Innate immune responses to influenza A H5N1: friend or foe?

Evolution and ecology of influenza A viruses

Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.152-179.1992 · Cited by 4,739 · see citing works

Incidence and Outcomes of Acute Lung Injury

Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684 · see citing works

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903810 · Cited by 3,047 · see citing works

The immunopathogenesis of sepsis

Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742 · see citing works

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.

de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Van Vinh Chau, N., Khanh, T. H., Dong, V. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1477 · Cited by 1,858 · see citing works

Emergence and pandemic potential of swine-origin H1N1 influenza virus

Neumann, G., Noda, T., & Kawaoka, Y. (2009) · Nature · doi:10.1038/nature08157 · Cited by 1,562 · see citing works

Influenza virus receptors in the human airway

Shinya, K., Ebina, M., Yamada, S., Ono, M., Kasai, N., & Kawaoka, Y. (2006) · Nature · doi:10.1038/440435a · Cited by 1,398 · see citing works

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356 · see citing works

Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

Hatta, M., Gao, P., Halfmann, P., & Kawaoka, Y. (2001) · Science · doi:10.1126/science.1062882 · Cited by 1,336 · see citing works

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico

Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325 · see citing works

The Pathology of Influenza Virus Infections

Taubenberger, J. K., & Morens, D. M. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154316 · Cited by 1,111 · see citing works

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

Bhatia, M., & Moochhala, S. (2003) · The Journal of Pathology · doi:10.1002/path.1491 · Cited by 1,087 · see citing works

Characterization of the 1918 influenza virus polymerase genes

Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,065 · see citing works

Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus

Yuen, K., Chan, P., Peiris, M. J. S., Tsang, D., Que, T., Shortridge, K. F., Cheung, P., To, W., Ho, E., Sung, R. Y. T., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,049 · see citing works

Avian Influenza Virus (H5N1): a Threat to Human Health

Peiris, M. J. S., de Jong, M. D., & Guan, Y. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-06 · Cited by 1,010 · see citing works

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.

Kobasa, D., Jones, S. M., Shinya, K., Kash, J. C., Copps, J., Ebihara, H., Hatta, Y., Hyun Kim, J., Halfmann, P., Hatta, M., et al. (2007) · Nature · doi:10.1038/nature05495 · Cited by 934 · see citing works

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

Cheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889 · see citing works

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008) · New England Journal of Medicine · doi:10.1056/nejmra0707279 · Cited by 860 · see citing works

Re-emergence of fatal human influenza A subtype H5N1 disease

Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15595-5 · Cited by 812 · see citing works

Genetic Characterization of the Pathogenic Influenza A/Goose/Guangdong/1/96 (H5N1) Virus: Similarity of Its Hemagglutinin Gene to Those of H5N1 Viruses from the 1997 Outbreaks in Hong Kong

Xu, X., Subbarao, K., Cox, N. J., & Guo, Y. (1999) · Virology · doi:10.1006/viro.1999.9820 · Cited by 802 · see citing works

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

Throsby, M., van den Brink, E. N., Jongeneelen, M. A. C., Poon, L. L. M., Alard, P., Cornelissen, L. A. H. M., Bakker, A. Q., Cox, F., van Deventer, E., Guan, Y., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003942 · Cited by 738 · see citing works

H5N1 Virus Attachment to Lower Respiratory Tract

van Riel, D. A. J., Munster, V. J., de Wit, E., Rimmelzwaan, G. F., Fouchier, R. A. M., Osterhaus, A. D. M. E., & Kuiken, T. (2006) · Science · doi:10.1126/science.1125548 · Cited by 690 · see citing works

Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.

Hayden, F. G., Fritz, R., Lobo, M. C., Alvord, W. G., Strober, W., & Straus, S. E. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1355 · Cited by 680 · see citing works

Textbook of Influenza

(2013) · Wiley eBooks · doi:10.1002/9781118636817 · Cited by 663 · see citing works

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

Perrone, L. A., Plowden, J., García‐Sastre, A., Katz, J. M., & Tumpey, T. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000115 · Cited by 623 · see citing works

Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus

Mibayashi, M., Martínez‐Sobrido, L., Loo, Y., Cardenas, W. B., Gale, M., & García‐Sastre, A. (2006) · Journal of Virology · doi:10.1128/jvi.01265-06 · Cited by 574 · see citing works

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Kash, J. C., Tumpey, T. M., Proll, S. C., Carter, V., Perwitasari, O., Thomas, M. J., Basler, C. F., Palese, P., Taubenberger, J. K., García-Sastre, A., et al. (2006) · Nature · doi:10.1038/nature05181 · Cited by 551 · see citing works

Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals

van Riel, D. A. J., Munster, V. J., de Wit, E., Rimmelzwaan, G. F., Fouchier, R. A. M., Osterhaus, A. D. M. E., & Kuiken, T. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070248 · Cited by 532 · see citing works

Fatal Avian Influenza A (H5N1) in a Child Presenting with Diarrhea Followed by Coma

de Jong, M. D., Cam, B. V., Qui, P. T., Hien, V. M., Thanh, T. T., Hue, N. B., Beld, M., Phuong, L. T., Khanh, T. H., Châu, N. V. V., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044307 · Cited by 530 · see citing works

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

Goffic, R. L., Balloy, V., Lagranderie, M., Alexopoulou, L., Escriou, N., Flavell, R. A., Chignard, M., & Si‐Tahar, M. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020053 · Cited by 512 · see citing works

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

Chan, M., Cheung, C., Chui, W., Tsao, S., Nicholls, J., Chan, Y., Chan, R., Long, H., Poon, L., Guan, Y., et al. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-135 · Cited by 510 · see citing works

Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine.

