations
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
Self-citationThe Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Self-citationBahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098
Self-citation2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism
Kahaly, G. J., Bartalena, L., Hegedüs, L., Leenhardt, L., Poppe, K. G., & Pearce, S. H. S. (2018) · European Thyroid Journal · doi:10.1159/000490384 · Cited by 1,025
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898
Self-citation
Metadata
- Authors
- Cooper, D. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Cooper, David S.
- ORCID
- Cooper, David S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-03
- Volume
- 352
- Issue
- 9
- Pages
- 905-917
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4243225672
- Cited by
- 1,008
- References
- 123
- Citations by year
- 2026: 35 · 2025: 36 · 2024: 51 · 2023: 50 · 2022: 45 · 2021: 52 · 2020: 62 · 2019: 38 · 2018: 62 · 2017: 51 · 2016: 66 · 2015: 51 · 2014: 48 · 2013: 56 · 2012: 49
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Keywords
- antithyroid drugs, hyperthyroidism, Graves' disease, adverse effects, drug response
- MeSH terms
- Agranulocytosis, Algorithms, Female, Graves Disease, Humans, Hyperthyroidism, Methimazole, Pregnancy, Pregnancy Complications, Propylthiouracil, Antithyroid Agents, Thyroid Gland, Thyrotoxicosis, Thyroxine, Triiodothyronine
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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