The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Nutrition in the Acute Phase of Critical Illness
Open accessAbstract
† No diagram showing how patients were selected was included in the study by Montejo et al. 10 ‡ No information on the way in which investigators concealed study-group assignments was included in the study by Acosta-Escribano et al. 13 § No sample-size calculation and only partial outcome data in the intention-to-treat population were included in the study by Pontes-Arruda et al., 22 and no diagram showing how patients were selected was included in the study by Umpierrez et al. 23¶ The study by Rice et al. 24 was stopped prematurely for futility at the first interim analysis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These findings may also explain differences in results of nutritional trials, depending on the clinical setting with several nutritional studies in the ICU setting or in patients with advanced cancer not showing significant benefits form nutrition in regard to clinical outcomes [165,168].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [168]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Data from studies conducted in the past 10 years challenge the appropriateness of these standard calorie and protein targets during the acute phase of critical illness.8,9”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696
Self-citationTaylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
Increased mortality associated with growth hormone treatment in critically ill adults
Takala, J., Ruokonen, E., Webster, N. R., Nielsen, M. S., Zandstra, D. F., Vundelinckx, G., & Hinds, C. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411102 · Cited by 1,023
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975
The National Heart, L., Rice, T. W., Wheeler, A. P., Thompson, B. T., Steingrub, J., Hite, R. D., Moss, M., Morris, A., Dong, N., & Rock, P. (2012) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.2012.137 · Cited by 935
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Heyland, D., Muscedere, J., Wischmeyer, P. E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M. M., & Day, A. G. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212722 · Cited by 904
INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS
Akala, J. U. T., Uokonen, E. S. R., Igel, N., Ebster, R. W., Ielsen, M. I. S. N., Andstra, D. U. F. Z., Undelinckx, G. U. V., & Inds, H. J. H. (1999) · Cited by 889
Heidegger, C. P., Berger, M. M., Graf, S., Zingg, W., Darmon, P., Costanza, M. C., Thibault, R., & Pichard, C. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61351-8 · Cited by 776
Glutamine supplementation in serious illness: A systematic review of the evidence*
Novak, F. J., Heyland, D. K., Avenell, A., Drover, J., & Su, X. (2002) · Critical Care Medicine · doi:10.1097/00003246-200209000-00011 · Cited by 706
Enteral compared with parenteral nutrition: a meta-analysis
Braunschweig, C. L., Levy, P. S., Sheean, P., & Wang, X. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.534 · Cited by 681
Singer, P., Anbar, R., Cohen, J., Shapiro, H., Shalita-Chesner, M., Lev, S., Grozovski, E., Theilla, M., Frishman, S., & Madar, Z. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2146-z · Cited by 566
Respiratory weakness is associated with limb weakness and delayed weaning in critical illness*
Jonghe, B. D., Bastuji‐Garin, S., Durand, M., Malissin, I., Rodrigues, P., Cerf, C., Outin, H., & Sharshar, T. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000281450.01881.d8 · Cited by 555
Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Rice, T. W. (2011) · JAMA · doi:10.1001/jama.2011.1435 · Cited by 552
Doig, G. S., Heighes, P. T., Simpson, F., Sweetman, E. A., & Davies, A. R. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1664-4 · Cited by 464
Martindale, R. G., McClave, S. A., Vanek, V. W., McCarthy, M. S., Roberts, P. R., Taylor, B. E., Ochoa, J. B., Napolitano, L. M., & Cresci, G. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a40116 · Cited by 432
Immune modulation by parenteral lipid emulsions
Wanten, G. J. A., & Calder, P. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1171 · Cited by 421
Taylor, S. J., Fettes, S. B., Jewkes, C., & Nelson, R. J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199911000-00033 · Cited by 413
Provision of protein and energy in relation to measured requirements in intensive care patients
Allingstrup, M. J., Esmailzadeh, N., Wilkens Knudsen, A., Espersen, K., Hartvig Jensen, T., Wiis, J., Perner, A., & Kondrup, J. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2011.12.006 · Cited by 381