Katz, J. D., Hancock, K., Veguilla, V., Zhong, W., Lü, X., Sun, H., Butler, E. N., Dong, L., Liu, F., Li, Z. N., et al. (2009) · MMWR Morbidity and Mortality Weekly Report · Cited by 499 · see citing works

Cell-mediated Protection in Influenza Infection

Thomas, P. G., Keating, R., Hulse-Post, D. J., & Doherty, P. C. (2006) · Emerging infectious diseases · doi:10.3201/eid1201.051237 · Cited by 466 · see citing works

Dating the emergence of pandemic influenza viruses

Smith, G. J. D., Bahl, J., Vijaykrishna, D., Zhang, J., Poon, L. L. M., Chen, H., Webster, R. G., Peiris, M. J. S., & Guan, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904991106 · Cited by 454 · see citing works

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

Aldridge, J. R., Moseley, C. E., Boltz, D. A., Negovetich, N. J., Reynolds, C., Franks, J., Brown, S. A., Doherty, P. C., Webster, R. G., & Thomas, P. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900655106 · Cited by 425 · see citing works

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

Lee, L. Y.-H., Do, L. A. H., Simmons, C. P., de Jong, M. D., Châu, N. V. V., Schumacher, R., Peng, Y. C., McMichael, A. J., Farrar, J., Smith, G. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32460 · Cited by 423 · see citing works

Pathology of fatal human infection associated with avian influenza A H5N1 virus

To, K., Chan, P. K. S., Chan, K.-F., Lee, W.-K., Lam, W.-Y., Wong, K.-F., Tang, N. L. S., Tsang, D. N. C., Sung, R. Y. T., Buckley, T. A., et al. (2001) · Journal of Medical Virology · doi:10.1002/1096-9071(200103)63:3 · Cited by 422 · see citing works

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R., & Lamb, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800482105 · Cited by 404 · see citing works

H5N1 influenza: A protean pandemic threat

Guan, Y., Poon, L. L. M., Cheung, C. Y., Ellis, T. M., Lim, W., Lipatov, A. S., Chan, K., Sturm-Ramirez, K. M., Cheung, C. L., Leung, C. Y. H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402443101 · Cited by 398 · see citing works

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia

McAuley, J. L., Hornung, F., Boyd, K. L., Smith, A. M., McKeon, R., Bennink, J., Yewdell, J. W., & McCullers, J. A. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.001 · Cited by 389 · see citing works

PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice

Shinya, K., Hamm, S., Hatta, M., Ito, H., Ito, T., & Kawaoka, Y. (2004) · Virology · doi:10.1016/j.virol.2003.11.030 · Cited by 377 · see citing works

Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1

Zamarin, D., García‐Sastre, A., Xiao, X., Wang, R., & Palese, P. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010004 · Cited by 376 · see citing works

Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice

Szretter, K. J., Gangappa, S., Lu, X., Smith, C. S., Shieh, W., Zaki, S. R., Sambhara, S. R., Tumpey, T. M., & Katz, J. M. (2006) · Journal of Virology · doi:10.1128/jvi.02336-06 · Cited by 373 · see citing works

H5N1 infection of the respiratory tract and beyond: a molecular pathology study

Gu, J., Xie, Z., Gao, Z., Liu, J., Korteweg, C., Ye, J., Lau, L. T., Lu, J., Gao, Z., Zhang, B., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61515-3 · Cited by 370 · see citing works

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

Baskin, C. R., Bielefeldt-Ohmann, H., Tumpey, T. M., Sabourin, P. J., Long, J. P., García-Sastre, A., Tolnay, A.-E., Albrecht, R., Pyles, J. A., Olson, P. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813234106 · Cited by 361 · see citing works

Pathology of human influenza revisited

Kuiken, T., & Taubenberger, J. K. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.07.025 · Cited by 359 · see citing works

Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine.

(2009) · PubMed · Cited by 351 · see citing works

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

Peiris, M. J. S., Poon, L. L. M., & Guan, Y. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.06.006 · Cited by 348 · see citing works

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04

Salomon, R., Franks, J., Govorkova, E. A., Ilyushina, N. A., Yen, H.-L., Hulse-Post, D. J., Humberd, J., Trichet, M., Rehg, J. E., Webby, R. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051938 · Cited by 348 · see citing works

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract

Nicholls, J. M., Chan, M. C. W., Chan, R. W. Y., Wong, H. K., Cheung, C. Y., Kwong, D. L. W., Wong, M. P., Chui, W. H., Poon, L. L. M., Tsao, S. W., et al. (2007) · Nature Medicine · doi:10.1038/nm1529 · Cited by 341 · see citing works

Growth of H5N1 Influenza A Viruses in the Upper Respiratory Tracts of Mice

Hatta, M., Hatta, Y., Kim, J., Watanabe, S., Shinya, K., Nguyen, T., PHUONG, L. S., Le, Q. M., & Kawaoka, Y. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030133 · Cited by 335 · see citing works

Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses

García‐Sastre, A. (2001) · Virology · doi:10.1006/viro.2000.0756 · Cited by 321 · see citing works

Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses

Nicholls, J. M., Bourne, A. J., Chen, H., Guan, Y., & Peiris, M. J. S. (2007) · Respiratory Research · doi:10.1186/1465-9921-8-73 · Cited by 313 · see citing works

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

Zheng, B.-J., Chan, K.-W., Lin, Y.-P., Zhao, G.-Y., Chan, C., Zhang, H.-J., Chen, H.-L., Wong, S. S. Y., Lau, S. K. P., Woo, P. C. Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711942105 · Cited by 302 · see citing works

Influenza A H5N1 Replication Sites in Humans

Uiprasertkul, M., Puthavathana, P., Sangsiriwut, K., Pooruk, P., Srisook, K., Peiris, M. J. S., Nicholls, J. M., Chokephaibulkit, K., Vanprapar, N., & Auewarakul, P. (2005) · Emerging infectious diseases · doi:10.3201/eid1107.041313 · Cited by 259 · see citing works

Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans

Tumpey, T. M., Lu, X., Morken, T., Zaki, S. R., & Katz, J. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6105-6116.2000 · Cited by 251 · see citing works

Influenza A Infection Is an Important Cause of Febrile Seizures

Chiu, S. S. S., Tse, C. Y. C., Lau, Y., & Peiris, M. J. S. (2001) · PEDIATRICS · doi:10.1542/peds.108.4.e63 · Cited by 241 · see citing works

Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model

Mubareka, S., Lowen, A. C., Steel, J., Coates, A. L., García‐Sastre, A., & Palese, P. (2009) · The Journal of Infectious Diseases · doi:10.1086/597073 · Cited by 211 · see citing works

Animal models for the study of influenza pathogenesis and therapy

Barnard, D. L. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2008.12.014 · Cited by 178 · see citing works

Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

Cameron, C., Cameron, M. J., Bermejo-Martín, J. F., Ran, L., Xu, L., Turner, P. V., Ran, R., Danesh, A., Yuan, F., Chan, P.-K., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00691-08 · Cited by 176 · see citing works

Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response

Maines, T. R., Szretter, K. J., Perrone, L. A., Belser, J. A., Bright, R. A., Zeng, H., Tumpey, T. M., & Katz, J. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00690.x · Cited by 172 · see citing works

Influenza‐Associated Mortality in Hong Kong

Wong, C., Chan, K.-P., Hedley, A. J., & Peiris, M. J. S. (2004) · Clinical Infectious Diseases · doi:10.1086/425315 · Cited by 169 · see citing works

Factors associated with case fatality of human H5N1 virus infections in Indonesia: a case series

Kandun, I. N., Tresnaningsih, E., Purba, W. H., Lee, V., Samaan, G., Harun, S., Soni, E., Septiawati, C., Setiawati, T., Sariwati, E., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61125-3 · Cited by 165 · see citing works

Highly Pathogenic Avian Influenza H5N1 Viruses Elicit an Attenuated Type I Interferon Response in Polarized Human Bronchial Epithelial Cells

Zeng, H., Goldsmith, C. S., Thawatsupha, P., Chittaganpitch, M., Waicharoen, S., Zaki, S. R., Tumpey, T. M., & Katz, J. M. (2007) · Journal of Virology · doi:10.1128/jvi.01134-07 · Cited by 162 · see citing works

Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK

Hui, K. P. Y., Lee, S. M. Y., Cheung, C. Y., Ng, I. H. Y., Poon, L. L. M., Guan, Y., Ip, N. Y., Lau, A. S. Y., & Peiris, M. J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1088 · Cited by 158 · see citing works

The development and genetic diversity of H5N1 influenza virus in China, 1996–2006

Duan, L., Bahl, J., Smith, G. J. D., Wang, J., Vijaykrishna, D., Zhang, L. J., Zhang, J., Li, K., Fan, X., Cheung, C. L., et al. (2008) · Virology · doi:10.1016/j.virol.2008.07.038 · Cited by 156 · see citing works

The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review

Ng, W. F., To, K. F., LAM, W., NG, T., & LEE, K. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.01.015 · Cited by 153 · see citing works

Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis

Mao, H., Tu, W., Qin, G., Law, H., Sia, S. F., Chan, P., Liu, Y., Lam, K.-T., Zheng, J. H., Peiris, M. J. S., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00805-09 · Cited by 150 · see citing works

Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses

Qin, G., Mao, H., Zheng, J. H., Sia, S. F., Liu, Y., Chan, P., Lam, K., Peiris, M. J. S., Lau, Y., & Tu, W. (2009) · The Journal of Infectious Diseases · doi:10.1086/605413 · Cited by 149 · see citing works

p38 Mitogen-Activated Protein Kinase-Dependent Hyperinduction of Tumor Necrosis Factor Alpha Expression in Response to Avian Influenza Virus H5N1

Lee, D. C. W., Cheung, C. Y., Law, A. H. Y., Mok, C. K. P., Peiris, M. J. S., & Lau, A. S. Y. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10147-10154.2005 · Cited by 146 · see citing works

Avian influenza receptor expression in H5N1‐infected and noninfected human tissues

Yao, L., Korteweg, C., Hsueh, W., & Gu, J. (2007) · The FASEB Journal · doi:10.1096/fj.06-7880com · Cited by 132 · see citing works

Influenza A/H5N1 virus infection in humans in Cambodia

Buchy, P., Mardy, S., Vong, S., Toyoda, T., Aubin, J., Miller, M., Touch, S., Ly, S., Dufourcq, J., Richner, B., et al. (2007) · Journal of Clinical Virology · doi:10.1016/j.jcv.2007.04.010 · Cited by 124 · see citing works

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

Ludwig, S. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp161 · Cited by 124 · see citing works

Hyperinduction of Cyclooxygenase‐2–Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection

Lee, S. M. Y., Cheung, C. Y., Nicholls, J. M., Hui, K. P. Y., Leung, C. Y. H., Uiprasertkul, M., Tipoe, G. L., Lau, Y., Poon, L. L. M., Ip, N. Y., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/590499 · Cited by 122 · see citing works

Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on the Host Response to Influenza A Viral Infection

Carey, M. A., Bradbury, J. A., Seubert, J. M., Langenbach, R. J., Zeldin, D. C., & Germolec, D. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6878 · Cited by 121 · see citing works

Continuing progress towards a unified nomenclature for the highly pathogenic H5N1 avian influenza viruses: divergence of clade 2·2 viruses

WHO/OIE/FAO H5N1 Evolution Working Group (2009) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2009.00078.x · Cited by 116 · see citing works

Cerebrospinal Fluid and Serum Levels of Cytokines and Soluble Tumor Necrosis Factor Receptor in Influenza Virus-associated Encephalopathy

Ichiyama, T., Isumi, H., Ozawa, H., Matsubara, T., Morishima, T., & Furukawa, S. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/0036554021000026986 · Cited by 116 · see citing works

Aspects on antibacterial treatment of anaerobic infections.

Nordbring, F., & Nord, C. E. (1982) · PubMed · Cited by 115 · see citing works

Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction

Svitek, N., Rudd, P. A., Obojes, K., Pillet, S., & von Messling, V. (2008) · Virology · doi:10.1016/j.virol.2008.02.035 · Cited by 113 · see citing works

Type I Interferon Induction Pathway, but Not Released Interferon, Participates in the Maturation of Dendritic Cells Induced by Negative‐Strand RNA Viruses

López, C. B., García‐Sastre, A., Williams, B. R. G., & Moran, T. M. (2003) · The Journal of Infectious Diseases · doi:10.1086/368381 · Cited by 109 · see citing works

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

Szretter, K. J., Gangappa, S., Belser, J. A., Zeng, H., Chen, H., Matsuoka, Y., Sambhara, S. R., Swayne, D. E., Tumpey, T. M., & Katz, J. M. (2009) · Journal of Virology · doi:10.1128/jvi.02144-08 · Cited by 101 · see citing works

Toward a broadly protective influenza vaccine

Doherty, P. C., & Kelso, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37232 · Cited by 101 · see citing works

High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus Infection and Protection by IFN-α and TLR Ligands

