Cited by 1,552Ophthalmology and Eye DisordersMyasthenia Gravis and ThymomaOcular Disorders and Treatments

Graves' Ophthalmopathy

Open access
Bahn, Rebecca S.·2010·New England Journal of Medicine

Abstract

This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease.

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Crossref · 10.1056/nejmra0905750

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Research works printed but not linked: 3

  1. [28]Riley FC Orbital pathology in Graves’ disease Mayo Clin Proc 1972 47 975 9 4344323
  2. [40]Rootman J Rootman J Pathophysiologic patterns of orbital disease Diseases of the orbit: a multidisciplinary approach 2 Philadelphia Lippincott Williams & Wilkins 2003 43 51
  3. [58]Endo T Ohno M Kotani S Gunji K Onaya T Thyrotropin receptor in nonthyroid tissues Biochem Biophys Res Commun 1993 190 774 9 8439328

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Authors
Bahn, R. S.
Affiliations
Mayo Clinic (US)
Corresponding author
Bahn, Rebecca S.
Venue
New England Journal of Medicine
Published
2010-02-25
Volume
362
Issue
8
Pages
726-738
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4240137178
Cited by
1,552
References
129
Citations by year
2026: 115 · 2025: 154 · 2024: 161 · 2023: 126 · 2022: 127 · 2021: 153 · 2020: 112 · 2019: 76 · 2018: 97 · 2017: 54 · 2016: 69 · 2015: 75 · 2014: 61 · 2013: 52 · 2012: 67
FWCI
6.48
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R56DK077814, R01DK077814, DK77814)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
  • Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
Keywords
Graves' ophthalmopathy, Graves' disease, autoimmunity, orbital inflammation, cytokines, T cells, B cells, macrophages, fibroblasts, adipose tissue, pathogenesis, treatment
MeSH terms
Humans, Hyperthyroidism, Skin Diseases, Antithyroid Agents, Thyroid Diseases, Thyroiditis, Autoimmune, Autoimmunity, Graves Ophthalmopathy

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