Martin, C. M., Doig, G. S., Heyland, D. K., Morrison, T., & Sibbald, W. J. (2004) · PubMed Central · Cited by 380
Andrews, P. J. D., Avenell, A., Noble, D. W., Campbell, M. K., Croal, B. L., Simpson, W. G., Vale, L. D., Battison, C. G., Jenkinson, D. J., Cook, J. A., et al. (2011) · BMJ · doi:10.1136/bmj.d1542 · Cited by 379
Hermans, G., Casaer, M. P., Clerckx, B., Güiza, F., Vanhullebusch, T., Derde, S., Meersseman, P., Derese, I., Mesotten, D., Wouters, P. J., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70183-8 · Cited by 376
Self-citationGastric residual volume during enteral nutrition in ICU patients: the REGANE study
Montejo, J. C., Miñambres, E., Bordejé, L., Mesejo, A., Acosta, J., Heras, A., Ferré, M. T. P., Fernández-Ortega, J. F., Alonso, C. V., & Manzanedo, R. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1856-y · Cited by 367
Peter, J. V., Moran, J. L., & Phillips-Hughes, J. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000150960.36228.c0 · Cited by 359
Arabi, Y. M., Tamim, H., Dhar, G. S., Al‐Dawood, A., Al-Sultan, M., Sakkijha, M. H., Kahoul, S. H., & Brits, R. J. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005074 · Cited by 355
Artinian, V., Krayem, H., & DiGiovine, B. (2006) · CHEST Journal · doi:10.1378/chest.129.4.960 · Cited by 354
Refeeding Hypophosphatemia in Critically Ill Patients in an Intensive Care Unit
Marik, P. E. (1996) · Archives of Surgery · doi:10.1001/archsurg.1996.01430220037007 · Cited by 324
Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial
Casaer, M. P., Wilmer, A., Hermans, G., Wouters, P. J., Mesotten, D., & Van den Berghe, G. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-0999oc · Cited by 307
Self-citationImmunonutrition in critically ill patients: a systematic review and analysis of the literature
Marik, P. E., & Zaloga, G. P. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1213-6 · Cited by 295
Needham, D. M., Dinglas, V. D., Morris, P. E., Jackson, J. C., Hough, C. L., Méndez-Téllez, P. A., Wozniak, A. W., Colantuoni, E., Ely, E. W., Rice, T. W., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0651oc · Cited by 287
Martin, C., Doig, G., Heyland, D. K., Morrison, T., & Sibbald, W. (2004) · Nutrition in Clinical Practice · doi:10.1177/0115426504019003309 · Cited by 271
Scheinkestel, C. D., Kar, L., Marshall, K., Bailey, M., Davies, A., Nyulasi, I., & Tuxen, D. V. (2003) · Nutrition · doi:10.1016/s0899-9007(03)00175-8 · Cited by 249
Early Versus Late Parenteral Nutrition in Critically Ill Adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Cromphaut, S. J. V., Ingels, C., Meersseman, P., Muller, J., et al. (2012) · Survey of Anesthesiology · doi:10.1097/01.sa.0000412381.92989.8e · Cited by 235
Self-citationAntioxidant micronutrients in the critically ill: a systematic review and meta-analysis
Manzanares, W., Dhaliwal, R., Jiang, X., Murch, L., & Heyland, D. K. (2012) · Critical Care · doi:10.1186/cc11316 · Cited by 234
Pontes‐Arruda, A., DeMichele, S., Seth, A., & Singer, P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324203 · Cited by 230
Reignier, J., Mercier, E., Gouge, A. L., Boulain, T., Desachy, A., Bellec, F., Clavel, M., Frat, J., Plantefève, G., Quenot, J., et al. (2014) · Survey of Anesthesiology · doi:10.1097/01.sa.0000446365.11416.b0 · Cited by 218
Liver dysfunction associated with artificial nutrition in critically ill patients
Grau, T., Bonet, A., Rubio, M., Mateo, D., Farré, M., Acosta, J. A., Blesa, A., Montejo, J. C., de Lorenzo, A. G., Mesejo, A., et al. (2007) · Critical Care · doi:10.1186/cc5670 · Cited by 177
Davies, A. R., Morrison, S. S., Bailey, M. J., Bellomo, R., Cooper, D. J., Doig, G. S., Finfer, S. R., & Heyland, D. K. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318255d87e · Cited by 168
Nguyen, N. Q., Chapman, M. J., Fraser, R. J., Bryant, L. K., & Holloway, R. H. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000253410.36492.e9 · Cited by 162
Dissanaike, S., Shelton, M., Warner, K. J., & O’Keefe, G. E. (2007) · Critical Care · doi:10.1186/cc6167 · Cited by 150
Pontes-Arruda, A., Martins, L. F., de Lima, S. M., Isola, A. M., Toledo, D., Rezende, E., Maia, M., Magnan, G. B., & the Investigating Nutritional Therapy with EPA, G. A. A. R. I. S. T. (. S. G. (2011) · Critical Care · doi:10.1186/cc10267 · Cited by 148
Acosta-Escribano, J., Fernández-Vivas, M., Grau Carmona, T., Caturla-Such, J., Garcia-Martinez, M., Menendez-Mainer, A., Solera-Suarez, M., & Sanchez-Payá, J. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1908-3 · Cited by 133