Thitithanyanont, A., Engering, A. J., Ekchariyawat, P., Wiboon-ut, S., Limsalakpetch, A., Yongvanitchit, K., Kum-Arb, U., Kanchongkittiphon, W., Utaisincharoen, P., Sirisinha, S., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5220 · Cited by 101 · see citing works

Risk Factors Associated with Subclinical Human Infection with Avian Influenza A (H5N1) Virus—Cambodia, 2006

Vong, S., Ly, S., Kerkhove, M. D. V., Achenbach, J. E., Holl, D., Buchy, P., Sorn, S., Seng, H., Uyeki, T. M., Touch, S., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/599208 · Cited by 98 · see citing works

Avian Influenza A (H5N1) Age Distribution in Humans

Smallman-Raynor, M. R., & Cliff, A. D. (2007) · Emerging infectious diseases · doi:10.3201/eid1303.060849 · Cited by 82 · see citing works

Functional Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand Production by Avian Influenza Virus–Infected Macrophages

Zhou, J., Law, H., Cheung, C. Y., Ng, I. H. Y., Peiris, M. J. S., & Lau, Y. (2006) · The Journal of Infectious Diseases · doi:10.1086/500954 · Cited by 79 · see citing works

Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN-γ-Dependent Pathway

Khoufache, K., LeBouder, F., Morello, E., Laurent, F., Riffault, S., Andrade‐Gordon, P., Boullier, S., Rousset, P., Vergnolle, N., & Riteau, B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803743 · Cited by 76 · see citing works

H5N1 Influenza A Virus and Infected Human Plasma

Chutinimitkul, S., Bhattarakosol, P., Srisuratanon, S., Eiamudomkan, A., Kongsomboon, K., Damrongwatanapokin, S., Chaisingh, A., Suwannakarn, K., Chieochansin, T., Theamboonlers, A., et al. (2006) · Emerging infectious diseases · doi:10.3201/eid1206.060227 · Cited by 71 · see citing works

Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages

Mok, C. K. P., Lee, D. C. W., Cheung, C. Y., Peiris, M. J. S., & Lau, A. S. Y. (2007) · Journal of General Virology · doi:10.1099/vir.0.82423-0 · Cited by 71 · see citing works

Avian influenza A H5N1 infections in Bali province, Indonesia: a behavioral, virological and seroepidemiological study

Santhia, K., Ramy, A., Jayaningsih, P., Samaan, G., Putra, A. A. G., Dibia, N., Sulaimin, C., Joni, G., Leung, C. Y. H., Peiris, M. J. S., et al. (2009) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2009.00069.x · Cited by 69 · see citing works

Interaction Between Humans and Poultry, Rural Cambodia

Ly, S., Kerkhove, M. D. V., Holl, D., Froehlich, Y., & Vong, S. (2007) · Emerging infectious diseases · doi:10.3201/eid1301.061014 · Cited by 69 · see citing works

Clinical Significance of Alimentary Tract Microbes in Bone Marrow Transplant Recipients

Yuen, K., Woo, P. C. Y., Liang, R. H. S., Chiu, E., Chen, F. E., Wong, S. S. Y., Lau, Y., Ha, S., Peiris, M. J. S., Siau, H., et al. (1998) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(97)00213-7 · Cited by 65 · see citing works

Pathogenicity of highly pathogenic avian influenza virus in mammals

de Wit, E., Kawaoka, Y., de Jong, M. D., & Fouchier, R. A. M. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.07.072 · Cited by 61 · see citing works

Viral Genetic Determinants of H5N1 Influenza Viruses That Contribute to Cytokine Dysregulation

Mok, C. K. P., Wong, C. H. K., Cheung, C. Y., Chan, M. C. W., Lee, S. M.-Y., Nicholls, J. M., Guan, Y., & Peiris, J. S. M. (2009) · The Journal of Infectious Diseases · doi:10.1086/605606 · Cited by 47 · see citing works

Age-specific infection and death rates for human A(H5N1) avian influenza in Egypt

Dudley, J. P. (2009) · Eurosurveillance · doi:10.2807/ese.14.18.19198-en · Cited by 40 · see citing works

A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia

Takano, R., Nidom, C. A., Kiso, M., Muramoto, Y., Yamada, S., Shinya, K., Sakai‐Tagawa, Y., & Kawaoka, Y. (2009) · Archives of Virology · doi:10.1007/s00705-009-0353-5 · Cited by 40 · see citing works

Pathology of human H5N1 infection: new findings

Ng, W. F., & To, K. F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61490-1 · Cited by 35 · see citing works

Enzyme Histochemistry of Bronchial Epithelium and Alveolar Cells in the Early Stages of Influenza-Virus Pneumonia of Mice

Hers, J. F. P., Willighagen, R. G. J., Tyrrell, D. A. J., Kuip, L., & HOS, M. A. C. (1962) · Nature · doi:10.1038/193348a0 · Cited by 5 · see citing works

Into the Eye of the Cytokine Storm

Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works

The cytokine storm of severe influenza and development of immunomodulatory therapy

Liu, Q., Zhou, Y., & Yang, Z. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.74 · Cited by 714 · see citing works

Host and viral determinants of influenza A virus species specificity

Long, J. S., Mistry, B., Haslam, S. M., & Barclay, W. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0115-z · Cited by 672 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

Pathogenesis of influenza-induced acute respiratory distress syndrome

Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 540 · see citing works

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Broggi, A., Ghosh, S., Sposito, B., Spreafico, R., Balzarini, F., Cascio, A. L., Clementi, N., Santis, M. D., Mancini, N., Granucci, F., et al. (2020) · Science · doi:10.1126/science.abc3545 · Cited by 398 · see citing works

Pathogenic potential of interferon αβ in acute influenza infection

Davidson, S., Crotta, S., McCabe, T. M., & Wack, A. (2014) · Nature Communications · doi:10.1038/ncomms4864 · Cited by 370 · see citing works

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent FcγR Pathway

Jaume, M., Yip, M., Cheung, C. Y., Leung, N., Li, P. H., Kien, F., Dutry, I., Callendret, B., Escriou, N., Altmeyer, R. M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.00671-11 · Cited by 312 · see citing works

New fronts emerge in the influenza cytokine storm

Guo, X.-Z. J., & Thomas, P. G. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0636-y · Cited by 295 · see citing works

