Acute effect of L‐796568, a novel β3‐adrenergic receptor agonist, on energy expenditure in obese men

New methods for calculating metabolic rate with special reference to protein metabolism

Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,608 · see citing works

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients.

Sjöström, L., Rissanen, A., Andersen, T., Boldrin, M., Golay, A., Koppeschaar, H. P., & Krempf, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11509-4 · Cited by 1,237 · see citing works

Effect of sibutramine on weight maintenance after weight loss: a randomised trial

James, W. P. T., Astrup, A., Finer, N., Hilsted, J., Kopelman, P., Rössner, S., Saris, W. H. M., & Gaal, L. F. V. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03491-7 · Cited by 817 · see citing works

Tissue distribution of beta 3-adrenergic receptor mRNA in man

Krief, S., Lönnqvist, F., Raimbault, S., Baude, B., Van Spronsen, A., Arner, P., Strosberg, A. D., Ricquier, D., & Emorine, L. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116191 · Cited by 528 · see citing works

Simple and fast solvent extraction system for selective and quantitative isolation of adrenaline, noradrenaline and dopamine from plasma and urine

Smedes, F., Kraak, J. C., & Poppe, H. (1982) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)80506-x · Cited by 429 · see citing works

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans.

Weyer, C., Tataranni, P. A., Snitker, S., Danforth, E., & Ravussin, E. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1555 · Cited by 188 · see citing works

β3-Adrenoceptors in the cardiovascular system

Gauthier, C., Langin, D., & Balligand, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01562-5 · Cited by 187 · see citing works

In situ assessment of the role of the β1, β2‐ and β3‐adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue

Barbe, P., Millet, L., Galitzky, J., Lafontan, M., & Berlan, M. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15279.x · Cited by 175 · see citing works

Distribution of β3-adrenoceptor mRNA in human tissues

Berkowitz, D. E., Nardone, N. A., Smiley, R. M., Price, D. T., Kreutter, D. K., Fremeau, R. T., & Schwinn, D. A. (1995) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(95)90098-5 · Cited by 153 · see citing works

Evidence for a functional β3‐adrenoceptor in man

Lönnqvist, F., Krief, S., Strosberg, A. D., Nyberg, SS., Emorine, L. J., & Arner, P. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13902.x · Cited by 150 · see citing works

Prospects for beta 3-adrenoceptor agonists in the treatment of obesity and diabetes.

Arch, J. R. S., & Wilson, S. (1996) · PubMed · Cited by 134 · see citing works

The tissue distribution of the human β3-adrenoceptor studied using a monoclonal antibody: Direct evidence of the β3-adrenoceptor in human adipose tissue, atrium and skeletal muscle

Chamberlain, P., Jennings, K., Paul, F., Cordell, J., Berry, A., Holmes, S., Park, J., Chambers, J., Sennitt, M. V., Stock, M. J., et al. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801039 · Cited by 127 · see citing works

The peripheral sympathetic nervous system in human obesity

van Baak, M. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00010.x · Cited by 114 · see citing works

Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men

Blaak, E. E., van Baak, M. A., Kemerink, G. J., Pakbiers, M. T. W., Heidendal, G. A. K., & Saris, W. H. M. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e306 · Cited by 111 · see citing works

Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans.

Liu, Y., Toubro, S., Astrup, A. V., & Stock, M. J. (1995) · PubMed · Cited by 89 · see citing works

β1- andβ2-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men1

Schiffelers, S. L. H., Saris, W. H. M., Boomsma, F., & van Baak, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7506 · Cited by 86 · see citing works

Discovery of a Potent, Orally Bioavailable β3 Adrenergic Receptor Agonist, (R)-N-[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, R. J., Tolman, J. S., Chitty, D., Candelore, M. R., Cascieri, M. A., Colwell, L. F., Deng, L., Feeney, W. P., Forrest, M. J., Hom, G. J., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000286i · Cited by 63 · see citing works

Evidence for the presence of β3-adrenergic receptor mRNA in the human brain

Rodriguez, M., Carillon, C., Coquerel, A., Fur, G. L., Ferrara, P., Caput, D., & Shire, D. J. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00274-i · Cited by 58 · see citing works

The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men

Schiffelers, S. L. H., Saris, W., & van Baak, M. A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801528 · Cited by 43 · see citing works

Measurement of leptin and leptin binding in the human circulation

Wallace, A. M. (2000) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/0004563001899311 · Cited by 36 · see citing works

Dobutamine as selective β1-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization

Schiffelers, S. L. H., van Harmelen, V., de Grauw, H. A. J., Saris, W. H. M., & van Baak, M. A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.977 · Cited by 34 · see citing works

In vivo β3-adrenergic stimulation of human thermogenesis and lipid use

Schiffelers, S. L. H. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.106794 · Cited by 34 · see citing works

Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man.