WERNERMAN, J., KIRKETEIG, T., ANDERSSON, B., BERTHELSON, H., ERSSON, A., FRIBERG, H., GUTTORMSEN, A. B., HENDRIKX, S., PETTILÄ, V., ROSSI, P., et al. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02453.x · Cited by 132
Alhazzani, W., Jacobi, J., Sindi, A., Hartog, C., Reinhart, K., Kokkoris, S., Gerlach, H., Andrews, P., Drabek, T., Manzanares, W., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828a24c6 · Cited by 118
MacLaren, R., Kiser, T. H., Fish, D. N., & Wischmeyer, P. E. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108319803 · Cited by 117
Kutsogiannis, J., Alberda, C., Gramlich, L., Cahill, N. E., Wang, M., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182282a83 · Cited by 112
Estimating Energy Needs in Nutrition Support Patients
Frankenfield, D. C., & Ashcraft, C. M. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415859 · Cited by 101
Parenteral Fish Oil Lipid Emulsions in the Critically Ill
Manzanares, W., Dhaliwal, R., Jurewitsch, B., Stapleton, R. D., Jeejeebhoy, K. N., & Heyland, D. K. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486006 · Cited by 92
Umpierrez, G. E., Spiegelman, R., Zhao, V., Smiley, D. D., Pinzon, I., Griffith, D. P., Peng, L., Morris, T., Luo, M., Garcia, H., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182474bf9 · Cited by 77
Early versus late parenteral nutrition in ICU patients: cost analysis of the EPaNIC trial
Vanderheyden, S., Casaer, M., Kesteloot, K., Simoens, S., Rijdt, T. D., Peers, G., Wouters, P., Coenegrachts, J., Grieten, T., Polders, K., et al. (2012) · Critical Care · doi:10.1186/cc11361 · Cited by 71
Self-citationA Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Heyland, D. K., Muscedere, J., Wischmeyer, P. E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M. M., & Day, A. G. (2014) · Survey of Anesthesiology · doi:10.1097/01.sa.0000441043.83064.4c · Cited by 63
Doig, G. S., Simpson, F., Sweetman, E. A., Finfer, S. R., Cooper, D. J., Heighes, P. T., Davies, A. R., O’Leary, M. J., Solano, T., & Peake, S. (2014) · Survey of Anesthesiology · doi:10.1097/01.sa.0000441042.75441.36 · Cited by 43
Enteral Nutrition: A Hard Look at Some Soft Evidence
Koretz, R. L. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609335378 · Cited by 31
Supplemental parenteral nutrition in critically ill patients – Authors' reply
Heidegger, C. P., Berger, M. M., Thibault, R., Zingg, W., & Pichard, C. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61072-7 · Cited by 14
Doig, G. S. (2008) · JAMA · doi:10.1001/jama.2008.826 · Cited by 1
Research works printed but not linked: 1
- Martin CM, 2004, CMAJ, 170, 197
Cited by
Sorted by citations
Schuetz, P., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Braun, N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32776-4 · Cited by 910
Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines
ESICM Working Group on Gastrointestinal Function, Reintam Blaser, A., Starkopf, J., Alhazzani, W., Berger, M. M., Casaer, M. P., Deane, A. M., Fruhwald, S., Hiesmayr, M., Ichai, C., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-016-4665-0 · Cited by 837
Self-citationReignier, J., Boisramé-Helms, J., Brisard, L., Lascarrou, J.-B., Ait Hssain, A., Anguel, N., Argaud, L., Asehnoune, K., Asfar, P., Bellec, F., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32146-3 · Cited by 595
Rahman, A., Hasan, R. M., Agarwala, R., Martin, C. M., Day, A. G., & Heyland, D. K. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.01.015 · Cited by 550
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579
Metadata
- Authors
- Casaer, M. P., & Van den Berghe, G.
- Affiliations
- KU Leuven (BE)
- ORCID
- Casaer, Michael P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-03-27
- Volume
- 370
- Issue
- 13
- Pages
- 1227-1236
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2167108605
- Semantic Scholar
- 0cb329f79bd3d2161f4d43c16bc04bf14fe369d7
- Cited by
- 335
- References
- 58
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 24 · 2021: 29 · 2020: 23 · 2019: 23 · 2018: 30 · 2017: 34 · 2016: 27 · 2015: 56 · 2014: 18
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- nutrition, critical illness, acute phase, critically ill patients, nutritional support, methodological quality, reporting quality, sample size determination, blinding, early trial termination
- MeSH terms
- Amino Acids, Animals, Anorexia, Enteral Nutrition, Food, Humans, Lipids, Nutritional Requirements, Parenteral Nutrition, Time Factors, Randomized Controlled Trials as Topic, Critical Illness, Micronutrients
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review