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

Gabriel, G., Klingel, K., Otte, A., Thiele, S., Hudjetz, B., Arman-Kalcek, G., Sauter, M., Shmidt, T., Rother, F., Baumgarte, S., et al. (2011) · Nature Communications · doi:10.1038/ncomms1158 · Cited by 255 · see citing works

A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead

Beauchemin, C. A. A., & Handel, A. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-s1-s7 · Cited by 245 · see citing works

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

Chan, M. C. W., Kuok, D. I. T., Leung, C. Y. H., Hui, K. P. Y., Valkenburg, S. A., Lau, E. H. Y., Nicholls, J. M., Fang, X., Guan, Y., Lee, J. W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601911113 · Cited by 196 · see citing works

Animal models for influenza virus pathogenesis, transmission, and immunology

Thangavel, R. R., & Bouvier, N. M. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.03.023 · Cited by 185 · see citing works

Host response to influenza virus: protection versus immunopathology

Peiris, M. J. S., Hui, K. P. Y., & Yen, H. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.003 · Cited by 160 · see citing works

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Dunning, J. W., Blankley, S., Hoang, L. T., Cox, M. J., Graham, C. M., James, P. L., Bloom, C. I., Chaussabel, D., Banchereau, J., Brett, S. J., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0111-5 · Cited by 156 · see citing works

Ferret models of viral pathogenesis

Enkirch, T., & von Messling, V. (2015) · Virology · doi:10.1016/j.virol.2015.03.017 · Cited by 156 · see citing works

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults

Lee, N. L. S., Wong, C. K., Chan, P. K. S., Chan, M. C. W., Wong, R. Y. K., Lun, S. W., Ngai, K. L. K., Lui, G. C.-Y., Wong, B. C. K., Lee, S. K. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026050 · Cited by 149 · see citing works

Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

Lejal, N., Tarus, B., Bouguyon, E., Chenavas, S., Bertho, N., Delmas, B., Ruigrok, R. W. H., Primo, C. D., & Slama‐Schwok, A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02335-12 · Cited by 144 · see citing works

The inflammatory response triggered by Influenza virus: a two edged sword

Tavares, L. P., Teixeira, M. M., & Garcia, C. C. (2016) · Inflammation Research · doi:10.1007/s00011-016-0996-0 · Cited by 142 · see citing works

Infection with Influenza Virus Induces IL-33 in Murine Lungs

Goffic, R. L., Arshad, M. I., Rauch, M., L’Helgoualc’h, A., Delmas, B., Piquet‐Pellorce, C., & Samson, M. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0516oc · Cited by 131 · see citing works

Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what do we know?

Minodier, L., Charrel, R. N., Ceccaldi, P., van der Werf, S., Blanchon, T., Hanslik, T., & Falchi, A. (2015) · Virology Journal · doi:10.1186/s12985-015-0448-4 · Cited by 128 · see citing works

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm

Younan, P. M., Iampietro, M., Nishida, A., Ramanathan, P., Santos, R. I., Dutta, M., Lubaki, N. M., Koup, R. A., Katze, M. G., & Bukreyev, A. A. (2017) · mBio · doi:10.1128/mbio.00845-17 · Cited by 122 · see citing works

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality

Zhang, H., Luo, J., Alcorn, J. F., Chen, K., Fan, S., Pilewski, J. M., Liu, A., Chen, W., Kolls, J. K., & Wang, J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600714 · Cited by 122 · see citing works

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs

Ramos, I., & Fernández-Sesma, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00361 · Cited by 120 · see citing works

Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patientsPreprint

Liu, Y., Huang, F., Xu, J., Yang, P., Qin, Y., Cao, M., Wang, Z., Li, X., Zhang, S., Ye, L., et al. (2020) · medRxiv · doi:10.1101/2020.03.20.20039586 · Cited by 114 · see citing works

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

Sun, S., Zhao, G., Liu, C., Wu, X., Guo, Y., Yu, H., Song, H., Du, L., Jiang, S., Guo, R., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0428oc · Cited by 110 · see citing works

Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection

Damjanovic, D., Divangahi, M., Kugathasan, K., Small, C.-L. N., Zganiacz, A., Brown, E. G., Hogaboam, C. M., Gauldie, J., & Xing, Z. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.003 · Cited by 101 · see citing works

Galectin-3 Enhances Avian H5N1 Influenza A Virus–Induced Pulmonary Inflammation by Promoting NLRP3 Inflammasome Activation

Chen, Y.-J., Wang, S., Weng, I., Hong, M.-H., Lo, T.-H., Jan, J., Hsu, L.-C., Chen, H., & Liu, F. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.12.014 · Cited by 102 · see citing works

A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection

O’Brien, K., Morrison, T. E., Dundore, D. Y., Heise, M. T., & Schultz‐Cherry, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017377 · Cited by 99 · see citing works

The Role of Extracellular Histones in Influenza Virus Pathogenesis

Ashar, H. K., Mueller, N. C., Rudd, J. M., Snider, T. A., Achanta, M., Maram, P., Sivasami, P., Thomas, P. G., Ramachandran, A., Malayer, J. R., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.09.014 · Cited by 99 · see citing works

Seasonal and pandemic influenza: 100 years of progress, still much to learn

Dunning, J. W., Thwaites, R. S., & Openshaw, P. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0287-5 · Cited by 99 · see citing works

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

Morris, G., Bortolasci, C. C., Puri, B. K., Marx, W., O'Neil, A. E., Athan, E., Walder, K. R., Berk, M., OLIVE, L. S., Carvalho, A. F., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155593 · Cited by 97 · see citing works

Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury

Huang, F., Zhang, C., Liu, Q., Zhao, Y., Zhang, Y., Qin, Y., Li, X., Li, C., Zhou, C., Jin, N., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008341 · Cited by 94 · see citing works

Endothelial Cells in Emerging Viral Infections

Fosse, J. H., Haraldsen, G., Falk, K., & Edelmann, R. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.619690 · Cited by 94 · see citing works

A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

Maelfait, J., Roose, K., Bogaert, P., Sze, M., Saelens, X., Pasparakis, M., Carpentier, I., Loo, G., & Beyaert, R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002570 · Cited by 91 · see citing works

Host Regulatory Network Response to Infection with Highly Pathogenic H5N1 Avian Influenza Virus