Blaak, E. E., SARIS, W. H. M., & van Baak, M. A. (1993) · PubMed · Cited by 31 · see citing works

The potential role of β3 adrenoceptor agonists In the treatment of obesity and diabetes

Himms‐Hagen, J., & Danforth, E. (1996) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199602000-00010 · Cited by 31 · see citing works

Effects of the two β3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects

Buemann, B., Toubro, S., & Astrup, A. V. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801452 · Cited by 30 · see citing works

Do β3-adrenoceptors mediate metabolic responses to isoprenaline

Wheeldon, N., McDEVITT, D. C., & Lipworth, B. (1993) · QJM · doi:10.1093/oxfordjournals.qjmed.a068850 · Cited by 30 · see citing works

Determination of β3‐Adrenoceptor Mediated Lipolysis in Human Fat Cells

Hoffstedt, J., Shimizu, M., Sjöstedt, S., & Lönnqvist, F. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00174.x · Cited by 25 · see citing works

1- and 2-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men

Schiffelers, S. L. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.5.2191 · Cited by 25 · see citing works

Determination of Glycerol in Plasma by an Automated Enzymatic Spectrophotometric Procedure

Li, R., Keymeulen, B., & Gerlo, E. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.006 · Cited by 11 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

Brown fat as a therapy for obesity and diabetes

Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376 · see citing works

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 279 · see citing works

Convertible visceral fat as a therapeutic target to curb obesity

Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 232 · see citing works

Human Brown Adipose Tissue: What We Have Learned So Far

Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223 · see citing works

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208 · see citing works

Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review

Montanari, T., Pošćić, N., & Colitti, M. (2017) · Obesity Reviews · doi:10.1111/obr.12520 · Cited by 189 · see citing works

Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works

The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation

Smorlesi, A., Frontini, A., Giordano, A., & Cinti, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01039.x · Cited by 163 · see citing works

Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men

Larsen, T. M., Toubro, S., van Baak, M. A., Gottesdiener, K. M., Larson, P., Saris, W. H., & Astrup, A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.780 · Cited by 179 · see citing works

Pharmacological Treatment of the Overweight Patient

Bray, G. A., & Greenway, F. L. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.2 · Cited by 167 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works

Brown adipose tissue and its therapeutic potential

Lidell, M. E., Betz, M. J., & Enerbäck, S. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12255 · Cited by 163 · see citing works

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works

The β3-adrenoceptor as a therapeutic target: Current perspectives

Ursino, M. G., Vasina, V. I., Raschi, E., Crema, F., & Ponti, F. D. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.002 · Cited by 156 · see citing works

The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes

Wang, L., Liu, J., Saha, P., Huang, J., Chan, L., Spiegelman, B. M., & Moore, D. D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.010 · Cited by 150 · see citing works

Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects

Belza, A., Frandsen, E., & Kondrup, J. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803351 · Cited by 149 · see citing works

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.074 · Cited by 148 · see citing works

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Schena, G., & Caplan, M. J. (2019) · Cells · doi:10.3390/cells8040357 · Cited by 146 · see citing works

Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

Wu, L., Xia, M., Duan, Y., Zhang, L., Jiang, H., Hu, X., Yan, H., Zhang, Y., Gu, Y., Shi, H., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1706-y · Cited by 135 · see citing works

Transdermal Delivery of Anti‐Obesity Compounds to Subcutaneous Adipose Tissue with Polymeric Microneedle Patches

Than, A., Liang, K., Xu, S., Sun, L., Duan, H., Xi, F., Xu, C., & Chen, P. (2017) · Small Methods · doi:10.1002/smtd.201700269 · Cited by 128 · see citing works

Small molecules for fat combustion: targeting obesity

Liu, J., Wang, Y., & Lin, L. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.09.007 · Cited by 123 · see citing works

Challenges in β 3 -adrenoceptor agonist drug development

Arch, J. R. S. (2011) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018811398517 · Cited by 117 · see citing works

HDAC11 suppresses the thermogenic program of adipose tissue via BRD2

Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120159 · Cited by 110 · see citing works

