Graves' Ophthalmopathy
Open accessAbstract
This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Experimental evidence suggests that TRAb antibodies are directly involved in GO pathogenesis.
“Experimental evidence suggests that these antibodies are directly involved in GO pathogenesis (516,542,543).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [516]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Smolen, J. S., Beaulieu, A. D., Rubbert‐Roth, A., Ramos-Remus, C., Rovensky, J., Alecock, E., WOODWORTH, T. G., & Alten, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60453-5 · Cited by 1,399 · see citing works
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
Keymeulen, B., Vandemeulebroucke, E., Ziegler, A. G., Mathieu, C., Kaufman, L., Hale, G., Gorus, F., Goldman, M., Walter, M., Candon, S., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043980 · Cited by 1,099 · see citing works
Kremer, J. M., Westhovens, R., Leon, M., Giorgio, E. D., Alten, R., Steinfeld, S. D., RUSSELL, A. S., Dougados, M., Emery, P., Nuamah, I. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035075 · Cited by 1,053 · see citing works
Emerging roles of PPARS in inflammation and immunity
Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 922 · see citing works
Management of Graves' Ophthalmopathy: Reality and Perspectives
Bartalena, L., Pinchera, A., & Marcocci, C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0393 · Cited by 673 · see citing works
Development of anti-TNF therapy for rheumatoid arthritis
Feldmann, M. (2002) · Nature reviews. Immunology · doi:10.1038/nri802 · Cited by 667 · see citing works
Interleukin 6: from bench to bedside
Nishimoto, N., & Kishimoto, T. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0338 · Cited by 639 · see citing works
New Drugs for Rheumatoid Arthritis
Olsen, N. J., & Stein, C. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032906 · Cited by 632 · see citing works
Pathogenesis of Graves' Ophthalmopathy
Epstein, F. H., Bahn, R. S., & Heufelder, A. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292007 · Cited by 610 · see citing works
Self-citationTGF-β and fibrosis in different organs — molecular pathway imprints
Pohlers, D., Brenmoehl, J., Loeffler, I., Müller, C. K., Leipner, C., Schultze–Mosgau, S., Stallmach, A., Kinne, R. W., & Wolf, G. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.06.004 · Cited by 576 · see citing works
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
Straus, D. S., & Glass, C. K. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.09.003 · Cited by 553 · see citing works
Molecular Cloning of the Thyrotropin Receptor
Parmentier, M., Libert, F., Maenhaut, C., Lefort, A., Gerard, C. M., Perret, J., SANDE, J. V., Dumont, J. E., & Vassart, G. (1989) · Science · doi:10.1126/science.2556796 · Cited by 527 · see citing works
Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
Nagayama, Y., Kaufman, K. D., Seto, P., & Rapoport, B. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92727-7 · Cited by 520 · see citing works
B-cell targeting in rheumatoid arthritis and other autoimmune diseases
Edwards, J., & Cambridge, G. (2006) · Nature reviews. Immunology · doi:10.1038/nri1838 · Cited by 508 · see citing works
Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy
Prabhakar, B. S., Bahn, R. S., & Smith, T. J. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0020 · Cited by 489 · see citing works
Self-citationEckstein, A. K., Plicht, M., Lax, H., Neuhäuser, M., Mann, K., Lederbogen, S., Heckmann, C., Esser, J., & Morgenthaler, N. G. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2813 · Cited by 477 · see citing works
Smoking and Risk of Graves' Disease
Prummel, M. F. (1993) · JAMA · doi:10.1001/jama.1993.03500040045034 · Cited by 464 · see citing works
Epidemiology and Prevention of Graves' Ophthalmopathy
Wiersinga, W. M., & Bartalena, L. (2002) · Thyroid · doi:10.1089/105072502761016476 · Cited by 454 · see citing works
The Role of CD40 Ligand in Costimulation and T‐Cell Activation
Grewal, I. S., & Flavell, R. A. (1996) · Immunological Reviews · doi:10.1111/j.1600-065x.1996.tb00921.x · Cited by 450 · see citing works
Bartalena, L., Baldeschi, L., Dickinson, A. J., Eckstein, A., Kendall-Taylor, P., Marcocci, C., Mourits, M. P., Perros, P., Boboridis, K., Boschi, A., et al. (2008) · Thyroid · doi:10.1089/thy.2007.0315 · Cited by 406 · see citing works
Menzinger, S., Kaya, A., Saurat, J. ‐., & Kaya, G. (2016) · Dermatopathology · doi:10.1159/000446699 · Cited by 398 · see citing works
A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro
Nordan, R. P., & Potter, M. (1986) · Science · doi:10.1126/science.3726549 · Cited by 375 · see citing works
The Role of the Interleukin-1–Receptor Antagonist in Blocking Inflammation Mediated by Interleukin-1
Dinarello, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009073431011 · Cited by 373 · see citing works
