Perspective: Fabrication of integrated organ-on-a-chip via bioprinting
Open accessAbstract
Organ-on-a-chip has emerged as a powerful platform with widespread applications in biomedical engineering, such as pathology studies and drug screening. However, the fabrication of organ-on-a-chip is still a challenging task due to its complexity. For an integrated organ-on-a-chip, it may contain four key elements, i.e., a microfluidic chip, live cells/microtissues that are cultured in this chip, components for stimulus loading to mature the microtissues, and sensors for results readout. Recently, bioprinting has been used for fabricating organ-on-a-chip as it enables the printing of multiple materials, including biocompatible materials and even live cells in a programmable manner with a high spatial resolution. Besides, all four elements for organ-on-a-chip could be printed in a single continuous procedure on one printer; in other words, the fabrication process is assembly free. In this paper, we discuss the recent advances of organ-on-a-chip fabrication by bioprinting. Light is shed on the printing strategies, materials, and biocompatibility. In addition, some specific bioprinted organs-on-chips are analyzed in detail. Because the bioprinted organ-on-a-chip is still in its early stage, significant efforts are still needed. Thus, the challenges presented together with possible solutions and future trends are also discussed.
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Photolithography and related methods are capable of fabricating only the microfluidic chip itself, while other elements (microtissues, stimulus-loading components, and results-readout sensors) require additional processes.
“Moreover, these methods are capable of fabricating only the microfluidic chip itself, while the other elements (i.e., microtissues, stimulus-loading components, and results-readout sensors) require additional processes130.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [130]
Various biofunctional materials and cell types can be printed simultaneously onto a substrate of cell-compatible biomaterials to build 3D complex constructs with good spatial resolution and reproducibility.
“Various biofunctional materials and cell types can thus be printed simultaneously onto a substrate of cell-compatible biomaterials to build 3D complex constructs with good spatial resolution and reproducibility (Fig. 3a)130,148–151.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [130]
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Çetinkaya, A., Kaya, S. I., Budak, F., & Özkan, S. A. (2024) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2024.2339962 · Cited by 4 · see citing works
Micro and nanoengineering advances for the development and commercialization of Organ-on-chips
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Wei, N., Yao, S., Rao, Y., Wang, K., & Peng, Y. L. (2022) · Mechanics of Advanced Materials and Structures · doi:10.1080/15376494.2022.2044569 · Cited by 4 · see citing works
Kim, Y., Park, D., Lee, D. H., & Chung, C. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114642 · Cited by 3 · see citing works
Bioprinting technologies in ophthalmology
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Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
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Novel Approaches to Studying SLC13A5 Disease
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Development of Human-on-a-Chip
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Strategies for the Selection and Application of Biological Scaffolds in Organ‐on‐a‐Chip Systems
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Development of bio-inks for bioprinting applications
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Technologies in medicine of the future (sociological view)
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Eye on-chip as new paradigm for drug discovery and disease modeling of dry eyes disease
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Advancing Biological Research and Drug Development Through Organ-On-A-Chip Technology
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- Authors
- Yang, Q., Lian, Q., & Xu, F.
- Affiliations
- Xi'an Jiaotong University (CN)
- Venue
- Biomicrofluidics
- Publisher
- AIP Publishing
- Published
- 2017-05-01
- Volume
- 11
- Issue
- 3
- Pages
- 031301-031301
- ISSN
- 1932-1058 (ISSN-L)
- PMC
- PMC5423813
- OpenAlex
- W2612055724
- Cited by
- 95
- References
- 14
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 18 · 2022: 18 · 2021: 12 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 3
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomicrofluidics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Engineering Laboratory for Highway Maintenance Equipment (310825161103)
- National Natural Science Foundation of China (11372243, 11522219, 51375371, 51605377)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, bioprinting, microfluidic chip fabrication, biomaterials, bioprinting materials, biocompatibility, drug screening, tissue engineering
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