Discovery of Vibegron: A Potent and Selective β3Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Edmondson, S. D., Zhu, C. G., Kar, N. F., Salvo, J. D., Nagabukuro, H., Sacre-Salem, B., Dingley, K. H., Berger, R., Goble, S. D., Morriello, G. J., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01372 · Cited by 101 · see citing works

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

Arch, J. R. S. (2008) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-008-0271-1 · Cited by 96 · see citing works

β-Adrenergic Receptors and Adipose Tissue Metabolism: Evolution of an Old Story

Collins, S. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092939 · Cited by 98 · see citing works

Tools to study β3-adrenoceptors

Vrydag, W., & Michel, M. C. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-006-0127-5 · Cited by 94 · see citing works

Cooperative role of the glucagon‐like peptide‐1 receptor and β3‐adrenergic‐mediated signalling on fat mass reduction through the downregulation of PKA / AKT / AMPK signalling in the adipose tissue and muscle of rats

Decara, J. M., Rivera, P., Arrabal, S., Vargas, A., Serrano, A., Pavón, F. J., Diéguez, C., Nogueiras, R., de Fonseca, F. R., & Suárez, J. (2017) · Acta Physiologica · doi:10.1111/apha.13008 · Cited by 76 · see citing works

Pharmacological strategies for targeting BAT thermogenesis

Whittle, A. J., Relat, J., & Vidal‐Puig, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.004 · Cited by 76 · see citing works

Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system

Moens, A. L., Yang, R., Watts, V. L., & Barouch, L. A. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.011 · Cited by 74 · see citing works

β3-Adrenoceptor Is the Predominant β-Adrenoceptor Subtype in Human Myometrium and Its Expression Is Up-Regulated in Pregnancy

Rouget, C., Bardou, M., Breuiller-Fouché, M., Loustalot, C., Qi, H., Naline, E., Croci, T., CABROL, D., Advenier, C., & Leroy, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0233 · Cited by 70 · see citing works

Administration of Cyperus rotundus tubers extract prevents weight gain in obese Zucker rats

Lemaure, B., Touché, A., Zbinden, I., Moulin, J., Courtois, D., Macé, K., & Darimont, C. (2007) · Phytotherapy Research · doi:10.1002/ptr.2147 · Cited by 57 · see citing works

Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity

Liu, X., Cervantes, C. L., & Liu, F. (2017) · Protein & Cell · doi:10.1007/s13238-017-0378-6 · Cited by 48 · see citing works

Browning Epicardial Adipose Tissue: Friend or Foe?

Doukbi, E., Soghomonian, A., Sengenès, C., Ahmed, S., Ancel, P., Dutour, A., & Gaborit, B. (2022) · Cells · doi:10.3390/cells11060991 · Cited by 56 · see citing works

Role of β-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotien (ZAG)

Russell, S. T., & Tisdale, M. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.12.003 · Cited by 54 · see citing works

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging

Lee, H. H., An, S. M., Ye, B. J., Lee, J. H., Yoo, E. J., Jeong, G. W., Kang, H. J., Alfadda, A. A., Lim, S. W., Park, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11302-w · Cited by 52 · see citing works

Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation

Belza, A., & Jessen, A. B. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602121 · Cited by 52 · see citing works

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

Peng, X., Gennemark, P., O’Mahony, G., & Bartesaghi, S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00174 · Cited by 49 · see citing works

Potent oxindole based human β3 adrenergic receptor agonists

Stevens, F. C., Bloomquist, W. E., Borel, A. G., Cohen, M. L., Droste, C. A., Heiman, M. L., Kriauciunas, A., Sall, D. J., Tinsley, F. C., & Jesudason, C. D. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.09.011 · Cited by 49 · see citing works

Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

Bardou, M., Rouget, C., Breuiller-Fouché, M., Loustalot, C., Naline, E., Sagot, P., Frydman, R., Morcillo, E. J., Advenier, C., Leroy, M., et al. (2007) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-7-s1-s14 · Cited by 48 · see citing works

Biarylaniline Phenethanolamines as Potent and Selective β3Adrenergic Receptor Agonists

Uehling, D., Shearer, B. G., Donaldson, K. H., Chao, E. Y. H., Deaton, D. N., Adkison, K. K., Brown, K. K., Cariello, N. F., Faison, W. L., Lancaster, M. E., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0509445 · Cited by 40 · see citing works

Drugs in the Pipeline for the Obesity Market

Klonoff, D. C., & Greenway, F. L. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200525 · Cited by 39 · see citing works

Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling

Bagchi, R. A., Robinson, E. L., Hu, T., Cao, J., Hong, J. Y., Tharp, C. A., Qasim, H., Gavin, K. M., Silva, J. P. D., Major, J. L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119678119 · Cited by 40 · see citing works

Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity

Reddy, N. L., Tan, B. K., Barber, T. M., & Randeva, H. S. (2014) · BMC Obesity · doi:10.1186/s40608-014-0013-5 · Cited by 36 · see citing works

Attenuation of haemodynamic, metabolic and energy expenditure responses to isoproterenol in patients with hypertension

Valentini, M., Julius, S., Palatini, P., Brook, R. D., Bard, R. L., Bisognano, J. D., & Kaciroti, N. (2004) · Journal of Hypertension · doi:10.1097/00004872-200410000-00024 · Cited by 36 · see citing works

Targeting Energy Expenditure—Drugs for Obesity Treatment

Jimenez-Muñoz, C. M., López, M., Alberício, F., & Makowski, K. (2021) · Pharmaceuticals · doi:10.3390/ph14050435 · Cited by 35 · see citing works

Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus

Liu, T., Ji, R.-L., & Tao, Y.-X. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108044 · Cited by 34 · see citing works

Physiology and pathophysiology of the β3-adrenergic receptor

Yang, L.-K., & Tao, Y. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.09.003 · Cited by 32 · see citing works

Brown Adipose Tissue: A Human Perspective

Boon, M. R., & Lichtenbelt, W. D. V. M. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_11 · Cited by 33 · see citing works

Taurine in adipocytes prevents insulin-mediated H2o2 generation and activates Pka and lipolysis

Piña-Zentella, G., de la Rosa-Cuevas, G., Vázquez‐Meza, H., Piña, E., & de Piña, M. Z. (2011) · Amino Acids · doi:10.1007/s00726-011-0919-x · Cited by 32 · see citing works

Human brown adipose tissue — function and therapeutic potential in metabolic disease

Bhatt, P. S., Dhillo, W. S., & Salem, V. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.07.004 · Cited by 30 · see citing works

Small-Molecule Compounds that Modulate Lipolysis in Adipose Tissue: Targeting Strategies and Molecular Classes

Wang, M., & Fotsch, C. H. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.010 · Cited by 30 · see citing works

Insulin sensitisation in the treatment of Type 2 diabetes

Tadayyon, M., & Smith, S. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.3.307 · Cited by 30 · see citing works

Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo

Powell, D. R. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00220.x · Cited by 28 · see citing works

Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications

Cheong, L. Y., & Xu, A. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab038 · Cited by 27 · see citing works

Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F‐FDG Injection: A Preliminary Study with MicroPET

Wu, C., Cheng, W., Xing, H., Dang, Y., Li, F., & Zhu, Z. (2011) · BioMed Research International · doi:10.1155/2011/159834 · Cited by 26 · see citing works

Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles

Lorca, M., Morales-Verdejo, C. A., Vásquez, D., Andrades-Lagos, J., Campanini-Salinas, J., Soto‐Delgado, J., Recabarren‐Gajardo, G., & Mella, J. (2018) · Molecules · doi:10.3390/molecules23051191 · Cited by 26 · see citing works

Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment

Larson, C. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_184 · Cited by 25 · see citing works

Therapeutic prospects of metabolically active brown adipose tissue in humans

Betz, M. J. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00086 · Cited by 24 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00046.x · Cited by 23 · see citing works

Hormonal factors in the control of the browning of white adipose tissue

Hu, J., & Christian, M. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0017 · Cited by 22 · see citing works

Structural Basis for the β-Adrenergic Receptor Subtype Selectivity of the Representative Agonists and Antagonists

Roy, K. K., & Saxena, A. K. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci2000874 · Cited by 22 · see citing works

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

Sum, F., Wong, V. D., Han, S. C.-H., Largis, E. E., Mulvey, R., & Tillett, J. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00387-1 · Cited by 22 · see citing works

Sympathetic nerve-adipocyte interactions in response to acute stress

Santos, G. S. P., Costa, A. C., Picoli, C. C., Rocha, B. G. S., Sulaiman, S. O., Radicchi, D. C., Pinto, M. C. X., Júnior, M. L. B., Amorim, J. H., Azevedo, V., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02157-0 · Cited by 21 · see citing works

HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance

Robinson, E. L., Bagchi, R. A., Major, J. L., Bergman, B. C., Matsuda, J. L., & McKinsey, T. A. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168192 · Cited by 17 · see citing works