Tsui, S., Naik, V. M., Hoa, N. T., Hwang, C. J., Afifiyan, N. F., Hikim, A. P. S., Gianoukakis, A. G., Douglas, R. S., & Smith, T. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4397 · Cited by 371 · see citing works
Bartley, G. B. (1994) · PubMed Central · Cited by 354 · see citing works
Anakinra for Rheumatoid Arthritis: A Systematic Review
Mertens, M. T., & Singh, J. A. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090074 · Cited by 342 · see citing works
KALUNIAN, K. C., Davis, J. C., Merrill, J. T., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10681 · Cited by 337 · see citing works
Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy
Gerding, M. N., Meer, J. W. C. V. D., Broenink, M., Bakker, O., Wiersinga, W. M., & Prummel, M. F. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.00959.x · Cited by 325 · see citing works
Connective Tissue, Glycosaminoglycans, and Diseases the Thyroid*
Smith, T. J., Bahn, R. S., & Gorman, C. A. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-366 · Cited by 320 · see citing works
Self-citationPritchard, J., Han, R., Horst, N., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.6348 · Cited by 297 · see citing works
Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
Feliciello, A., Ciullo, I., Fenzi, G., Bonavolontà, G., Porcellini, A., & Avvedimento, E. V. (1993) · The Lancet · doi:10.1016/0140-6736(93)91475-2 · Cited by 287 · see citing works
Design of effective immunotherapy for human autoimmunity
Feldmann, M., & Steinman, L. (2005) · Nature · doi:10.1038/nature03727 · Cited by 277 · see citing works
Thy-1 Expression in Human Fibroblast Subsets Defines Myofibroblastic or Lipofibroblastic Phenotypes
Koumas, L., Smith, T. J., Feldon, S. E., Blumberg, N., & Phipps, R. P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63488-8 · Cited by 277 · see citing works
Salvi, M., Vannucchi, G. M., Campi, I., Currò, N., Dazzi, D., Simonetta, S., Bonara, P., Rossi, S., Sina, C., Guastella, C., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje.1.02325 · Cited by 262 · see citing works
Management of Graves' Ophthalmopathy: Reality and Perspectives
Bartalena, L. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.168 · Cited by 257 · see citing works
Knouff, C., & Auwerx, J. H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0036 · Cited by 256 · see citing works
Smith, T. J., & Hoa, N. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0716 · Cited by 256 · see citing works
Cigarette smoking and autoimmune disease: what can we learn from epidemiology?
Costenbader, K. H., & Karlson, E. W. (2006) · Lupus · doi:10.1177/0961203306069344 · Cited by 237 · see citing works
Pathophysiology of Graves’ Ophthalmopathy: The Cycle of Disease
Bahn, R. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030010 · Cited by 231 · see citing works
Self-citationBahn, R. S., Dutton, C. M., Natt, N., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4676 · Cited by 228 · see citing works
Self-citationWakelkamp, I. M. M. J., Bakker, O., Baldeschi, L., et al. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01708.x · Cited by 223 · see citing works
Smith, T. J., Koumas, L., Gagnon, A.-M., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8164 · Cited by 210 · see citing works
Fatourechi, V. (2005) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200506050-00003 · Cited by 209 · see citing works
Bahn, R. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.998 · Cited by 201 · see citing works
Self-citationSmoking and Thyroid-Associated Ophthalmopathy: A Novel Explanation of the Biological Link
Cawood, T., Moriarty, P., O’Farrelly, C., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1824 · Cited by 200 · see citing works
The effect of etanercept on Graves' ophthalmopathy: a pilot study
Paridaens, D. A., van den Bosch, W. A., Tl, V. D. L., Krenning, E. P., & van Hagen, P. M. (2004) · Eye · doi:10.1038/sj.eye.6701768 · Cited by 192 · see citing works
Appearance of Gravesʼ Disease on Orbital Computed Tomography
Enzmann, D. R., Donaldson, S. S., & Kriss, J. P. (1979) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-197903060-00019 · Cited by 185 · see citing works
Hiromatsu, Y., Yang, D., Bednarczuk, T., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6433 · Cited by 184 · see citing works
Evidence of adipocyte differentiation in human orbital fibroblasts in primary culture
Sorisky, A., Pardasani, D., Gagnon, A., & Smith, T. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784110 · Cited by 180 · see citing works
Valyasevi, R. W., Erickson, D. Z., Harteneck, D. A., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5838 · Cited by 173 · see citing works
Heufelder, A. E., Dutton, C. M., Sarkar, G., et al. (1993) · Thyroid · doi:10.1089/thy.1993.3.297 · Cited by 170 · see citing works
Ophthalmopathy of Graves' disease: computerized volume measurements of the orbital fat and muscle.