Li, C., Bankhead, A., Eisfeld, A. J., Hatta, Y., Jeng, S., Chang, J. H., Aicher, L. D., Proll, S. C., Ellis-Connell, A. L., Law, G. L., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05792-11 · Cited by 88 · see citing works

Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19

Syed, F., Li, W., Relich, R. F., Russell, P. M., Zhang, S., Zimmerman, M. K., & Yu, Q. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab167 · Cited by 88 · see citing works

Suppression of Innate Immune Pathology by Regulatory T Cells during Influenza A Virus Infection of Immunodeficient Mice

Antunes, I., & Kassiotis, G. (2010) · Journal of Virology · doi:10.1128/jvi.01559-10 · Cited by 84 · see citing works

PAR1 contributes to influenza A virus pathogenicity in mice

Khoufache, K., Berri, F., Nacken, W. K. F., Vogel, A. B., Delenne, M., Camerer, E., Coughlin, S. R., Carmeliet, P., Lina, B., Rimmelzwaan, G. F., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61667 · Cited by 83 · see citing works

Perspectives on influenza evolution and the role of research

Forrest, H. L., & Webster, R. G. (2010) · Animal Health Research Reviews · doi:10.1017/s1466252310000071 · Cited by 81 · see citing works

H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2

Li, X., Fu, Z., Liang, H., Wang, Y., Qi, X., Ding, M., Sun, X., Zhou, Z., Huang, Y., Gu, H., et al. (2018) · Cell Research · doi:10.1038/cr.2018.3 · Cited by 79 · see citing works

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding

Qi, L., Kash, J. C., Dugan, V. G., Jagger, B. W., Lau, Y.-F., Sheng, Z.-M., Crouch, E. C., Hartshorn, K. L., & Taubenberger, J. K. (2011) · Virology · doi:10.1016/j.virol.2011.01.029 · Cited by 73 · see citing works

The fate of influenza A virus after infection of human macrophages and dendritic cells

Short, K. R., Brööks, A. G., Reading, P. C., & Londrigan, S. L. (2012) · Journal of General Virology · doi:10.1099/vir.0.045021-0 · Cited by 71 · see citing works

Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice

Mok, C. K. P., Lee, H. H. Y., Chan, M. C. W., Sia, S. F., Lestra, M., Nicholls, J. M., Zhu, H., Guan, Y., & Peiris, J. M. S. (2013) · mBio · doi:10.1128/mbio.00362-13 · Cited by 72 · see citing works

Initial infectious dose dictates the innate, adaptive, and memory responses to influenza in the respiratory tract

Marois, I., Cloutier, A., Garneau, É., & Richter, M. V. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011490 · Cited by 71 · see citing works

Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice

Li, Y., Peng, S., Chen, H., Zhang, F., Xu, P., Xie, J., He, J., Chen, J., Lai, X., & Su, Z. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.12.007 · Cited by 70 · see citing works

Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)

Song, H., Wang, Q., Guo, Y., Liu, S., Song, R., Gao, X., Li, D., Li, B., Zhang, D., & Cheng, J. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-257 · Cited by 69 · see citing works

Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

Hu, X., Zhao, Y., Yang, Y. P., Gong, W., Sun, X., Yang, L., Zhang, Q., & Jin, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.586476 · Cited by 67 · see citing works

A novel chicken lung epithelial cell line: Characterization and response to low pathogenicity avian influenza virus

Esnault, E., Bonsergent, C., Larcher, T., Bed’Hom, B., Vautherot, J.-F., Delaleu, B., Guigand, L., Soubieux, D., Marc, D., & Quéré, P. (2011) · Virus Research · doi:10.1016/j.virusres.2011.04.022 · Cited by 67 · see citing works

Role of human Toll‐like receptors in naturally occurring influenza A infections

Lee, N. L. S., Wong, C. K., Hui, D. S. C., Lee, S. K. W., Wong, R. Y. K., Ngai, K. L. K., Chan, M. C. W., Chu, Y. J., Ho, A. M. ‐., Lui, G. C.-Y., et al. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12109 · Cited by 64 · see citing works

Characteristics of human infection with avian influenza viruses and development of new antiviral agents

Liu, Q., Liu, D., & Yang, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.121 · Cited by 64 · see citing works

Expression of interferon gamma by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens

Susta, L., Cornax, I., Diel, D. G., Garcia, S. C., Miller, P. J., Liu, X., Hu, S., Brown, C. C., & Afonso, C. L. (2013) · Microbial Pathogenesis · doi:10.1016/j.micpath.2013.05.009 · Cited by 64 · see citing works

14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes

Cai, W., Li, Y., Chen, S., Wang, M., Zhang, A., Zhou, H., Chen, H., & Jin, M. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.03.008 · Cited by 62 · see citing works

Immune Control of Avian Influenza Virus Infection and Its Vaccine Development

Dey, P., Ahuja, A., Panwar, J., Choudhary, P., Rani, S., Kaur, M., Sharma, A., Kaur, J. K., Yadav, A. K., Sood, V., et al. (2023) · Vaccines · doi:10.3390/vaccines11030593 · Cited by 63 · see citing works

Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques

Wonderlich, E. R., Swan, Z. D., Bissel, S. J., Hartman, A. L., Carney, J., O’Malley, K. J., Obadan, A. O., Santos, J. J. D. S., Walker, R. C., Sturgeon, T. J., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601770 · Cited by 57 · see citing works

Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice

Marathe, B. M., Wong, S., Vogel, P., García-Alcalde, F., Webster, R. G., Webby, R. J., Nájera, I., & Govorkova, E. A. (2016) · Scientific Reports · doi:10.1038/srep26742 · Cited by 57 · see citing works

Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection

Fraternale, A., Zara, C., Angelis, M. D., Nencioni, L., Palamara, A. T., Retini, M., Mambro, T. D., Magnani, M., & Crinelli, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073603 · Cited by 52 · see citing works

Seasonal Influenza A Virus in Feces of Hospitalized Adults

Chan, M. C. W., Lee, N. L. S., Chan, P. K. S., To, K. F., Wong, R. Y. K., Ho, W.-S., Ngai, K. L. K., & Sung, J. J. �. (2011) · Emerging infectious diseases · doi:10.3201/eid1711.110205 · Cited by 53 · see citing works