Potent and selective, sulfamide-based human β3-adrenergic receptor agonists

Dow, R. L., Paight, E. S., Schneider, S. R., Hadcock, J. R., Hargrove, D. M., Martin, K. A., Maurer, T. S., Nardone, N. A., Tess, D. A., & DaSilva-Jardine, P. A. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.03.089 · Cited by 16 · see citing works

Change in β1-adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss

RASMUSSEN, M., Belza, A., Almdal, T., Toubro, S., Bratholm, P. S., Astrup, A. V., & CHRISTENSEN, N. J. (2005) · Clinical Science · doi:10.1042/cs20040238 · Cited by 16 · see citing works

Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review

Perez, L. C., Perez, L. T., Nene, Y., Umpierrez, G. E., Davis, G. M., & Pasquel, F. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1037458 · Cited by 17 · see citing works

β3-Adrenoceptor ligand development history through patent review

Perrone, M. G., & Scilimati, A. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.561316 · Cited by 15 · see citing works

Short-term sympathoadrenal inhibition augments the thermogenic response to β-adrenergic receptor stimulation

Newsom, S. A., Richards, J. C., Johnson, T. K., Kuzma, J. N., Lonac, M. C., Paxton, R. J., Rynn, G. M., Voyles, W. F., & Bell, C. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0152 · Cited by 15 · see citing works

Distribution and quantification of β-3 adrenergic receptor in tissues of sheep

Wu, J. L., Wei-yi, L. I. U., Liu, J. H., Qiao, L., & Yuan, Y. (2010) · animal · doi:10.1017/s1751731110001564 · Cited by 14 · see citing works

Integrated control of brown adipose tissue.

Marzetti, E., D’Angelo, E., Savera, G., Leeuwenburgh, C., & Calvani, R. (2016) · PubMed · Cited by 13 · see citing works

Is the β3-Adrenoceptor a Valid Target for the Treatment of Obesity and/or Type 2 Diabetes?

Dwaib, H. S., & Michel, M. C. (2023) · Biomolecules · doi:10.3390/biom13121714 · Cited by 12 · see citing works

Physiological and metabolic functions of the β3-adrenergic receptor and an approach to therapeutic achievements

Samanta, S., Bagchi, D., & Bagchi, M. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01040-z · Cited by 12 · see citing works

Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes

Scheideler, M., Herzig, S., & Georgiadi, A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0043 · Cited by 12 · see citing works

The involvement of the adrenergic nervous system in activating human brown adipose tissue and browning

Pinto, Y. O., Festuccia, W. T., & Magdalon, J. (2022) · HORMONES · doi:10.1007/s42000-022-00361-2 · Cited by 12 · see citing works

Modulation of adipose tissue thermogenesis as a method for increasing energy expenditure

Sammons, M. F., & Price, D. A. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.12.016 · Cited by 12 · see citing works

Brown adipose tissue and its therapeutic application

Yuan, X., Dong, M., Lee, H. J., & Jin, W. (2016) · 中国科学通报：英文版 · doi:10.1007/s11434-016-1051-9 · Cited by 11 · see citing works

Pharmacological Treatment of the Overweight Patient

(2007) · Humana Press eBooks · doi:10.1007/978-1-59745-431-5_9 · Cited by 9 · see citing works

Potent benzimidazolone based human β3-adrenergic receptor agonists

Finley, D. R., Bell, M. G., Borel, A. G., Bloomquist, W. E., Cohen, M. L., Heiman, M. L., Kriauciunas, A., Matthews, D. P., Miles, T., Neel, D. A., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.010 · Cited by 9 · see citing works

Combination of a Beta Adrenoceptor Modulator and a Norepinephrine-Serotonin Uptake Inhibitor for the Treatment of Obesity

Jesudason, C. D., Baker, J. E., Bryant, R. D., Fisher, J. W., O’Farrell, L. S., Gaich, G. A., He, M. M., Kahl, S. D., Kriauciunas, A., Heiman, M. L., et al. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200071k · Cited by 7 · see citing works

Increased thermogenic responsiveness to intravenous β‐adrenergic stimulation in habitually exercising humans is not related to skeletal muscle β2‐adrenergic receptor density

Stob, N. R., Seals, D. R., Jensen, J., van Baak, M. A., Steig, A. J., Lindstrom, R. C., Bikman, B. T., & Bell, C. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.038174 · Cited by 7 · see citing works

Thermogenic responsiveness to nonspecific β-adrenergic stimulation is not related to genetic variation in codon 16 of the β2-adrenergic receptor