Forbes, G. S., Gorman, C. A., BRENNAN, M. D., et al. (1986) · PubMed · Cited by 168 · see citing works
Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades
MORSHED, S. A., Latif, R., & Davies, T. F. (2008) · Endocrinology · doi:10.1210/en.2008-0878 · Cited by 165 · see citing works
Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production
Sempowski, G. D., Rozenblit, J., Smith, T. J., & Phipps, R. P. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.3.c707 · Cited by 162 · see citing works
Kroll, A. J. (1966) · Archives of Ophthalmology · doi:10.1001/archopht.1966.03850010246017 · Cited by 154 · see citing works
Temporal relationship between onset of Graves’ ophthalmopathy and onset of thyroidal Graves’ disease
Wiersinga, W. M., Smit, T. J., van der Gaag, R. D., & Koornneef, L. (1988) · Journal of Endocrinological Investigation · doi:10.1007/bf03350193 · Cited by 150 · see citing works
The Thyrotropin Receptor in Graves' Disease
Rapoport, B., & McLachlan, S. M. (2007) · Thyroid · doi:10.1089/thy.2007.0170 · Cited by 143 · see citing works
Eckstein, A. K., Lösch, C., Glowacka, D., et al. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.137265 · Cited by 142 · see citing works
Khoo, D. H. C., Eng, P., Ho, S.-C., Tai, E. S., Morgenthaler, N. G., Seah, L. L., Fong, K. S., Chee, S.-P., Choo, C. T., & Aw, S. E. (2000) · Thyroid · doi:10.1089/thy.2000.10.1093 · Cited by 138 · see citing works
Aniszewski, J. P., Valyasevi, R. W., & Bahn, R. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6333 · Cited by 136 · see citing works
Self-citationThyrotropin Receptor Transcripts in Human Adipose Tissue
Crisp, M., Lane, C., Halliwell, M., Wynford‐Thomas, D., & Ludgate, M. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.2003 · Cited by 134 · see citing works
Rapoport, B., Alsabeh, R., Aftergood, D., & McLachlan, S. M. (2000) · Thyroid · doi:10.1089/10507250050137761 · Cited by 130 · see citing works
Insight into Graves’ Hyperthyroidism from Animal Models
McLachlan, S. M., Nagayama, Y., & Rapoport, B. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0023 · Cited by 129 · see citing works
Valyasevi, R. W., Harteneck, D. A., Dutton, C. M., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8472 · Cited by 129 · see citing works
Clinical Presentation of Graves’ Ophthalmopathy
Wiersinga, W. M., Smit, T. J., van der Gaag, R., et al. (2009) · Ophthalmic Research · doi:10.1159/000266782 · Cited by 120 · see citing works
Long-term effects of Graves' ophthalmopathy on health-related quality of life.
Terwee, C., Wakelkamp, I., Tan, S. H., Dekker, F., Prummel, M., & Wiersinga, W. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460751 · Cited by 120 · see citing works
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts
Smith, T. J., Wang, H. S., & Evans, C. H. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.2.c382 · Cited by 118 · see citing works
Feldon, S. E., Park, D. J. J., O’Loughlin, C. W., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0605 · Cited by 117 · see citing works
Retrobulbar pressures measured during surgical decompression of the orbit.