Persistent Release of IL-1s from Skin Is Associated with Systemic Cardio-Vascular Disease, Emaciation and Systemic Amyloidosis: The Potential of Anti-IL-1 Therapy for Systemic Inflammatory Diseases

Yamanaka, K., Nakanishi, T., Saito, H., Maruyama, J., Isoda, K., Yokochi, A., Imanaka‐Yoshida, K., Tsuda, K., Kakeda, M., Okamoto, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104479 · Cited by 53 · see citing works

Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses

Chakrabarti, A. K., Vipat, V., Mukherjee, S., Singh, R., Pawar, S. D., & Mishra, A. C. (2010) · Virology Journal · doi:10.1186/1743-422x-7-219 · Cited by 53 · see citing works

Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly

Tsukamoto, H., Kouwaki, T., & Oshiumi, H. (2020) · iScience · doi:10.1016/j.isci.2020.101520 · Cited by 52 · see citing works

Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus

Ewald, S. J., Kapczynski, D. R., Livant, E. J., Suarez, D. L., Ralph, J., McLeod, S., & Miller, C. (2011) · Immunogenetics · doi:10.1007/s00251-010-0509-1 · Cited by 50 · see citing works

Lactobacillus fermentum CJL-112 protects mice against influenza virus infection by activating T-helper 1 and eliciting a protective immune response

Yeo, J.-M., Lee, H., Kim, J.-W., Lee, J., Park, S., Choi, I., & Song, C. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.10.020 · Cited by 48 · see citing works

CD 8+ T reg cells suppress CD 8+ T cell‐responses by IL ‐10‐dependent mechanism during H 5 N 1 influenza virus infection

Zou, Q., Wu, B., Xue, J., Fan, X., Feng, C., Geng, S., Wang, M., & Wang, B. (2013) · European Journal of Immunology · doi:10.1002/eji.201343583 · Cited by 47 · see citing works

Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Yan, W., Wei, J., Deng, X., Shi, Z., Zhu, Z., Shao, D., Li, B., Wang, S., Tong, G., & Ma, Z. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0127-8 · Cited by 47 · see citing works

Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro

Lee, S. M.-Y., Gai, W., Cheung, T., & Peiris, M. J. S. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.07.011 · Cited by 46 · see citing works

H5N1 Influenza Virus–Induced Mediators Upregulate RIG-I in Uninfected Cells by Paracrine Effects Contributing to Amplified Cytokine Cascades

Hui, K. P. Y., Lee, S. M. Y., Cheung, C. Y., Mao, H., Lai, A. K. W., Chan, R. W. Y., Chan, M. C. W., Tu, W., Guan, Y., Lau, Y., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir665 · Cited by 46 · see citing works

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

Tundup, S., Kandasamy, M., Perez, J. T., Mena, I., Steel, J., Nagy, T., Albrecht, R. A., & Manicassamy, B. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006270 · Cited by 46 · see citing works

Transcription analysis on response of swine lung to H1N1 swine influenza virus

Li, Y., Zhou, H., Wen, Z., Wu, S., Huang, C., Jia, G., Chen, H., & Jin, M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-398 · Cited by 45 · see citing works

Influenza Vaccines

Schultz‐Cherry, S., & Jones, J. C. (2010) · Advances in virus research · doi:10.1016/b978-0-12-385034-8.00003-x · Cited by 44 · see citing works

Neurologic aspects of influenza viruses

Davis, L. E., Koster, F. T., & Cawthon, A. G. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53488-0.00030-4 · Cited by 44 · see citing works

Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse

Yan, Y., Liu, Q., Li, N., Du, J., Li, X., Li, C., Jin, N., & Jiang, C. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4814-7 · Cited by 43 · see citing works

Human H7N9 and H5N1 Influenza Viruses Differ in Induction of Cytokines and Tissue Tropism

Meliopoulos, V., Karlsson, E. A., Kercher, L., Cline, T. D., Freiden, P. J., Duan, S., Vogel, P., Webby, R. J., Guan, Y., Peiris, M. J. S., et al. (2014) · Journal of Virology · doi:10.1128/jvi.01571-14 · Cited by 43 · see citing works

Host Cytokine Responses of Pigeons Infected with Highly Pathogenic Thai Avian Influenza Viruses of Subtype H5N1 Isolated from Wild Birds

Hayashi, T., Hiromoto, Y., Chaichoun, K., Patchimasiri, T., Chakritbudsabong, W., Prayoonwong, N., Chaisilp, N., Wiriyarat, W., Parchariyanon, S., Ratanakorn, P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023103 · Cited by 42 · see citing works

Age-related sensitivity and pathological differences in infections by 2009 pandemic influenza A (H1N1) virus

Sun, S., Zhao, G., Xiao, W., Hu, J., Guo, Y., Yu, H., Wu, X., Tan, Y., & Zhou, Y. (2011) · Virology Journal · doi:10.1186/1743-422x-8-52 · Cited by 42 · see citing works

Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis

Lin, X., Huang, C., Shi, J., Wang, R., Sun, X., Liu, X., Zhao, L., & Jin, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124086 · Cited by 41 · see citing works

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

McDermott, J., Shankaran, H., Eisfeld, A. J., Belisle, S. E., Neumann, G., Li, C., McWeeney, S. K., Sabourin, C. L. K., Kawaoka, Y., Katze, M. G., et al. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-190 · Cited by 41 · see citing works

A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level

Tian, J., Qi, W., Li, X., He, J., Jiao, P., Zhang, C., Liu, G.-Q., & Liao, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038233 · Cited by 40 · see citing works

Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection

Leymarie, O., Jouvion, G., Hervé, P., Chevalier, C., Lorin, V., Lecardonnel, J., da Costa, B. R., Delmas, B., Escriou, N., & Goffic, R. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057894 · Cited by 40 · see citing works

Expression of chicken interleukin-2 by a highly virulent strain of Newcastle disease virus leads to decreased systemic viral load but does not significantly affect mortality in chickens

Susta, L., Diel, D. G., Courtney, S. C., Garcia, S. C., Sundick, R. S., Miller, P. J., Brown, C. C., & Afonso, C. L. (2015) · Virology Journal · doi:10.1186/s12985-015-0353-x · Cited by 40 · see citing works

Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway

Zhang, Y., Wang, R., Shi, W., Zheng, Z., Wang, X., Li, C., Zhang, S., & Zhang, P. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114063 · Cited by 40 · see citing works

