Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates
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In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.
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FUS-MB induces temporary BBB opening even in NHPs.
“A more localized transient disruption of BBB is accomplished by using magnetic resonance imaging-guided focused ultrasound in combination with IV infusion of microbubbles (FUS-MB) (Fig. 4b), which induce temporary BBB opening even in NHPs [134–137].”
From Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside (2024) · cites this paper as [134]
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Self-citation
- Authors
- Tung, Y.-S., Marquet, F., Teichert, T., Ferrera, V., & Konofagou, E. E.
- Affiliations
- Columbia University (US)
- Columbia University Irving Medical Center (US)
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2011-04-18
- Volume
- 98
- Issue
- 16
- Pages
- 163704-163704
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- PMC
- PMC3094460
- OpenAlex
- W2094621092
- Cited by
- 119
- References
- 13
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 13 · 2015: 14 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Applied Physics Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Science Foundation (0644713, MH059244)
- National Institutes of Health (NIHR01EB009041)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Materials Chemistry › Ultrasound and Cavitation Phenomena
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- blood-brain barrier opening, focused ultrasound, microbubbles, cavitation detection, transcranial ultrasound, non-human primates, monkeys, passive cavitation detection, real-time feedback
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