Otto, A. J., Koornneef, L., Mourits, M. P., et al. (1996) · British Journal of Ophthalmology · doi:10.1136/bjo.80.12.1042 · Cited by 116 · see citing works
Fassi, D. E., Nielsen, C. H., Hasselbalch, H. C., & Hegedűs, L. D. (2006) · Thyroid · doi:10.1089/thy.2006.16.709 · Cited by 116 · see citing works
Infliximab: A Novel Treatment for Sight-Threatening Thyroid Associated Ophthalmopathy
Durrani, O. M., Reuser, T. Q., & Murray, P. I. (2005) · Orbit · doi:10.1080/01676830590912562 · Cited by 111 · see citing works
Smith, T. J., Tsai, C., Shih, M.-J., et al. (2008) · Thyroid · doi:10.1089/thy.2007.0404 · Cited by 108 · see citing works
Leukoregulin Induction of Prostaglandin-Endoperoxide H Synthase-2 in Human Orbital Fibroblasts
Wang, H.-S., Cao, H., Winn, V. D., Rezanka, L. J., Frobert, Y., Evans, C. H., Sciaky, D., Young, D. A., & Smith, T. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22718 · Cited by 108 · see citing works
Feldon, S. E., O’Loughlin, C. W., Ray, D. M., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060434 · Cited by 100 · see citing works
Neumann, S., Kleinau, G., Costanzi, S., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0836 · Cited by 100 · see citing works
Smoking and risk of Graves' disease
Prummel, M. F. (1993) · JAMA · doi:10.1001/jama.269.4.479 · Cited by 100 · see citing works
Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts.
Jm, K., Loftus, S. J., & Bahn, R. S. (1992) · PubMed · Cited by 99 · see citing works
Self-citationMORRIS, J. C., HAY, I. D., NELSON, R. E., & Jiang, N. (1988) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65533-5 · Cited by 97 · see citing works
Fassi, D. E., Banga, J. P., Gilbert, J. A., Padoa, C. J., Hegedűs, L. D., & Nielsen, C. H. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.09.007 · Cited by 92 · see citing works
Starkey, K., Janezić, A., Jones, G., et al. (2003) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0300369 · Cited by 90 · see citing works
Starkey, K. J., Heufelder, A. E., Baker, G. R. C., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020987 · Cited by 89 · see citing works
Chan, L. L., Tan, H.-E., Fook-Chong, S. M. C., et al. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1413 · Cited by 89 · see citing works
Kumar, S., & Bahn, R. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030380 · Cited by 89 · see citing works
Self-citationThyrotropin Receptor Activation Increases Hyaluronan Production in Preadipocyte Fibroblasts
Zhang, L., Bowen, T., Grennan-Jones, F., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003616 · Cited by 84 · see citing works
Biological Effects of Thyrotropin Receptor Activation on Human Orbital Preadipocytes
Zhang, L., Baker, G. R. C., Januś, D., et al. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0596 · Cited by 84 · see citing works
Susceptibility genes in Graves’ ophthalmopathy: searching for a needle in a haystack?
