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Cited by 284

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

The rheology of direct and suspended extrusion bioprinting

Open access
Cooke, Megan E., Rosenzweig, Derek H.·2021·APL Bioengineering

Abstract

Bioprinting is a tool increasingly used in tissue engineering laboratories around the world. As an extension to classic tissue engineering, it enables high levels of control over the spatial deposition of cells, materials, and other factors. It is a field with huge promise for the production of implantable tissues and even organs, but the availability of functional bioinks is a barrier to success. Extrusion bioprinting is the most commonly used technique, where high-viscosity solutions of materials and cells are required to ensure good shape fidelity of the printed tissue construct. This is contradictory to hydrogels used in tissue engineering, which are generally of low viscosity prior to cross-linking to ensure cell viability, making them not directly translatable to bioprinting. This review provides an overview of the important rheological parameters for bioinks and methods to assess printability, as well as the effect of bioink rheology on cell viability. Developments over the last five years in bioink formulations and the use of suspended printing to overcome rheological limitations are then discussed.

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Metadata

Authors
Cooke, M. E., & Rosenzweig, D. H.
Venue
APL Bioengineering
Published
2021-02-04
Volume
5
Issue
1
Pages
011502-011502
ISSN
2473-2877 (ISSN-L)
OpenAlex
W3126242426
Cited by
284
References
132
FWCI
12.46
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The rheology of direct and suspended extrusion bioprinting. https://app.cochat.ai/papers/10.1063/5.0031475
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Cooke, M. E., & Rosenzweig, D. H. (2021). The rheology of direct and suspended extrusion bioprinting. APL Bioengineering. https://doi.org/10.1063/5.0031475

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