The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tapping mode atomic force microscopy in liquids
Abstract
Tapping mode atomic force microscopy in liquids gives a substantial improvement in imaging quality and stability over standard contact mode. In tapping mode the probe-sample separation is modulated as the probe scans over the sample. This modulation causes the probe to tap on the surface only at the extreme of each modulation cycle and therefore minimizes frictional forces that are present when the probe is constantly in contact with the surface. This imaging mode increases resolution and reduces sample damage on soft samples. For our initial experiments we used a tapping frequency of 17 kHz to image deoxyribonucleic acid plasmids on mica in water. When we imaged the same sample region with the same cantilever, the plasmids appeared 18 nm wide in contact mode and 5 nm in tapping mode.
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Citations
Cites
Atomic force microscopy of DNA in aqueous solutions
Hansma, H. G., Bezanilla, M., Zenhausern, F., Adrian, M., & Sinsheimer, R. L. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.3.505 · Cited by 207
Cited by
Short cantilevers for atomic force microscopy
Walters, D. A., Cleveland, J. P., Thomson, N. H., Hansma, P. K., Wendman, M. A., Gurley, G., & Elings, V. (1996) · Review of Scientific Instruments · doi:10.1063/1.1147177 · Cited by 494
Self-citationAFM: a versatile tool in biophysics
Alessandrini, A., & Facci, P. (2005) · Measurement Science and Technology · doi:10.1088/0957-0233/16/6/r01 · Cited by 384
Escherichia coli RNA Polymerase Activity Observed Using Atomic Force Microscopy
Kasas, S., Thomson, N. H., Smith, B. L., Hansma, H. G., Zhu, X., Guthold, M., Bustamante, C., Kool, E. T., Kashlev, M., & Hansma, P. K. (1997) · Biochemistry · doi:10.1021/bi9624402 · Cited by 339
Self-citationPhysical Morphology and Surface Properties of Unsaturated Pseudomonas putida Biofilms
Auerbach, I. D., Sorensen, C., Hansma, H. G., & Holden, P. A. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.13.3809-3815.2000 · Cited by 144
Self-citationThe applications of atomic force microscopy to vision science
Last, J. A., Russell, P., Nealey, P. F., & Murphy, C. J. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5470 · Cited by 100
Metadata
- Authors
- Hansma, P. K., Cleveland, J. P., Radmacher, M., Walters, D. A., Hillner, P. E., Bezanilla, M., Fritz, M., Vie, D., Hansma, H. G., Prater, C. B., Massie, J., Fukunaga, L., Gurley, J., & Elings, V.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 1994-03-28
- Volume
- 64
- Issue
- 13
- Pages
- 1738-1740
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2568203515
- Cited by
- 875
- References
- 1
- FWCI
- 20.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tapping mode atomic force microscopy in liquids. https://app.cochat.ai/papers/10.1063/1.111795
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- Hansma, P. K., Cleveland, J. P., Radmacher, M., Walters, D. A., Hillner, P. E., Bezanilla, M., Fritz, M., Vie, D., Hansma, H. G., Prater, C. B., Massie, J., Fukunaga, L., Gurley, J., & Elings, V. (1994). Tapping mode atomic force microscopy in liquids. Applied Physics Letters. https://doi.org/10.1063/1.111795
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