Bell, C., Stob, N. R., & Seals, D. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00411.2005 · Cited by 7 · see citing works

Effect of the β3 adrenoceptor agonist CL 316243 on hypothalamic 5-HT synthesis and suppression of REM sleep in the rat

Conley, R. K., Li, J., Ivarsson, M., & Hutson, P. H. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106070424 · Cited by 6 · see citing works

Weight-Loss Drugs

Bray, G. A., & Greenway, F. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_18 · Cited by 4 · see citing works

Targeting Thermogenesis in the Development of Antiobesity Drugs

McPherson, R., Tesson, F., Dent, R., & Harper, M. (2004) · CRC Press eBooks · doi:10.1201/9780203508756.ch18 · Cited by 3 · see citing works

Targeting Thermogenesis in the Development of Antiobesity Drugs

Mcpherson, R., Tesson, F., Dent, R., & Harper, M.-E. (2004) · CRC Press eBooks · doi:10.1201/9780203508756-30 · Cited by 3 · see citing works

Brown Adipose Tissue: A New Target for Antiobesity Therapy

Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i2.115 · Cited by 2 · see citing works

β 3 -AR Agonists for the Treatment of Overactive Bladder

Edmondson, S. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12788-x · Cited by 2 · see citing works

Effects of ethanol extract of Polygonatum sibiricum rhizome on obesity-related genes

Jeon, W.-J., Lee, D.-S., Shon, S.-Y., Seo, Y.-J., Yeon, S.-W., & Kang, J. (2016) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2016.48.4.384 · Cited by 1 · see citing works

Genetics and Potential Treatments of Obesity

Fernández, J. R., & GOLDSTEIN, D. J. (2005) · Humana Press eBooks · doi:10.1385/1-59259-865-x:293 · Cited by 1 · see citing works

A Status of Drugs on the Horizon for Obesity and the Metabolic Syndrome—a Comprehensive Review 2005

Greenway, F. L., & Bray, G. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-32164-6_16

Zukunftsperspektiven der medikamentösen Therapie bei Adipositas

Pichler, B., & Ludvik, B. H. (2003) · Journal für Kardiologie (Krause & Pachernegg GmbH)

Browning of Adipose Organ

Cinti, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_6

Temperature effects on human leptin physiology: possible implications for the regulation of body composition

Zeyl, A. (2006) · Research Online (University of Wollongong)

First step to losing fat: central melanocortin signaling and sympathetic lipolytic drive

Berthoud, H.-R. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00575.2005

Pharmacotherapy of obesity in the near term

Penn, M., & GOLDSTEIN, D. J. (2003) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200310000-00001

A Função Endócrino-Metabólica do Tecido Adiposo Castanho e a sua aplicabilidade na prevenção e tratamento da obesidade

Teixeira, J. P. L. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/qkgy-km28

Future Developments in the Area of Pharmacotherapy

Barb, D., Shetty, G. K., & Mantzoros, C. S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_29

Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men

Larsen, T. M., Toubro, S., van Baak, M. A., Gottesdiener, K. M., Larson, P., Saris, W. H., & Astrup, A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.780 · Cited by 179 · see citing works

Acute effect of L-796568, a novel beta3-adrenergic receptor agonist, on nergy expenditure in obese men

van Baak, M. A., Hul, G. B. J., Toubro, S., Astrup, A., Gotteschiener, K. M., DeSmet, M., & Saris, W. H. M. (2002) · Research at the University of Copenhagen (University of Copenhagen)

Effect of a 28-d treatment with L-796568, a novel ß3-adrenergic receptor agonist, on energy expenditure and body composition in obese men

Larsen, T. M., Toubro, S., van Baak, M. A., Gotteschiener, K. M., Larson, P., Saris, W. H. M., & Astrup, A. (2002) · Research at the University of Copenhagen (University of Copenhagen)

Acute and chronic effects of FR-149175, a β3-adrenergic receptor agonist, on energy expenditure in Zucker fatty rats

Hatakeyama, Y., Sakata, Y., Takakura, S., Manda, T., & Mutoh, S. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00131.2004 · Cited by 16 · see citing works

No thermogenic effect after 28 days treatment with L-796,568 a novel beta3-adrenoceptor agonist, in obese men

Larsen, T. M., Toubro, S., van Baak, M. A., Gotteschiener, K. M., Larson, P., Saris, W. H. M., & Astrup, A. (2000) · Research at the University of Copenhagen (University of Copenhagen)