Bednarczuk, T., Gopinath, B., Płoski, R., & Wall, J. R. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02854.x · Cited by 83 · see citing works
Dysthyroid Optic Neuropathy Without Extraocular Muscle Involvement
Anderson, R. L., Tweeten, J. P., Patrinely, J. R., Garland, P. E., & Thiese, S. M. (1989) · Ophthalmic surgery, lasers & imaging retina · doi:10.3928/1542-8877-19890801-09 · Cited by 83 · see citing works
Valyasevi, R. W. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.7.2557 · Cited by 82 · see citing works
B Cells, Be Gone — B-Cell Depletion in the Treatment of Rheumatoid Arthritis
Tsokos, G. C. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048114 · Cited by 79 · see citing works
TSH receptor gene expression in retroocular fibroblasts
Mengistu, M. E., Lukes, Y. G., Nagy, E. V., Burch, H. B., Carr, F. E., LAHIRI, S., & Burman, K. D. (1994) · Journal of Endocrinological Investigation · doi:10.1007/bf03347732 · Cited by 77 · see citing works
Thyrotropin Receptor Expression in Adrenal, Kidney, and Thymus
Dutton, C. M., Joba, W., Spitzweg, C., et al. (1997) · Thyroid · doi:10.1089/thy.1997.7.879 · Cited by 75 · see citing works
Hiromatsu, Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.3.1194 · Cited by 75 · see citing works
Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes
Davies, T. F., TENG, C. S., McLachlan, S. M., et al. (1978) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(78)90072-2 · Cited by 74 · see citing works
Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy (TAO)
Pappa, A., Calder, V. L., Ajjan, R., Fells, P., Ludgate, M. E., Weetman, A. P., & Lightman, S. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.4491347.x · Cited by 74 · see citing works
Tan, G. H., Dutton, C. M., & Bahn, R. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636247 · Cited by 73 · see citing works
Self-citationSerum Selenium Levels in Patients with Remission and Relapse of Graves Disease
Wertenbruch, T., Willenberg, H. S., Sagert, C., Nguyen, T.-B.-T., Pavlicek‐Bahlo, M., Feldkamp, J., Groeger, C., Hermsen, D. F., Scherbaum, W. A., & Schott, M. (2007) · Medicinal Chemistry · doi:10.2174/157340607780620662 · Cited by 71 · see citing works
Daumerie, C., Ludgate, M. E., Costagliola, S., et al. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460035 · Cited by 70 · see citing works
Overexpression of Immediate Early Genes in Active Graves’ Ophthalmopathy
Lantz, M., Vondrichova, T., Parikh, H. M., Frenander, C., Ridderstråle, M., Åsman, P., Åberg, M., Groop, L., & Hallengren, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2275 · Cited by 68 · see citing works
Kumar, S., Leontovich, A. A., Coenen, M. J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2239 · Cited by 68 · see citing works
Thyrotropin Receptor in Non-thyroid Tissues
Endo, T., Ohno, M., Kotani, S., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1116 · Cited by 68 · see citing works
Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.
Paschke, R., Metcalfe, A., Alcalde, L., et al. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962314 · Cited by 67 · see citing works
Otto, E. A., Ochs, K., Hansen, C., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768872 · Cited by 64 · see citing works
Valyasevi, R. W., Jyonouchi, S. C., Dutton, C. M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7188 · Cited by 60 · see citing works
Salvi, M., Vannucchi, G. M., Campi, I., et al. (2009) · Clinical Immunology · doi:10.1016/j.clim.2008.12.005 · Cited by 58 · see citing works
Smith, T. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.1.385 · Cited by 58 · see citing works
PRESENT CONCEPTS OF THE PATHOLOGIC PHYSIOLOGY OF EXOPHTHALMOS*†
DOBYNS, B. M. (1950) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-10-10-1202 · Cited by 57 · see citing works
Reevaluating Thyrotropin Receptor-Induced Mouse Models of Graves’ Disease and Ophthalmopathy
Baker, G. R. C., Mazziotti, G., von Ruhland, C., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1015 · Cited by 54 · see citing works
Eckstein, A. K. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.035915 · Cited by 54 · see citing works
Aniszewski, J. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.776 · Cited by 54 · see citing works
Khoo, T. K., Coenen, M. J., Schiefer, A. R., et al. (2008) · Thyroid · doi:10.1089/thy.2008.0255 · Cited by 53 · see citing works
TSH stimulates adipogenesis in mouse embryonic stem cells
Lu, M., & Lin, R.-Y. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0452 · Cited by 52 · see citing works
Mullin, B. R., Lee, G., Ledley, F. D., et al. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(76)80271-9 · Cited by 49 · see citing works
Valyasevi, R. W. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2352 · Cited by 41 · see citing works
Dorkhan, M., Lantz, M., Frid, A. H., et al. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02542.x · Cited by 36 · see citing works
Otto, E. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.8.3045 · Cited by 32 · see citing works
Tan, G. H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.2.449 · Cited by 32 · see citing works
Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues
Paschke, R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.5.1234 · Cited by 32 · see citing works
Misharin, A. V., Nagayama, Y., Aliesky, H. A., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0181 · Cited by 27 · see citing works
Cao, H., Han, R., & Smith, T. J. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00354.2002 · Cited by 26 · see citing works
Valyasevi, R. W. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.903 · Cited by 25 · see citing works
KONUK, E. B. Y., Konuk, O., Mısırlıoğlu, M., et al. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02280 · Cited by 22 · see citing works
Surgical management of ophthalmopathy in Graves' disease. Transfrontal orbital decompression.
