Human Brown Adipose Tissue: What We Have Learned So Far

Brown Adipose Tissue: Function and Physiological Significance

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Identification and Importance of Brown Adipose Tissue in Adult Humans

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Cold-Activated Brown Adipose Tissue in Healthy Men

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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

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Functional Brown Adipose Tissue in Healthy Adults

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PRDM16 controls a brown fat/skeletal muscle switch

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

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Unexpected evidence for active brown adipose tissue in adult humans

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Brown adipose tissue activity controls triglyceride clearance

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A role for brown adipose tissue in diet-induced thermogenesis

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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

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Transcriptional Control of Brown Fat Determination by PRDM16

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

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Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

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Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

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Recruited brown adipose tissue as an antiobesity agent in humans

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Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

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Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

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The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

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Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

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Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

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Evidence for two types of brown adipose tissue in humans

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Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

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Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

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Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

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The distribution of brown adipose tissue in the human.

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BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

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Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

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Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans

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FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

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Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

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A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

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Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

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Brown Adipose Tissue, Whole‐Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

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Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

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β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse

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Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

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Brown Adipose Tissue in Morbidly Obese Subjects

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Human Brown Adipose Tissue

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A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

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Cold but not sympathomimetics activates human brown adipose tissue in vivo

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Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

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"USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT.

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Strain-Specific Response toβ3-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice1

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Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

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Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats

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Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue

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Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man

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Impaired expression and functional activity of the beta 3- and beta 1- adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice

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Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

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Functional thermogenic beige adipogenesis is inducible in human neck fat

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Uncoupling protein 1 expression and high-fat diets

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Ephedrine activates brown adipose tissue in lean but not obese humans

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White-to-brown metabolic conversion of human adipocytes by JAK inhibition

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Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature

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Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

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Growth and distribution of human fetal brown fat

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Browning of white fat: does irisin play a role in humans?

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High Prevalence of Brown Adipose Tissue in Adult Humans

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Thyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats

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Hyperthyroidism Increases Brown Fat Metabolism in Humans

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