The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage

Li, W., Lee, H. H. Y., Li, R. F., Zhu, H., Guan, Y., Peiris, M. J. S., Yang, Z. F., & Mok, C. K. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-02598-z · Cited by 39 · see citing works

The highly pathogenic H5N1 influenza A virus down‐regulated several cellular Micro RNA s which target viral genome

Wang, R., Zhang, Y., Lu, J., Xia, B., Yang, Z., Zhu, X., Zhou, X., & Huang, P. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13219 · Cited by 39 · see citing works

Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology

Lu, J., Duan, X., Zhao, W., Wang, J., Wang, H., Zhou, K., & Fang, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0701 · Cited by 38 · see citing works

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice

Leung, C. Y. H., Nicholls, J. M., Ho, C.-K., Sia, S. F., Mok, C. K. P., Valkenburg, S. A., Cheung, P. P., Hui, K. P. Y., Chan, R. W. Y., Guan, Y., et al. (2014) · Journal of General Virology · doi:10.1099/vir.0.066258-0 · Cited by 38 · see citing works

Reduction of influenza virus-induced lung inflammation and mortality in animals treated with a phosophodisestrase-4 inhibitor and a selective serotonin reuptake inhibitor

Sharma, G., Sharma, D. C., Fen, L. H., Pathak, M., BETHUR, N., Pendharkar, V. V., Peiris, M. J. S., & Altmeyer, R. M. (2013) · Emerging Microbes & Infections · doi:10.1038/emi.2013.52 · Cited by 37 · see citing works

Comparison of Pandemic (H1N1) 2009 and Seasonal Influenza Viral Loads, Singapore

Lee, C. K., Lee, H. K., Loh, T. P., Lai, F. Y., Tambyah, P. A., Chiu, L., Koay, E. S.-C., & Tang, J. W.-T. (2011) · Emerging infectious diseases · doi:10.3201/eid1702.100282 · Cited by 37 · see citing works

Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells

Mok, C. K. P., Kang, S. S. R., Chan, R. W. Y., Yue, P. Y. K., Mak, N. K., Poon, L. L. M., Wong, R. N., Peiris, M. J. S., & Chan, M. C. W. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2014.03.019 · Cited by 36 · see citing works

The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence

Sattler, S., Smits, H. H., Xu, D., & Huang, F. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0208-8 · Cited by 35 · see citing works

IFN-λ: A new spotlight in innate immunity against influenza virus infection

Sun, Y., Jiang, J., Tien, P., Liu, W., & Li, J. (2018) · Protein & Cell · doi:10.1007/s13238-017-0503-6 · Cited by 35 · see citing works

The Role of Macrophages in Influenza a Virus Infection

Nicol, M. Q., & Dutia, B. M. (2014) · Future Virology · doi:10.2217/fvl.14.65 · Cited by 35 · see citing works

Mammalian Innate Resistance to Highly Pathogenic Avian Influenza H5N1 Virus Infection Is Mediated through Reduced Proinflammation and Infectious Virus Release

Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Pérez, B., Chang, P., Ghaemmaghami, A. M., Brookes, S. M., Brown, I. H., & Chang, K. (2012) · Journal of Virology · doi:10.1128/jvi.00244-12 · Cited by 33 · see citing works

Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency

Sologuren, I., Martínez-Saavedra, M. T., Solé‐Violán, J., de Oliveira, E. D. B., Betancor, E., Casas, I., Oleaga‐Quintas, C., Martínez‐Gallo, M., Zhang, S., Pestano, J., et al. (2018) · Journal of Clinical Immunology · doi:10.1007/s10875-018-0512-0 · Cited by 33 · see citing works

Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

Nicol, M. Q., Campbell, G. M., Shaw, D. J., Dransfield, I., Ligertwood, Y., Beard, P. M., Nash, A. A., & Dutia, B. M. (2018) · Virology · doi:10.1016/j.virol.2018.10.017 · Cited by 32 · see citing works

ROS induced by spring viraemia of carp virus activate the inflammatory response via the MAPK/AP-1 and PI3K signaling pathways

Sun, J., Wang, J., Li, L., Wu, Z., Chen, X., & Yuan, J. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.03.056 · Cited by 30 · see citing works

Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis

An, C., Wu, Y., Wu, J., Liu, H., Zhou, S., Ge, D., Dong, R., You, L., & Hao, Y. (2022) · Drug Development Research · doi:10.1002/ddr.21995 · Cited by 33 · see citing works

Avian and human influenza A virus receptors in trachea and lung of animals

Thongratsakul, S., Suzuki, Y., Hiramatsu, H., Sakpuaram, T., Sirinarumitr, T., Poolkhet, C., Moonjit, P., Yodsheewan, R., & Songserm, T. (2010) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/2010-28-294 · Cited by 32 · see citing works

Functions of MAP3Ks in antiviral immunity

Guan, J., Fan, Y., Wang, S., & Zhou, F. (2023) · Immunologic Research · doi:10.1007/s12026-023-09401-4 · Cited by 30 · see citing works

14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses

Cai, W., Chen, S., Li, Y., Zhang, A., Zhou, H., Chen, H., & Jin, M. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.07.020 · Cited by 31 · see citing works

Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation

Markov, A. V., Васильевна, С. А., Warszycki, D., Salomatina, O. V., Salakhutdinov, N. F., Аркадьевна, З. М., & Logashenko, E. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-14029-0 · Cited by 28 · see citing works

Innate Immunity to H5N1 Influenza Viruses in Humans

Ramos, I., & Fernández-Sesma, A. (2012) · Viruses · doi:10.3390/v4123363 · Cited by 40 · see citing works

Avian influenza virus infection in human innate immune cells

Westenius, V. (2019) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)

Human H5N1 influenza: Current insight into pathogenesis

Thanh, T. T., van Doorn, H. R., & de Jong, M. D. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.019 · Cited by 37 · see citing works

Avian influenza and the threat of the next human pandemic

Nguyen‐Van‐Tam, J. S. (2007) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2007.09.011

Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response

Maines, T. R., Szretter, K. J., Perrone, L. A., Belser, J. A., Bright, R. A., Zeng, H., Tumpey, T. M., & Katz, J. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00690.x · Cited by 172 · see citing works