The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Nutrition in the Acute Phase of Critical Illness
Open accessAbstract
† No diagram showing how patients were selected was included in the study by Montejo et al. 10 ‡ No information on the way in which investigators concealed study-group assignments was included in the study by Acosta-Escribano et al. 13 § No sample-size calculation and only partial outcome data in the intention-to-treat population were included in the study by Pontes-Arruda et al., 22 and no diagram showing how patients were selected was included in the study by Umpierrez et al. 23¶ The study by Rice et al. 24 was stopped prematurely for futility at the first interim analysis.
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“These findings may also explain differences in results of nutritional trials, depending on the clinical setting with several nutritional studies in the ICU setting or in patients with advanced cancer not showing significant benefits form nutrition in regard to clinical outcomes [165,168].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [168]
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“Data from studies conducted in the past 10 years challenge the appropriateness of these standard calorie and protein targets during the acute phase of critical illness.8,9”
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Cites
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696
Self-citationTaylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
Increased mortality associated with growth hormone treatment in critically ill adults
Takala, J., Ruokonen, E., Webster, N. R., Nielsen, M. S., Zandstra, D. F., Vundelinckx, G., & Hinds, C. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411102 · Cited by 1,023
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975
The National Heart, L., Rice, T. W., Wheeler, A. P., Thompson, B. T., Steingrub, J., Hite, R. D., Moss, M., Morris, A., Dong, N., & Rock, P. (2012) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.2012.137 · Cited by 935
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Heyland, D., Muscedere, J., Wischmeyer, P. E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M. M., & Day, A. G. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212722 · Cited by 904
INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS
Akala, J. U. T., Uokonen, E. S. R., Igel, N., Ebster, R. W., Ielsen, M. I. S. N., Andstra, D. U. F. Z., Undelinckx, G. U. V., & Inds, H. J. H. (1999) · Cited by 889
Heidegger, C. P., Berger, M. M., Graf, S., Zingg, W., Darmon, P., Costanza, M. C., Thibault, R., & Pichard, C. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61351-8 · Cited by 776
Research works printed but not linked: 1
- Martin CM, 2004, CMAJ, 170, 197
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Schuetz, P., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Braun, N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32776-4 · Cited by 910
Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines
ESICM Working Group on Gastrointestinal Function, Reintam Blaser, A., Starkopf, J., Alhazzani, W., Berger, M. M., Casaer, M. P., Deane, A. M., Fruhwald, S., Hiesmayr, M., Ichai, C., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-016-4665-0 · Cited by 837
Self-citationReignier, J., Boisramé-Helms, J., Brisard, L., Lascarrou, J.-B., Ait Hssain, A., Anguel, N., Argaud, L., Asehnoune, K., Asfar, P., Bellec, F., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32146-3 · Cited by 595
Rahman, A., Hasan, R. M., Agarwala, R., Martin, C. M., Day, A. G., & Heyland, D. K. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.01.015 · Cited by 550
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579
Metadata
- Authors
- Casaer, M. P., & Van den Berghe, G.
- Affiliations
- KU Leuven (BE)
- ORCID
- Casaer, Michael P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-03-27
- Volume
- 370
- Issue
- 13
- Pages
- 1227-1236
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2167108605
- Semantic Scholar
- 0cb329f79bd3d2161f4d43c16bc04bf14fe369d7
- Cited by
- 335
- References
- 58
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 24 · 2021: 29 · 2020: 23 · 2019: 23 · 2018: 30 · 2017: 34 · 2016: 27 · 2015: 56 · 2014: 18
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- nutrition, critical illness, acute phase, critically ill patients, nutritional support, methodological quality, reporting quality, sample size determination, blinding, early trial termination
- MeSH terms
- Amino Acids, Animals, Anorexia, Enteral Nutrition, Food, Humans, Lipids, Nutritional Requirements, Parenteral Nutrition, Time Factors, Randomized Controlled Trials as Topic, Critical Illness, Micronutrients
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