Riley, F. C. (1972) · PubMed · Cited by 16 · see citing works
Smith, T. J. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212175 · Cited by 15 · see citing works
Cozma, I., Zhang, L., Uddin, J., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00177.2007 · Cited by 11 · see citing works
B-cell inhibitors as therapy for rheumatoid arthritis: An update
Kwan‐Morley, J., & Albert, D. (2007) · Current Rheumatology Reports · doi:10.1007/s11926-007-0064-4 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [28]Riley FC Orbital pathology in Graves’ disease Mayo Clin Proc 1972 47 975 9 4344323
- [40]Rootman J Rootman J Pathophysiologic patterns of orbital disease Diseases of the orbit: a multidisciplinary approach 2 Philadelphia Lippincott Williams & Wilkins 2003 43 51
- [58]Endo T Ohno M Kotani S Gunji K Onaya T Thyrotropin receptor in nonthyroid tissues Biochem Biophys Res Commun 1993 190 774 9 8439328
Cited by
Sorted by citations
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098 · see citing works
Bartalena, L., Baldeschi, L., Boboridis, K., Eckstein, A., Kahaly, G. J., Marcocci, C., Perros, P., Salvi, M., & Wiersinga, W. M. (2016) · European Thyroid Journal · doi:10.1159/000443828 · Cited by 943 · see citing works
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898 · see citing works
Self-citationTanda, M. L., Piantanida, E., Liparulo, L., Veronesi, G., Lai, A., Sassi, L., Pariani, N., Gallo, D., Azzolini, C., Ferrario, M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3873 · Cited by 328 · see citing works
Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy
Min, L., Vaidya, A., & Becker, C. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-0833 · Cited by 179 · see citing works
Laurberg, P., Berman, D. C., Bülow Pedersen, I., Andersen, S., & Carlé, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1275 · Cited by 133 · see citing works
The Dilemma of How to Manage Graves' Hyperthyroidism in Patients with Associated Orbitopathy
Bartalena, L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2329 · Cited by 93 · see citing works
Wang, Y., Chen, Z., Wang, T., Guo, H., Liu, Y., Dang, N., Hu, S., Wu, L., Zhang, C., Ye, K., et al. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00615-2 · Cited by 82 · see citing works
Thyroid-Like Ophthalmopathy in a Euthyroid Patient Receiving Ipilimumab
McElnea, E., Ní Mhéalóid, Á., Moran, S., Kelly, R., & Fulcher, T. (2014) · Orbit · doi:10.3109/01676830.2014.949792 · Cited by 93 · see citing works
Turcu, A. F., Kumar, S., Neumann, S., Coenen, M., Iyer, S., Chiriboga, P., Gershengorn, M. C., & Bahn, R. S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1149 · Cited by 84 · see citing works
Self-citationKahaly, G. J., Bartalena, L., & Hegedüs, L. (2011) · Thyroid® · doi:10.1089/thy.2011.2106.ed3 · Cited by 80 · see citing works
- Authors
- Bahn, R. S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Bahn, Rebecca S.
- ORCID
- Bahn, Rebecca S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-02-25
- Volume
- 362
- Issue
- 8
- Pages
- 726-738
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3902010
- OpenAlex
- W4240137178
- Cited by
- 1,552
- References
- 129
- Citations by year
- 2026: 115 · 2025: 154 · 2024: 161 · 2023: 126 · 2022: 127 · 2021: 153 · 2020: 112 · 2019: 76 · 2018: 97 · 2017: 54 · 2016: 69 · 2015: 75 · 2014: 61 · 2013: 52 · 2012: 67
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK077814, R01DK077814, DK77814)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
- Keywords
- Graves' ophthalmopathy, Graves' disease, autoimmunity, orbital inflammation, cytokines, T cells, B cells, macrophages, fibroblasts, adipose tissue, pathogenesis, treatment
- MeSH terms
- Humans, Hyperthyroidism, Skin Diseases, Antithyroid Agents, Thyroid Diseases, Thyroiditis, Autoimmune, Autoimmunity, Graves Ophthalmopathy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review